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Circulation (New York, N.Y.), ISSN 1524-4539, 03/2007, Volume 115, Issue 12, pp. 1599 - 1608
Background-Stroke is the second to third leading cause of death. Toll-like receptor 4 (TLR4... 
Infection | Cerebral ischemia | Stroke | Nitric oxide synthase | Inflammation | Metalloproteinases | Immune system | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Interferons - biosynthesis | Nitric Oxide Synthase Type II - biosynthesis | Oxidative Stress | Tumor Necrosis Factor-alpha - genetics | Nitrobenzenes - therapeutic use | Male | NF-kappa B - metabolism | Interleukin-1beta - genetics | Cyclooxygenase 2 - biosynthesis | Toll-Like Receptor 4 - deficiency | Cyclooxygenase 2 - genetics | Infarction, Middle Cerebral Artery - complications | Matrix Metalloproteinase 9 - genetics | Cyclooxygenase 2 Inhibitors - therapeutic use | Brain Damage, Chronic - metabolism | Interferons - genetics | Interferon Regulatory Factor-1 - biosynthesis | Encephalitis - pathology | Mice, Knockout | Toll-Like Receptor 4 - physiology | Brain Damage, Chronic - etiology | Cerebral Infarction - etiology | Brain Chemistry | Mice | Tumor Necrosis Factor-alpha - biosynthesis | Brain Damage, Chronic - prevention & control | Encephalitis - etiology | Dinoprostone - analysis | Infarction, Middle Cerebral Artery - metabolism | Cerebral Infarction - metabolism | Encephalitis - drug therapy | Nitric Oxide Synthase Type II - antagonists & inhibitors | Encephalitis - metabolism | Inflammation Mediators - metabolism | Nerve Tissue Proteins - biosynthesis | Interleukin-1beta - biosynthesis | Brain Damage, Chronic - pathology | Cerebral Infarction - pathology | Matrix Metalloproteinase 9 - biosynthesis | Mice, Inbred C57BL | Gene Expression Regulation | Infarction, Middle Cerebral Artery - pathology | Nerve Tissue Proteins - genetics | Mice, Inbred C3H | Interferon Regulatory Factor-1 - genetics | Animals | Nitric Oxide Synthase Type II - genetics | Sulfonamides - therapeutic use | Lipid Peroxidation | Nitric Oxide - metabolism | Stroke (Disease) | Complications and side effects | Patient outcomes | Physiological aspects | Development and progression | Research | Chemokines | Index Medicus | Abridged Index Medicus
Journal Article
Molecular neurobiology, ISSN 1559-1182, 11/2014, Volume 52, Issue 3, pp. 1547 - 1560
In this study, we tried to explore the molecular mechanism that Corilagin protected against herpes simplex virus-1 encephalitis through inhibiting the TLR2... 
Signaling pathways | Neurology | Neurosciences | Biomedicine | Toll-like receptor 2 | Neurobiology | Corilagin | Inflammation | Herpes simplex virus-1 | Cell Biology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Microglia - metabolism | RNA, Small Interfering - genetics | TNF Receptor-Associated Factor 6 - biosynthesis | Toll-Like Receptor 2 - antagonists & inhibitors | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - biosynthesis | Receptors, Interleukin-1 - genetics | Tumor Necrosis Factor-alpha - genetics | Male | Brain - metabolism | RNA, Messenger - biosynthesis | Protein Processing, Post-Translational - drug effects | RNA Interference | Nerve Tissue Proteins - biosynthesis | Hydrolyzable Tannins - pharmacology | Encephalitis, Herpes Simplex - prevention & control | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | TNF Receptor-Associated Factor 6 - genetics | Intracellular Signaling Peptides and Proteins - genetics | Lipopeptides - toxicity | Antiviral Agents - pharmacology | Glucosides - pharmacology | Interleukin-6 - genetics | Microglia - drug effects | RNA, Messenger - genetics | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Receptors, Interleukin-1 - biosynthesis | Down-Regulation - drug effects | Intracellular Signaling Peptides and Proteins - biosynthesis | Nerve Tissue Proteins - genetics | Toll-Like Receptor 2 - biosynthesis | Herpesvirus 1, Human | Membrane Glycoproteins - genetics | Animals | NF-kappa B - genetics | Signal Transduction - drug effects | NF-kappa B - biosynthesis | Brain - pathology | Interleukin-6 - biosynthesis | Mice | Mice, Inbred BALB C | Myeloid Differentiation Factor 88 - biosynthesis | Tumor Necrosis Factor-alpha - biosynthesis | RNA | Yuan (China) | Encephalitis | Signaling | Tumor necrosis factor-TNF | Molecular biology | Neurons | Index Medicus
Journal Article
Journal of neurochemistry, ISSN 1471-4159, 07/2007, Volume 102, Issue 1, pp. 37 - 50
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 04/2004, Volume 172, Issue 8, pp. 4733 - 4743
.... In this study, we demonstrate that different Toll-like receptor (TLR) ligands induce distinct dendritic cell (DC... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Toll-Like Receptor 2 | Receptors, Immunologic - physiology | Spleen - immunology | Toll-Like Receptor 4 | Membrane Glycoproteins - metabolism | Ovalbumin - immunology | Dendritic Cells - immunology | Proto-Oncogene Proteins c-fos - biosynthesis | Male | Th2 Cells - immunology | CD4-Positive T-Lymphocytes - immunology | Toll-Like Receptors | Membrane Glycoproteins - physiology | Receptors, Cell Surface - physiology | Dipeptides - metabolism | CD11c Antigen - biosynthesis | Interleukin-12 - biosynthesis | CD4-Positive T-Lymphocytes - metabolism | Mitogen-Activated Protein Kinases - biosynthesis | Receptors, Immunologic - deficiency | Mice, Transgenic | Spleen - cytology | Antigens, Differentiation - physiology | Mice, Knockout | Mitogen-Activated Protein Kinases - deficiency | Adaptor Proteins, Signal Transducing | Dendritic Cells - enzymology | Receptors, Cell Surface - deficiency | Lipopolysaccharides - pharmacology | Ligands | Mitogen-Activated Protein Kinases - genetics | Antigens, Differentiation - genetics | Mice | Protein Subunits - antagonists & inhibitors | Receptors, Immunologic - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Receptors, Cell Surface - genetics | Phosphorylation | Lipopolysaccharides - metabolism | Genes, Immediate-Early - immunology | Enzyme Induction - immunology | MAP Kinase Signaling System - immunology | Interleukin-12 - antagonists & inhibitors | Lipoproteins - metabolism | Epitopes, T-Lymphocyte - immunology | Dendritic Cells - metabolism | Dipeptides - pharmacology | Mice, Inbred C57BL | Escherichia coli - immunology | Receptors, Cell Surface - metabolism | Protein Subunits - biosynthesis | Myeloid Differentiation Factor 88 | Th2 Cells - metabolism | Membrane Glycoproteins - genetics | Animals | Mitogen-Activated Protein Kinases - physiology | Lipoproteins - pharmacology | Interleukin-10 - biosynthesis | CD11b Antigen - metabolism | Proto-Oncogene Proteins c-fos - physiology | Membrane Glycoproteins - deficiency | Mitogen-Activated Protein Kinase 3 | Mitogen-Activated Protein Kinases - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 06/2008, Volume 180, Issue 12, pp. 7847 - 7858
.... Macrophages, critical cell determinants of this system, recognize microbes through pattern recognition receptors such as TLRs, which typically mediate proinflammatory responses... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Tumor Necrosis Factor-alpha - metabolism | Pulmonary Surfactant-Associated Protein A - biosynthesis | Intracellular Fluid - immunology | Toll-Like Receptor 2 - antagonists & inhibitors | Toll-Like Receptor 4 - biosynthesis | Monocytes - cytology | Humans | Pulmonary Surfactant-Associated Protein A - physiology | Monocytes - metabolism | Monocytes - immunology | RNA, Messenger - biosynthesis | RNA, Messenger - antagonists & inhibitors | Adult | Cell Membrane - metabolism | Toll-Like Receptors - metabolism | Intracellular Fluid - metabolism | Macrophages, Alveolar - immunology | Pulmonary Surfactant-Associated Protein A - genetics | Cells, Cultured | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 2 - metabolism | Protein Binding - immunology | Toll-Like Receptors - biosynthesis | Toll-Like Receptor 2 - biosynthesis | Toll-Like Receptor 4 - metabolism | Toll-Like Receptor 4 - physiology | Cell Differentiation - immunology | Models, Immunological | Up-Regulation - immunology | Toll-Like Receptor 2 - physiology | Toll-Like Receptors - genetics | Macrophages, Alveolar - cytology | Cell Membrane - immunology | Macrophages, Alveolar - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 10/2011, Volume 108, Issue 42, pp. 17408 - 17413
...), is a potent inhibitor of TNF biosynthesis in human macrophages. This difference in response is not because of variation in Toll-like receptor 2-dependent activation of the signaling kinase MAPK p38... 
Untranslated regions | RNA stability | Cell culture techniques | Messenger RNA | MicroRNA | Mycobacterium tuberculosis | Infections | Biosynthesis | Physiological regulation | Macrophages | Innate immunity | Intracellular pathogen | Cell signaling | Lipoglycans | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Promoter Regions, Genetic | Phosphorylation | Humans | Tumor Necrosis Factor-alpha - genetics | Mycobacterium tuberculosis - immunology | MicroRNAs - metabolism | MAP Kinase Kinase 2 - metabolism | Toll-Like Receptor 2 - metabolism | RNA Stability | Lipopolysaccharides - immunology | MAP Kinase Signaling System - immunology | Mycobacterium tuberculosis - pathogenicity | Macrophages - metabolism | Virulence - immunology | Lipopolysaccharides - pharmacology | Macrophages - drug effects | MicroRNAs - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | In Vitro Techniques | Proto-Oncogene Proteins c-akt - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | Macrophages - immunology | Macrophages - microbiology | Tumor necrosis factor | Physiological aspects | Genetic aspects | Research | Mitogen-activated protein kinases | Gram-positive bacteria | Signal transduction | Kinases | Ribonucleic acid--RNA | Gene expression | Index Medicus | 1-Phosphatidylinositol 3-kinase | Biological Sciences | lipoglycans | innate immunity | intracellular pathogen | cell signaling
Journal Article