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1994, ISBN 0120329298, Volume 29A., xv, 320
Book
1994, ISBN 9780120329304, Volume 29B., xvii, 315
Book
Current Medicinal Chemistry, ISSN 0929-8673, 12/2010, Volume 17, Issue 35, pp. 4270 - 4290
Journal Article
International Journal of Oncology, ISSN 1019-6439, 11/2018, Volume 53, Issue 5, pp. 1897 - 1912
The aim of the present study was to determine the role of topoisomerase 1 (TOP1) and topoisomerase 2A (TOP2A) in liver cancer (LC), and to investigate the... 
Clinical value | Liver cancer | Topoisomerase 1 | Topoisomerase 2A | Nitidine chloride | HEPATOCELLULAR-CARCINOMA CELLS | NATURAL-PRODUCT MODULATORS | topoisomerase 2A | ANTICANCER AGENTS | topoisomerase 1 | nitidine chloride | THERAPY | ONCOLOGY | SIGNALING PATHWAY | GROWTH | DRUGS | liver cancer | clinical value | INHIBITORS | MULTIDRUG-RESISTANCE | EXPRESSION | Immunohistochemistry | Poly-ADP-Ribose Binding Proteins - metabolism | Humans | DNA Topoisomerases, Type I - chemistry | Male | Liver Neoplasms - mortality | Topoisomerase II Inhibitors - chemistry | DNA Topoisomerases, Type II - chemistry | Female | Liver Neoplasms - pathology | Gene Expression Regulation, Neoplastic - drug effects | Molecular Targeted Therapy - methods | DNA Topoisomerases, Type II - metabolism | DNA Topoisomerases, Type I - metabolism | Liver Neoplasms - genetics | DNA Topoisomerases, Type I - genetics | Liver Neoplasms - drug therapy | Poly-ADP-Ribose Binding Proteins - genetics | Poly-ADP-Ribose Binding Proteins - chemistry | Topoisomerase II Inhibitors - pharmacology | Benzophenanthridines - pharmacology | Xenograft Model Antitumor Assays | Disease-Free Survival | Animals | DNA Topoisomerases, Type II - genetics | Biomarkers, Tumor - genetics | Mice, Inbred BALB C | Molecular Docking Simulation | Polymerase chain reaction | Cytotoxicity | Standard deviation | Laboratory animals | Experiments | Cancer therapies | Deoxyribonucleic acid--DNA | Tumors
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 318 - 333
Novel series of conformationally constrained 2,4-chloro- and hydroxy-substituted diphenyl benzofuro[3,2- ]pyridines were rationally designed and synthesized.... 
Dual topoisomerase I and II inhibition | Non-intercalative catalytic inhibiton | Anticancer agent | 2,4-chloro- and hydroxy-substituted diphenyl benzofuro[3,2-b]pyridines | Antiproliferative activity | APOPTOSIS | CHEMISTRY, MEDICINAL | PROLIFERATION | 2,4-chloro- and hydroxy-substituted | diphenyl benzofuro[3,2-b]pyridines | CANCER | DISCOVERY | ANTICANCER ACTIVITY | POTENT | BIOLOGICAL EVALUATION | DNA TOPOISOMERASES | CELL-CYCLE | DERIVATIVES | Topoisomerase I Inhibitors - metabolism | Apoptosis - drug effects | Pyridines - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Antineoplastic Agents - metabolism | Benzofurans - chemistry | Topoisomerase I Inhibitors - pharmacology | Topoisomerase II Inhibitors - chemistry | Drug Design | Antineoplastic Agents - pharmacology | Topoisomerase II Inhibitors - chemical synthesis | Topoisomerase I Inhibitors - chemistry | DNA Topoisomerases, Type II - metabolism | Biocatalysis | Chemistry Techniques, Synthetic | DNA Topoisomerases, Type I - metabolism | Pyridines - chemical synthesis | Topoisomerase II Inhibitors - pharmacology | DNA - metabolism | Topoisomerase II Inhibitors - metabolism | Antineoplastic Agents - chemistry | Topoisomerase I Inhibitors - chemical synthesis | Pyridines - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Pyridines - pharmacology | Drugstores | Alkaloids | Pyridine | Design and construction | Analysis | Pharmacy
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2015, Volume 92, pp. 540 - 553
Journal Article
1990, Cold Spring Harbor monograph series, ISBN 9780879693480, Volume 20, ix, 480
Book
Journal Article
Science, ISSN 0036-8075, 7/2011, Volume 333, Issue 6041, pp. 459 - 462
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2013, Volume 21, Issue 17, pp. 5198 - 5208
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2013, Volume 56, Issue 18, pp. 7396 - 7415
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2015, Volume 23, Issue 22, pp. 7302 - 7312
Journal Article