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1. Full Text Human monocyte subsets are transcriptionally and functionally altered in aging in response to pattern recognition receptor agonists
by Metcalf, Talibah U and Wilkinson, Peter A and Cameron, Mark J and Ghneim, Khader and Chiang, Cindy and Wertheimer, Anne M and Hiscott, John B and Nikolich-Zugich, Janko and Haddad, Elias K
The Journal of immunology (1950), ISSN 0022-1767, 08/2017, Volume 199, Issue 4, pp. 1405 - 1417
Life Sciences & Biomedicine | Immunology | Science & Technology | Interferons - biosynthesis | Humans | Middle Aged | Male | Gene Expression Profiling | Monocytes - immunology | Interferons - immunology | Lipopolysaccharide Receptors - analysis | Young Adult | Receptors, Pattern Recognition - metabolism | Toll-Like Receptor 8 - immunology | Aging - immunology | Receptors, IgG - analysis | Toll-Like Receptor 7 - immunology | Aged, 80 and over | Receptors, Pattern Recognition - agonists | Toll-Like Receptor 4 - agonists | Adult | Female | Transcription, Genetic | Monocytes - classification | Monocytes - physiology | Cytokines - genetics | Cytokines - immunology | Toll-Like Receptor 8 - agonists | Toll-Like Receptor 7 - agonists | Toll-Like Receptor 7 - metabolism | GPI-Linked Proteins - analysis | Toll-Like Receptor 4 - immunology | Immunity, Innate | Toll-Like Receptor 4 - metabolism | Receptors, Pattern Recognition - genetics | Aged | Cytokines - biosynthesis | Toll-Like Receptor 8 - metabolism | Transcription | CX3CR1 protein | Infections | Vaccines | CD14 antigen | Immunity | Impact analysis | Receptors | Biological effects | Peripheral blood | Toll-like receptors | CCL20 protein | Aging | Immune system | Antigen presentation | Immunization | Immune response | TLR7 protein | Pattern recognition | TLR4 protein | IL-1β | Biological activity | Signaling | Monocytes | CD16 antigen | γ-Interferon | Interferon | Adults | Retinoic acid | Alternations | Index Medicus | Abridged Index Medicus
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2. Full Text Toll‐like receptors 7, 8, and 9: linking innate immunity to autoimmunity
by Krieg, Arthur M and Vollmer, Jörg
Immunological reviews, ISSN 0105-2896, 12/2007, Volume 220, Issue 1, pp. 251 - 269
Toll‐like receptor | autoimmunity | innate immunity | oligodeoxynucleotide | Autoimmunity | Oligodeoxynucleotide | Innate immunity | Toll-like receptor | Life Sciences & Biomedicine | Immunology | Science & Technology | Toll-Like Receptor 7 - agonists | CpG Islands - immunology | Toll-Like Receptor 9 - antagonists & inhibitors | DNA - immunology | RNA - immunology | Humans | Autoimmune Diseases - immunology | Toll-Like Receptor 7 - drug effects | Toll-Like Receptor 9 - physiology | Immunity, Innate | Toll-Like Receptor 9 - agonists | Toll-Like Receptors - agonists | Animals | Toll-Like Receptor 8 - antagonists & inhibitors | Toll-Like Receptor 7 - physiology | Toll-Like Receptor 8 - physiology | Drug Design | Toll-Like Receptors - antagonists & inhibitors | Toll-Like Receptors - physiology | Mice | Autoimmune Diseases - drug therapy | Toll-Like Receptor 8 - agonists | Nucleic acids | Index Medicus
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3. Full Text The use of Toll-like receptor 7/8 agonists as vaccine adjuvants
by Vasilakos, John P and Tomai, Mark A
Expert review of vaccines, ISSN 1476-0584, 07/2013, Volume 12, Issue 7, pp. 809 - 819
dendritic cells | imiquimod | imidazoquinolines | TLR8 | TLR7 | Aldara | resiquimod (R-848) | Life Sciences & Biomedicine | Immunology | Science & Technology | Antiviral agents | Biological and medical sciences | Medical sciences | Immunomodulators | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Toll-Like Receptor 7 - agonists | Adjuvants, Immunologic - administration & dosage | Adjuvants, Immunologic - pharmacology | Humans | Aminoquinolines - administration & dosage | Drug Discovery - trends | Imidazoles - administration & dosage | Vaccines - immunology | Clinical Trials as Topic | Imidazoles - pharmacology | Toll-Like Receptor 8 - immunology | Toll-Like Receptor 7 - immunology | Aminoquinolines - pharmacology | Toll-Like Receptor 8 - agonists | Toll-like receptors | Physiological aspects | Adjuvants, Pharmaceutic | Vaccines | Research | Health aspects | Index Medicus
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4. Full Text Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines
by Kužnik, Alenka and Benčina, Mojca and Švajger, Urban and Jeras, Matjaž and Rozman, Blaž and Jerala, Roman
The Journal of immunology (1950), ISSN 0022-1767, 04/2011, Volume 186, Issue 8, pp. 4794 - 4804
Life Sciences & Biomedicine | Immunology | Science & Technology | Humans | Toll-Like Receptor 9 - genetics | Toll-Like Receptor 3 - antagonists & inhibitors | Endosomes - metabolism | Quinolines - pharmacology | Chloroquine - pharmacology | Quinacrine - pharmacology | Transfection | Hydrogen-Ion Concentration - drug effects | HEK293 Cells | Toll-Like Receptors - antagonists & inhibitors | Toll-Like Receptor 3 - genetics | Culture Media - chemistry | Imidazoles - metabolism | Toll-Like Receptor 8 - agonists | Binding, Competitive | Toll-Like Receptor 7 - agonists | Toll-Like Receptor 7 - genetics | Cell Line | Antimalarials - metabolism | Toll-Like Receptor 7 - metabolism | Toll-Like Receptor 9 - antagonists & inhibitors | Cytokines - metabolism | Cells, Cultured | Imidazoles - pharmacology | Nucleic Acids - metabolism | Toll-Like Receptor 3 - metabolism | Toll-Like Receptors - agonists | Antimalarials - pharmacology | Quinolines - metabolism | Animals | Toll-Like Receptors - genetics | Culture Media - pharmacology | Toll-Like Receptor 8 - genetics | Endosomes - chemistry | Toll-Like Receptor 9 - metabolism | Toll-Like Receptor 8 - metabolism | Serum - chemistry | Index Medicus | Abridged Index Medicus
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5. Full Text Anti-tumor activity of toll-like receptor 7 agonists
by Chi, Huju and Li, Chunman and Zhao, Flora Sha and Zhang, Li and Ng, Tzi Bun and Jin, Guangyi and Sha, Ou
Frontiers in pharmacology, ISSN 1663-9812, 05/2017, Volume 8, Issue MAY, pp. 304 - 304
Agonists | TLR7 | Immune stimulation | Toll-Like receptors (TLRs) | Anti-tumor activity | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | immune stimulation | agonists | anti-tumor activity
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6. Full Text Design and synthesis of tetrahydropyridopyrimidine based Toll-Like Receptor (TLR) 7/8 dual agonists
by McGowan, David C and Herschke, Florence and Khamlichi, Mourad D and Rosauro, Mari Luz and Benedicto, Sara M. Pérez and Pauwels, Frederik and Stoops, Bart and Pande, Vineet and Scholliers, Annick and Van Schoubroeck, Bertrand and Mostmans, Wendy and Van Dijck, Kris and Thoné, Tine and Horton, Helen and Fanning, Gregory and Jonckers, Tim H.M and Raboisson, Pierre
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 10/2018, Volume 28, Issue 19, pp. 3216 - 3221
Immunomodulator | TLR7/8 | Tetrahydropyridopyrimidine | Toll-Like Receptor | Biological response modifiers | Interferon | Index Medicus
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7. Full Text Nucleic acid agonists for Toll‐like receptor 7 are defined by the presence of uridine ribonucleotides
by Diebold, Sandra S and Massacrier, Catherine and Akira, Shizuo and Paturel, Carine and Morel, Yannis and Reis e Sousa, Caetano
European journal of immunology, ISSN 0014-2980, 12/2006, Volume 36, Issue 12, pp. 3256 - 3267
Dendritic cells | RNA | TLR7 | Life Sciences & Biomedicine | Immunology | Science & Technology | Endosomes - virology | Poly U - agonists | Toll-Like Receptor 7 - agonists | Toll-Like Receptor 7 - chemistry | Endosomes - immunology | Poly U - chemistry | Humans | Membrane Glycoproteins - chemistry | Mice, Inbred C57BL | Uridine - physiology | Cells, Cultured | Membrane Glycoproteins - agonists | Mice, Knockout | Membrane Glycoproteins - physiology | Animals | RNA, Viral - agonists | RNA, Viral - chemistry | Toll-Like Receptor 7 - physiology | Deoxyribonucleotides - chemistry | Mice | Deoxyribonucleotides - physiology | Amino Acid Motifs - genetics | Cytokines - biosynthesis | Uridine - chemistry | Index Medicus
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