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NATURE MEDICINE, ISSN 1078-8956, 07/2017, Volume 23, Issue 7, pp. 890 - 890
The extracellular matrix (ECM) is a master regulator of cellular phenotype and behavior. It has a crucial role in both normal tissue homeostasis and disease... 
MEDICINE, RESEARCH & EXPERIMENTAL | NERVE | COLLAGEN | LAMININ | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | MOUSE MAMMARY-TUMOR | CELL BIOLOGY | BLOOD-VESSELS | SINGLE-CELL RESOLUTION | GLAND | BRAIN | BASEMENT-MEMBRANE | Optical Imaging | Peripheral Nerves - ultrastructure | Basement Membrane - ultrastructure | Lactation | Mammary Neoplasms, Experimental - ultrastructure | Humans | Lung Neoplasms - metabolism | Extracellular Matrix - metabolism | Tumor Microenvironment | Melanoma, Experimental - metabolism | Mammary Glands, Human - metabolism | Mammary Neoplasms, Experimental - metabolism | Breast Neoplasms - metabolism | Lung Neoplasms - secondary | Melanoma, Experimental - ultrastructure | Female | Peripheral Nerves - metabolism | Imaging, Three-Dimensional | Tongue Neoplasms - metabolism | Breast Neoplasms - ultrastructure | Lymph Nodes - metabolism | Lymphatic Metastasis | Basement Membrane - metabolism | Lymph Nodes - ultrastructure | Extracellular Matrix - ultrastructure | Animals | Mammary Glands, Human - ultrastructure | Lung Neoplasms - ultrastructure | Proteomics | Mice | Tongue Neoplasms - ultrastructure | Proteins | Extracellular matrix | Phenotype | Research | Health aspects | Cancer | Structural integrity | Image resolution | High resolution | Medical imaging | Architecture | Vessels | Organs | Electrochemical machining | Homeostasis | Blood vessels | Fluorescence | Topology | Remodeling | Tissues | Metastases | Tissue | Topography | Imaging | Interrogation | Basic Medicine | Medical and Health Sciences | Mechanisms of disease | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cell biology | Cell and Molecular Biology | Cell- och molekylärbiologi | Cancer microenvironment
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2012, Volume 82, Issue 1, pp. 299 - 307
To correlate proton magnetic resonance spectroscopy ( H-MRS), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and F-labeled fluorodeoxyglucose... 
Proton magnetic resonance spectroscopy | Dynamic contrast-enhanced MRI | Head and neck squamous cell carcinoma | Short-term treatment response | [ 18F]FDG-PET | F]FDG-PET | Choline - metabolism | Fluorodeoxyglucose F18 - pharmacokinetics | Nasopharyngeal Neoplasms - metabolism | Prospective Studies | Carcinoma, Squamous Cell - metabolism | Humans | Middle Aged | Magnetic Resonance Imaging - methods | Male | Antineoplastic Agents - therapeutic use | Head and Neck Neoplasms - metabolism | Bevacizumab | Feasibility Studies | Nasopharyngeal Neoplasms - pathology | Tonsillar Neoplasms - metabolism | Diagnostic Imaging - methods | Fluorouracil - therapeutic use | Extracellular Space - metabolism | Statistics, Nonparametric | Adult | Female | Tonsillar Neoplasms - therapy | Tongue Neoplasms - metabolism | Tonsillar Neoplasms - pathology | Chemoradiotherapy - methods | Antibodies, Monoclonal, Humanized - therapeutic use | Magnetic Resonance Spectroscopy - methods | Radiopharmaceuticals - pharmacokinetics | Tongue Neoplasms - therapy | Nasopharyngeal Neoplasms - therapy | Head and Neck Neoplasms - therapy | Carcinoma, Squamous Cell - therapy | Lymphatic Metastasis | Positron-Emission Tomography - methods | Tongue Neoplasms - pathology | Head and Neck Neoplasms - pathology | Regression Analysis | Contrast Media | Cisplatin - therapeutic use | Glucose - metabolism | Glycolysis | Carcinoma, Squamous Cell - secondary | Aged | Gadolinium DTPA
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 42, pp. 44538 - 44550
Chemoresistance is often associated with other clinical characteristics such as enhanced migratory/invasive potential. However, the correlation and underlying... 
Metastasis | Tongue squamous cell carcinoma | Cisplatin | Chemoresistance | ABCG2 | Head and Neck Neoplasms - secondary | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Drug Resistance, Neoplasm | MicroRNAs - metabolism | Neoplasm Proteins - metabolism | Head and Neck Neoplasms - metabolism | Tongue Neoplasms - drug therapy | Antineoplastic Agents - metabolism | Dose-Response Relationship, Drug | Squamous Cell Carcinoma of Head and Neck | Transfection | ATP-Binding Cassette Transporters - genetics | Lung Neoplasms - secondary | RNA Interference | Time Factors | ATP-Binding Cassette Transporters - metabolism | Inhibitory Concentration 50 | Female | Antineoplastic Agents - pharmacology | Tumor Cells, Cultured | Neoplasm Proteins - genetics | Tongue Neoplasms - metabolism | Lung Neoplasms - genetics | ATP Binding Cassette Transporter, Subfamily G, Member 2 | Neoplasm Invasiveness | Tongue Neoplasms - genetics | Head and Neck Neoplasms - drug therapy | Cisplatin - pharmacology | Tongue Neoplasms - pathology | Cisplatin - metabolism | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Animals | Carcinoma, Squamous Cell - drug therapy | Lung Neoplasms - prevention & control | Signal Transduction - drug effects | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Carcinoma, Squamous Cell - secondary | Head and Neck Neoplasms - genetics | Mice, Inbred BALB C | MicroRNAs - genetics
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2012, Volume 287, Issue 9, pp. 6668 - 6678
Activity of heparanase is implicated strongly in dissemination of metastatic tumor cells and cells of the immune system. In addition, heparanase enhances the... 
LOCALIZATION | REGULATOR | PROTEOGLYCANS | METASTASIS | TUMOR PROGRESSION | CONSTITUTIVE ACTIVATION | SULFATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | EXPRESSION | CONTRIBUTES | Phosphorylation - physiology | Prostatic Neoplasms - metabolism | Fibroblasts - enzymology | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Glucuronidase - metabolism | Male | Head and Neck Neoplasms - metabolism | Breast Neoplasms - metabolism | Laryngeal Neoplasms - pathology | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Receptor, Epidermal Growth Factor - metabolism | STAT1 Transcription Factor - metabolism | Tumor Suppressor Proteins - genetics | Female | Nose Neoplasms - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Tongue Neoplasms - metabolism | Prostatic Neoplasms - pathology | Nose Neoplasms - pathology | Tumor Suppressor Proteins - metabolism | Laryngeal Neoplasms - metabolism | Cells, Cultured | Multiple Myeloma - metabolism | STAT1 Transcription Factor - genetics | Tongue Neoplasms - pathology | Disease Progression | Head and Neck Neoplasms - pathology | Multiple Myeloma - pathology | Animals | Breast Neoplasms - pathology | Fibroblasts - cytology | Mice | Phosphorylation | Epidermal Growth Factor Receptor (EGFR) | STAT3 | Cell Signaling | Heparan Sulfate | Heparanase | Glycosaminoglycan | Glycobiology and Extracellular Matrices | Cancer Biology | Head And Neck Cancer | Localization
Journal Article
Anticancer Research, ISSN 0250-7005, 10/2017, Volume 37, Issue 10, pp. 5319 - 5328
Human papillomavirus (HPV)-positive tonsillar- and base of tongue cancer is increasing epidemically and has much better outcome than corresponding HPV-negative... 
Base of tongue cancer | Tonsillar cancer | Oropharyngeal cancer | CD8+ TIL | MHC class I | Head and neck cancer | Review | VEGF-A | FGFR3 | CD44 | HPV | FAVORABLE PROGNOSTIC-FACTOR | IMMUNE-RESPONSE | OROPHARYNGEAL CANCER INCIDENCE | ADVANCED SOLID TUMORS | PIK3CA MUTATIONS | head and neck cancer | base of tongue cancer | VIRAL-INDUCED CARCINOMA | NECK-CANCER | HPV-POSITIVE TONSILLAR | ONCOLOGY | CD8(+) TIL | review | oropharyngeal cancer | QUALITY-OF-LIFE | GENETIC ALTERATIONS | Predictive Value of Tests | Head and Neck Neoplasms - virology | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - virology | Humans | Head and Neck Neoplasms - metabolism | Papillomaviridae - genetics | Papillomavirus Infections - therapy | Patient Selection | Tonsillar Neoplasms - metabolism | Squamous Cell Carcinoma of Head and Neck | Neoplastic Stem Cells - metabolism | Tongue Neoplasms - virology | Biomarkers, Tumor - metabolism | Papillomavirus Infections - virology | Tonsillar Neoplasms - therapy | Tongue Neoplasms - metabolism | Papillomavirus Infections - complications | Tongue Neoplasms - genetics | Tongue Neoplasms - therapy | Head and Neck Neoplasms - therapy | Tonsillar Neoplasms - genetics | Carcinoma, Squamous Cell - therapy | Neoplastic Stem Cells - virology | Treatment Outcome | Papillomaviridae - isolation & purification | Tonsillar Neoplasms - virology | Papillomaviridae - classification | Head and Neck Neoplasms - genetics | Biomarkers, Tumor - genetics | Human Papillomavirus DNA Tests | Neoplasm Staging | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Clinical Medicine | Cancer and Oncology | Cancer och onkologi
Journal Article
Journal of Oral Pathology & Medicine, ISSN 0904-2512, 10/2015, Volume 44, Issue 9, pp. 699 - 706
BackgroundNaturally occurring agents, such as resveratrol, have been determined to benefit health. Numerous studies have demonstrated that resveratrol has... 
MMP | invasion | resveratrol | oral cancer | Oral cancer | MMP-9 | Invasion | Resveratrol | SQUAMOUS-CELL | TUMOR INVASION | ACTIVATION | MMP-9 EXPRESSION | METASTASIS | CARCINOMA CELLS | PROTEIN-KINASE | PATHOLOGY | MATRIX METALLOPROTEINASES | DENTISTRY, ORAL SURGERY & MEDICINE | GENE-EXPRESSION | SECRETION | Mouth Neoplasms - drug therapy | Stilbenes - administration & dosage | Tetradecanoylphorbol Acetate - pharmacology | Stilbenes - therapeutic use | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Mouth Neoplasms - metabolism | Stilbenes - metabolism | Mitogen-Activated Protein Kinase 1 - drug effects | Stilbenes - pharmacology | Head and Neck Neoplasms - metabolism | Tongue Neoplasms - drug therapy | Mitogen-Activated Protein Kinase 3 - drug effects | Neoplasm Metastasis | Squamous Cell Carcinoma of Head and Neck | Head and Neck Neoplasms - enzymology | Tongue Neoplasms - metabolism | Mouth Neoplasms - enzymology | Cell Survival - drug effects | Carcinoma, Squamous Cell - enzymology | Matrix Metalloproteinase 9 - biosynthesis | Neoplasm Invasiveness | Head and Neck Neoplasms - drug therapy | Down-Regulation - drug effects | Enzyme Activation - drug effects | Tongue Neoplasms - pathology | Head and Neck Neoplasms - pathology | Cell Movement - drug effects | Carcinoma, Squamous Cell - drug therapy | Tongue Neoplasms - enzymology | Signal Transduction - drug effects | Cell Line, Tumor | Mouth Neoplasms - pathology | Antineoplastic Agents, Phytogenic - pharmacology | Analysis | Mouth cancer | Cancer cells
Journal Article
International Journal of Cancer, ISSN 0020-7136, 12/2016, Volume 139, Issue 11, pp. 2598 - 2605
The aim was to explore the overall survival (OS) for palatine tonsillar squamous cell carcinoma (TSCC), subdivided, according to certainty of tonsillar tumour... 
base of the tongue cancer | tonsillar cancer | p16 | survival | HPV | HEAD | INTEGRATION | ONCOLOGY | OROPHARYNGEAL CANCER | SQUAMOUS-CELL CARCINOMA | HUMAN-PAPILLOMAVIRUS | COMORBIDITY | Head and Neck Neoplasms - virology | Prognosis | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - virology | Humans | Middle Aged | DNA, Viral - analysis | Male | Head and Neck Neoplasms - metabolism | Tonsillar Neoplasms - metabolism | Squamous Cell Carcinoma of Head and Neck | Carcinoma, Squamous Cell - mortality | Tongue Neoplasms - virology | Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis | Female | Papillomavirus Infections - virology | Tongue Neoplasms - metabolism | Tongue Neoplasms - mortality | Biomarkers, Tumor - analysis | Papillomavirus Infections - epidemiology | Kaplan-Meier Estimate | Tonsillar Neoplasms - mortality | Papillomavirus Infections - metabolism | Tonsillar Neoplasms - virology | Denmark - epidemiology | Biomarkers, Tumor - genetics | Head and Neck Neoplasms - mortality | DNA, Viral - genetics | Human papillomavirus 16 - genetics | Immunohistochemistry | Squamous cell carcinoma | Oncology, Experimental | Tongue cancer | Research | Papillomavirus infections | Cancer | Human papillomavirus | Neck | Medical prognosis | Deoxyribonucleic acid--DNA | Tongue | Data banks | Cell survival | Tonsil | Information retrieval | Population studies | Phospholipids | Radiation therapy | Gene expression | Patients | Cisplatin | Data bases | Databases | Head and neck cancer | Tonsillar carcinoma | Tumors
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Journal Article
Cancer Research, ISSN 0008-5472, 01/2017, Volume 77, Issue 2, pp. 532 - 544
Circadian clock genes regulate cancer development and chemotherapy susceptibility. Accordingly, chronotherapy based on circadian phenotypes might be applied to... 
OVEREXPRESSION | CARBOPLATIN | DISRUPTION | INDUCTION CHEMOTHERAPY | ONCOLOGY | TELOMERASE | TRANSCRIPTION | TUMOR-SUPPRESSOR | CANCER | DELIVERY | CHRONOPHARMACOLOGY | Paclitaxel - pharmacology | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Circadian Clocks - genetics | Head and Neck Neoplasms - metabolism | Gene Knockdown Techniques | Squamous Cell Carcinoma of Head and Neck | Chromatin Immunoprecipitation | Polymerase Chain Reaction | Antineoplastic Agents - pharmacology | Genes, Tumor Suppressor | Tongue Neoplasms - metabolism | Tongue Neoplasms - genetics | Carcinogenesis - genetics | ARNTL Transcription Factors - metabolism | Tongue Neoplasms - pathology | Blotting, Western | Head and Neck Neoplasms - pathology | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Head and Neck Neoplasms - genetics | Mice | Mice, Inbred BALB C | Drug Resistance, Neoplasm - physiology | Cell proliferation | Animal models | Tongue | Transcription | Homology | CLOCK protein | Recruitment | Cell growth | Paclitaxel | Xenografts | Tumorigenesis | Bioindicators | Neck | Inhibition | Circadian rhythms | Squamous cell carcinoma | Head | Rhythms | Circadian rhythm | Sensitivity | Chemotherapy | Cell lines | BMAL1 protein | Biomarkers | Tumor suppressor genes | Head and neck cancer | In vivo methods and tests | Cell migration | Cancer | Apoptosis
Journal Article
JAMA Otolaryngology–Head & Neck Surgery, ISSN 2168-6181, 12/2016, Volume 142, Issue 12, pp. 1208 - 1215
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