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Inorganic Chemistry, ISSN 0020-1669, 08/2013, Volume 52, Issue 15, pp. 8895 - 8908
Journal Article
Journal Article
JBIC Journal of Biological Inorganic Chemistry, ISSN 0949-8257, 1/2012, Volume 17, Issue 1, pp. 81 - 96
DNA topoisomerases (I and II) have been one of the excellent targets in anticancer drug development. Here two chiral ruthenium(II) anthraquinone complexes, Δ-... 
Life Sciences | Biochemistry, general | Microbiology | Ruthenium(II) complexes | Topoisomerase inhibition | Cytotoxicity | DNA binding | Apoptosis | Cytotoxicity Apoptosis | DEOXYRIBONUCLEIC-ACID | INDIVIDUAL CELLS | DNA-BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEIC ACIDS | CHEMISTRY, INORGANIC & NUCLEAR | PROGRAMMED CELL-DEATH | POLYPYRIDYL COMPLEXES | ANTICANCER DRUGS | ANTITUMOR PROSTAGLANDINS | ETHIDIUM BROMIDE | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Thymus Gland - enzymology | Ruthenium - chemistry | Topoisomerase I Inhibitors - pharmacology | Topoisomerase II Inhibitors - chemistry | Cattle | Antineoplastic Agents - pharmacology | Topoisomerase II Inhibitors - chemical synthesis | Cell Death - drug effects | Topoisomerase I Inhibitors - chemistry | DNA Topoisomerases, Type II - metabolism | Escherichia coli - enzymology | DNA Topoisomerases, Type I - metabolism | Topoisomerase II Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Topoisomerase I Inhibitors - chemical synthesis | Animals | Organometallic Compounds - chemical synthesis | Cell Line, Tumor | Organometallic Compounds - chemistry | Cell Proliferation - drug effects | Anthraquinones - chemistry | Organometallic Compounds - pharmacology | Drug Screening Assays, Antitumor | Chromatin | Ruthenium | Cell death | Analysis | DNA | Tumors
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2018, Volume 61, Issue 20, pp. 8947 - 8980
DNA topoisomerase II (topo II) is an important enzyme involved in DNA replication, recombination, and repair. Despite the popular applications of topo II... 
DNA TOPOISOMERASE | ANTICANCER ACTIVITY | IN-VITRO | ANTIPROLIFERATIVE ACTIVITY | CHEMISTRY, MEDICINAL | STRUCTURAL BASIS | BIOLOGICAL EVALUATION | CHIRAL RUTHENIUM(II) COMPLEXES | ACUTE MYELOID-LEUKEMIA | ANTITUMOR-ACTIVITY | STRUCTURE-BASED DESIGN
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 01/2014, Volume 130, Issue 1, pp. 15 - 27
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2006, Volume 16, Issue 2, pp. 437 - 442
The high resolution X-ray crystal structure of the adduct of human carbonic anhydrase (CA, EC 4.2.1.1) isoform II (hCA II) with the clinically used painkiller... 
X-ray crystallography | Sulfonamide | Carbonic anhydrase | COX-2 selective inhibitors | Isoform II | Acetazolamide | Valdecoxib | Celecoxib | DESIGN | CHEMISTRY, MEDICINAL | celecoxib | CRYSTAL-STRUCTURE | TRANSMEMBRANE | CHEMISTRY, ORGANIC | SULFONAMIDES | isoform II | ADDUCT | ANTITUMOR | RAY CRYSTALLOGRAPHIC STRUCTURE | valdecoxib | sulfonamide | acetazolamide | carbonic anhydrase | HUMAN ISOZYME-II | Carbonic Anhydrase Inhibitors - chemistry | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Carbonic Anhydrases - chemistry | Carbonic Anhydrases - metabolism | Pyrazoles - chemistry | Protein Binding - drug effects | Topoisomerase II Inhibitors | Molecular Structure | Drug Evaluation, Preclinical | Binding Sites - drug effects | Pyrazoles - pharmacology | Protein Structure, Tertiary | Cyclooxygenase Inhibitors - metabolism | Sulfonamides - chemistry | Isoxazoles - metabolism | Models, Molecular | Cyclooxygenase 2 - drug effects | Cyclooxygenase Inhibitors - chemistry | Carbonic Anhydrase Inhibitors - pharmacology | Isoxazoles - chemistry | Pyrazoles - metabolism | Sulfonamides - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Isoxazoles - pharmacology | Sulfonamides - metabolism | Protein Conformation | Carbonic Anhydrase Inhibitors - metabolism | Carbonic Anhydrases - drug effects | Isoenzymes - antagonists & inhibitors | Angiogenesis inhibitors | Sulfonamides
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 12, p. e84409
Increasing resistance to every major class of antibiotics and a dearth of novel classes of antibacterial agents in development pipelines has created a... 
GYRASE B GYRB | PYRROLOPYRIMIDINE INHIBITORS | ANTIBIOTICS | TOPOISOMERASE-IV PARE | MULTIDISCIPLINARY SCIENCES | DNA GYRASE | VALIDATION | AMINOBENZIMIDAZOLE CLASS | CRYSTAL-STRUCTURES | OPTIMIZATION | DISCOVERY | DNA Topoisomerase IV - chemistry | DNA Gyrase - chemistry | Bacteria - drug effects | Indoles - chemical synthesis | Models, Molecular | Topoisomerase II Inhibitors - pharmacology | Anti-Bacterial Agents - chemical synthesis | Microbial Sensitivity Tests | DNA Gyrase - metabolism | Animals | Topoisomerase II Inhibitors - chemistry | Anti-Bacterial Agents - chemistry | DNA Topoisomerase IV - antagonists & inhibitors | Drug Design | Bacteria - enzymology | Female | Indoles - pharmacology | Protein Conformation | Anti-Bacterial Agents - pharmacology | Mice | Topoisomerase II Inhibitors - chemical synthesis | Drug Resistance, Bacterial - drug effects | Indoles - chemistry | Drug resistance in microorganisms | Bacterial infections | Lead compounds | Drug therapy | Health aspects | Antibacterial agents | Fluoroquinolones | Laboratories | Pipelines | Gram-positive bacteria | DNA topoisomerase IV | Infections | Drug development | Crystallography | Proteins | Antibacterial activity | Bacteria | Life sciences | Catalysis | Deoxyribonucleic acid--DNA | Pathogens | Enzymes | Multidrug resistance | DNA topoisomerase | Inhibitors | Antibiotics | Natural products | Mutation | Binding sites | BASIC BIOLOGICAL SCIENCES | Deoxyribonucleic acid | DNA
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2015, Volume 92, pp. 540 - 553
Journal Article