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Journal of Immunology, ISSN 0022-1767, 04/2011, Volume 186, Issue 8, pp. 4794 - 4804
Endosomal TLRs play an important role in innate immune response as well as in autoimmune processes. In the therapy of systemic lupus erythematosus,... 
IMMUNOSTIMULATORY CPG-OLIGODEOXYNUCLEOTIDES | CELLS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVATION | DNA | COMPLEXES | TOLL-LIKE RECEPTORS | H+-ATPASE | IFN-ALPHA INDUCER | IMMUNOLOGY | NUCLEIC-ACIDS | Humans | Toll-Like Receptor 9 - genetics | Toll-Like Receptor 3 - antagonists & inhibitors | Endosomes - metabolism | Quinolines - pharmacology | Chloroquine - pharmacology | Quinacrine - pharmacology | Transfection | Hydrogen-Ion Concentration - drug effects | HEK293 Cells | Toll-Like Receptors - antagonists & inhibitors | Toll-Like Receptor 3 - genetics | Culture Media - chemistry | Imidazoles - metabolism | Toll-Like Receptor 8 - agonists | Binding, Competitive | Toll-Like Receptor 7 - agonists | Toll-Like Receptor 7 - genetics | Cell Line | Antimalarials - metabolism | Toll-Like Receptor 7 - metabolism | Toll-Like Receptor 9 - antagonists & inhibitors | Cytokines - metabolism | Cells, Cultured | Imidazoles - pharmacology | Nucleic Acids - metabolism | Toll-Like Receptor 3 - metabolism | Toll-Like Receptors - agonists | Antimalarials - pharmacology | Quinolines - metabolism | Animals | Toll-Like Receptors - genetics | Culture Media - pharmacology | Toll-Like Receptor 8 - genetics | Endosomes - chemistry | Toll-Like Receptor 9 - metabolism | Toll-Like Receptor 8 - metabolism | Serum - chemistry | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2014, Volume 10, Issue 6, pp. e1004210 - e1004210
The ability of innate immune cells to sense and respond to impending danger varies by anatomical location. The liver is considered tolerogenic but is still... 
BORRELIA-BURGDORFERI | RESPONSES | INVARIANT T-CELLS | HEPATITIS-B-VIRUS | REPLICATION | VIROLOGY | RECOGNITION | RNA | DISTINCT | KUPFFER CELLS | MICROBIOLOGY | PARASITOLOGY | Leukocytes, Mononuclear - metabolism | Liver - pathology | Hepatitis B - metabolism | Coculture Techniques | Humans | Hepatitis B - virology | Liver - microbiology | Hepacivirus - pathogenicity | Monocytes - immunology | Oligoribonucleotides - pharmacology | Hepatitis C - immunology | Liver - immunology | Liver - drug effects | Pseudomonas aeruginosa - metabolism | T-Lymphocyte Subsets - drug effects | Enterococcus faecalis - immunology | Enterococcus faecalis - pathogenicity | Riboflavin - biosynthesis | Leukocytes, Mononuclear - drug effects | Monocytes - drug effects | Enterococcus faecalis - metabolism | Hepatitis C - virology | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | Toll-Like Receptor 8 - metabolism | Pseudomonas aeruginosa - immunology | T-Lymphocyte Subsets - immunology | Adjuvants, Immunologic - pharmacology | Hepatitis C - metabolism | Hepacivirus - immunology | Hepatitis B virus - pathogenicity | Monocytes - metabolism | Hepatitis B - immunology | Pseudomonas aeruginosa - pathogenicity | Escherichia coli - pathogenicity | Leukocytes, Mononuclear - immunology | Escherichia coli - metabolism | Killer Cells, Natural - immunology | Hepatitis B virus - immunology | Toll-Like Receptor 8 - agonists | Immunity, Innate - drug effects | Interferon-gamma Release Tests | Cells, Cultured | Hepatitis B - pathology | Escherichia coli - immunology | Up-Regulation - drug effects | Leukocytes, Mononuclear - pathology | T-Lymphocyte Subsets - metabolism | Hepatitis C - pathology | Liver diseases | Toll-like receptors | Physiological aspects | Development and progression | Interferon | Drug therapy | Health aspects | Index Medicus | Bacterial infections | Liver | Rodents | Immune system
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2011, Volume 121, Issue 5, pp. 1782 - 1796
Journal Article
Nature immunology, ISSN 1529-2908, 2010, Volume 11, Issue 5, pp. 419 - U81
Pattern-recognition receptors (PRRs) elicit antiviral immune responses to human immunodeficiency virus type 1 (HIV-1). Here we show that HIV-1 required... 
MYCOBACTERIUM-TUBERCULOSIS | TUMOR-NECROSIS-FACTOR | ACTIVATION | LONG TERMINAL REPEAT | IMMUNE-RESPONSES | IMMUNOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | NF-KAPPA-B | MEDIATED INTERNALIZATION | T-CELLS | LANGERHANS CELLS | HIV Envelope Protein gp120 - genetics | HIV-1 - pathogenicity | Phosphorylation | Protein Binding - genetics | Transcriptional Activation - genetics | Virus Replication - genetics | Dendritic Cells - immunology | Humans | Lectins, C-Type - immunology | Dendritic Cells - pathology | NF-kappa B - metabolism | Cell Adhesion Molecules - immunology | Positive Transcriptional Elongation Factor B - metabolism | RNA Polymerase II - metabolism | Transcriptional Activation - immunology | HIV Envelope Protein gp120 - metabolism | HIV Infections - immunology | Lectins, C-Type - metabolism | Toll-Like Receptor 8 - immunology | HIV-1 - physiology | Second Messenger Systems - genetics | Protein Engineering | Dendritic Cells - virology | Dendritic Cells - metabolism | Virus Replication - drug effects | HIV Infections - genetics | HIV Infections - virology | Cells, Cultured | Receptors, Cell Surface - metabolism | Virus Replication - immunology | Immunity, Innate | Cell Adhesion Molecules - metabolism | Receptors, Cell Surface - immunology | Second Messenger Systems - immunology | Proto-Oncogene Proteins c-raf - metabolism | NF-kappa B - genetics | Toll-Like Receptor 8 - metabolism | HIV Infections - metabolism | Sequence Deletion - genetics | Prevention | Transcription factors | Immune response | Dendritic cells | Physiological aspects | Causes of | Genetic aspects | Research | HIV (Viruses) | Health aspects | HIV infection | Index Medicus
Journal Article
IMMUNITY, ISSN 1074-7613, 11/2005, Volume 23, Issue 5, pp. 465 - 478
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, pp. e41884 - e41884
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 07/2017, Volume 214, Issue 7, pp. 2103 - 2119
Neutrophils play a crucial role in host defense. However, neutrophil activation is also linked to autoimmune diseases such as systemic lupus erythematosus... 
PLASMACYTOID DENDRITIC CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | NADPH OXIDASE | SYSTEMIC-LUPUS-ERYTHEMATOSUS | PROPROTEIN CONVERTASES | C1Q DEFICIENCY | INFLAMMATION | FC-GAMMA-RIIIB | TOLL-LIKE RECEPTORS | ALPHA | IMMUNOLOGY | EXTRACELLULAR TRAPS | Extracellular Traps - metabolism | Dendritic Cells - immunology | Humans | Complement C5a - metabolism | Lupus Erythematosus, Systemic - metabolism | Monocytes - metabolism | Monocytes - immunology | Complement Activation - immunology | Receptors, IgG - metabolism | Toll-Like Receptor 8 - immunology | Extracellular Traps - immunology | Flow Cytometry | Toll-Like Receptor 7 - immunology | Lupus Erythematosus, Systemic - immunology | Neutrophils - metabolism | Dendritic Cells - metabolism | Toll-Like Receptor 7 - metabolism | Cells, Cultured | Neutrophils - immunology | Phagocytosis - immunology | Receptors, IgG - immunology | Blotting, Western | Complement C5a - immunology | Antigen-Antibody Complex - immunology | Toll-Like Receptor 8 - metabolism | Shedding | Complement component C5a | Immune clearance | Activation | Proteins | Cell activation | Systemic lupus erythematosus | Proteolysis | Toll-like receptors | Furin | Cleavage | Antigen-antibody complexes | TLR7 protein | Dendritic cells | Neutrophils | Leukocytes (neutrophilic) | Inflammation | Nucleic acids | Immune systems | Signaling | Monocytes | Chronic conditions | Complement activation | Information processing | Autoimmune diseases | Phagocytosis | Index Medicus | s | 311 | 300
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2014, Volume 193, Issue 10, pp. 5118 - 5128
Nucleic acid-sensing TLRs are involved in both antimicrobial immune responses and autoimmune inflammation. TLR8 is phylogenetically and structurally related to... 
CATHEPSINS | HUMAN DENDRITIC CELLS | MESSENGER-RNA | NUCLEIC-ACID | TOLL-LIKE RECEPTORS | TOLL-LIKE-RECEPTOR-9 | IMMUNOLOGY | EXPRESSION | PATHOGEN RECOGNITION | BACTERIAL-DNA | INNATE IMMUNITY | Macrophages - chemistry | Monocytes - cytology | Humans | Toll-Like Receptor 9 - genetics | Molecular Sequence Data |