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Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2018, Volume 61, Issue 20, pp. 8947 - 8980
DNA topoisomerase II (topo II) is an important enzyme involved in DNA replication, recombination, and repair. Despite the popular applications of topo II... 
POTENTIAL ANTICANCER AGENTS | DNA TOPOISOMERASE | IN-VITRO | ANTIPROLIFERATIVE ACTIVITY | CHEMISTRY, MEDICINAL | BIOLOGICAL EVALUATION | CANCER-CELL-LINES | ACUTE MYELOID-LEUKEMIA | CHIRAL RUTHENIUM(II) COMPLEXES | CATALYTIC INHIBITORS | STRUCTURE-BASED DESIGN
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 10/2018, Volume 38, Issue 10, pp. 2382 - 2395
OBJECTIVE—Vascular calcification is a major risk factor for rupture of atherosclerotic plaques. High expression of BMP2 (bone morphogenetic protein 2) in... 
atherosclerosis | ATHEROSCLEROTIC LESIONS | ACTIVATION | type II | DNA topoisomerases | STABILITY | PLAQUE | p53 | BMP2 | MACROPHAGE ABCA1 EXPRESSION | CHOLESTEROL EFFLUX | PROTEIN EXPRESSION | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | MICE | calcification | HEMATOLOGY
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 12/2010, Volume 17, Issue 35, pp. 4270 - 4290
Journal Article
Expert Opinion on Pharmacotherapy, ISSN 1465-6566, 09/2019, Volume 20, Issue 13, pp. 1637 - 1644
Introduction: Topoisomerase II inhibitors have long been used in the frontline and as salvage therapy for AML, with daunorubicin and idarubicin being... 
mitoxantrone | vosaroxin | Topoisomerase II inhibitors | annamycin | idarubicin | etoposide | daunorubicin | CPX-351 | ADULT PATIENTS | CYTOSINE-ARABINOSIDE | INDUCTION CHEMOTHERAPY | RANDOMIZED-TRIAL | PHASE-II | INTERMEDIATE-DOSE CYTARABINE | ACUTE MYELOID-LEUKEMIA | G-CSF | OLDER PATIENTS | PHARMACOLOGY & PHARMACY | TRIAL COMPARING IDARUBICIN
Journal Article
Journal Article
Update on Cancer Therapeutics, ISSN 1872-115X, 2008, Volume 3, Issue 1, pp. 13 - 26
Topoisomerase II is an enzyme essential for DNA replication, chromosome condensation and chromosome segregation. Inhibitors of topoisomerase II are important... 
Etoposide | Chemotherapy | Anthracyclines | Pharmacology | Topoisomerase II | DNA replication | Enzyme inhibitors
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2018, Volume 157, pp. 81 - 87
The identification of novel Topoisomerase II (Topo II) inhibitors is one of the most attractive directions in the field of bactericide research and... 
3D-QSAR | Antibacterial activity | Topoisomerase II inhibitors | Coumarin | Pyrazole | Molecular docking | CHEMISTRY, MEDICINAL | SERIES | MECHANISM | ANALOGS | ESCHERICHIA-COLI | DNA GYRASE INHIBITORS | ANTIOXIDANT | PURIFICATION | BIOLOGICAL EVALUATION | AGENTS | HYBRIDS | Antibacterial agents | Analysis | Escherichia coli | Pharmaceutical biotechnology
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2015, Volume 92, pp. 540 - 553
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 51, pp. 21011 - 21022
Resveratrol, a polyphenol found in various plant sources, has gained attention as a possible agent responsible for the purported health benefits of certain... 
BREAST-CANCER | DNA TOPOISOMERASE | ATPASE ACTIVITY | MECHANISM | GYRASE-B-PROTEIN | DIETARY-SUPPLEMENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLINICAL-TRIALS | N-TERMINAL FRAGMENT | STEADY-STATE | CATALYTIC INHIBITOR | Dexrazoxane - chemistry | Poly-ADP-Ribose Binding Proteins - metabolism | Allosteric Regulation | Humans | Poly-ADP-Ribose Binding Proteins - antagonists & inhibitors | Resveratrol - chemistry | Topoisomerase II Inhibitors - chemistry | DNA Topoisomerases, Type II - chemistry | Molecular Structure | DNA Topoisomerases, Type II - metabolism | Mutagenesis, Site-Directed | Protein Interaction Domains and Motifs - drug effects | Resveratrol - pharmacology | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Adenosine Triphosphatases - metabolism | Models, Molecular | Poly-ADP-Ribose Binding Proteins - chemistry | Topoisomerase II Inhibitors - pharmacology | Dexrazoxane - pharmacology | Adenosine Triphosphatases - antagonists & inhibitors | Saccharomyces cerevisiae Proteins - metabolism | Adenosine Triphosphatases - chemistry | DNA Topoisomerases, Type II - genetics | Protein Multimerization - drug effects | Amino Acid Substitution | Saccharomyces cerevisiae Proteins - chemistry | Index Medicus | site-directed mutagenesis | inhibition mechanism | enzyme inhibitor | protein drug interaction | DNA topoisomerase | Enzymology | conformational change | resveratrol
Journal Article