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1. Full Text Eight versus four induction cycles of Carfilzomib, Thalidomide and Low-dose Dexamethasone: the Carthadex trial
by Wester, Ruth and Zweegman, Sonja and Van der Holt, Bronno and Jose, Kersten Marie and Vellenga, Edo and van Marwijk-Kooy, Marinus and Asselbergs, Emelie and de Weerdt, Okke and Minnema, Monique and Lonergan, Sarah and Palumbo, Antonio and Broijl, Annemiek and Sonneveld, Pieter
Clinical lymphoma, myeloma and leukemia, ISSN 2152-2650, 10/2019, Volume 19, Issue 10, pp. e220 - e221
treatment | Tolerability | survival
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2. Full Text Phase 3 randomized, placebo-controlled, double-blind study of lasmiditan for acute treatment of migraine
by Goadsby, Peter J and Wietecha, Linda A and Dennehy, Ellen B and Kuca, Bernice and Case, Michael G and Aurora, Sheena K and Gaul, Charly
Brain (London, England : 1878), ISSN 0006-8950, 07/2019, Volume 142, Issue 7, pp. 1894 - 1904
phase 3 | migraine | safety/tolerability | lasmiditan | efficacy | Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Double-Blind Method | Cardiovascular Diseases - drug therapy | Humans | Risk Factors | Male | Migraine Disorders - drug therapy | Dose-Response Relationship, Drug | Young Adult | Serotonin Receptor Agonists - therapeutic use | Cardiovascular Diseases - complications | Pyridines - adverse effects | Benzamides - therapeutic use | Time Factors | Piperidines - therapeutic use | Piperidines - adverse effects | Migraine Disorders - complications | Adult | Female | Benzamides - adverse effects | Pyridines - therapeutic use | Index Medicus | Abridged Index Medicus | Clinical Trial | Editor's Choice | safety | tolerability
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3. Full Text Carprofen Permeation Test through Porcine Ex Vivo Mucous Membranes and Ophthalmic Tissues for Tolerability Assessments: Validation and Histological Study
by Lidia Gómez-Segura and Alexander Parra and Ana C. Calpena and Álvaro Gimeno and Antonio Boix-Montañes
Veterinary sciences, 10/2020, Volume 7, Issue 4, p. 152
permeation test | ophthalmic tolerability | carprofen | HPLC | mucous tolerability | histological integrity
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4. Full Text Cenobamate (YKP3089) as adjunctive treatment for uncontrolled focal seizures in a large, phase 3, multicenter, open‐label safety study
by Sperling, Michael R and Klein, Pavel and Aboumatar, Sami and Gelfand, Michael and Halford, Jonathan J and Krauss, Gregory L and Rosenfeld, William E and Vossler, David G and Wechsler, Robert and Borchert, Leona and Kamin, Marc
Epilepsia (Copenhagen), ISSN 0013-9580, 06/2020, Volume 61, Issue 6, pp. 1099 - 1108
antiepileptic drugs | DRESS | safety/tolerability | refractory epilepsy | cenobamate | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Convulsions & seizures | Phenobarbital | Epilepsy | Titration | Plasma levels | Safety | Eosinophilia | Phenytoin | Seizures | Index Medicus | safety | tolerability | Full‐length Original Research
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5. Full Text Phase I study to evaluate the pharmacokinetics, safety, and tolerability of two dosing regimens of oral fosfomycin tromethamine in healthy adult participants
by Wenzler, Eric and Bleasdale, Susan C and Sikka, Monica and Bunnell, Kristen L and Finnemeyer, Matthew and Rosenkranz, Susan L and Danziger, Larry H and Rodvold, Keith A and Antibacterial Resistance Leadership Group
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 08/2018, Volume 62, Issue 8
Antimicrobial safety | Tolerability | Safety | Pharmacokinetics | Fosfomycin | Index Medicus
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6. Full Text Safety, Tolerability and Pharmacokinetics of Bencycloquidium Bromide, a Novel Inhaled Anticholinergic Bronchodilator, in Healthy Subjects: Results from Phase I Studies
by Luo, Zhu and Hu, Chao and Pan, Yuanyuan and Miao, Jia and Wang, Ying and Ding, Li and Liang, Maozhi
European journal of pharmaceutical sciences, ISSN 0928-0987, 02/2021, Volume 157, pp. 105646 - 105646
Bencycloquidium bromide | Tolerability | Anticholinergic bronchodilator | Phase I | Pharmacokinetics | Index Medicus
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7. Full Text Comparative analysis of the safety and tolerability of eslicarbazepine acetate in older (≥60 years) and younger (18–59 years) adults
by Andermann, Eva and Rosenfeld, William and Penovich, Patricia and Rogin, Joanne and Cendes, Fernando and Carreño, Mar and Ramsay, R. Eugene and Ben-Menachem, Elinor and Gama, Helena and Rocha, Francisco and Soares-da-Silva, Patrício and Tosiello, Robert and Blum, David and Grinnell, Todd
Epilepsy research, ISSN 0920-1211, 01/2021, Volume 169, pp. 106478 - 106478
Tolerability | Safety | Elderly | Older adults | Eslicarbazepine acetate | Age | Index Medicus
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8. Full Text Effect of lifetime antiepileptic drug treatment history on efficacy and tolerability of adjunctive brivaracetam in adults with focal seizures: Post-hoc analysis of a randomized, placebo-controlled trial
by Klein, Pavel and McLachlan, Richard and Foris, Kathy and Nondonfaz, Xavier and Elmoufti, Sami and Dimova, Svetlana and Brandt, Christian
Epilepsy research, ISSN 0920-1211, 11/2020, Volume 167, pp. 106369 - 106369
Efficacy | Tolerability | Lifetime antiepileptic drugs | Treatment history | Brivaracetam | Index Medicus
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9. Full Text Effect of Dose Adjustments on the Safety and Efficacy of Afatinib in Chinese Patients with EGFR- Mutated Non-Small Cell Lung Cancer Who Participated in the LUX-Lung Clinical Trial Program
by Tu, Hai-Yan and Wu, Yi-Long
OncoTargets and therapy, ISSN 1178-6930, 2020, Volume 13, pp. 12539 - 12547
dose-adjustment | afatinib | efficacy | tolerability
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10. Full Text Efficacy of Ledipasvir and Sofosbuvir Treatment of HCV Infection in Patients Coinfected With HBV
by Liu, Chun-Jen and Chuang, Wan-Long and Sheen, I-Shyan and Wang, Horng-Yuan and Chen, Chi-Yi and Tseng, Kuo-Chih and Chang, Ting-Tsung and Massetto, Benedetta and Yang, Jenny C and Yun, Chohee and Knox, Steven J and Osinusi, Anu and Camus, Gregory and Jiang, Deyuan and Brainard, Diana M and McHutchison, John G and Hu, Tsung-Hui and Hsu, You-Chun and Lo, Gin-Ho and Chu, Chi-Jen and Chen, Jyh-Jou and Peng, Cheng-Yuan and Chien, Ron-Nan and Chen, Pei-Jer
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 03/2018, Volume 154, Issue 4, pp. 989 - 997
ALT | Tolerability | DAA | Immune Suppression | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Index Medicus | Abridged Index Medicus
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11. Full Text A prospective, multicenter, noninterventional study in Taiwan to evaluate the safety and tolerability of lacosamide as adjunctive therapy for epilepsy in clinical practice
by Wu, Tony and Chuang, Yao-Chung and Huang, Hui-Chun and Lim, Siew-Na and Hsieh, Peiyuan F and Lee, Wang-Tso and Cheng, Mei-Yun and Tsai, Meng-Han and Jou, Shuo-Bin and Chang, Chun-Wei and Hsieh, Hsiang-Yao and Du, Xinlu and Hellot, Scarlett and McClung, Carrie and Hung, Connie
Epilepsy & behavior, ISSN 1525-5050, 12/2020, Volume 113, pp. 107464 - 107464
Focal seizures | Tolerability | Effectiveness | Epilepsy | Taiwan | Lacosamide | Index Medicus
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12. Full Text Positioning of darunavir/cobicistat-containing antiretroviral regimens in real life: results from a large multicentre observational prospective cohort (SCOLTA)
by Taramasso, Lucia and Ricci, Elena and Cascio, Antonio and Valsecchi, Laura and Menzaghi, Barbara and Squillace, Nicola and Maggi, Paolo and De Socio, Giuseppe Vittorio and Dentone, Chiara and Madeddu, Giordano and Pellicano, Giovanni F and Calza, Leonardo and Angioni, Goffredo and Bonfanti, Paolo and Di Biagio, Antonio and Sarchi, E and Chichino, G and Bellacosa, C and Angarano, G and Menzaghi, B and Farinazzo, M and Angioni, G and Gussio, M and Celesia, B. M and Falasca, K and Mastroianni, A and Guadagnino, G and Vichi, F and Salomoni, E and Martinelli, C and Nicolini, L and Cenderello, G and Bonfanti, P and Molteni, C and Nunnari, A and Cordier, L and Parisini, S and Rizzardini, G and Rusconi, S and Conti, F and Bandera, A and Taramasso, L and Gori, A and Motta, D and Puoti, M and Squillace, N and Migliorino, G. M and Martini, S and Cascio, A and Trizzino, M and Gulminetti, R and De Socio, G. V and Cibelli, D and Parruti, G and Dentone, C and Madeddu, G and Mameli, M. S and Orofino, G and Guastavigna, M and CISAI Study Grp and CISAI Study Group
AIDS research and therapy, ISSN 1742-6405, 08/2019, Volume 16, Issue 1, pp. 21 - 21
Life Sciences & Biomedicine | Infectious Diseases | Science & Technology | Anti-Retroviral Agents - therapeutic use | Prospective Studies | HIV-1 - drug effects | Humans | Middle Aged | Male | Adult | Female | HIV Infections - drug therapy | Cobicistat - therapeutic use | Drug Therapy, Combination | Viral Load - drug effects | Darunavir - therapeutic use | Medicine, Experimental | Medical research | Dosage and administration | Darunavir | Drug therapy | HIV infection | Antiviral agents | Care and treatment | Hypercholesterolemia | Analysis | Low density lipoproteins | Cholesterol | Anti-HIV agents | Rank tests | Lipoproteins (low density) | Toxicity | Antiretroviral agents | Hypertriglyceridemia | Durability | Lipids | Triglycerides | Index Medicus | AIDS/HIV | Darunavir/cobicistat | Tolerability | Adverse events | Dual | CISAI
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13. Full Text Is the anticonvulsant activity of levetiracetam dose-dependent?
by Lamouret, Valerija and Kurth, Christoph and Intravooth, Tassanai and Steinhoff, Bernhard J
Seizure (London, England), ISSN 1059-1311, 12/2020, Volume 83, pp. 197 - 202
Efficacy | Focal epilepsy | Tolerability | Levetiracetam | Dose-Dependence | Index Medicus
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14. Full Text Brivaracetam efficacy and tolerability in clinical practice: A UK-based retrospective multicenter service evaluation
by Adewusi, J and Burness, C and Ellawela, S and Emsley, H and Hughes, R and Lawthom, C and Maguire, M and McLean, B and Mohanraj, R and Oto, M and Singhal, S and Reuber, M
Epilepsy & behavior, ISSN 1525-5050, 05/2020, Volume 106, pp. 106967 - 106967
Tolerability | Seizure control | Brivaracetam | Learning disability | Epilepsy | Levetiracetam | Index Medicus
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15. Full Text Regorafenib as second-line therapy for intermediate or advanced hepatocellular carcinoma: Multicentre, open-label, phase II safety study
by Bruix, Jordi and Tak, Won-Young and Gasbarrini, Antonio and Santoro, Armando and Colombo, Massimo and Lim, Ho-Yeong and Mazzaferro, Vincenzo and Wiest, Reiner and Reig, María and Wagner, Andrea and Bolondi, Luigi
European journal of cancer (1990), ISSN 0959-8049, 2013, Volume 49, Issue 16, pp. 3412 - 3419
Hematology, Oncology and Palliative Medicine | Second line | Regorafenib | Hepatocellular carcinoma | Tolerability | Safety | Receptor kinase inhibition | Safety Second line | Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Pharmacology. Drug treatments | Tumors | Carcinoma, Hepatocellular - mortality | Humans | Middle Aged | Pyridines - pharmacokinetics | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Liver Neoplasms - mortality | Pyridines - adverse effects | Carcinoma, Hepatocellular - drug therapy | Time Factors | Antineoplastic Agents - adverse effects | Phenylurea Compounds - adverse effects | Adult | Female | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacokinetics | Phenylurea Compounds - pharmacokinetics | Liver Neoplasms - enzymology | Pyridines - therapeutic use | Protein Kinase Inhibitors - pharmacokinetics | Pyridines - administration & dosage | Drug Administration Schedule | Europe | Kaplan-Meier Estimate | Liver Neoplasms - drug therapy | Phenylurea Compounds - therapeutic use | Treatment Outcome | Carcinoma, Hepatocellular - enzymology | Disease Progression | Protein Kinase Inhibitors - administration & dosage | Phenylurea Compounds - administration & dosage | Asia | Protein Kinase Inhibitors - therapeutic use | Carcinoma, Hepatocellular - pathology | Aged | Neoplasm Staging | Care and treatment | Safety and security measures | Hepatoma | Index Medicus
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