X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (5713) 5713
humans (5421) 5421
toll-like receptors (4923) 4923
mice (3471) 3471
immunology (3366) 3366
inflammation (3293) 3293
signal transduction (2034) 2034
male (2018) 2018
activation (1935) 1935
cytokines (1932) 1932
toll-like receptor 4 - metabolism (1747) 1747
female (1604) 1604
nf-kappa-b (1595) 1595
innate immunity (1584) 1584
expression (1541) 1541
cell biology (1472) 1472
proteins (1457) 1457
cells, cultured (1405) 1405
mice, inbred c57bl (1392) 1392
immune system (1303) 1303
dendritic cells (1287) 1287
biochemistry & molecular biology (1102) 1102
macrophages (1087) 1087
gene expression (1074) 1074
tlr4 protein (1047) 1047
lipopolysaccharides - pharmacology (1031) 1031
research (1025) 1025
cell line (1006) 1006
lipopolysaccharide (998) 998
immune response (974) 974
signal transduction - drug effects (969) 969
toll-like receptor (959) 959
nf-kappa b - metabolism (951) 951
mice, knockout (930) 930
health aspects (929) 929
toll-like receptor 4 - genetics (920) 920
rodents (917) 917
research article (901) 901
tlr4 (866) 866
apoptosis (846) 846
multidisciplinary sciences (844) 844
analysis (831) 831
toll-like receptor 4 - antagonists & inhibitors (819) 819
lipopolysaccharides (812) 812
ligands (798) 798
cytokines - metabolism (793) 793
toll-like receptor 4 (791) 791
medicine (778) 778
disease models, animal (763) 763
rats (760) 760
cells (747) 747
toll-like receptors - metabolism (735) 735
neurosciences (712) 712
immunity, innate (711) 711
pharmacology & pharmacy (703) 703
physiological aspects (675) 675
kinases (656) 656
microbiology (647) 647
immunity (645) 645
gene-expression (633) 633
science (628) 628
medicine, research & experimental (610) 610
review (593) 593
infection (592) 592
receptors (568) 568
biology (565) 565
macrophages - metabolism (559) 559
recognition (555) 555
toll-like receptor 2 - metabolism (553) 553
adult (548) 548
phosphorylation (544) 544
toll-like receptor-4 (542) 542
infections (536) 536
disease (535) 535
macrophages - immunology (535) 535
interferon (534) 534
pathogenesis (530) 530
genetic aspects (526) 526
tumor-necrosis-factor (524) 524
cancer (516) 516
signal transduction - immunology (516) 516
toll-like receptor 4 - immunology (500) 500
inhibition (483) 483
sepsis (481) 481
inflammation - immunology (477) 477
enzyme-linked immunosorbent assay (473) 473
middle aged (473) 473
dendritic cells - immunology (472) 472
toll-like receptors - immunology (465) 465
abridged index medicus (463) 463
lipids (459) 459
mitogens (456) 456
mice, inbred balb c (447) 447
inflammation - metabolism (446) 446
bacteria (444) 444
macrophages - drug effects (441) 441
cutting edge (438) 438
signaling (434) 434
necrosis-factor-alpha (427) 427
oxidative stress (425) 425
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (9713) 9713
Japanese (24) 24
Chinese (23) 23
Portuguese (7) 7
Norwegian (5) 5
German (3) 3
Russian (3) 3
Spanish (2) 2
Polish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of medicinal chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 7, pp. 2895 - 2909
The structure–activity relationship was investigated in a series of synthetic TLR4 antagonists formed by a glucosamine core linked to two phosphate esters and two linear carbon chains... 
CHEMISTRY, MEDICINAL | N-LINKED GLYCOSYLATIONS | LIPID-A ANALOGS | CELL ACTIVATION | ENDOTOXIN | MD-2 | CD14 | BINDING | ERITORAN | SEVERE SEPSIS
Journal Article
Biological psychiatry (1969), ISSN 0006-3223, 2013, Volume 73, Issue 8, pp. 729 - 737
Journal Article
British journal of pharmacology, ISSN 0007-1188, 2016, Volume 173, Issue 5, pp. 856 - 869
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 03/2013, Volume 168, Issue 6, pp. 1421 - 1429
.... Recently, Watkins and colleagues hypothesized that opioid agonists activate toll‐like receptor 4 (TLR4) signalling, which leads to neuroinflammation... 
lipopolysaccharide (LPS) | naltrexone | opioid‐immune crosstalk | toll‐like receptor 4 (TLR4) | fentanyl | FNA | opioids | morphine | opioid-immune crosstalk | toll-like receptor 4 (TLR4) | DELTA | NALOXONE | MU | KAPPA-B | ACTIVATED ASTROCYTES | INHIBITION | MICROGLIA | BETA-FUNALTREXAMINE | PHARMACOLOGY & PHARMACY | EXPRESSION | Analgesics, Opioid - antagonists & inhibitors | Lymphocyte Antigen 96 - metabolism | Humans | Analgesics, Opioid - pharmacology | Lipopolysaccharides - antagonists & inhibitors | NF-kappa B p50 Subunit - genetics | Receptors, Opioid, mu - agonists | Narcotic Antagonists - chemistry | Lipopolysaccharide Receptors - metabolism | Lymphocyte Antigen 96 - genetics | Escherichia coli K12 - metabolism | HEK293 Cells | Rhodobacter sphaeroides - metabolism | Toll-Like Receptor 4 - agonists | Toll-Like Receptor 4 - antagonists & inhibitors | Binding, Competitive | Recombinant Proteins - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | Recombinant Proteins - antagonists & inhibitors | NF-kappa B p50 Subunit - metabolism | Receptors, Opioid, mu - metabolism | Nerve Tissue Proteins - agonists | Toll-Like Receptor 4 - genetics | Recombinant Proteins - agonists | Receptors, Opioid, mu - antagonists & inhibitors | Nerve Tissue Proteins - genetics | Toll-Like Receptor 4 - metabolism | Analgesics, Opioid - agonists | Nerve Tissue Proteins - metabolism | Drug Antagonism | Signal Transduction - drug effects | Narcotic Antagonists - pharmacology | Lipopolysaccharides - pharmacology | Lipopolysaccharide Receptors - genetics | Genes, Reporter - drug effects | Ligands | Kinetics | NF-kappa B p50 Subunit - agonists | Morphine | Chemical properties | Mitogens | Analysis | Research Papers
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 1/2010, Volume 107, Issue 1, pp. 222 - 227
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2012, Volume 122, Issue 10, pp. 3476 - 3489
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 497, Issue 7450, pp. 498 - 502
.... Previous studies reported that acute lung injury caused by chemical or microbial insults is secondary to the generation of host-derived, oxidized phospholipid that potently stimulates Toll-like receptor 4 (TLR4... 
UNITED-STATES | 1918 SPANISH INFLUENZA | ACTIVATION | VIRUS | ENDOTOXIN ANTAGONIST | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | LIPOPOLYSACCHARIDE | INHIBITORS | TETRASODIUM E5564 | SEVERE SEPSIS | Disaccharides - metabolism | Lymphocyte Antigen 96 - metabolism | Lipopolysaccharide Receptors - metabolism | Disaccharides - pharmacology | Sugar Phosphates - pharmacology | Time Factors | Acute Lung Injury - prevention & control | Female | Acute Lung Injury - drug therapy | Disaccharides - therapeutic use | Toll-Like Receptor 4 - antagonists & inhibitors | Cytokines - genetics | Orthomyxoviridae Infections - drug therapy | Cytokines - immunology | Antiviral Agents - pharmacology | Sugar Phosphates - therapeutic use | Antiviral Agents - therapeutic use | Mice, Inbred C57BL | Orthomyxoviridae Infections - pathology | Influenza A Virus, H1N1 Subtype - pathogenicity | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Influenza A Virus, H1N1 Subtype - drug effects | Acute Lung Injury - pathology | Animals | Sugar Phosphates - metabolism | Survival Analysis | Toll-Like Receptor 2 - immunology | Ligands | Mice | Orthomyxoviridae Infections - virology | Orthomyxoviridae Infections - immunology | Acute Lung Injury - complications | Prevention | Toll-like receptors | Health aspects | Influenza | Pathology | Cell culture | Respiratory distress syndrome | Cytokines | Mortality | Rodents | Sepsis | Infections | Gene expression | Drug dosages
Journal Article
The European journal of neuroscience, ISSN 0953-816X, 2008, Volume 28, Issue 1, pp. 20 - 29
Journal Article
Brain, behavior, and immunity, ISSN 0889-1591, 2010, Volume 24, Issue 1, pp. 83 - 95
Journal Article
Journal Article