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Inorganic Chemistry, ISSN 0020-1669, 08/2013, Volume 52, Issue 15, pp. 8895 - 8908
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 318 - 333
Novel series of conformationally constrained 2,4-chloro- and hydroxy-substituted diphenyl benzofuro[3,2-b]pyridines were rationally designed and synthesized.... 
Dual topoisomerase I and II inhibition | Non-intercalative catalytic inhibiton | Anticancer agent | 2,4-chloro- and hydroxy-substituted diphenyl benzofuro[3,2-b]pyridines | Antiproliferative activity | APOPTOSIS | CHEMISTRY, MEDICINAL | PROLIFERATION | 2,4-chloro- and hydroxy-substituted | diphenyl benzofuro[3,2-b]pyridines | CANCER | DISCOVERY | ANTICANCER ACTIVITY | POTENT | BIOLOGICAL EVALUATION | DNA TOPOISOMERASES | CELL-CYCLE | DERIVATIVES | Topoisomerase I Inhibitors - metabolism | Apoptosis - drug effects | Pyridines - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Antineoplastic Agents - metabolism | Benzofurans - chemistry | Topoisomerase I Inhibitors - pharmacology | Topoisomerase II Inhibitors - chemistry | Drug Design | Antineoplastic Agents - pharmacology | Topoisomerase II Inhibitors - chemical synthesis | Topoisomerase I Inhibitors - chemistry | DNA Topoisomerases, Type II - metabolism | Biocatalysis | Chemistry Techniques, Synthetic | DNA Topoisomerases, Type I - metabolism | Pyridines - chemical synthesis | Topoisomerase II Inhibitors - pharmacology | DNA - metabolism | Topoisomerase II Inhibitors - metabolism | Antineoplastic Agents - chemistry | Topoisomerase I Inhibitors - chemical synthesis | Pyridines - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Pyridines - pharmacology | Drugstores | Alkaloids | Pyridine | Design and construction | Analysis | Pharmacy
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 123, pp. 704 - 717
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2006, Volume 16, Issue 2, pp. 437 - 442
The high resolution X-ray crystal structure of the adduct of human carbonic anhydrase (CA, EC 4.2.1.1) isoform II (hCA II) with the clinically used painkiller... 
X-ray crystallography | Sulfonamide | Carbonic anhydrase | COX-2 selective inhibitors | Isoform II | Acetazolamide | Valdecoxib | Celecoxib | DESIGN | CHEMISTRY, MEDICINAL | celecoxib | CRYSTAL-STRUCTURE | TRANSMEMBRANE | CHEMISTRY, ORGANIC | SULFONAMIDES | isoform II | ADDUCT | ANTITUMOR | RAY CRYSTALLOGRAPHIC STRUCTURE | valdecoxib | sulfonamide | acetazolamide | carbonic anhydrase | HUMAN ISOZYME-II | Carbonic Anhydrase Inhibitors - chemistry | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Carbonic Anhydrases - chemistry | Carbonic Anhydrases - metabolism | Pyrazoles - chemistry | Protein Binding - drug effects | Topoisomerase II Inhibitors | Molecular Structure | Drug Evaluation, Preclinical | Binding Sites - drug effects | Pyrazoles - pharmacology | Protein Structure, Tertiary | Cyclooxygenase Inhibitors - metabolism | Sulfonamides - chemistry | Isoxazoles - metabolism | Models, Molecular | Cyclooxygenase 2 - drug effects | Cyclooxygenase Inhibitors - chemistry | Carbonic Anhydrase Inhibitors - pharmacology | Isoxazoles - chemistry | Pyrazoles - metabolism | Sulfonamides - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Isoxazoles - pharmacology | Sulfonamides - metabolism | Protein Conformation | Carbonic Anhydrase Inhibitors - metabolism | Carbonic Anhydrases - drug effects | Isoenzymes - antagonists & inhibitors | Angiogenesis inhibitors | Sulfonamides
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2017, Volume 27, Issue 20, pp. 4687 - 4693
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e76676 - e76676
Anthracyclines (such as doxorubicin or daunorubicin) are among the most effective anticancer drugs, but their usefulness is hampered by the risk of... 
DRUG | DEXRAZOXANE ICRF-187 | LABILE IRON | INDUCED CARDIOTOXICITY | OXIDATIVE STRESS | IRON CHELATORS | MULTIDISCIPLINARY SCIENCES | DOXORUBICIN | BIS(2,6-DIOXOPIPERAZINE) | CYTOTOXICITY | BETA | Rats, Wistar | Glutathione - metabolism | Humans | Daunorubicin - pharmacology | Glutathione Disulfide - metabolism | Caspases - metabolism | Drug Interactions | Flow Cytometry | Anthracyclines - pharmacology | Biocatalysis - drug effects | Animals, Newborn | Cell Survival - drug effects | DNA Topoisomerases, Type II - metabolism | Thiobarbiturates - pharmacology | Myocytes, Cardiac - cytology | Cells, Cultured | Rats | Topoisomerase II Inhibitors - pharmacology | Piperazines - pharmacology | Dexrazoxane - pharmacology | Animals | Myocytes, Cardiac - drug effects | HL-60 Cells | Myocytes, Cardiac - metabolism | Cell Proliferation - drug effects | Cell Cycle - drug effects | Doxorubicin - pharmacology | Anthracyclines | Leukemia | Cancer cells | Heart | Neonates | Oxidative stress | Hydrogen peroxide | Razoxane | Toxicity | Iron | Cancer therapies | Doxorubicin | Anticancer properties | Poisons | Antitumor agents | Daunorubicin | Cell cycle | Chelation | Catalysis | Heart diseases | Deoxyribonucleic acid--DNA | DNA topoisomerase (ATP-hydrolysing) | Ion cyclotron radiation | Cyclotron frequency | Caspase | Cardiomyocytes | Metabolism | Gene expression | Inhibitors | Anthracycline | Pharmacy | Isoforms | Chelates | Cancer | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Journal Article