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1994, ISBN 9780120329304, Volume 29B., xvii, 315
Book
1994, ISBN 0120329298, Volume 29A., xv, 320
Book
Current Medicinal Chemistry, ISSN 0929-8673, 12/2010, Volume 17, Issue 35, pp. 4270 - 4290
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 318 - 333
Novel series of conformationally constrained 2,4-chloro- and hydroxy-substituted diphenyl benzofuro[3,2- ]pyridines were rationally designed and synthesized.... 
Dual topoisomerase I and II inhibition | Non-intercalative catalytic inhibiton | Anticancer agent | 2,4-chloro- and hydroxy-substituted diphenyl benzofuro[3,2-b]pyridines | Antiproliferative activity | APOPTOSIS | CHEMISTRY, MEDICINAL | PROLIFERATION | 2,4-chloro- and hydroxy-substituted | diphenyl benzofuro[3,2-b]pyridines | CANCER | DISCOVERY | ANTICANCER ACTIVITY | POTENT | BIOLOGICAL EVALUATION | DNA TOPOISOMERASES | CELL-CYCLE | DERIVATIVES | Topoisomerase I Inhibitors - metabolism | Apoptosis - drug effects | Pyridines - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Antineoplastic Agents - metabolism | Benzofurans - chemistry | Topoisomerase I Inhibitors - pharmacology | Topoisomerase II Inhibitors - chemistry | Drug Design | Antineoplastic Agents - pharmacology | Topoisomerase II Inhibitors - chemical synthesis | Topoisomerase I Inhibitors - chemistry | DNA Topoisomerases, Type II - metabolism | Biocatalysis | Chemistry Techniques, Synthetic | DNA Topoisomerases, Type I - metabolism | Pyridines - chemical synthesis | Topoisomerase II Inhibitors - pharmacology | DNA - metabolism | Topoisomerase II Inhibitors - metabolism | Antineoplastic Agents - chemistry | Topoisomerase I Inhibitors - chemical synthesis | Pyridines - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Pyridines - pharmacology | Drugstores | Alkaloids | Pyridine | Design and construction | Analysis | Pharmacy
Journal Article
1990, Cold Spring Harbor monograph series, ISBN 9780879693480, Volume 20., ix, 480
Book
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2015, Volume 92, pp. 540 - 553
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2013, Volume 56, Issue 18, pp. 7396 - 7415
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2015, Volume 23, Issue 22, pp. 7302 - 7312
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2013, Volume 21, Issue 17, pp. 5198 - 5208
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2017, Volume 27, Issue 15, pp. 3353 - 3358
Novel (non-fluoroquinolone) inhibitors of bacterial type II topoisomerases (NBTIs) are an emerging class of antibacterial agents. We report an optimized series... 
Topoisomerase | Antibacterial | Fluoroquinoline | Gyrase | NBTI | MRSA | BROAD-SPECTRUM | CHEMISTRY, MEDICINAL | IIA TOPOISOMERASES | TRICYCLICS E.G | CHEMISTRY, ORGANIC | RESISTANT STAPHYLOCOCCUS-AUREUS | CARDIAC INSTABILITY | GRAM-POSITIVE ACTIVITY | ACTION-POTENTIAL DURATION | SUBSTITUTED 1,5-NAPHTHYRIDINE ANALOGS | SPECTRUM ANTIBACTERIAL AGENTS | SAFETY PROFILE | DNA Topoisomerase IV - metabolism | Staphylococcus aureus - enzymology | Humans | Ether-A-Go-Go Potassium Channels - metabolism | Structure-Activity Relationship | Quinolines - pharmacology | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Topoisomerase Inhibitors - pharmacology | Topoisomerase Inhibitors - chemical synthesis | Topoisomerase II Inhibitors - chemistry | Anti-Bacterial Agents - chemistry | Molecular Structure | Topoisomerase II Inhibitors - chemical synthesis | Guinea Pigs | Streptococcus pyogenes - drug effects | Quinolines - chemistry | Topoisomerase II Inhibitors - pharmacology | Anti-Bacterial Agents - chemical synthesis | Quinolines - chemical synthesis | DNA Gyrase - metabolism | Animals | Streptococcus pyogenes - enzymology | DNA Topoisomerase IV - antagonists & inhibitors | Anti-Bacterial Agents - pharmacology | Topoisomerase Inhibitors - chemistry | Staphylococcus aureus - drug effects | Bacterial genetics | DNA | Medical colleges | Antibacterial agents
Journal Article
International Journal of Oncology, ISSN 1019-6439, 11/2018, Volume 53, Issue 5, pp. 1897 - 1912
Journal Article
Science, ISSN 0036-8075, 7/2011, Volume 333, Issue 6041, pp. 459 - 462
Journal Article