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Journal of Biological Chemistry, ISSN 0021-9258, 09/2007, Volume 282, Issue 36, pp. 26014 - 26025
.... The total fraction of Mycobacterium bovis BCG LM was shown both to induce macrophage activation and pro-inflammatory cytokines through Toll-like receptor 2 (TLR2... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Mannose-Binding Lectins - metabolism | Mycobacterium bovis - immunology | Toll-Like Receptor 2 - agonists | Membrane Glycoproteins - metabolism | Humans | Lectins, C-Type - immunology | Mycobacterium tuberculosis - immunology | Lipopolysaccharides - metabolism | Cell Adhesion Molecules - immunology | Lipopolysaccharides - immunology | Lectins, C-Type - metabolism | Signal Transduction - immunology | Inflammation - metabolism | Macrophages - secretion | Toll-Like Receptor 1 - agonists | Myeloid Differentiation Factor 88 - immunology | Tumor Necrosis Factor-alpha - immunology | Toll-Like Receptor 4 - agonists | Interleukin-12 Subunit p40 - immunology | Membrane Glycoproteins - immunology | Macrophages - immunology | Acylation | Cell Line | Nitric Oxide - immunology | Immunity, Innate - drug effects | Macrophage Activation - immunology | Receptors, Interleukin-1 - immunology | Tumor Necrosis Factor-alpha - secretion | Receptors, Cell Surface - metabolism | Inflammation - immunology | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Cell Adhesion Molecules - metabolism | Receptors, Cell Surface - immunology | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Nitric Oxide - secretion | Animals | Mannose-Binding Lectins - immunology | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Mice | Toll-Like Receptor 1 - immunology | Macrophage Activation - drug effects | Myeloid Differentiation Factor 88 - metabolism | Index Medicus | Toll-Like Receptor 1 | Toll-Like Receptor 2 | Toll-Like Receptor 4 | Cell Adhesion Molecules | Receptors, Cell Surface | Macrophages | Lipopolysaccharides | Life Sciences | Immunology | Membrane Glycoproteins | Mannose-Binding Lectins | Mycobacterium bovis | Signal Transduction | Lectins, C-Type | Inflammation | Myeloid Differentiation Factor 88 | Nitric Oxide | Tumor Necrosis Factor-alpha | Immunity, Natural | Macrophage Activation | Mycobacterium tuberculosis | Receptors, Interleukin-1 | Interleukin-12 Subunit p40
Journal Article
Nature immunology, ISSN 1529-2916, 03/2010, Volume 11, Issue 5, pp. 411 - 418
Sensors of pathogens, such as Toll-like receptors (TLRs), detect microbes to activate transcriptional programs that orchestrate adaptive responses to specific insults... 
Life Sciences & Biomedicine | Immunology | Science & Technology | RNA, Small Interfering - genetics | Endoribonucleases - genetics | Tularemia - metabolism | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lipopeptides - pharmacology | Transcriptional Activation - drug effects | NADPH Oxidases - metabolism | Tularemia - genetics | Protein Splicing - genetics | Transcriptional Activation - immunology | X-Box Binding Protein 1 | Protein Splicing - drug effects | NADPH Oxidases - genetics | Stress, Physiological - drug effects | TNF Receptor-Associated Factor 6 - genetics | Transcription Factor CHOP - biosynthesis | Transcription Factors - immunology | Cytokines - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Macrophages - pathology | Stress, Physiological - genetics | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | Signal Transduction - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Macrophages - metabolism | Signal Transduction - drug effects | Tunicamycin - pharmacology | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Mice | Stress, Physiological - immunology | Endoribonucleases - immunology | Transcription Factor CHOP - genetics | NADPH Oxidases - immunology | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Macrophages - virology | Mice, Mutant Strains | Tularemia - immunology | Membrane Glycoproteins - immunology | Macrophages - immunology | Cytokines - immunology | Cell Line | Francisella tularensis - immunology | Protein Splicing - immunology | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Immunity, Innate | NADPH Oxidase 2 | Regulatory Factor X Transcription Factors | Mice, Inbred C3H | Membrane Glycoproteins - genetics | Transcription Factors - metabolism | Animals | TNF Receptor-Associated Factor 6 - metabolism | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Francisella tularensis - pathogenicity | Myeloid Differentiation Factor 88 - metabolism | Cytokines - biosynthesis | Cell receptors | Transcription factors | Immune response | Physiological aspects | Genetic aspects | Research | Health aspects | Francisella tularensis | Index Medicus
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2010, Volume 126, Issue 5, pp. 985 - 993.e3
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 09/2009, Volume 284, Issue 36, pp. 24035 - 24048
..., macrophages need double stimulation with ligands to both Toll-like receptors (TLRs) for IL-1β... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Toll-Like Receptor 2 - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Immunity, Innate - genetics | Extracellular Matrix - metabolism | Caspase 1 - metabolism | Male | Ureteral Obstruction - metabolism | Interleukin-1beta - genetics | Inflammation - metabolism | Kidney - metabolism | Carrier Proteins - immunology | Signal Transduction | Proteoglycans - immunology | Extracellular Matrix Proteins - genetics | Proteoglycans - metabolism | Toll-Like Receptor 4 - genetics | Biglycan | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Ureteral Obstruction - immunology | Macrophages - metabolism | Receptors, Purinergic P2 - metabolism | Toll-Like Receptor 2 - immunology | Mice | Proteoglycans - genetics | Extracellular Matrix - immunology | Kidney - immunology | Caspase 1 - immunology | Extracellular Matrix - genetics | Receptors, Purinergic P2 - genetics | Ureteral Obstruction - genetics | Interleukin-1beta - biosynthesis | Lung - metabolism | Receptors, Purinergic P2 - immunology | Extracellular Matrix Proteins - metabolism | Macrophages - immunology | Carrier Proteins - biosynthesis | Interleukin-1beta - immunology | Inflammation - immunology | Protein Structure, Tertiary - genetics | Receptors, Purinergic P2X7 | Carrier Proteins - genetics | Immunity, Innate - immunology | Animals | Caspase 1 - genetics | Extracellular Matrix Proteins - immunology | Receptors, Purinergic P2X4 | Inflammation - genetics | Lung - immunology | Animal models | Reactive oxygen species | Oligomerization | Proteoglycans | Transcription | Lung | Inflammation | Macrophages | Kidney | Stress | Caspase-1 | Purine P2X receptors | Signal transduction | Cell activation | TLR2 protein | Interleukin 1 | Toll-like receptors | Extracellular matrix | Sepsis | Cooperativity | Injuries | Index Medicus | Glycobiology and Extracellular Matrices
Journal Article
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 11/2009, Volume 183, Issue 10, pp. 6244 - 6250
... to stimulate macrophages to secrete proinflammatory cytokines. HMGB1 acts as a ligand of receptor for advanced glycation end products (RAGE... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Toll-Like Receptor 2 - agonists | Toll-Like Receptor 2 - genetics | Arthritis, Experimental - metabolism | Arthritis, Experimental - pathology | HMGB1 Protein - pharmacology | Receptors, Immunologic - agonists | Toll-Like Receptor 4 - agonists | Female | Mice, Inbred DBA | Flavonoids - pharmacology | Phosphorylation - immunology | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Receptors, Immunologic - immunology | Glycation End Products, Advanced - immunology | Macrophages, Peritoneal - drug effects | Receptor for Advanced Glycation End Products | Cytokines - immunology | Cytokines - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Macrophages, Peritoneal - immunology | Toll-Like Receptor 4 - genetics | Up-Regulation - genetics | Arthritis, Experimental - immunology | Imidazoles - pharmacology | Toll-Like Receptor 4 - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Anthracenes - pharmacology | Mice, Knockout | Animals | Cytokines - drug effects | Up-Regulation - immunology | Glycation End Products, Advanced - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Mice | Pyridines - pharmacology | Macrophages, Peritoneal - metabolism | Receptors, Immunologic - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 11, pp. e15041 - e15041
.... Here, we applied the most comprehensive analysis focused on the innate immune response following TLR stimulation over the first 2 years of life in the largest such longitudinal cohort studied to-date (35 subjects... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Leukocytes, Mononuclear - metabolism | Toll-Like Receptor 2 - agonists | Age Factors | Lipopeptides - pharmacology | Dendritic Cells - immunology | Humans | Middle Aged | Child, Preschool | Infant | Toll-Like Receptor 9 - agonists | Toll-Like Receptor 9 - immunology | Young Adult | Toll-Like Receptor 8 - immunology | Leukocytes, Mononuclear - immunology | Toll-Like Receptor 7 - immunology | Toll-Like Receptor 4 - agonists | Adult | Dendritic Cells - drug effects | Dendritic Cells - metabolism | Infant, Newborn | Cytokines - immunology | Toll-Like Receptor 8 - agonists | Toll-Like Receptor 7 - agonists | Antigen-Presenting Cells - metabolism | Leukocytes, Mononuclear - drug effects | Cytokines - metabolism | Antigen-Presenting Cells - drug effects | Toll-Like Receptors - immunology | Toll-Like Receptor 4 - immunology | Antigen-Presenting Cells - immunology | Toll-Like Receptors - agonists | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Oligodeoxyribonucleotides - pharmacology | Cohort Studies | Infants (Newborn) | Cytokines | Mortality | Vaccines | B cells | Comparative analysis | Health aspects | Neonates | Flow cytometry | Pediatrics | Helper cells | Leukocytes (mononuclear) | Stimulation | Interleukin 23 | Infants | Lymphocytes T | Infections | Ontogeny | Birth | Immunity | Interleukin 6 | Proteins | Immunology | Newborn babies | Toll-like receptors | Children | Age | Immune system | Medical research | Antigens | Immune response | Fetuses | Interleukin 12 | T cell receptors | Tumor necrosis factor-α | Morbidity | Childbirth & labor | Herpes viruses | γ-Interferon | Interleukin 10 | Interferon | Adults | Human behavior | Index Medicus
Journal Article