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Journal of Immunology, ISSN 0022-1767, 04/2011, Volume 186, Issue 8, pp. 4794 - 4804
Endosomal TLRs play an important role in innate immune response as well as in autoimmune processes. In the therapy of systemic lupus erythematosus,... 
IMMUNOSTIMULATORY CPG-OLIGODEOXYNUCLEOTIDES | CELLS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVATION | DNA | COMPLEXES | TOLL-LIKE RECEPTORS | H+-ATPASE | IFN-ALPHA INDUCER | IMMUNOLOGY | NUCLEIC-ACIDS | Humans | Toll-Like Receptor 9 - genetics | Toll-Like Receptor 3 - antagonists & inhibitors | Endosomes - metabolism | Quinolines - pharmacology | Chloroquine - pharmacology | Quinacrine - pharmacology | Transfection | Hydrogen-Ion Concentration - drug effects | HEK293 Cells | Toll-Like Receptors - antagonists & inhibitors | Toll-Like Receptor 3 - genetics | Culture Media - chemistry | Imidazoles - metabolism | Toll-Like Receptor 8 - agonists | Binding, Competitive | Toll-Like Receptor 7 - agonists | Toll-Like Receptor 7 - genetics | Cell Line | Antimalarials - metabolism | Toll-Like Receptor 7 - metabolism | Toll-Like Receptor 9 - antagonists & inhibitors | Cytokines - metabolism | Cells, Cultured | Imidazoles - pharmacology | Nucleic Acids - metabolism | Toll-Like Receptor 3 - metabolism | Toll-Like Receptors - agonists | Antimalarials - pharmacology | Quinolines - metabolism | Animals | Toll-Like Receptors - genetics | Culture Media - pharmacology | Toll-Like Receptor 8 - genetics | Endosomes - chemistry | Toll-Like Receptor 9 - metabolism | Toll-Like Receptor 8 - metabolism | Serum - chemistry | Index Medicus | Abridged Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2012, Volume 18, Issue 8, pp. 1286 - 1290
Exposure to ultraviolet B (UVB) radiation from the sun can result in sunburn, premature aging and carcinogenesis, but the mechanism responsible for acute... 
MEDICINE, RESEARCH & EXPERIMENTAL | IRRADIATION | CELLS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | LIGHT | KERATINOCYTES | NECROSIS-FACTOR-ALPHA | NF-KAPPA-B | SKIN-CANCER | CELL BIOLOGY | Keratinocytes - radiation effects | Humans | Tumor Necrosis Factor-alpha - genetics | Up-Regulation - radiation effects | Adaptor Proteins, Vesicular Transport - deficiency | Male | RNA, Double-Stranded - radiation effects | Toll-Like Receptor 3 - antagonists & inhibitors | Leukocytes - radiation effects | RNA, Small Nuclear - genetics | Toll-Like Receptor 3 - deficiency | Female | Toll-Like Receptor 3 - genetics | Adaptor Proteins, Vesicular Transport - physiology | Interleukin-6 - genetics | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Inflammation | Ultraviolet Rays - adverse effects | Mice, Knockout | Toll-Like Receptor 3 - physiology | Animals | Keratinocytes - metabolism | Skin - radiation effects | RNA, Double-Stranded - genetics | Gene Expression Regulation - radiation effects | Interleukin-6 - biosynthesis | RNA, Small Nuclear - radiation effects | Mice | Leukocytes - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | Ultraviolet radiation | Synthesis | Research | RNA | Tumor necrosis factor | Health aspects | Skin | Sunburn & sun tanning | Cytokines | Ribonucleic acid--RNA | Immune system | Index Medicus
Journal Article
European Journal of Immunology, ISSN 0014-2980, 03/2016, Volume 46, Issue 3, pp. 772 - 781
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2018, Volume 200, Issue 7, pp. 2291 - 2303
Binge/moderate alcohol suppresses TLR4-MyD88 proinflammatory cytokines; however, alcohol's effects on TLR-TRIF signaling, especially after in vivo exposure in... 
TOLL-LIKE RECEPTOR | IN-VIVO | FACTOR-KAPPA-B | ENDOPLASMIC-RETICULUM STRESS | PROINFLAMMATORY CYTOKINES | IMMUNOLOGY | PATTERN-RECOGNITION RECEPTORS | HUMAN MONOCYTES | RESPIRATORY SYNCYTIAL VIRUS | IFN-BETA INDUCTION | INNATE IMMUNITY | Inflammation - pathology | Interleukin-6 - antagonists & inhibitors | Binge Drinking - pathology | Ethanol - toxicity | Humans | Middle Aged | Receptors, Neuropeptide Y - metabolism | Male | Monocytes - immunology | X-Box Binding Protein 1 - drug effects | Toll-Like Receptor 3 - antagonists & inhibitors | Lipopolysaccharides - immunology | Chemokine CCL5 - antagonists & inhibitors | Young Adult | Myeloid Differentiation Factor 88 - antagonists & inhibitors | Adult | Female | Poly I-C - immunology | Toll-Like Receptor 4 - antagonists & inhibitors | Macrophages - immunology | Cell Line | Adaptor Proteins, Vesicular Transport - antagonists & inhibitors | Chemokine CXCL10 - antagonists & inhibitors | Interferon-beta - antagonists & inhibitors | HSP70 Heat-Shock Proteins - metabolism | Monocytes - drug effects | Animals | Signal Transduction - drug effects | Adolescent | Macrophages - drug effects | RAW 264.7 Cells | Mice | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Phosphoprotein phosphatase | β-Interferon | RANTES | Alcohol | Macrophages | Lipopolysaccharides | Interleukin 6 | Proteins | Signal transduction | Drug tolerance | Rodents | Toll-like receptors | IP-10 protein | Inhibition | Enzyme-linked immunosorbent assay | Ethanol | Cytokines | Immunoregulation | Exposure | Inflammation | Poly (I:C) | TLR4 protein | TLR3 protein | Signaling | Monocytes | Interferon regulatory factor 3 | Tumor necrosis factor | Alcoholic beverages | MyD88 protein | Protein phosphatase | Stress proteins | Chemokines | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2016, Volume 291, Issue 3, pp. 1251 - 1266
HIV-1 infection results in a chronic illness because long-term highly active antiretroviral therapy can lower viral titers to an undetectable level. However,... 
Exosomes - metabolism | eIF-2 Kinase - metabolism | Humans | MicroRNAs - metabolism | Lymphotoxin-alpha - metabolism | Toll-Like Receptor 3 - antagonists & inhibitors | Leukocytes - immunology | HIV Infections - immunology | Lymphotoxin-alpha - secretion | Activating Transcription Factors - metabolism | Exosomes - immunology | Toll-Like Receptor 3 - genetics | Active Transport, Cell Nucleus | Interleukin-6 - metabolism | Exosomes - virology | eIF-2 Kinase - genetics | HIV Infections - blood | Cell Line | Cytokines - metabolism | HIV Infections - virology | Cells, Cultured | Cytokines - secretion | Mice, Transgenic | Toll-Like Receptor 3 - metabolism | Interleukin-6 - secretion | eIF-2 Kinase - antagonists & inhibitors | HIV-1 - immunology | Animals | Leukocytes - virology | Leukocytes - secretion | Mice, Inbred NOD | MicroRNAs - blood | Leukocytes - metabolism | Cell Line, Transformed | Cell Transformation, Viral | TOLL-LIKE-RECEPTORS | DOUBLE-STRANDED-RNA | TUMOR-NECROSIS-FACTOR | MULTIPLE-SCLEROSIS | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMMUNODEFICIENCY-VIRUS TYPE-1 | MONONUCLEAR-CELLS | INFECTED-CELLS | SMALL NONCODING RNAS | NF-KAPPA-B | Index Medicus | exosome (vesicle) | Molecular Bases of Disease | protein kinase RNA-activated (PKR) | TAR RNA | human immunodeficiency virus (HIV) | cytokinesis | macrophage | toll-like receptor (TLR)
Journal Article
PLoS Pathogens, ISSN 1553-7366, 11/2010, Volume 6, Issue 11, pp. e1001178 - e1001178
The relative roles of the endosomal TLR3/7/8 versus the intracellular RNA helicases RIG-I and MDA5 in viral infection is much debated. We investigated the... 
IMMUNE-RESPONSE | DOUBLE-STRANDED-RNA | RESPIRATORY ILLNESS | MICROBIOLOGY | TOLL-LIKE RECEPTOR-3 | VIRAL-INFECTIONS | DIFFERENTIATION-ASSOCIATED GENE-5 | ANTIVIRAL RESPONSES | VIROLOGY | INDUCIBLE GENE-I | ASTHMA EXACERBATIONS | NF-KAPPA-B | PARASITOLOGY | RNA, Small Interfering - genetics | Bronchi - virology | Humans | Receptor, Interferon alpha-beta - physiology | Rhinovirus - pathogenicity | Toll-Like Receptor 3 - antagonists & inhibitors | Bronchi - immunology | Picornaviridae Infections - virology | Interferon-Induced Helicase, IFIH1 | Epithelium - immunology | RNA, Viral - genetics | DEAD-box RNA Helicases - antagonists & inhibitors | Bronchi - metabolism | Female | Toll-Like Receptor 3 - genetics | DEAD-box RNA Helicases - metabolism | Picornaviridae Infections - metabolism | DEAD Box Protein 58 | Picornaviridae Infections - immunology | Epithelium - metabolism | RNA, Messenger - genetics | Cells, Cultured | Immunity, Innate | Reverse Transcriptase Polymerase Chain Reaction | Toll-Like Receptor 3 - metabolism | Blotting, Western | Epithelium - virology | Mice, Knockout | DEAD-box RNA Helicases - genetics | Animals | Fluorescent Antibody Technique | Mice | RNA, Double-Stranded | HeLa Cells | Rhinoviruses | Analysis | Physiological aspects | Toll-like receptors | Respiratory tract diseases | Cellular signal transduction | Research | Gene expression | Risk factors | Index Medicus | Proteins | Medical research | Cytokines | Kinases | Viral infections
Journal Article
Journal Article
Endocrinology, ISSN 0013-7227, 07/2011, Volume 152, Issue 7, pp. 2827 - 2836
The testis is an immunoprivileged site, where the local cell-initiated testicular innate immune responses play a crucial role in defense against microbial... 
ACTIVATION | EPITHELIAL-CELLS | RECOGNITION | TYRO-3 FAMILY RECEPTORS | REPRODUCTIVE-TRACT | IN-VIVO | ENDOCRINOLOGY & METABOLISM | SERTOLI-CELLS | NF-KAPPA-B | EXPRESSION | T-CELLS | Leydig Cells - cytology | Cholesterol Side-Chain Cleavage Enzyme - metabolism | Testis - metabolism | Male | Leydig Cells - immunology | Leydig Cells - drug effects | Toll-Like Receptor 3 - antagonists & inhibitors | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Leydig Cells - metabolism | Mice, Mutant Strains | c-Mer Tyrosine Kinase | Testis - immunology | Toll-Like Receptors - antagonists & inhibitors | Toll-Like Receptor 4 - agonists | Toll-Like Receptor 3 - genetics | Toll-Like Receptor 4 - antagonists & inhibitors | Toll-Like Receptors - metabolism | Cytokines - genetics | Proto-Oncogene Proteins - metabolism | Cytokines - metabolism | Testis - cytology | Mice, Inbred C57BL | Cells, Cultured | Toll-Like Receptor 4 - genetics | Proto-Oncogene Proteins - genetics | Toll-Like Receptor 3 - agonists | Immunity, Innate | Receptor Protein-Tyrosine Kinases - metabolism | Toll-Like Receptor 3 - metabolism | Toll-Like Receptor 4 - metabolism | Toll-Like Receptors - agonists | Gene Expression Regulation - drug effects | Animals | Receptor Protein-Tyrosine Kinases - genetics | Toll-Like Receptors - genetics | Mice | Steroid 17-alpha-Hydroxylase - metabolism | Immune response | Data processing | Inflammation | TLR4 protein | Immunity | TLR3 protein | Axl protein | Lipopolysaccharides | Infection | Interleukin 6 | beta -Interferon | Interleukin 1 | Leydig cells | Toll-like receptors | Protein-tyrosine kinase receptors | alpha -Interferon | Interferon | Steroidogenesis | Testes | Tumor necrosis factor- alpha | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 06/2009, Volume 15, Issue 12, pp. 4114 - 4122
Purpose: To evaluate whether ( a ) Wnt5a expression in pancreatic cancer and malignant melanoma cells might be associated with constitutive levels of Toll-like... 
Wnt5a | Toll-like receptors | phenylmethimazole | IP-10 GENE-TRANSCRIPTION | ACTIVATION | ONCOLOGY | KAPPA-B SITE | PROSTATE-CANCER | DISEASE | VASCULAR INFLAMMATION | PROLIFERATION | TNF-ALPHA | VISCERAL FAT ACCUMULATION | STAT3 SER727 PHOSPHORYLATION | Interleukin-6 - antagonists & inhibitors | Pancreatic Neoplasms - metabolism | Skin Neoplasms - drug therapy | Humans | Toll-Like Receptor 3 - antagonists & inhibitors | Wnt-5a Protein | Wnt Proteins - metabolism | Gene Knockdown Techniques | Pancreatic Neoplasms - drug therapy | Toll-Like Receptor 3 - genetics | Interleukin-6 - metabolism | Methimazole - analogs & derivatives | STAT3 Transcription Factor - metabolism | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Skin Neoplasms - pathology | Proto-Oncogene Proteins - antagonists & inhibitors | Methimazole - pharmacology | Pancreatic Neoplasms - pathology | Chemokine CXCL10 - antagonists & inhibitors | Melanoma - pathology | Mice, SCID | Toll-Like Receptor 3 - metabolism | Interferon-beta - antagonists & inhibitors | Skin Neoplasms - metabolism | Animals | Interferon-beta - metabolism | Signal Transduction - drug effects | Mice, Nude | Melanoma - drug therapy | Cell Line, Tumor | Signal Transduction - physiology | Mice | Thiones - pharmacology | STAT3 Transcription Factor - antagonists & inhibitors | Wnt Proteins - antagonists & inhibitors | Chemokine CXCL10 - metabolism | Antithyroid Agents - pharmacology | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 07/2016, Volume 6, Issue 1, pp. 24530 - 24530
A marked increase in the rate of dengue virus (DENV) infection has resulted in more than 212 deaths in Taiwan since the beginning of 2015, mostly from fatal... 
IMMUNITY | NONSTRUCTURAL PROTEIN NS1 | HUMAN DENDRITIC CELLS | ACTIVATOR | EPITHELIAL-CELLS | MULTIDISCIPLINARY SCIENCES | DISEASE | GENE-EXPRESSION | CYTOMEGALOVIRUS | NF-KAPPA-B | HEPATITIS-C | Epithelial Cells - metabolism | Nitriles - pharmacology | Humans | NF-kappa B - metabolism | Toll-Like Receptor 3 - antagonists & inhibitors | Sulfones - pharmacology | Dengue - pathology | Interferon Regulatory Factor-3 - genetics | Viral Load | RNA Interference | Receptors, CCR7 - metabolism | Toll-Like Receptor 3 - genetics | Interferons - genetics | Dendritic Cells - virology | Dengue - immunology | Epithelial Cells - cytology | Interferons - antagonists & inhibitors | Dendritic Cells - metabolism | Chemokine CCL21 - pharmacology | Receptors, CCR7 - antagonists & inhibitors | Viral Nonstructural Proteins - immunology | A549 Cells | Signal Transduction | Cells, Cultured | Receptors, CCR7 - genetics | Dengue - virology | Recombinant Proteins - pharmacology | Toll-Like Receptor 3 - metabolism | Cell Movement - drug effects | Chemokine CCL19 - pharmacology | Epithelial Cells - virology | Interferon Regulatory Factor-3 - antagonists & inhibitors | Interferon Regulatory Factor-3 - metabolism | Interferons - metabolism | Viral Nonstructural Proteins - metabolism | Dendritic Cells - cytology | Dengue Virus - metabolism | RNA, Small Interfering - metabolism | Index Medicus
Journal Article