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Journal of Virology, ISSN 0022-538X, 2015, Volume 89, Issue 17, pp. 8880 - 8896
.... Several entry and/or adhesion factors, including DC-SIGN, AXL, Tyro3, and, to a lesser extent, TIM-1, permitted ZIKV entry, with a major role for the TAM receptor... 
ACTIVATION | DENGUE-VIRUS | ENTRY | VIROLOGY | MOSQUITOS | WEST-NILE-VIRUS | MACHINERY | HEPARAN-SULFATE | AUTOPHAGY | RECEPTORS | I INTERFERON | Keratinocytes - virology | Membrane Glycoproteins - metabolism | Dendritic Cells - immunology | Humans | Flaviviridae - physiology | Virus Internalization | Interferon-Induced Helicase, IFIH1 | Lectins, C-Type - metabolism | Phagosomes - immunology | RNA Interference | Vero Cells | Myxovirus Resistance Proteins - biosynthesis | DEAD Box Protein 58 | Toll-Like Receptor 3 - immunology | Receptor Protein-Tyrosine Kinases - metabolism | Toll-Like Receptor 3 - metabolism | Cell Adhesion Molecules - metabolism | RNA, Small Interfering | Receptors, Cell Surface - genetics | Cell Adhesion Molecules - genetics | Ubiquitins - biosynthesis | Interferon-beta - immunology | Receptors, Virus - metabolism | Cercopithecus aethiops | Receptors, Virus - genetics | Lectins, C-Type - genetics | Insect Vectors - virology | Autophagy - immunology | Aedes - virology | Flaviviridae - immunology | Toll-Like Receptor 7 - immunology | HEK293 Cells | Toll-Like Receptor 3 - genetics | DEAD-box RNA Helicases - metabolism | Dendritic Cells - virology | Skin - virology | Flaviviridae Infections - immunology | Skin - immunology | Fibroblasts - virology | Proto-Oncogene Proteins - metabolism | Cells, Cultured | Interferon-beta - biosynthesis | Receptors, Cell Surface - metabolism | Proto-Oncogene Proteins - genetics | Hepatitis A Virus Cellular Receptor 1 | Flaviviridae Infections - virology | Membrane Glycoproteins - genetics | DEAD-box RNA Helicases - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Virus Replication | Cytokines - biosynthesis | Life Sciences | Microbiology and Parasitology | Cellular Biology | Biochemistry, Molecular Biology | Virology
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2009, Volume 284, Issue 36, pp. 24035 - 24048
..., macrophages need double stimulation with ligands to both Toll-like receptors (TLRs) for IL-1β... 
GENE | LEUCINE-RICH PROTEOGLYCANS | CASPASE-1 | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | HYALURONAN | IL-1-BETA | SECRETION | ATP | NALP3 INFLAMMASOME | Toll-Like Receptor 2 - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Immunity, Innate - genetics | Extracellular Matrix - metabolism | Caspase 1 - metabolism | Male | Ureteral Obstruction - metabolism | Interleukin-1beta - genetics | Inflammation - metabolism | Kidney - metabolism | Carrier Proteins - immunology | Signal Transduction | Proteoglycans - immunology | Extracellular Matrix Proteins - genetics | Proteoglycans - metabolism | Toll-Like Receptor 4 - genetics | Biglycan | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Ureteral Obstruction - immunology | Macrophages - metabolism | Receptors, Purinergic P2 - metabolism | Toll-Like Receptor 2 - immunology | Mice | Proteoglycans - genetics | Extracellular Matrix - immunology | Kidney - immunology | Caspase 1 - immunology | Extracellular Matrix - genetics | Receptors, Purinergic P2 - genetics | Ureteral Obstruction - genetics | Interleukin-1beta - biosynthesis | Lung - metabolism | Receptors, Purinergic P2 - immunology | Extracellular Matrix Proteins - metabolism | Macrophages - immunology | Carrier Proteins - biosynthesis | Interleukin-1beta - immunology | Inflammation - immunology | Protein Structure, Tertiary - genetics | Receptors, Purinergic P2X7 | Carrier Proteins - genetics | Immunity, Innate - immunology | Animals | Caspase 1 - genetics | Extracellular Matrix Proteins - immunology | Receptors, Purinergic P2X4 | Inflammation - genetics | Lung - immunology | Animal models | Reactive oxygen species | Oligomerization | Proteoglycans | Transcription | Lung | Inflammation | Macrophages | Kidney | Stress | Caspase-1 | Purine P2X receptors | Signal transduction | Cell activation | TLR2 protein | Interleukin 1 | Toll-like receptors | Extracellular matrix | Sepsis | Cooperativity | Injuries | Glycobiology and Extracellular Matrices
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 18, pp. 15918 - 15928
Journal Article
Immunological Reviews, ISSN 0105-2896, 11/2011, Volume 244, Issue 1, pp. 55 - 74
A large and diverse group of receptors utilizes the family of cytoplasmic signaling proteins known as tumor necrosis factor receptor (TNFR)‐associated factors (TRAFs... 
tumor necrosis factor receptor | lymphocyte activation | signal transduction | tumor necrosis factor receptor associated factor | Signal transduction | Lymphocyte activation | Tumor necrosis factor receptor associated factor | Tumor necrosis factor receptor | CPG OLIGODEOXYNUCLEOTIDES | ACTIVATED PROTEIN-KINASE | HUMAN CD40 RECEPTOR | IMMUNOLOGY | TERMINAL KINASE | LYMPHOTOXIN-BETA-RECEPTOR | TOLL-LIKE RECEPTORS | LATENT MEMBRANE-PROTEIN | FAMILY-MEMBER TALL-1 | NF-KAPPA-B | T-CELLS | Tumor Necrosis Factor-alpha - metabolism | Humans | Protein Processing, Post-Translational - genetics | Tumor Necrosis Factor-alpha - genetics | NF-kappa B - immunology | Ubiquitin - metabolism | Cell Survival - genetics | TNF Receptor-Associated Factor 5 - immunology | NF-kappa B - metabolism | Signal Transduction - immunology | T-Lymphocytes - metabolism | Myeloid Cells - immunology | TNF Receptor-Associated Factor 3 - genetics | Gene Expression - immunology | Tumor Necrosis Factor-alpha - immunology | Protein Processing, Post-Translational - immunology | B-Lymphocytes - metabolism | Receptors, Tumor Necrosis Factor - genetics | Receptors, Tumor Necrosis Factor - metabolism | TNF Receptor-Associated Factor 3 - metabolism | Signal Transduction - genetics | Ubiquitin - genetics | TNF Receptor-Associated Factor 5 - metabolism | Cell Survival - immunology | Immunity, Innate | Mice, Knockout | TNF Receptor-Associated Factor 5 - genetics | Animals | B-Lymphocytes - immunology | NF-kappa B - genetics | TNF Receptor-Associated Factor 3 - immunology | Myeloid Cells - metabolism | Protein Binding | T-Lymphocytes - immunology | Mice | Receptors, Tumor Necrosis Factor - immunology | Ubiquitin - immunology | Ubiquitin | T cells | Tumor necrosis factor | Necrosis | Tumors
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2011, Volume 286, Issue 7, pp. 5519 - 5528
Toll-like receptors 3 and 4 utilize adaptor TRIF to activate interferon regulatory factor 3 (IRF3... 
SYSTEMIC-LUPUS-ERYTHEMATOSUS | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MURINE LUPUS | PPAR-GAMMA | MEDIATED DEGRADATION | NF-KAPPA-B | ADAPTER PROTEIN | EXPRESSION | AGONISTS | I INTERFERON | Phosphorylation - physiology | Transcription, Genetic - drug effects | Interferon-beta - immunology | PPAR gamma - immunology | PPAR gamma - metabolism | Interferon Regulatory Factor-3 - genetics | Macrophages, Peritoneal - cytology | STAT1 Transcription Factor - metabolism | Chromans - pharmacology | Protein Binding - drug effects | Interferon-beta - genetics | Female | Antineoplastic Agents - pharmacology | Toll-Like Receptor 3 - genetics | Phosphorylation - drug effects | Thiazolidinediones - pharmacology | Interferon Regulatory Factor-3 - immunology | PPAR gamma - genetics | Poly I-C - pharmacology | Interferon-beta - biosynthesis | Macrophages, Peritoneal - immunology | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 3 - immunology | Toll-Like Receptor 4 - immunology | STAT1 Transcription Factor - genetics | Toll-Like Receptor 3 - metabolism | Toll-Like Receptor 4 - metabolism | STAT1 Transcription Factor - immunology | Transcription, Genetic - physiology | Animals | Promoter Regions, Genetic - physiology | Lipopolysaccharides - pharmacology | Interferon Regulatory Factor-3 - metabolism | Mice | Macrophages, Peritoneal - metabolism | Interferon Inducers - pharmacology | Protein Binding - physiology | Index Medicus | Toll-like Receptors (TLR) | Signal Transduction | PPAR | IRF3 | Innate Immunity | Interferon | Macrophage
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 06/2012, Volume 91, Issue 6, pp. 921 - 932
.... Anti-Mer antibody significantly reduced LPS-induced Mer activation, phosphorylation of Akt and FAK, STAT1 activation, and expression of SOCS1 and -3... 
Pulmonary inflammation | Mer signaling | Soluble Mer | Inflammatory mediators | Alveolar macrophages | PHAGOCYTOSIS | GAS6 RECEPTORS | DENDRITIC CELLS | alveolar macrophages | pulmonary inflammation | IMMUNOLOGY | CELL BIOLOGY | inflammatory mediators | APOPTOTIC-CELLS | PLASMA-CONCENTRATIONS | soluble Mer | TNF-ALPHA | PROTEIN-S | HEMATOLOGY | TYRO-3 FAMILY | EXPRESSION | MURINE ALVEOLAR MACROPHAGES | Macrophages, Alveolar - pathology | Matrix Metalloproteinase 9 - immunology | NF-kappa B - immunology | Receptor Protein-Tyrosine Kinases - immunology | Suppressor of Cytokine Signaling 1 Protein | Acute Lung Injury - genetics | Male | Enzyme Activation - immunology | Phosphorylation - genetics | Matrix Metalloproteinase 9 - genetics | c-Mer Tyrosine Kinase | Proto-Oncogene Proteins - immunology | Toll-Like Receptor 4 - agonists | Phosphorylation - immunology | Phosphorylation - drug effects | Cytokines - genetics | Macrophages, Alveolar - immunology | Cytokines - immunology | Inflammation Mediators - immunology | Lipopolysaccharides - toxicity | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Suppressor of Cytokine Signaling Proteins - immunology | Suppressor of Cytokine Signaling Proteins - genetics | Toll-Like Receptor 4 - genetics | Proto-Oncogene Proteins - genetics | Toll-Like Receptor 4 - immunology | Enzyme Activation - drug effects | STAT1 Transcription Factor - genetics | STAT1 Transcription Factor - immunology | Gene Expression Regulation - drug effects | Suppressor of Cytokine Signaling 3 Protein | Animals | Acute Lung Injury - chemically induced | NF-kappa B - genetics | Receptor Protein-Tyrosine Kinases - genetics | Acute Lung Injury - immunology | Mice | Mice, Inbred BALB C | Enzyme Activation - genetics
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 10, p. e0205303
.... Surprisingly, its action in a physiological context is that of an antagonist of Toll-like receptor (TLR)-mediated signaling... 
CELLS | SIGNALING PATHWAYS | SPECIFICITY | RNA | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | MICE | TOLL | RECEPTORS | MYD88 | Humans | Receptors, Interleukin-1 - genetics | NF-kappa B - immunology | Toll-Like Receptor 9 - genetics | Green Fluorescent Proteins - genetics | Receptors, G-Protein-Coupled - immunology | Toll-Like Receptor 9 - immunology | Toll-Like Receptor 7 - immunology | HEK293 Cells | Myeloid Differentiation Factor 88 - immunology | Toll-Like Receptor 3 - genetics | Membrane Glycoproteins - immunology | Genes, Reporter | Toll-Like Receptor 7 - genetics | Luminescent Proteins - immunology | Signal Transduction | Receptors, Interleukin-1 - immunology | Gene Expression Regulation | Myeloid Differentiation Factor 88 - genetics | THP-1 Cells | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 3 - immunology | Toll-Like Receptor 4 - immunology | Immunity, Innate | Membrane Glycoproteins - genetics | Mice, Knockout | Animals | Green Fluorescent Proteins - immunology | Receptors, G-Protein-Coupled - deficiency | NF-kappa B - genetics | Lipopolysaccharides - pharmacology | Luminescent Proteins - genetics | Mice | Receptors, G-Protein-Coupled - genetics | Adaptive systems | Laboratories | Genomes | Biology | Kinases | Macrophages | Medical schools | Proteins | Signal transduction | Ubiquitination | Immunology | Toll-like receptors | Fibroblasts | Immune system | NF-κB protein | CRISPR | Immune response | Cytokines | Cloning | TLR4 protein | Medicine | Vertebrates | Signaling | Interferon regulatory factor 3 | Stem cells | MyD88 protein
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2013, Volume 288, Issue 43, pp. 31268 - 31279
Journal Article
Journal Article
Genes and immunity, ISSN 1476-5470, 2007, Volume 8, Issue 6, pp. 456 - 467
Journal Article
Journal of investigative dermatology, ISSN 0022-202X, 2007, Volume 127, Issue 2, pp. 331 - 341
.... Pathogen-associated molecular patterns (PAMPs) are recognized, among others, by Toll-like receptors (TLRs... 
TOLL-LIKE-RECEPTORS | DOUBLE-STRANDED-RNA | DENDRITIC CELLS | SKIN-ASSOCIATED CHEMOKINE | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | INNATE IMMUNE-RESPONSE | INFLAMMATORY PROTEIN 3-ALPHA | NECROSIS-FACTOR-ALPHA | FACTOR-KAPPA-B | HUMAN EPIDERMAL-KERATINOCYTES | DERMATOLOGY | Oligonucleotides - genetics | Phosphorylation | Toll-Like Receptor 5 - genetics | Humans | Toll-Like Receptor 9 - genetics | I-kappa B Proteins - metabolism | RNA, Messenger - metabolism | Flagellin - pharmacology | Tissue Distribution | Cell Nucleus - metabolism | Protein Isoforms - metabolism | Biological Transport | Oligonucleotides - pharmacology | Toll-Like Receptor 3 - genetics | Toll-Like Receptors - metabolism | Chemokine CXCL9 | Toll-Like Receptor 5 - metabolism | Poly I-C - pharmacology | Cytokines - metabolism | Cells, Cultured | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 3 - metabolism | Toll-Like Receptor 4 - metabolism | Chemokine CXCL10 | Transcription Factor RelA - metabolism | Keratinocytes - metabolism | Toll-Like Receptors - genetics | Chemokines, CXC - metabolism | Lipopolysaccharides - pharmacology | CpG Islands | Ligands | Chemokines - metabolism | Toll-Like Receptor 9 - metabolism | CD40 antigen | Oligonucleotides | Flagellin | mRNA | intercellular adhesion molecule 1 | Immunity | Lipopolysaccharides | CXC chemokines | CCL20 protein | Toll-like receptors | CpG islands | TLR7 protein | Dermatology | Keratinocytes | Nuclear transport | Stress | TLR3 protein | TLR9 protein | TLR1 protein | External stimuli | CXCL10 protein | Histocompatibility antigen HLA | Interferon | Internet | Monocyte chemoattractant protein 1 | Tumor necrosis factor- alpha
Journal Article