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Journal Article
Drug Delivery System, ISSN 0913-5006, 01/2019, Volume 34, Issue 1, p. 52
Antibody-drug conjugate (ADC) represents a promising class of drugs with a wider therapeutic index than conventional chemotherapy due to their efficient and... 
Drug delivery systems | Xenotransplantation | DNA topoisomerase | Clinical trials | Antibodies | Radioactive half-life | Breast cancer | Drug delivery | ErbB-2 protein | Anticancer properties | Refractory materials | Chemotherapy | Inhibitors | Antitumor agents | Technology | Xenografts | Gastric cancer | Deoxyribonucleic acid--DNA | Trastuzumab | Tumors
Journal Article
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2017, Volume 65, Issue 12, pp. 1179 - 1184
Three new compounds, a sesquilignan (1) and two glucosylated phenylpropanoids (2, 3), and seven known compounds (4-10), were isolated from the fruits of... 
Journal Article
Chemical & Pharmaceutical Bulletin, ISSN 0009-2363, 2013, Volume 61, Issue 6, pp. 631 - 636
A novel series of quinolone derivatives (6a-n) were designed and synthesized, and their biological activities were evaluated as potential antitumor... 
Journal Article
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2016, Volume 64, Issue 3, pp. 276 - 281
Fourteen compounds were isolated from the flowers of Inula japonica THUNB. (Asteraceae), including two new compounds,... 
Journal Article
Weishengwuxue Tongbao = Microbiology, ISSN 0253-2654, 01/2018, Issue 2, p. 347
[Background] Escherichia coli topoisomerase Ⅰ(E. coli TopA) plays essential role in DNA replication, transcription, recombination and regulation of gene... 
Recombination | Enzyme activity | Transcription | Arsenic | Toxicity | Gene regulation | Fluorescence | Iron | Cobalt | Proteins | E coli | Enzymatic activity | Lead | Bacteria | Copper | Deoxyribonucleic acid--DNA | Cadmium | DNA topoisomerase | Mass spectroscopy | Gene expression | Zinc | Heavy metals | Mutants | DNA biosynthesis | Inductively coupled plasma | Chromium | Nickel | Mercury | Mass spectrometry | Viability | Protein structure | Binding sites | Mercury (metal)
Journal Article
Biological & Pharmaceutical Bulletin, ISSN 0918-6158, 2009, Volume 32, Issue 4, pp. 724 - 727
DNA topoisomerase I (Top1) is a ubiquitous nuclear enzyme that plays essential roles in various cellular processes, such as transcription or replication.... 
Journal Article
Zhonghua yi xue za zhi, ISSN 0376-2491, 12/2013, Volume 93, Issue 48, p. 3852
To explore the clinical values of detecting drug related molecules excision repair cross complementing 1 (ERCC1) and top-isomerase I (TOPO I) in individualized... 
Endonucleases - genetics | Prognosis | Humans | Middle Aged | DNA Topoisomerases, Type I - genetics | Male | DNA-Binding Proteins - genetics | Colorectal Neoplasms - diagnosis | Neoplasm Metastasis | Colorectal Neoplasms - drug therapy | Adult | Female | Aged | Colorectal Neoplasms - pathology | Pathology, Molecular
Journal Article
Chemical & Pharmaceutical Bulletin, ISSN 0009-2363, 2007, Volume 55, Issue 4, pp. 526 - 531
We show that the trefoil, figure-eight knot, and mini circular closed DNA are formed by the reaction of cis-DDP-modified φX174DNA-histoneLNCaP complexes as a... 
Journal Article
Zhonghua zhong liu za zhi [Chinese journal of oncology], ISSN 0253-3766, 02/2007, Volume 29, Issue 2, p. 124
To investigate the expression and its significance of DNA topoisomerase I (Topo I) in small cell lung cancer (SCLC). Topo I expression was detected by... 
Immunohistochemistry - methods | Lung Neoplasms - enzymology | DNA Topoisomerases, Type I - metabolism | Humans | Middle Aged | Female | Lung Neoplasms - pathology | Male | Lymphatic Metastasis | Carcinoma, Small Cell - pathology | Neoplasm Staging | Carcinoma, Small Cell - enzymology
Journal Article
Revista Brasileira de Reumatologia, ISSN 0482-5004, 05/2015, Volume 55, Issue 3, pp. 229 - 239
a esclerose sistêmica (ES) é uma enfermidade do tecido conjuntivo de caráter autoimune caracterizada pela tríade de injúria vascular, autoimunidade (celular e... 
Anti‐topoisomerase I | Autoanticorpos | Anti‐RNA polymerase III | Autoantibodies | Systemic sclerosis | Anti‐centromere | Antitopoisomerase I | Esclerose sistêmica | Anticentrômero | Anti‐RNA polimerase III
Journal Article
Biological & Pharmaceutical Bulletin, ISSN 0918-6158, 2006, Volume 29, Issue 7, pp. 1493 - 1497
We evaluated the cytotoxicity and underlying mechanisms of cardiac glycosides, including digoxin, onabain and proscillaridin A, on the proliferation of breast... 
Journal Article
Biological & Pharmaceutical Bulletin, ISSN 0918-6158, 2004, Volume 27, Issue 7, pp. 1147 - 1150
Activity-guided fractionation based on topoisomerase I inhibitory activity lead to the isolation of ten lignans (1-10) from the methylene chloride extract of... 
Journal Article
by Ma, HG and Wang, LP and Xu, ZH and Zhang, YP and Li, X and Zhu, WM
CHINESE JOURNAL OF ORGANIC CHEMISTRY, ISSN 0253-2786, 08/2016, Volume 36, Issue 8, pp. 1839 - 1846
Nine new N-12-ethyl substituted indolocarbazole derivatives were synthesized. Their structures were identified by NMR, C-13 NMR and HRESIMS. The thiazolyl blue... 
synthesis | PROTEIN-KINASE-C | STAUROSPORINE | CHEMISTRY, ORGANIC | TOPOISOMERASE-I | ENZASTAURIN | ACUTE MYELOID-LEUKEMIA | N-12-ethyl indolocarbazole | MARINE NATURAL-PRODUCTS | TRIAL | ORIGIN | MIDOSTAURIN PKC412 | INHIBITOR | cytotoxicity
Journal Article
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