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Science, ISSN 0036-8075, 11/2010, Volume 330, Issue 6005, pp. 831 - 835
The dose-limiting side effect of the common colon cancer chemotherapeutic CPT-11 is severe diarrhea caused by symbiotic bacterial β-glucuronidases that... 
Enzymes | Anaerobic bacteria | Toxicity | REPORTS | Colorectal cancer | Diarrhea | Anaerobic conditions | Bacteria | Mice | Monomers | Crystal structure | IRINOTECAN CPT-11 | DIARRHEA | METABOLISM | COLITIS | MULTIDISCIPLINARY SCIENCES | BETA-GLUCURONIDASE | CAMPTOTHECINS | TOPOISOMERASE-I | PHARMACOGENETICS | GUT FLORA | CARCINOMA | Camptothecin - toxicity | Humans | Colon - drug effects | Glucuronidase - metabolism | Crystallography, X-Ray | Diarrhea - prevention & control | Intestinal Mucosa - drug effects | Prodrugs - metabolism | Enzyme Inhibitors - chemistry | Female | Glucuronidase - antagonists & inhibitors | Antineoplastic Agents, Phytogenic - metabolism | Escherichia coli Proteins - antagonists & inhibitors | Bacteria, Anaerobic - drug effects | Drug Evaluation, Preclinical | Camptothecin - analogs & derivatives | Camptothecin - metabolism | Escherichia coli - enzymology | Enzyme Inhibitors - metabolism | Colon - pathology | Glucuronidase - isolation & purification | Enzyme Inhibitors - pharmacology | Models, Molecular | Escherichia coli Proteins - metabolism | Glucuronidase - chemistry | Intestinal Mucosa - microbiology | Escherichia coli Proteins - isolation & purification | Antineoplastic Agents, Phytogenic - toxicity | Animals | Prodrugs - toxicity | Cell Line, Tumor | Protein Conformation | Colon - microbiology | Mice, Inbred BALB C | Glucuronidase - pharmacology | Escherichia coli Proteins - chemistry | Intestinal Mucosa - pathology | Antimitotic agents | Drugs | Prevention | Complications and side effects | Care and treatment | Dosage and administration | Antineoplastic agents | Health aspects | Cancer | Chemotherapy | Side effects | Index Medicus | Microorganisms | Inhibitors | LARGE INTESTINE | BACTERIA | NEOPLASMS | BASIC BIOLOGICAL SCIENCES | CRYSTAL STRUCTURE | TOXICITY | 60 APPLIED LIFE SCIENCES | ENZYMES | ORAL ADMINISTRATION | TARGETS | MICE | SIDE EFFECTS
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e76676 - e76676
Anthracyclines (such as doxorubicin or daunorubicin) are among the most effective anticancer drugs, but their usefulness is hampered by the risk of... 
DRUG | DEXRAZOXANE ICRF-187 | LABILE IRON | INDUCED CARDIOTOXICITY | OXIDATIVE STRESS | IRON CHELATORS | MULTIDISCIPLINARY SCIENCES | DOXORUBICIN | BIS(2,6-DIOXOPIPERAZINE) | CYTOTOXICITY | BETA | Rats, Wistar | Glutathione - metabolism | Humans | Daunorubicin - pharmacology | Glutathione Disulfide - metabolism | Caspases - metabolism | Drug Interactions | Flow Cytometry | Anthracyclines - pharmacology | Biocatalysis - drug effects | Animals, Newborn | Cell Survival - drug effects | DNA Topoisomerases, Type II - metabolism | Thiobarbiturates - pharmacology | Myocytes, Cardiac - cytology | Cells, Cultured | Rats | Topoisomerase II Inhibitors - pharmacology | Piperazines - pharmacology | Dexrazoxane - pharmacology | Animals | Myocytes, Cardiac - drug effects | HL-60 Cells | Myocytes, Cardiac - metabolism | Cell Proliferation - drug effects | Cell Cycle - drug effects | Doxorubicin - pharmacology | Anthracyclines | Leukemia | Cancer cells | Heart | Neonates | Oxidative stress | Hydrogen peroxide | Razoxane | Toxicity | Iron | Cancer therapies | Doxorubicin | Anticancer properties | Poisons | Antitumor agents | Daunorubicin | Cell cycle | Chelation | Catalysis | Heart diseases | Deoxyribonucleic acid--DNA | DNA topoisomerase (ATP-hydrolysing) | Ion cyclotron radiation | Cyclotron frequency | Caspase | Cardiomyocytes | Metabolism | Gene expression | Inhibitors | Anthracycline | Pharmacy | Isoforms | Chelates | Cancer | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2014, Volume 57, Issue 21, pp. 9139 - 9151
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2012, Volume 55, Issue 15, pp. 6916 - 6933
Journal Article
Cancer Letters, ISSN 0304-3835, 2017, Volume 403, pp. 98 - 107
Abstract Organometallic complexes offer the prospect of targeting multiple pathways that are important in cancer biology. Here, the preclinical activity and... 
Hematology, Oncology and Palliative Medicine | Thioredoxin reductase inhibitor | Silver-N-heterocyclic carbene | PARP1 inhibitor | Topoisomerase inhibitor | Glycolytic inhibitor | TARGET | APOPTOSIS | DNA-BINDING | MAMMALIAN THIOREDOXIN | CANCER | ONCOLOGY | THIOREDOXIN REDUCTASE | AGENTS | INHIBITORS | TUMOR-GROWTH | CYTOTOXICITY | Neoplasms - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Imidazoles - chemistry | Drug Resistance, Neoplasm | Glycolysis - drug effects | Antineoplastic Agents - toxicity | Antineoplastic Combined Chemotherapy Protocols - pharmacology | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Topoisomerase I Inhibitors - pharmacology | Dacarbazine - pharmacology | Dacarbazine - analogs & derivatives | Antigens, Neoplasm - metabolism | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Imidazoles - toxicity | Cell Survival - drug effects | DNA Topoisomerases, Type II - metabolism | Organometallic Compounds - toxicity | DNA Topoisomerases, Type I - metabolism | Poly (ADP-Ribose) Polymerase-1 - metabolism | Imidazoles - pharmacology | Topoisomerase II Inhibitors - pharmacology | Cisplatin - pharmacology | Antineoplastic Agents - chemistry | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Neoplasms - drug therapy | Drug Synergism | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Signal Transduction - drug effects | Cell Line, Tumor | Thioredoxin Reductase 1 - antagonists & inhibitors | Organometallic Compounds - chemistry | DNA Damage | Oxidative Stress - drug effects | Neoplasms - pathology | Organometallic Compounds - pharmacology | Thioredoxin Reductase 1 - metabolism | Glucose metabolism | Enzymes | Care and treatment | Cell death | Heterocyclic compounds | DNA damage | Cancer
Journal Article
Environmental Toxicology, ISSN 1520-4081, 06/2017, Volume 32, Issue 6, pp. 1836 - 1843
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2013, Volume 23, Issue 11, pp. 3320 - 3324
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2001, Volume 276, Issue 50, pp. 47107 - 47115
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2014, Volume 57, Issue 14, pp. 6008 - 6018
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2013, Volume 21, Issue 17, pp. 5198 - 5208
Journal Article
Neoplasia, ISSN 1476-5586, 2011, Volume 13, Issue 11, pp. 1043 - IN30
Journal Article