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Science, ISSN 0036-8075, 5/2009, Volume 324, Issue 5928, pp. 787 - 790
Metastatic prostate cancer is treated with drugs that antagonize androgen action, but most patients progress to a more aggressive form of the disease called... 
COS cells | Androgens | Cell lines | Agonists | Oncology | Reports | Androgen antagonists | Prostate cancer | Heterologous transplantation | Tumors | Vehicles | NONSTEROIDAL ANTIANDROGENS | STRUCTURAL BASIS | AFFINITY | MULTIDISCIPLINARY SCIENCES | ANDROGEN-RECEPTOR | RESISTANCE | ANTAGONISM | LIGAND | MODEL | BICALUTAMIDE | Transcription, Genetic - drug effects | Nitriles - pharmacology | Phenylthiohydantoin - therapeutic use | Humans | Receptors, Androgen - metabolism | Biological Availability | Male | Antineoplastic Agents - therapeutic use | Tosyl Compounds - pharmacology | Antineoplastic Agents - metabolism | Cell Nucleus - metabolism | Receptors, Androgen - chemistry | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Prostatic Neoplasms - drug therapy | Androgen Antagonists - pharmacokinetics | Phenylthiohydantoin - pharmacology | Nitriles - metabolism | Prostatic Neoplasms - pathology | Androgen Antagonists - metabolism | Androgen Antagonists - pharmacology | Anilides - metabolism | DNA - metabolism | Phenylthiohydantoin - analogs & derivatives | Xenograft Model Antitumor Assays | Animals | Receptors, Androgen - genetics | Anilides - pharmacology | Tosyl Compounds - metabolism | Androgen Antagonists - therapeutic use | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Phenylthiohydantoin - metabolism | Drug Screening Assays, Antitumor | Phenylthiohydantoin - pharmacokinetics | Care and treatment | Antiandrogens | Dosage and administration | Drug therapy | Methods | Cancer | Chemotherapy | Pharmacology | Binding sites
Journal Article
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2016, Volume 118, pp. 230 - 243
Prostate cancer (PC) is one of the major causes of male death worldwide and the development of new and more potent anti-PC compounds is a constant requirement.... 
Bicalutamide | Perfluoroalkyl | Enzalutamide | Antiproliferative activity | Prostate cancer | Androgen receptor | IN-VITRO | ANTIANDROGEN MONOTHERAPY | CHEMISTRY, MEDICINAL | CASTRATION-RESISTANT | Phenylthiohydantoin - chemistry | Phenylthiohydantoin - chemical synthesis | Nitriles - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Microsomes, Liver - metabolism | Receptors, Androgen - metabolism | Anilides - chemistry | Male | Nitriles - chemical synthesis | Anilides - chemical synthesis | Tosyl Compounds - pharmacology | Antineoplastic Agents - metabolism | Tosyl Compounds - chemical synthesis | Drug Design | Receptors, Androgen - chemistry | Antineoplastic Agents - pharmacology | Caco-2 Cells | Phenylthiohydantoin - pharmacology | Nitriles - metabolism | Prostatic Neoplasms - pathology | Chemistry Techniques, Synthetic | Anilides - metabolism | Tosyl Compounds - chemistry | Permeability | Antineoplastic Agents - chemistry | Molecular Dynamics Simulation | Phenylthiohydantoin - analogs & derivatives | Anilides - pharmacology | Nitriles - chemistry | Tosyl Compounds - metabolism | Cell Line, Tumor | Protein Conformation | Cell Proliferation - drug effects | Molecular Docking Simulation | Phenylthiohydantoin - metabolism | Drug Resistance, Neoplasm - drug effects | Care and treatment | Drug therapy | Drug approval | Analysis | Cancer
Journal Article
Oncogene, ISSN 0950-9232, 07/2015, Volume 34, Issue 28, pp. 3700 - 3710
Androgen receptor splicing variants (ARVs) that lack the ligand-binding domain (LBD) are associated with the development of castration-resistant prostate... 
ACTIVATION | SOLID TUMORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHROMOGRANIN-A | MECHANISMS | ANTITUMOR-ACTIVITY | SPLICE VARIANTS | CELL BIOLOGY | LYMPH-NODE METASTASES | NUCLEAR-LOCALIZATION | ONCOLOGY | GENETICS & HEREDITY | TRAIL-INDUCED APOPTOSIS | PROGRESSION | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Nitriles - pharmacology | Humans | Pyrazines - administration & dosage | Receptors, Androgen - metabolism | Male | NF-kappa B - metabolism | Antineoplastic Agents - administration & dosage | Prostatic Neoplasms, Castration-Resistant - genetics | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Tosyl Compounds - pharmacology | Nitriles - administration & dosage | Antineoplastic Agents - pharmacology | Boronic Acids - administration & dosage | NF-kappa B - antagonists & inhibitors | Bortezomib | Tosyl Compounds - administration & dosage | Androgen Antagonists - pharmacology | Prostatic Neoplasms, Castration-Resistant - drug therapy | Prostatic Neoplasms, Castration-Resistant - metabolism | Xenograft Model Antitumor Assays | Receptors, Androgen - genetics | Anilides - administration & dosage | Signal Transduction - drug effects | Anilides - pharmacology | Cell Line, Tumor | Androgen Antagonists - administration & dosage | Pyrazines - pharmacology | Boronic Acids - pharmacology | Androgens | Drug therapy | Gene expression | Neurons | Prostate cancer
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 20, Issue 1, pp. 119 - 131
Journal Article
Genome Biology, ISSN 1474-7596, 01/2016, Volume 17, Issue 1, p. 10
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2008, Volume 51, Issue 6, pp. 1791 - 1799
Journal Article
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 08/2017, Volume 16, Issue 8, pp. 1521 - 1530
Journal Article