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Gastroenterology, ISSN 0016-5085, 2014, Volume 146, Issue 7, pp. 1763 - 1774
Background & Aims The NACHT, LRR, and pyrin domain–containing protein 3 (NLRP3) inflammasome induces inflammation in response to organ injury, but little is... 
Gastroenterology and Hepatology | Innate Immune Response | Immune Regulation | Pancreas | Mouse Model | ACTIVATION | NLRP3 INFLAMMASOME | GPR81 | AGONISTS | GENE | TLR9 | MICE | HEPATOTOXICITY | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | SEVERITY | Liver - pathology | Inflammasomes - metabolism | Receptors, G-Protein-Coupled - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Male | NF-kappa B - metabolism | Monocytes - immunology | Lipopolysaccharides | Liver - immunology | Liver - drug effects | RNA Interference | Interleukin-1beta - metabolism | Toll-Like Receptors - drug effects | Anti-Inflammatory Agents - administration & dosage | Toll-Like Receptors - metabolism | Cytoprotection | Disease Models, Animal | Galactosamine | Chemical and Drug Induced Liver Injury - prevention & control | Anti-Inflammatory Agents - pharmacology | Down-Regulation | Liver - metabolism | Injections, Intraperitoneal | Pancreas - pathology | Pancreas - metabolism | Pancreas - immunology | Toll-Like Receptor 4 - metabolism | Chemical and Drug Induced Liver Injury - immunology | Monocytes - drug effects | Macrophages - metabolism | Signal Transduction - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Sodium Lactate - pharmacology | beta-Arrestins | Mice | Receptors, G-Protein-Coupled - genetics | RNA, Small Interfering - metabolism | Monocytes - metabolism | Pancreatitis - prevention & control | Arrestins - metabolism | Dose-Response Relationship, Drug | Pancreatitis - genetics | Transfection | Inflammasomes - drug effects | Sodium Lactate - administration & dosage | Pancreatitis - immunology | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology | Macrophages - immunology | Cell Line | Immunity, Innate - drug effects | Toll-Like Receptor 4 - drug effects | Mice, Inbred C57BL | Pancreas - drug effects | Chemical and Drug Induced Liver Injury - genetics | Pancreatitis - chemically induced | Animals | Carrier Proteins - metabolism | beta-Arrestin 2 | Inflammasomes - immunology | Macrophages - drug effects | Pancreatitis - pathology | Pancreatitis - metabolism | Ceruletide | Lactates | Gastrointestinal diseases | Inflammation
Journal Article
世界胃肠病学杂志:英文版(电子版), ISSN 1007-9327, 2014, Volume 20, Issue 23, pp. 7381 - 7391
Emerging data have shown a close association between compositional changes in gut microbiota and the development of nonalcoholic fatty liver disease(NAFLD).The... 
disease | stea | fatty | liver | Nonalcoholic | Gut microbiota | Probiotics | Nonalcoholic fatty liver disease | Nonalcoholic steatohepatitis | Toll-like receptor | Prebiotics | METABOLIC SYNDROME | NECROSIS-FACTOR-ALPHA | DIET-INDUCED OBESITY | TOTAL PARENTERAL-NUTRITION | INCREASED INTESTINAL PERMEABILITY | HEPATIC STELLATE CELLS | INSULIN-RESISTANCE | KUPFFER CELLS | TNF-ALPHA | GASTROENTEROLOGY & HEPATOLOGY | PATTERN-RECOGNITION RECEPTORS | Intestines - drug effects | Humans | Bacteria - drug effects | Liver - microbiology | Pediatric Obesity - microbiology | Intestines - metabolism | Intestines - immunology | Bacteria - immunology | Liver - immunology | Liver - drug effects | Toll-Like Receptors - drug effects | Toll-Like Receptors - metabolism | Cytokines - immunology | Inflammation Mediators - immunology | Pediatric Obesity - immunology | Bacteria - metabolism | Signal Transduction | Liver - metabolism | Non-alcoholic Fatty Liver Disease - immunology | Non-alcoholic Fatty Liver Disease - microbiology | Risk Factors | Toll-Like Receptors - immunology | Non-alcoholic Fatty Liver Disease - therapy | Lipid Metabolism | Non-alcoholic Fatty Liver Disease - metabolism | Permeability | Bacterial Translocation | Host-Pathogen Interactions | Animals | Intestines - microbiology | Probiotics - therapeutic use | Immunologic Factors - therapeutic use | Topic Highlight
Journal Article
Nature Reviews Microbiology, ISSN 1740-1526, 07/2007, Volume 5, Issue 7, pp. 505 - 517
Journal Article
Handbook of Experimental Pharmacology, ISSN 0171-2004, 2008, Volume 183, Issue 183, pp. 21 - 50
Since Toll-like receptor (TLR) signaling was found crucial for the activation of innate and adaptive immunity, it has been the focus of immunological research.... 
Animals | Signal Transduction - drug effects | Humans | Toll-Like Receptors - drug effects | Toll-Like Receptors - physiology | Ligands | Signal Transduction - physiology | Toll-Like Receptors - chemistry
Conference Proceeding
Journal Article
Nature Immunology, ISSN 1529-2908, 09/2008, Volume 9, Issue 9, pp. 1028 - 1036
Journal Article
Addiction Biology, ISSN 1355-6215, 05/2018, Volume 23, Issue 3, pp. 889 - 903
Chronic ethanol consumption stimulates neuroimmune signaling in the brain, and Toll‐like receptor (TLR) activation plays a key role in ethanol‐induced... 
neuroimmune | oll‐like receptors | chronic ethanol | mlexanox | TRIF | prefrontal cortex | Toll-like receptors | Amlexanox | TOLL-LIKE-RECEPTORS | ACTIVATION | GABAERGIC TRANSMISSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BRAIN-DAMAGE | SUBSTANCE ABUSE | ALCOHOL-CONSUMPTION | MOUSE CENTRAL AMYGDALA | MICE | NF-KAPPA-B | INNATE IMMUNITY | Neuroimmunomodulation - immunology | Amygdala - drug effects | Adaptor Proteins, Vesicular Transport - genetics | RNA, Messenger - metabolism | Central Nervous System Depressants - pharmacology | Prefrontal Cortex - drug effects | Chemokine CXCL10 - drug effects | I-kappa B Kinase - antagonists & inhibitors | Chemokine CXCL10 - immunology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Toll-Like Receptor 2 - drug effects | Lipopolysaccharide Receptors - drug effects | Toll-Like Receptor 3 - genetics | Adaptor Proteins, Vesicular Transport - drug effects | RNA, Messenger - drug effects | Prefrontal Cortex - immunology | Signal Transduction | Toll-Like Receptor 4 - drug effects | Mice, Inbred C57BL | Lipopolysaccharide Receptors - immunology | Toll-Like Receptor 3 - immunology | Amygdala - immunology | Toll-Like Receptor 4 - immunology | Adaptor Proteins, Vesicular Transport - immunology | Brain - drug effects | Ethanol - pharmacology | Animals | Aminopyridines - pharmacology | Toll-Like Receptor 3 - drug effects | Toll-Like Receptor 2 - immunology | Mice | Nucleus Accumbens - immunology | Nucleus Accumbens - drug effects | Brain - immunology | Neuroimmunomodulation - drug effects | Alcohol | Interferon | Alcohol, Denatured | RNA | Biological response modifiers | Analysis | Cortex (prefrontal) | Immune response | Ethanol | Amygdala | Drinking behavior | mRNA | TLR3 protein | Nucleus accumbens | Signal transduction | Rodents | CXCL10 protein | MyD88 protein
Journal Article