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Nature, ISSN 0028-0836, 04/2017, Volume 544, Issue 7651, pp. 488 - 492
Journal Article
Laboratory Investigation, ISSN 0023-6837, 09/2010, Volume 90, Issue 9, pp. 1365 - 1372
Journal Article
American Journal of Surgery, The, ISSN 0002-9610, 2016, Volume 211, Issue 1, pp. 197 - 205
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2005, Volume 25, Issue 20, pp. 4917 - 4929
Although traditionally recognized for maintaining extracellular matrix integrity during morphogenesis, the function of matrix metalloproteinases ( MMPs) and... 
MMP | Integrin | Cell cycle | Proliferation | Differentiation | Neurogenesis | Neurite outgrowth | TIMP | ACTIVATION | differentiation | proliferation | cell cycle | MAP KINASE | CELL-ADHESION | NEUROSCIENCES | NERVE GROWTH-FACTOR | MATRIX METALLOPROTEINASES | neurogenesis | neurite outgrowth | integrin | PC12 CELLS | EXPRESSION | SPATIAL-DISTRIBUTION | Phosphotransferases - metabolism | Flow Cytometry - methods | Neurons - cytology | Cerebral Cortex - cytology | Molecular Biology - methods | Mitogen-Activated Protein Kinase Kinases - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Drug Interactions | Isoquinolines - pharmacology | Transfection - methods | Time Factors | Tissue Inhibitor of Metalloproteinase-2 - pharmacology | Bromodeoxyuridine - metabolism | Tissue Inhibitor of Metalloproteinase-2 - deficiency | Neurons - drug effects | Cell Differentiation - physiology | Cyclic AMP - metabolism | Animals, Newborn | Green Fluorescent Proteins - metabolism | rap1 GTP-Binding Proteins - metabolism | Blotting, Western - methods | ras GTPase-Activating Proteins - metabolism | Adenine - analogs & derivatives | Immunoprecipitation - methods | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Cells, Cultured | Enzyme Inhibitors - pharmacology | Nerve Growth Factor - pharmacology | Rats | Adenine - pharmacology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Cyclin-Dependent Kinase 5 - metabolism | Mice, Knockout | Gene Expression Regulation - drug effects | Immunohistochemistry - methods | Electrophoretic Mobility Shift Assay - methods | Animals | Mitosis - drug effects | Neurturin - drug effects | Mitosis - physiology | Signal Transduction - drug effects | Cell Differentiation - drug effects | Cell Cycle - physiology | Blotting, Northern - methods | Mice | Cell Cycle - drug effects | Index Medicus
Journal Article
Microbial Cell Factories, ISSN 1475-2859, 04/2017, Volume 16, Issue 1, pp. 73 - 73
Background: As regulators of multifunctional metalloproteinases including MMP, ADAM and ADAMTS families, tissue inhibitors of metalloproteinases (TIMPs) play a... 
Tissue inhibitor of metalloproteinase | Periplasmic expression | Disulfide isomerase | Matrix metalloproteinase | Contact guidance | CELLS | TIMP-1 | BINDING-PROTEIN | GLYCOSYLATION | AMINO-TERMINAL DOMAIN | MATRIX METALLOPROTEINASES | OVEREXPRESSION | PROGELATINASE | IN-VITRO | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PURIFICATION | Recombinant Proteins - metabolism | Tissue Inhibitor of Metalloproteinase-1 - pharmacology | Periplasm - enzymology | Protein Disulfide-Isomerases - metabolism | Humans | Solubility | Protein Folding | Tissue Inhibitor of Metalloproteinase-2 - genetics | Epitopes - immunology | Metalloproteases - antagonists & inhibitors | Tissue Inhibitor of Metalloproteinase-1 - genetics | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Protein Disulfide-Isomerases - genetics | Periplasm - metabolism | Tissue Inhibitor of Metalloproteinase-2 - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Tissue Inhibitor of Metalloproteinase-2 - pharmacology | Tissue Inhibitor of Metalloproteinase-1 - chemistry | Cell culture | Media (culture) | Leukocyte migration | Escherichia coli | Cytology | Antibodies | Arthritis | Metastasis | Tissue inhibitor of metalloproteinase 2 | Tissue inhibitor of metalloproteinase 1 | Monomers | Cell morphology | Proteins | E coli | Inclusion bodies | Periplasmic space | Fibroblasts | Chemical bonds | Extracellular matrix | Physiology | Enzyme-linked immunosorbent assay | Interstitial collagenase | Disulfide bonds | ADAM protein | Secretion | Bioassays | T cell receptors | Epitopes | Mutants | Neurological diseases | Inhibitors | Insects | Arteriosclerosis | Culture media | Cell migration | Cancer | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 2003, Volume 114, Issue 2, pp. 171 - 180
Tissue inhibitors of metalloproteinases (TIMPs) suppress matrix metalloproteinase (MMP) activity critical for extracellular matrix turnover associated with... 
ACTIVATION | INVASION | ENDOTHELIAL-CELL PROLIFERATION | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | METALLOPROTEINASE INHIBITORS | TISSUE INHIBITOR | ALPHA-3-BETA-1 | TUMOR-GROWTH | CANCER | PROTEIN-TYROSINE-PHOSPHATASE | CELL BIOLOGY | Endothelium, Vascular - cytology | Neovascularization, Physiologic - drug effects | Vascular Endothelial Growth Factor A | Endothelial Growth Factors - metabolism | Receptor, Fibroblast Growth Factor, Type 1 | Humans | Endothelium, Vascular - drug effects | Protein Tyrosine Phosphatases - metabolism | Protein Tyrosine Phosphatases - drug effects | Tissue Inhibitor of Metalloproteinase-2 - genetics | Dose-Response Relationship, Drug | Integrin alpha3beta1 - metabolism | Vanadates - pharmacology | Tissue Inhibitor of Metalloproteinase-2 - pharmacology | Fibroblast Growth Factor 2 - metabolism | Receptors, Fibroblast Growth Factor | Fibroblasts - metabolism | Binding, Competitive | Angiogenesis Inhibitors - genetics | Receptor Protein-Tyrosine Kinases - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Angiogenesis Inhibitors - pharmacology | Intracellular Signaling Peptides and Proteins | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Recombinant Proteins - pharmacology | Cell Division - drug effects | Neovascularization, Physiologic - physiology | Animals | Embryo, Mammalian - cytology | Endothelium, Vascular - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 | Mice | Matrix Metalloproteinases - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 | Cell proliferation | Chemical inhibitors | Cell research | Analysis | Physiological aspects | Genetic aspects | Neovascularization | Metalloproteins | Endothelium | Index Medicus
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 28, pp. 26322 - 26334
Recent studies have shown that MMP-14 is highly expressed in a panel of human solid tumors and poses as a potential molecular target for anticancer drugs.... 
TIMP2 | Targeted therapeutics | Fusion protein | Antitumor efficacy | MMP-14 | TIMP-2 | ANGIOGENESIS | MATRIX METALLOPROTEINASE-14 | TISSUE INHIBITORS | antitumor efficacy | CANCER | CELL BIOLOGY | fusion protein | INVASION | PEPTIDES | GROWTH | targeted therapeutics | TUMOR MICROENVIRONMENT | Neovascularization, Physiologic - drug effects | Recombinant Fusion Proteins - pharmacology | Aminoglycosides - genetics | Humans | Molecular Targeted Therapy | Tissue Inhibitor of Metalloproteinase-2 - genetics | Esophageal Neoplasms - pathology | Dose-Response Relationship, Drug | Time Factors | Colorectal Neoplasms - drug therapy | Drug Design | Protein Engineering | Tissue Inhibitor of Metalloproteinase-2 - biosynthesis | Tissue Inhibitor of Metalloproteinase-2 - pharmacology | Antineoplastic Agents - pharmacology | Colorectal Neoplasms - enzymology | Human Umbilical Vein Endothelial Cells - drug effects | Angiogenesis Inhibitors - pharmacology | Matrix Metalloproteinase 14 - metabolism | Xenograft Model Antitumor Assays | Matrix Metalloproteinase Inhibitors - pharmacology | Esophageal Neoplasms - enzymology | Animals | Human Umbilical Vein Endothelial Cells - enzymology | Tumor Burden - drug effects | Mice, Nude | Aminoglycosides - biosynthesis | Cell Line, Tumor | Enediynes - pharmacology | Protein Binding | Aminoglycosides - pharmacology | Colorectal Neoplasms - pathology | Esophageal Neoplasms - drug therapy | Index Medicus
Journal Article
Journal Article
Blood, ISSN 0006-4971, 12/2012, Volume 120, Issue 24, pp. 4892 - 4902
Journal Article
Journal Article