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Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 09/2014, Volume 34, Issue 9, pp. 2078 - 2085
OBJECTIVE—In a phase III clinical trial (PLATelet inhibition and patient Outcomes, PLATO), ticagrelor provided better clinical outcomes than clopidogrel in... 
adenosine | aspirin | cyclooxygenase | platelet aggregation inhibitors | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Receptor, Adenosine A1 - physiology | Ticlopidine - therapeutic use | Nitric Oxide Synthase Type III - biosynthesis | Adenosine A1 Receptor Antagonists - pharmacology | Male | Receptor, Adenosine A2A - physiology | Cardiotonic Agents - therapeutic use | Cyclooxygenase 2 - biosynthesis | Myocardial Reperfusion Injury - pathology | Cyclooxygenase 2 - genetics | Adenosine - therapeutic use | Myocardial Infarction - pathology | Enzyme Induction - drug effects | Nitric Oxide Synthase Type III - physiology | Aspirin - pharmacology | Myocardial Reperfusion Injury - drug therapy | Drug Evaluation, Preclinical | Pyrazoles - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Rats | Cyclooxygenase 2 - physiology | Adenosine - pharmacology | Cardiotonic Agents - pharmacology | Nitric Oxide Synthase Type III - genetics | Rats, Sprague-Dawley | Ticlopidine - analogs & derivatives | Triazoles - pharmacology | Up-Regulation - drug effects | Adenosine A2 Receptor Antagonists - pharmacology | Animals | Myocardial Infarction - drug therapy | Adenosine - analogs & derivatives | Adenosine - physiology | 6-Ketoprostaglandin F1 alpha - metabolism | Quinazolines - pharmacology | Lipoxins - metabolism | Myocardial Reperfusion Injury - prevention & control | Index Medicus
Journal Article
Journal Article
European heart journal, ISSN 0195-668X, 09/2012, Volume 33, Issue 17, pp. 2151 - 2162
Aims CYP3A4-metabolized statins can influence the pharmacodynamic effect of clopidogrel. We sought to assess the impact of switching to a... 
Atorvastatin | Clopidogrel | Platelet | Non-CYP3A4-metabolized statin | High platelet reactivity | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Prospective Studies | Ticlopidine - therapeutic use | Heptanoic Acids - therapeutic use | Humans | Middle Aged | Calcium Channel Blockers - therapeutic use | Cytochrome P-450 CYP3A - physiology | Male | Pyrimidines - metabolism | Fluorobenzenes - pharmacology | Cytochrome P-450 CYP3A - genetics | Platelet Aggregation Inhibitors - pharmacology | Female | Aspirin - therapeutic use | Platelet Aggregation - drug effects | Drug Therapy, Combination | Platelet Aggregation Inhibitors - therapeutic use | Pyrroles - therapeutic use | Pravastatin - therapeutic use | Heptanoic Acids - pharmacology | Pravastatin - pharmacology | Fluorobenzenes - metabolism | Pravastatin - metabolism | Rosuvastatin Calcium | Genotype | Coronary Artery Disease - drug therapy | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Ticlopidine - analogs & derivatives | Adenosine Diphosphate - pharmacology | Pyrroles - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Sulfonamides - therapeutic use | Pyrimidines - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Sulfonamides - metabolism | Drug Substitution | Fluorobenzenes - therapeutic use | Percutaneous Coronary Intervention | Index Medicus
Journal Article
Journal of thrombosis and haemostasis, ISSN 1538-7836, 12/2007, Volume 5, Issue 12, pp. 2429 - 2436
Background: Thienopyridines are metabolized to active metabolites that irreversibly inhibit the platelet P2Y12 adenosine diphosphate receptor. The... 
clopidogrel | P2Y12 receptor | prasugrel | platelet function | thienopyridines | cytochrome P450 enzymes | Prasugrel | Cytochrome P450 enzymes | receptor | P2Y | Platelet function | Thienopyridines | Clopidogrel | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Cytochrome P-450 CYP2C9 | Prasugrel Hydrochloride | Ticlopidine - pharmacology | Area Under Curve | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Male | Mixed Function Oxygenases - metabolism | Reference Values | Thiophenes - blood | Platelet Aggregation Inhibitors - blood | Receptors, Purinergic P2Y12 | Platelet Aggregation Inhibitors - pharmacology | Adult | Female | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - pharmacokinetics | Retrospective Studies | Ticlopidine - pharmacokinetics | Piperazines - pharmacokinetics | Blood Platelets - drug effects | Piperazines - blood | Purinergic P2 Receptor Antagonists | Thiophenes - pharmacology | Genotype | Clinical Trials as Topic | Piperazines - pharmacology | Ticlopidine - analogs & derivatives | Aryl Hydrocarbon Hydroxylases - metabolism | Polymorphism, Genetic | Cross-Over Studies | Thiophenes - pharmacokinetics | Phenotype | Prodrugs - pharmacokinetics | Blood Platelets - metabolism | Cytochrome P-450 CYP2C19 | Receptors, Purinergic P2 - metabolism | Mixed Function Oxygenases - genetics | Prodrugs - pharmacology | Research Design | Ticlopidine - blood | Adenosine diphosphate | Genetic aspects | Metabolites | Cytochrome P-450 | Index Medicus
Journal Article