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Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2016, Volume 478, Issue 2, pp. 845 - 851
Platelet-derived growth factor D (PDGF-D) signaling plays significant roles during the development and progression of human malignancies via interacting with... 
TSCC | PDGF-D/PDGFRβ | p38/AKT/ERK/EMT signal pathway | HEAD | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MICROENVIRONMENTAL REGULATION | EMT | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | OVEREXPRESSION | BIOPHYSICS | DISSEMINATION | PDGF-D/PDGFR beta | NECK | BIOLOGICAL INSIGHTS | RNA, Small Interfering - genetics | Phosphorylation | Cadherins - metabolism | Vimentin - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Gene Expression Regulation, Neoplastic | Epithelial-Mesenchymal Transition - genetics | Receptor, Platelet-Derived Growth Factor beta - genetics | Antigens, CD - genetics | Platelet-Derived Growth Factor - genetics | Proto-Oncogene Proteins c-akt - genetics | Antigens, CD - metabolism | Receptor, Platelet-Derived Growth Factor beta - antagonists & inhibitors | Lymphokines - genetics | Snail Family Transcription Factors - genetics | Vimentin - genetics | Lymphokines - antagonists & inhibitors | Lymphokines - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Cadherins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Tongue Neoplasms - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Snail Family Transcription Factors - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Neoplasm Invasiveness | Tongue Neoplasms - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Tongue Neoplasms - pathology | Disease Progression | Platelet-Derived Growth Factor - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Line, Tumor | Platelet-Derived Growth Factor - antagonists & inhibitors | Cell Movement | RNA, Small Interfering - metabolism
Journal Article
Neurogastroenterology & Motility, ISSN 1350-1925, 01/2016, Volume 28, Issue 1, pp. 91 - 100
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2012, Volume 287, Issue 9, pp. 6668 - 6678
Activity of heparanase is implicated strongly in dissemination of metastatic tumor cells and cells of the immune system. In addition, heparanase enhances the... 
LOCALIZATION | REGULATOR | PROTEOGLYCANS | METASTASIS | TUMOR PROGRESSION | CONSTITUTIVE ACTIVATION | SULFATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | EXPRESSION | CONTRIBUTES | Phosphorylation - physiology | Prostatic Neoplasms - metabolism | Fibroblasts - enzymology | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Glucuronidase - metabolism | Male | Head and Neck Neoplasms - metabolism | Breast Neoplasms - metabolism | Laryngeal Neoplasms - pathology | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Receptor, Epidermal Growth Factor - metabolism | STAT1 Transcription Factor - metabolism | Tumor Suppressor Proteins - genetics | Female | Nose Neoplasms - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Tongue Neoplasms - metabolism | Prostatic Neoplasms - pathology | Nose Neoplasms - pathology | Tumor Suppressor Proteins - metabolism | Laryngeal Neoplasms - metabolism | Cells, Cultured | Multiple Myeloma - metabolism | STAT1 Transcription Factor - genetics | Tongue Neoplasms - pathology | Disease Progression | Head and Neck Neoplasms - pathology | Multiple Myeloma - pathology | Animals | Breast Neoplasms - pathology | Fibroblasts - cytology | Mice | Phosphorylation | Epidermal Growth Factor Receptor (EGFR) | STAT3 | Cell Signaling | Heparan Sulfate | Heparanase | Glycosaminoglycan | Glycobiology and Extracellular Matrices | Cancer Biology | Head And Neck Cancer | Localization
Journal Article
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 07/2012, Volume 303, Issue 2, pp. R199 - R208
Journal Article
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 07/2017, Volume 23, Issue 7, pp. 890 - 890
The extracellular matrix (ECM) is a master regulator of cellular phenotype and behavior. It has a crucial role in both normal tissue homeostasis and disease... 
MEDICINE, RESEARCH & EXPERIMENTAL | NERVE | COLLAGEN | LAMININ | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | MOUSE MAMMARY-TUMOR | CELL BIOLOGY | BLOOD-VESSELS | SINGLE-CELL RESOLUTION | GLAND | BRAIN | BASEMENT-MEMBRANE | Optical Imaging | Peripheral Nerves - ultrastructure | Basement Membrane - ultrastructure | Lactation | Mammary Neoplasms, Experimental - ultrastructure | Humans | Lung Neoplasms - metabolism | Extracellular Matrix - metabolism | Tumor Microenvironment | Melanoma, Experimental - metabolism | Mammary Glands, Human - metabolism | Mammary Neoplasms, Experimental - metabolism | Breast Neoplasms - metabolism | Lung Neoplasms - secondary | Melanoma, Experimental - ultrastructure | Female | Peripheral Nerves - metabolism | Imaging, Three-Dimensional | Tongue Neoplasms - metabolism | Breast Neoplasms - ultrastructure | Lymph Nodes - metabolism | Lymphatic Metastasis | Basement Membrane - metabolism | Lymph Nodes - ultrastructure | Extracellular Matrix - ultrastructure | Animals | Mammary Glands, Human - ultrastructure | Lung Neoplasms - ultrastructure | Proteomics | Mice | Tongue Neoplasms - ultrastructure | Proteins | Extracellular matrix | Phenotype | Research | Health aspects | Cancer | Structural integrity | Image resolution | High resolution | Medical imaging | Architecture | Vessels | Organs | Electrochemical machining | Homeostasis | Blood vessels | Fluorescence | Topology | Remodeling | Tissues | Metastases | Tissue | Topography | Imaging | Interrogation | Basic Medicine | Medical and Health Sciences | Mechanisms of disease | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cell biology | Cell and Molecular Biology | Cell- och molekylärbiologi | Cancer microenvironment
Journal Article
Journal Article
Molecular and Cellular Biochemistry, ISSN 0300-8177, 2/2011, Volume 348, Issue 1, pp. 89 - 98
Klotho mutant (kl/kl) mice, a type of short-lived mouse models, display several aging-related phenotypes. To investigate whether the atrophy of skeletal... 
Life Sciences | Biochemistry, general | Tongue | Autophagic-lysosomal pathway | Ubiquitin–proteasomal pathway | Masseter | Oncology | Medical Biochemistry | Cardiology | Klotho | Ubiquitin-proteasomal pathway | OXIDATIVE STRESS | HORMONE KLOTHO | FOXO TRANSCRIPTION FACTORS | CELL BIOLOGY | SKELETAL-MUSCLE | PHOSPHATE HOMEOSTASIS | PROTEIN-DEGRADATION | AMINO-ACID REGULATION | GENE-EXPRESSION | ALPHA-KLOTHO | UBIQUITIN-PROTEASOME PATHWAY | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Ubiquitin - metabolism | Tongue - pathology | Phosphoproteins - metabolism | Autophagy | Atrophy | Lysosomes - metabolism | Aging - genetics | Forkhead Transcription Factors - metabolism | Mice, Mutant Strains | Masseter Muscle - pathology | Tongue - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Genotype | Aging - pathology | Masseter Muscle - metabolism | Amino Acids, Essential - deficiency | Insulin - metabolism | Phenotype | Animals | Carrier Proteins - metabolism | Glucuronidase - genetics | Mice | Mice, Inbred BALB C | Mutation | Proteasome Endopeptidase Complex - metabolism | Insulin-Like Growth Factor I - metabolism | Aging - metabolism | Ubiquitin | Muscles | Comparative analysis | Proteolysis | Aging | Signal transduction | Biochemistry | Rodents
Journal Article
Journal Article