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Nature immunology, ISSN 1529-2916, 2010, Volume 11, Issue 5, pp. 411 - 418
Sensors of pathogens, such as Toll-like receptors (TLRs), detect microbes to activate transcriptional programs that orchestrate adaptive responses to specific insults... 
UNFOLDED PROTEIN RESPONSE | PATHWAY | ER STRESS | HOST-DEFENSE | ENDOPLASMIC-RETICULUM STRESS | FRANCISELLA-TULARENSIS INFECTION | IMMUNOLOGY | LIVE VACCINE STRAIN | INFLAMMATORY RESPONSE | NEGATIVE REGULATOR | SYSTEMS BIOLOGY | RNA, Small Interfering - genetics | Endoribonucleases - genetics | Tularemia - metabolism | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lipopeptides - pharmacology | Transcriptional Activation - drug effects | NADPH Oxidases - metabolism | Tularemia - genetics | Protein Splicing - genetics | Transcriptional Activation - immunology | X-Box Binding Protein 1 | Protein Splicing - drug effects | NADPH Oxidases - genetics | Stress, Physiological - drug effects | TNF Receptor-Associated Factor 6 - genetics | Transcription Factor CHOP - biosynthesis | Transcription Factors - immunology | Cytokines - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Macrophages - pathology | Stress, Physiological - genetics | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | Signal Transduction - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Macrophages - metabolism | Signal Transduction - drug effects | Tunicamycin - pharmacology | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Mice | Stress, Physiological - immunology | Endoribonucleases - immunology | Transcription Factor CHOP - genetics | NADPH Oxidases - immunology | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Macrophages - virology | Mice, Mutant Strains | Tularemia - immunology | Membrane Glycoproteins - immunology | Macrophages - immunology | Cytokines - immunology | Cell Line | Francisella tularensis - immunology | Protein Splicing - immunology | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Immunity, Innate | NADPH Oxidase 2 | Regulatory Factor X Transcription Factors | Mice, Inbred C3H | Membrane Glycoproteins - genetics | Transcription Factors - metabolism | Animals | TNF Receptor-Associated Factor 6 - metabolism | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Francisella tularensis - pathogenicity | Myeloid Differentiation Factor 88 - metabolism | Cytokines - biosynthesis | Cell receptors | Transcription factors | Immune response | Physiological aspects | Genetic aspects | Research | Health aspects | Francisella tularensis
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2009, Volume 284, Issue 36, pp. 24035 - 24048
..., macrophages need double stimulation with ligands to both Toll-like receptors (TLRs) for IL-1β... 
GENE | LEUCINE-RICH PROTEOGLYCANS | CASPASE-1 | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | HYALURONAN | IL-1-BETA | SECRETION | ATP | NALP3 INFLAMMASOME | Toll-Like Receptor 2 - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Immunity, Innate - genetics | Extracellular Matrix - metabolism | Caspase 1 - metabolism | Male | Ureteral Obstruction - metabolism | Interleukin-1beta - genetics | Inflammation - metabolism | Kidney - metabolism | Carrier Proteins - immunology | Signal Transduction | Proteoglycans - immunology | Extracellular Matrix Proteins - genetics | Proteoglycans - metabolism | Toll-Like Receptor 4 - genetics | Biglycan | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Ureteral Obstruction - immunology | Macrophages - metabolism | Receptors, Purinergic P2 - metabolism | Toll-Like Receptor 2 - immunology | Mice | Proteoglycans - genetics | Extracellular Matrix - immunology | Kidney - immunology | Caspase 1 - immunology | Extracellular Matrix - genetics | Receptors, Purinergic P2 - genetics | Ureteral Obstruction - genetics | Interleukin-1beta - biosynthesis | Lung - metabolism | Receptors, Purinergic P2 - immunology | Extracellular Matrix Proteins - metabolism | Macrophages - immunology | Carrier Proteins - biosynthesis | Interleukin-1beta - immunology | Inflammation - immunology | Protein Structure, Tertiary - genetics | Receptors, Purinergic P2X7 | Carrier Proteins - genetics | Immunity, Innate - immunology | Animals | Caspase 1 - genetics | Extracellular Matrix Proteins - immunology | Receptors, Purinergic P2X4 | Inflammation - genetics | Lung - immunology | Animal models | Reactive oxygen species | Oligomerization | Proteoglycans | Transcription | Lung | Inflammation | Macrophages | Kidney | Stress | Caspase-1 | Purine P2X receptors | Signal transduction | Cell activation | TLR2 protein | Interleukin 1 | Toll-like receptors | Extracellular matrix | Sepsis | Cooperativity | Injuries | Glycobiology and Extracellular Matrices
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 5/2013, Volume 110, Issue 20, pp. 8134 - 8139
Journal Article
Journal of cellular and molecular medicine, ISSN 1582-1838, 2018, Volume 22, Issue 6, pp. 3246 - 3258
Toll‐like receptor 4 (TLR4) which acts as a receptor for lipopolysaccharide (LPS) has been reported to be involved in carcinogenesis... 
Toll‐like receptor 4 | heterochromatin protein 1 | cancer stem cells | telomeres | Toll-like receptor 4 | MEDICINE, RESEARCH & EXPERIMENTAL | SUPPRESSOR | SUV39H2 | RNA | VARIANTS | RESECTION | CELL BIOLOGY | GENOMIC INSTABILITY | TERRA | GROWTH | TLR4 | BINDING | Histone-Lysine N-Methyltransferase - genetics | Liver - pathology | Liver Neoplasms - genetics | Humans | Liver - metabolism | Gene Expression Regulation, Neoplastic | Toll-Like Receptor 4 - genetics | RNA, Long Noncoding - genetics | Telomere Homeostasis - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | DNA (Cytosine-5-)-Methyltransferases - genetics | Telomerase - genetics | Neoplastic Stem Cells - metabolism | Cell Line, Tumor | Neoplastic Stem Cells - pathology | Liver Neoplasms - pathology | Telomeric Repeat Binding Protein 2 - genetics | Protein Isoforms - genetics | Telomere - genetics | Prevention | Telomeres | Liver cancer | Methyltransferases | Stem cells | Mediation | Telomerase | Cancer | Protein binding | Transcription elongation | Telomerase reverse transcriptase | RNA-directed DNA polymerase | Liver | Heterochromatin protein 1 | Carcinogenesis | DNA-directed RNA polymerase | Lipopolysaccharides | Proteins | Heterochromatin | Carcinogens | Toll-like receptors | Catalysis | Elongation | Deoxyribonucleic acid--DNA | Binding | Urothelial cancer | Telomere-binding protein | Therapeutic applications | Inflammation | TLR4 protein | Ribonucleic acid--RNA | Loci | Polymerase | Hepatocytes | TRF2 protein | Lysine | Isoforms | Regulatory mechanisms (biology) | DNA methyltransferase | RNA polymerase II | Histone H3 | Index Medicus | Original
Journal Article
Mucosal immunology, ISSN 1935-3456, 2015, Volume 8, Issue 5, pp. 1166 - 1179
Journal Article
Science signaling, ISSN 1937-9145, 2011, Volume 4, Issue 199, pp. ra75 - ra75
... (programmed cell death 4) and miR-21 (microRNA-21) by two mechanisms. First, decorin acted as an endogenous ligand of Toll-like receptors 2 and 4 and stimulated production of proinflammatory molecules, including PDCD4, in macrophages... 
BREAST-CANCER | GROWTH-FACTOR-BETA | TGF-BETA | PROTEIN | MESSENGER-RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR PDCD4 | TOLL-LIKE RECEPTORS | CELL-DEATH 4 | EXPRESSION | PROGRAMMED CELL-DEATH-4 | CELL BIOLOGY | Inflammation - pathology | Toll-Like Receptor 2 - genetics | Humans | Transforming Growth Factor beta1 - metabolism | MicroRNAs - metabolism | Inflammation - metabolism | Sepsis - metabolism | Toll-Like Receptor 4 - agonists | Decorin - genetics | Apoptosis Regulatory Proteins - immunology | Signal Transduction | RNA-Binding Proteins - immunology | Macrophages, Peritoneal - immunology | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | MicroRNAs - immunology | Toll-Like Receptor 4 - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Mice, Nude | Neoplasms - immunology | Interleukin-10 - genetics | Cell Line, Tumor | Toll-Like Receptor 2 - immunology | Mice | MicroRNAs - genetics | Macrophages, Peritoneal - metabolism | Interleukin-10 - immunology | RNA-Binding Proteins - metabolism | Neoplasms - metabolism | Neoplasm Transplantation | RNA-Binding Proteins - genetics | Toll-Like Receptor 2 - agonists | Macrophages, Peritoneal - pathology | Transplantation, Heterologous | Transforming Growth Factor beta1 - immunology | Decorin - immunology | Sepsis - pathology | Neoplasms - genetics | Apoptosis Regulatory Proteins - genetics | Interleukin-10 - metabolism | Sepsis - immunology | Inflammation - immunology | Transforming Growth Factor beta1 - genetics | Mice, Inbred C3H | Sepsis - genetics | Animals | Inflammation - genetics | Neoplasms - pathology | Decorin - metabolism | Life Sciences | Cellular Biology
Journal Article
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2012, Volume 209, Issue 13, pp. 2395 - 2408
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2017, Volume 152, Issue 4, pp. 851 - 866.e24
Journal Article