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European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 235 - 249
A novel series of bis(hydroxymethyl)indolizino[8,7- ]indole hybrids composed of β-carboline (topoisomerase I/II inhibition) and bis(hydroxymethyl)pyrrole (DNA... 
Topoisomerase inhibition | β-carboline | indolizino[8,7-b]indole | bis(hydroxymethyl)pyrrole | DNA cross-linking | Anti-SCLC hybrids | CHEMISTRY, MEDICINAL | ANTICANCER AGENTS | BETA-CARBOLINE DERIVATIVES | ANTITUMOR-ACTIVITY | COMBINATION | BINDING PROPERTIES | ETOPOSIDE | DRUGS | TOPOTECAN | beta-carboline | MYELOID-LEUKEMIA | MOLECULAR-BASIS | Topoisomerase I Inhibitors - metabolism | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Lung Neoplasms - pathology | Antineoplastic Agents - metabolism | Indoles - metabolism | Topoisomerase I Inhibitors - pharmacology | Topoisomerase II Inhibitors - chemistry | Drug Design | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Topoisomerase II Inhibitors - chemical synthesis | Topoisomerase I Inhibitors - chemistry | DNA Topoisomerases, Type II - metabolism | Topoisomerase II Inhibitors - pharmacology | DNA - metabolism | Topoisomerase II Inhibitors - metabolism | Antineoplastic Agents - chemistry | Xenograft Model Antitumor Assays | Small Cell Lung Carcinoma - pathology | Topoisomerase I Inhibitors - chemical synthesis | Animals | Cell Line, Tumor | Mice | Cell Cycle - drug effects | Indoles - chemistry | Crosslinked polymers | Analysis | DNA | Etoposide | Genetic research | Lung cancer, Small cell | Respiratory agents | Genetic aspects | Thiophene | Molecular biology | Cancer | Chemical tests and reagents | Lung cancer, Non-small cell | Antineoplastic agents | Antimitotic agents | Colon cancer | Prostate cancer
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2013, Volume 23, Issue 11, pp. 3320 - 3324
Journal Article
Journal Article
Journal Article
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 12/2014, Volume 53, Issue 52, pp. 14605 - 14609
Journal Article
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 12/2017, Volume 636, pp. 28 - 41
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 12, p. e84409
Increasing resistance to every major class of antibiotics and a dearth of novel classes of antibacterial agents in development pipelines has created a... 
GYRASE B GYRB | PYRROLOPYRIMIDINE INHIBITORS | ANTIBIOTICS | TOPOISOMERASE-IV PARE | MULTIDISCIPLINARY SCIENCES | DNA GYRASE | VALIDATION | AMINOBENZIMIDAZOLE CLASS | CRYSTAL-STRUCTURES | OPTIMIZATION | DISCOVERY | DNA Topoisomerase IV - chemistry | DNA Gyrase - chemistry | Bacteria - drug effects | Indoles - chemical synthesis | Models, Molecular | Topoisomerase II Inhibitors - pharmacology | Anti-Bacterial Agents - chemical synthesis | Microbial Sensitivity Tests | DNA Gyrase - metabolism | Animals | Topoisomerase II Inhibitors - chemistry | Anti-Bacterial Agents - chemistry | DNA Topoisomerase IV - antagonists & inhibitors | Drug Design | Bacteria - enzymology | Female | Indoles - pharmacology | Protein Conformation | Anti-Bacterial Agents - pharmacology | Mice | Topoisomerase II Inhibitors - chemical synthesis | Drug Resistance, Bacterial - drug effects | Indoles - chemistry | Drug resistance in microorganisms | Bacterial infections | Lead compounds | Drug therapy | Health aspects | Antibacterial agents | Fluoroquinolones | Laboratories | Pipelines | Gram-positive bacteria | DNA topoisomerase IV | Infections | Drug development | Crystallography | Proteins | Antibacterial activity | Bacteria | Life sciences | Catalysis | Deoxyribonucleic acid--DNA | Pathogens | Enzymes | Multidrug resistance | DNA topoisomerase | Inhibitors | Antibiotics | Natural products | Mutation | Binding sites | BASIC BIOLOGICAL SCIENCES | Deoxyribonucleic acid | DNA
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2012, Volume 49, pp. 379 - 396
A library of substituted chromeno[3,4- ]indoles was developed as Lamellarin isosters. Synthesis was achieved from indoles after a four-step pathway sequence... 
DYRK1A | Topoisomerase inhibition | Indoles | Kinase | Lamellarin | CHEMISTRY, MEDICINAL | AZIDOACRYLATES | METHYL | BIOLOGICAL EVALUATION | CYTOTOXIC AGENTS | DERIVATIVES | Protein-Tyrosine Kinases - metabolism | Humans | Indoles - chemical synthesis | Coumarins - chemistry | Heterocyclic Compounds, 4 or More Rings - chemical synthesis | Structure-Activity Relationship | Heterocyclic Compounds, 4 or More Rings - pharmacology | Isoquinolines - chemistry | Protein Kinase Inhibitors - chemistry | Topoisomerase I Inhibitors - pharmacology | Isoquinolines - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Indoles - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Topoisomerase I Inhibitors - chemistry | DNA Topoisomerases, Type I - metabolism | Heterocyclic Compounds, 4 or More Rings - chemistry | Models, Molecular | Coumarins - pharmacology | Topoisomerase I Inhibitors - chemical synthesis | Coumarins - chemical synthesis | Isoquinolines - chemical synthesis | Protein Kinase Inhibitors - pharmacology | Indoles - chemistry | Protein-Tyrosine Kinases - antagonists & inhibitors | Heterocyclic compounds | Phosphotransferases | Lead compounds | Isoquinolines | Protein-Serine-Threonine Kinases | Biochemistry, Molecular Biology | DNA Topoisomerases, Type I | Topoisomerase I Inhibitors | Coumarins | Life Sciences | Protein Kinase Inhibitors | Protein-Tyrosine Kinases | Heterocyclic Compounds with 4 or More Rings
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 09/2017, Volume 45, Issue 17, pp. 9850 - 9859
The question of how self-interacting chromatin domains in interphase chromosomes are structured and generated dominates current discussions on eukaryotic... 
RNA-POLYMERASE-II | COLI TOPOISOMERASE-IV | HUMAN GENOME | 3D GENOME | SINGLE-MOLECULE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | CHROMOSOMES | MOLECULAR-DYNAMICS SIMULATIONS | TOPOLOGICAL DOMAINS | DNA-MOLECULES |