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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/1999, Volume 96, Issue 4, pp. 1603 - 1608
Mutations in the adenomatous polyposis coli or β -catenin gene lead to cytosolic accumulation of β -catenin and, subsequently, to increased transcriptional... 
Messenger RNA | Transfection | Tissue samples | RNA | B lymphocytes | Epithelial cells | Genes | Cell lines | Colorectal neoplasms | Genetic mutation | COLON-CANCER | RECEPTOR-BOUND UROKINASE | TRANSCRIPTIONAL ACTIVATION | PROTEIN | PLASMINOGEN-ACTIVATOR | ALPHA-CATENIN | MULTIDISCIPLINARY SCIENCES | XENOPUS EMBRYOS | E-CADHERIN | EXPRESSION | BINDING | Adenocarcinoma | Cell Polarity | Intestinal Mucosa - metabolism | Cytoskeletal Proteins - genetics | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | NF-kappa B - metabolism | Transcription Factor AP-1 - metabolism | Genes, APC | Intestinal Mucosa - cytology | Receptors, Urokinase Plasminogen Activator | Cytoskeletal Proteins - metabolism | Transcription, Genetic | Tumor Cells, Cultured | Colorectal Neoplasms - metabolism | Genes, jun | Recombinant Proteins - metabolism | Cell Line | Promoter Regions, Genetic | Signal Transduction | beta Catenin | Colon - pathology | Membrane Proteins - genetics | Proto-Oncogene Proteins c-jun - genetics | Trans-Activators | Cadherins - physiology | Phosphoproteins - genetics | Zonula Occludens-1 Protein | NF-kappa B - genetics | Urokinase-Type Plasminogen Activator - metabolism | Models, Biological | Proto-Oncogene Proteins c-fos - genetics | Colorectal Neoplasms - pathology | Neoplasm Staging | Colonic Neoplasms | Intestinal Mucosa - pathology | Receptors, Cell Surface - genetics | T cells | Colorectal cancer | Research | Biological Sciences
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 05/2013, Volume 138, Issue 2, pp. 155 - 175
Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are important for... 
Parkinson's | GDNF | NGF | Trk | BDNF | Alzheimer's | FOREBRAIN CHOLINERGIC NEURONS | NERVE-GROWTH-FACTOR | AMYOTROPHIC-LATERAL-SCLEROSIS | NEUROTROPHIC FACTOR GDNF | NIGRAL DOPAMINERGIC-NEURONS | MOUSE MODEL | PHARMACOLOGY & PHARMACY | BASAL FOREBRAIN | LONG-TERM POTENTIATION | CONVECTION-ENHANCED DELIVERY | UP-REGULATES BDNF | Humans | Models, Molecular | Nerve Growth Factors - administration & dosage | Nerve Growth Factors - chemistry | Nerve Growth Factors - metabolism | Neurodegenerative Diseases - metabolism | Neurodegenerative Diseases - drug therapy | Glial Cell Line-Derived Neurotrophic Factor - administration & dosage | Nerve Growth Factors - therapeutic use | Brain-Derived Neurotrophic Factor - administration & dosage | Brain-Derived Neurotrophic Factor - chemistry | Glial Cell Line-Derived Neurotrophic Factor - metabolism | Animals | Glial Cell Line-Derived Neurotrophic Factor - therapeutic use | Ligands | Brain-Derived Neurotrophic Factor - metabolism | Brain-Derived Neurotrophic Factor - therapeutic use | Glial Cell Line-Derived Neurotrophic Factor - chemistry | Brain | Enzymes | Care and treatment | Inositol | Glycogen | Tissue plasminogen activator | Amyloid beta-protein | Amyotrophic lateral sclerosis | Nerve growth factor | Superoxide | Apolipoproteins | Transforming growth factors | Synthesis | Choline | Bone morphogenetic proteins | Dopa | Alzheimer's disease | Intermediate filament proteins | Injuries | Protein binding
Journal Article
Cancer Science, ISSN 1347-9032, 07/2016, Volume 107, Issue 7, pp. 1039 - 1046
Antibody–drug conjugates deliver anticancer agents selectively and efficiently to tumor tissue and have significant antitumor efficacy with a wide therapeutic... 
topoisomerase I inhibitor | HER | bystander killing | Antibody‐drug conjugate | T-DM | HER2 | Antibody-drug conjugate | HODGKINS LYMPHOMA | GEMTUZUMAB OZOGAMICIN | ADVANCED BREAST-CANCER | BRENTUXIMAB VEDOTIN | ACUTE MYELOID-LEUKEMIA | TRASTUZUMAB EMTANSINE | CHALLENGES | THERAPY | ONCOLOGY | EXPRESSION | CATHEPSIN-B | Receptor, ErbB-2 - genetics | Breast Neoplasms - immunology | Humans | Stomach Neoplasms - pathology | Maytansine - pharmacology | Immunoconjugates - immunology | Breast Neoplasms - enzymology | Immunoconjugates - pharmacology | Topoisomerase I Inhibitors - pharmacology | Neoplasms - genetics | Antibodies, Monoclonal, Humanized - pharmacology | Female | Camptothecin - immunology | Receptor, ErbB-2 - immunology | Camptothecin - analogs & derivatives | Stomach Neoplasms - enzymology | Stomach Neoplasms - genetics | Maytansine - analogs & derivatives | Neoplasms - enzymology | Stomach Neoplasms - immunology | Animals | Breast Neoplasms - genetics | Bystander Effect - drug effects | Breast Neoplasms - pathology | Mice, Nude | Neoplasms - immunology | Cell Membrane Permeability - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Antibodies, Monoclonal, Humanized - immunology | Neoplasms - pathology | Camptothecin - pharmacology | Maytansine - immunology | Trastuzumab | Viral antibodies | Epidermal growth factor | Imaging systems | Antibodies | Permeability | Drug therapy | Biopharmaceutics | Tumors | Antigens | Hematology | Laboratories | Toxicity | DNA topoisomerase | Polymerization | Clinical trials | Cytotoxicity | Breast cancer | ErbB-2 protein | Stomach cancer | Hypotheses | Antitumor agents | Xenografts | Antitumor activity | Lymphomas | Drug dosages | Payloads | Index Medicus | T‐DM | Original
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 07/2009, Volume 9, Issue 7, pp. 491 - 502
Journal Article
Genes and Development, ISSN 0890-9369, 05/2008, Volume 22, Issue 10, pp. 1276 - 1312
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as prototypes for growth factor and receptor tyrosine kinase function for more... 
Development | PDGF receptor | Platelet-derived growth factor | Fibrosis | Cancer | development | platelet-derived growth factor | DEVELOPMENTAL BIOLOGY | FACTOR-B-CHAIN | FACTOR-RECEPTOR-BETA | CELL BIOLOGY | SIMIAN SARCOMA-VIRUS | GENETICS & HEREDITY | PDGF-ALPHA-RECEPTOR | FACTOR-A-CHAIN | TYROSINE KINASE INHIBITOR | cancer | fibrosis | SMOOTH-MUSCLE-CELLS | IDIOPATHIC HYPEREOSINOPHILIC SYNDROME | HEPARAN-SULFATE PROTEOGLYCANS | GASTROINTESTINAL STROMAL TUMORS | Receptors, Vascular Endothelial Growth Factor - physiology | Genetic Predisposition to Disease | Receptors, Platelet-Derived Growth Factor - antagonists & inhibitors | Embryo, Mammalian | Humans | Embryonic Development - genetics | Receptors, Platelet-Derived Growth Factor - genetics | Receptors, Platelet-Derived Growth Factor - physiology | Vascular Endothelial Growth Factor A - genetics | Platelet-Derived Growth Factor - genetics | Organogenesis | Disease - etiology | Tissue Distribution | Platelet-Derived Growth Factor - metabolism | Animals | Models, Biological | Signal Transduction - physiology | Polymorphism, Single Nucleotide | Receptors, Vascular Endothelial Growth Factor - genetics | Bone and Bones - embryology | Nervous System - embryology | Platelet-Derived Growth Factor - physiology | Vascular Endothelial Growth Factor A - physiology | Cardiovascular System - embryology | Tyrosine | Hematopoiesis | Pharmacology | Research | Chemical properties | Phosphotransferases | Health aspects | Review
Journal Article