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Brain, ISSN 0006-8950, 2012, Volume 135, Issue 11, pp. 3251 - 3264
The neurovascular unit provides a dynamic interface between the circulation and central nervous system. Disruption of neurovascular integrity occurs in... 
traumatic brain injury | matrix metalloproteinase-3 | plasminogen activator inhibitor-1 | tissue plasminogen activator | neurovascular unit | MULTIPLE-SCLEROSIS LESIONS | RECEPTOR-RELATED PROTEIN | TPA | FOCAL CEREBRAL-ISCHEMIA | BARRIER BREAKDOWN | NEUROSCIENCES | CLINICAL NEUROLOGY | STROKE | MATRIX METALLOPROTEINASES | CENTRAL-NERVOUS-SYSTEM | EXPRESSION | BLOOD | Capillary Permeability - physiology | Tissue Plasminogen Activator - metabolism | Brain Injuries - drug therapy | Humans | Middle Aged | Injections, Intraventricular | Capillary Permeability - drug effects | Male | Brain Injuries - metabolism | Brain Injuries - physiopathology | Plasminogen Activator Inhibitor 1 - physiology | Matrix Metalloproteinase Inhibitors - therapeutic use | Brain - metabolism | Dose-Response Relationship, Drug | Brain - blood supply | Tissue Plasminogen Activator - antagonists & inhibitors | Plasminogen Activator Inhibitor 1 - metabolism | Aged, 80 and over | Recovery of Function - physiology | Adult | Disease Models, Animal | Albumins - metabolism | Mice, Inbred C57BL | Plasminogen Activator Inhibitor 1 - administration & dosage | Tissue Plasminogen Activator - administration & dosage | Tissue Plasminogen Activator - physiology | Animals | Brain Injuries - cerebrospinal fluid | Aged | Mice | Matrix Metalloproteinases - metabolism | Stroke | Central nervous system | Membrane permeability | Albumin | Homeostasis | Cerebrospinal fluid | Matrix metalloproteinase | Permeability | Trauma | Plasmin | t-Plasminogen activator | lipoprotein receptors | neuroserpin | plasminogen | Proteolysis | Plasma membranes | Chromium | Serine proteinase | Brain injury | Original
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2008, Volume 14, Issue 7, pp. 731 - 737
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2005, Volume 280, Issue 43, pp. 36529 - 36540
The invasive ability of tumor cells plays a key role in prostate cancer metastasis and is a major cause of treatment failure. Urokinase plasminogen... 
MIGRATION | VITRO | GROWTH-FACTOR-RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | GENE-EXPRESSION | DOWN-REGULATION | UPA PROMOTER | TUMOR-GROWTH | ANTISENSE OLIGONUCLEOTIDES | CATHEPSIN-B | Laminin - pharmacology | Neoplasm Transplantation | Prostatic Neoplasms - metabolism | Cell Proliferation | Humans | Extracellular Matrix - metabolism | Collagen - chemistry | Immunoblotting | Male | Proteoglycans - chemistry | Neoplasm Metastasis | Transfection | RNA Interference | Time Factors | Collagen - pharmacology | Prostatic Neoplasms - pathology | Signal Transduction | Cell Survival | Neoplasm Invasiveness | Electrophoresis, Polyacrylamide Gel | Gene Silencing | Tetrazolium Salts - pharmacology | Urokinase-Type Plasminogen Activator - genetics | Reverse Transcriptase Polymerase Chain Reaction | Plasmids - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Proteoglycans - pharmacology | Urokinase-Type Plasminogen Activator - metabolism | Mice, Nude | Cell Line, Tumor | Laminin - chemistry | Mice | Thiazoles - pharmacology | Neoplasms - pathology | Drug Combinations | Microscopy, Fluorescence | Apoptosis | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | RNAi | uPAR (uPA receptor) | shRNA (small hairpin RNA) | uPA (urokinaseplasminogen activator) | survival | siRNA (small interfering RNA) | prostate cancer | invasion | uPA and uPAR | ANOVA (analysis of variance) | RNAi (RNA interference) | RT (reverse transcription) | TPBS (tween-20 (0.1%) phospate buffered saline) | BSA (bovine serum albumin)
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 05/2013, Volume 32, Issue 18, pp. 2282 - 2291
Cystic fibrosis (CF) transmembrane conductance regulator (CFTR) is expressed in the epithelial cells of a wide range of organs/tissues from which most cancers... 
CFTR | miR-193b | uPA | MUC4 EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC ADENOCARCINOMA | CELL MIGRATION | MESENCHYMAL TRANSITION | MIR-200 FAMILY | CELL BIOLOGY | TRANSMEMBRANE CONDUCTANCE REGULATOR | BREAST-CANCER | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | GENETICS & HEREDITY | NF-KAPPA-B | CYSTIC-FIBROSIS GENE | Prostatic Neoplasms - metabolism | Receptors, Urokinase Plasminogen Activator - immunology | Humans | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Male | Cell Movement - genetics | Gene Knockdown Techniques | Prostatic Neoplasms - genetics | Base Sequence | Female | Urokinase-Type Plasminogen Activator - immunology | Prostatic Neoplasms - pathology | Down-Regulation | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Urokinase-Type Plasminogen Activator - genetics | Receptors, Urokinase Plasminogen Activator - metabolism | Xenograft Model Antitumor Assays | Animals | Urokinase-Type Plasminogen Activator - metabolism | Mice, Nude | Cell Line, Tumor | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Mice | MicroRNAs - genetics | Receptors, Urokinase Plasminogen Activator - genetics | Urokinase | Tissue plasminogen activator | Physiological aspects | Development and progression | Tumor suppressor genes | Genetic aspects | Research | Prostate cancer | Cystic fibrosis | Membranes | Tumors
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2003, Volume 112, Issue 10, pp. 1533 - 1540
The regulation of cerebrovascular permeability is critical for normal brain homeostasis, and the "breakdown" of the blood-brain barrier (BBB) is associated... 
THERAPEUTIC WINDOW | MEDICINE, RESEARCH & EXPERIMENTAL | TPA-DEFICIENT MICE | NERVOUS-SYSTEM | WILD-TYPE | GENE | FOCAL CEREBRAL-ISCHEMIA | GELATINASE-B | MATRIX-METALLOPROTEINASE-9 | LIPOPROTEIN RECEPTOR | LONG-TERM POTENTIATION
Journal Article