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Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 05/2016, Volume 22, Issue 20, pp. 6759 - 6763
Journal Article
Journal Article
JBIC Journal of Biological Inorganic Chemistry, ISSN 0949-8257, 1/2012, Volume 17, Issue 1, pp. 81 - 96
DNA topoisomerases (I and II) have been one of the excellent targets in anticancer drug development. Here two chiral ruthenium(II) anthraquinone complexes, Δ-... 
Life Sciences | Biochemistry, general | Microbiology | Ruthenium(II) complexes | Topoisomerase inhibition | Cytotoxicity | DNA binding | Apoptosis | Cytotoxicity Apoptosis | DEOXYRIBONUCLEIC-ACID | INDIVIDUAL CELLS | DNA-BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEIC ACIDS | CHEMISTRY, INORGANIC & NUCLEAR | PROGRAMMED CELL-DEATH | POLYPYRIDYL COMPLEXES | ANTICANCER DRUGS | ANTITUMOR PROSTAGLANDINS | ETHIDIUM BROMIDE | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Thymus Gland - enzymology | Ruthenium - chemistry | Topoisomerase I Inhibitors - pharmacology | Topoisomerase II Inhibitors - chemistry | Cattle | Antineoplastic Agents - pharmacology | Topoisomerase II Inhibitors - chemical synthesis | Cell Death - drug effects | Topoisomerase I Inhibitors - chemistry | DNA Topoisomerases, Type II - metabolism | Escherichia coli - enzymology | DNA Topoisomerases, Type I - metabolism | Topoisomerase II Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Topoisomerase I Inhibitors - chemical synthesis | Animals | Organometallic Compounds - chemical synthesis | Cell Line, Tumor | Organometallic Compounds - chemistry | Cell Proliferation - drug effects | Anthraquinones - chemistry | Organometallic Compounds - pharmacology | Drug Screening Assays, Antitumor | Chromatin | Ruthenium | Cell death | Analysis | DNA | Tumors
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2015, Volume 92, pp. 540 - 553
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 143, pp. 1563 - 1577
Journal Article
Journal Article
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 12/2010, Volume 17, Issue 35, pp. 4270 - 4290
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 143, pp. 2005 - 2014
Recent studies have demonstrated enhanced anticancer effects of combination therapy consisting of camptothecin derivatives and HDAC inhibitors. To exploit this... 
Camptothecin | Dual-action inhibitors | Antitumor activity | Psammaplin | HDAC inhibitors | Antiproliferative activity | CHEMISTRY, MEDICINAL | ANTITUMOR-ACTIVITY | NATURAL-PRODUCT PSAMMAPLIN | CELL LUNG-CANCER | 5-FLUOROURACIL | SPONGE | BIOLOGICAL-ACTIVITY | FORCE-FIELD | AGENTS | HISTONE DEACETYLASE INHIBITORS | DERIVATIVES | Tyrosine - pharmacology | Camptothecin - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Tyrosine - analogs & derivatives | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Histone Deacetylase Inhibitors - chemical synthesis | Topoisomerase I Inhibitors - pharmacology | Disulfides - chemistry | Disulfides - pharmacology | Antineoplastic Agents - pharmacology | Molecular Structure | Topoisomerase I Inhibitors - chemistry | Tyrosine - chemistry | DNA Topoisomerases, Type I - metabolism | Cells, Cultured | Models, Molecular | Histone Deacetylases - metabolism | Antineoplastic Agents - chemistry | Histone Deacetylase Inhibitors - chemistry | Topoisomerase I Inhibitors - chemical synthesis | Animals | Mice, Nude | Histone Deacetylase Inhibitors - pharmacology | Cell Proliferation - drug effects | Mice | Camptothecin - pharmacology | Neoplasms, Experimental - drug therapy | Drug Screening Assays, Antitumor | Molecular biology
Journal Article
International Journal of Cancer, ISSN 0020-7136, 10/2017, Volume 141, Issue 8, pp. 1682 - 1689
Anti‐HER2 therapies are beneficial for patients with HER2‐positive breast or gastric cancer. T‐DM1 is a HER2‐targeting antibody–drug conjugate (ADC) comprising... 
ADC | gastric cancer | HER2 | ABC transporter | T‐DM1 | T-DM1 | MONOCLONAL-ANTIBODY | ANTITUMOR-ACTIVITY | TUMORS | TRASTUZUMAB EMTANSINE | BREAST-CANCER | POTENT | AMPLIFICATION | ONCOLOGY | DX-8951F | PLUS | Camptothecin - chemistry | Humans | Drug Resistance, Neoplasm | Maytansine - pharmacology | Immunoconjugates - pharmacology | Topoisomerase I Inhibitors - pharmacology | Antibodies, Monoclonal, Humanized - pharmacology | Female | Topoisomerase I Inhibitors - chemistry | Camptothecin - analogs & derivatives | Stomach Neoplasms - enzymology | Receptor, ErbB-2 - biosynthesis | Maytansine - analogs & derivatives | Random Allocation | Stomach Neoplasms - drug therapy | Immunoconjugates - chemistry | Stomach Neoplasms - immunology | Animals | Mice, Nude | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Camptothecin - pharmacology | Trastuzumab | Antibodies, Monoclonal, Humanized - chemistry | Viral antibodies | Analysis | DNA | DNA topoisomerase I | Antibodies | Genetic aspects | Stomach cancer | Biopharmaceutics | Cancer | Efflux | DNA topoisomerase | Breast cancer | Drug resistance | Patients | ErbB-2 protein | Epidermal growth factor | Inhibitors | Tubulin | Xenografts | Breast | ATP-binding protein | Inhibition | Aberration | Gastric cancer | ATP | In vitro methods and tests | Deoxyribonucleic acid--DNA
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2012, Volume 49, pp. 379 - 396
A library of substituted chromeno[3,4- ]indoles was developed as Lamellarin isosters. Synthesis was achieved from indoles after a four-step pathway sequence... 
DYRK1A | Topoisomerase inhibition | Indoles | Kinase | Lamellarin | CHEMISTRY, MEDICINAL | AZIDOACRYLATES | METHYL | BIOLOGICAL EVALUATION | CYTOTOXIC AGENTS | DERIVATIVES | Protein-Tyrosine Kinases - metabolism | Humans | Indoles - chemical synthesis | Coumarins - chemistry | Heterocyclic Compounds, 4 or More Rings - chemical synthesis | Structure-Activity Relationship | Heterocyclic Compounds, 4 or More Rings - pharmacology | Isoquinolines - chemistry | Protein Kinase Inhibitors - chemistry | Topoisomerase I Inhibitors - pharmacology | Isoquinolines - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Indoles - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Topoisomerase I Inhibitors - chemistry | DNA Topoisomerases, Type I - metabolism | Heterocyclic Compounds, 4 or More Rings - chemistry | Models, Molecular | Coumarins - pharmacology | Topoisomerase I Inhibitors - chemical synthesis | Coumarins - chemical synthesis | Isoquinolines - chemical synthesis | Protein Kinase Inhibitors - pharmacology | Indoles - chemistry | Protein-Tyrosine Kinases - antagonists & inhibitors | Heterocyclic compounds | Phosphotransferases | Lead compounds | Isoquinolines | Protein-Serine-Threonine Kinases | Biochemistry, Molecular Biology | DNA Topoisomerases, Type I | Topoisomerase I Inhibitors | Coumarins | Life Sciences | Protein Kinase Inhibitors | Protein-Tyrosine Kinases | Heterocyclic Compounds with 4 or More Rings
Journal Article