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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2006, Volume 16, Issue 23, pp. 6067 - 6072
The synthesis and structure–activity studies of a series of quinoline-3-carbonitriles as inhibitors of Tpl2 kinase are described. Potent inhibitors of Tpl2... 
Quinoline-3-carbonitrile | Tpl2 kinase
Journal Article
Translational Cancer Research, ISSN 2218-676X, 12/2017, Volume 6, Issue S9, pp. S1428 - S1430
Journal Article
Immunobiology, ISSN 0171-2985, 05/2019, Volume 224, Issue 3, pp. 383 - 387
Tumor progression locus 2 (TPL2) is a serine/threonine kinase that belongs to the MAP3K family. The activated TPL2 regulates the innate immune-relevant... 
Innate immune | Regulation | Research progress | TPL2 | TPL2 ACTIVATION | MAP KINASE | LIPOPOLYSACCHARIDE ACTIVATION | IMMUNOLOGY | NEUTROPHIL RECRUITMENT | PATHWAY | TOLL-LIKE RECEPTORS | TNF-ALPHA | SIGNAL-REGULATED KINASE | NF-KAPPA-B | T-CELLS | Killer cells | Immune response | Research institutes
Journal Article
Comparative Medicine, ISSN 1532-0820, 07/2017, Volume 67, Issue 4, pp. 344 - 349
Staphylococcus xylosus is a commensal bacterium found on the skin and mucosal surfaces of SPF mice. S. xylosus is rarely pathogenic, most often causing skin... 
NADPH OXIDASE | COAGULASE-NEGATIVE STAPHYLOCOCCI | BACTERIA | ZOOLOGY | TPL2 KINASE | HUMAN SKIN | COMPONENTS | MONOCYTES | VETERINARY SCIENCES | TNF-ALPHA | IDENTIFICATION | HOST-RESISTANCE | Mouse Models | Tpl2, tumor progression locus 2
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 11/2016, Volume 37, Issue 2, pp. 237 - 246
OBJECTIVE—Map3k8 (Cot/Tpl2) activates the MKK1/2-ERK1/2, MAPK pathway downstream from interleukin-1R, tumor necrosis factor-αR, NOD-2R, adiponectinR, and... 
atherosclerosis | Toll-like receptors | monocytes | apoptosis | bone marrow | ACTIVATION | TPL2 | MACROPHAGES | COT/TPL2 | BONE-MARROW | KINASE | HYPERCHOLESTEROLEMIA | PATHWAY | INFLAMMATION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Chemotaxis, Leukocyte | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Male | Monocytes - metabolism | Aorta - metabolism | Aortic Diseases - metabolism | CD11c Antigen - metabolism | MAP Kinase Kinase Kinases - deficiency | Diet, High-Fat | Monocytes - pathology | Aortic Diseases - prevention & control | Antigens, Ly - metabolism | Aortic Diseases - pathology | Disease Models, Animal | Proto-Oncogene Proteins - metabolism | Atherosclerosis - pathology | Genetic Predisposition to Disease | Cytokines - metabolism | Signal Transduction | MAP Kinase Kinase Kinases - genetics | Proto-Oncogene Proteins - genetics | MAP Kinase Kinase Kinases - metabolism | Proto-Oncogene Proteins - deficiency | Plaque, Atherosclerotic | Cell Adhesion | Atherosclerosis - metabolism | Mice, Knockout | Aorta - pathology | Aortic Diseases - genetics | Phenotype | Receptors, CCR2 - metabolism | Animals | Spleen - metabolism | Apolipoproteins E - genetics | Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism | Macrophages, Peritoneal - metabolism | Atherosclerosis - prevention & control | Apoptosis
Journal Article
Biology Open, ISSN 2046-6390, 2019, Volume 8, Issue 5, p. bio034215
New blood vessel sprouting (angiogenesis) and vascular physiology are fundamental features of metazoan species but we do not fully understand how signal... 
Endothelial | Angiogenesis | Signal transduction | VEGF-A | Tpl2
Journal Article
BIOINFORMATICS, ISSN 1367-4803, 07/2019, Volume 35, Issue 13, pp. 2267 - 2275
Motivation Val600Glu (V600E) mutation is the most common BRAF mutation detected in thyroid cancer. Hence, recent research efforts have been performed trying to... 
DIAGNOSIS | ACTIVATION | MECHANISM | TPL2 | KINASE | BIOCHEMICAL RESEARCH METHODS | SIMULATION | ONCOGENE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BRAF MUTATIONS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | CARCINOMA | PROGRESSION
Journal Article
Hepatology, ISSN 0270-9139, 02/2019, Volume 69, Issue 2, pp. 524 - 544
Tumor progression locus 2 (TPL2), a serine/threonine kinase, has been regarded as a potentially interesting target for the treatment of various diseases with... 
LIPID-ACCUMULATION | ACTIVATION | TPL2 KINASE | PROTEIN-KINASE | INSULIN-RESISTANCE | INFLAMMATION | DISEASE | NONALCOHOLIC STEATOHEPATITIS | GASTROENTEROLOGY & HEPATOLOGY | NF-KAPPA-B | EXPRESSION | Phenotypes | Liver diseases | Fatty liver | Threonine | Hepatocytes | Liver | Protein-serine/threonine kinase | Kinases | Insulin | Metabolic disorders | High fat diet
Journal Article
Molecular BioSystems, ISSN 1742-206X, 2017, Volume 13, Issue 9, pp. 1898 - 1911
Non-Alcoholic Fatty Liver Disease (NAFLD) is a complex spectrum of diseases ranging from simple steatosis to Non-Alcoholic Steatohepatitis (NASH) with... 
FIBROSIS | PATHOGENESIS | OBESITY | ADIPOCYTES | TPL2 KINASE | METABOLISM | INSULIN-RESISTANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADIPOSE-TISSUE INFLAMMATION | STEATOHEPATITIS | DYSFUNCTION
Journal Article
by Xu, J and Pei, SY and Wang, Y and Liu, JL and Qian, YC and Huang, MZ and Zhang, YY and Xiao, YC
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 08/2019, Volume 10, p. 1980
Myeloid derived suppressor cells (MDSC) in the liver microenvironment protects against the inflammation-induced liver injury in fulminant hepatitis (FH).... 
chemokine | ACTIVATION | TPL2 | myeloid-derive suppressor cells (MDSCs) | KINASE | IL-25 | IMMUNOLOGY | hepatitis | HEPATOCELLULAR-CARCINOMA | LIVER-INJURY | IMMUNE-RESPONSES | INFLAMMATION | EXPANSION | PROMOTES | EXPRESSION | PROGRESSION | Hepatitis | Liver
Journal Article
Head & Neck, ISSN 1043-3074, 04/2019, Volume 41, Issue 4, pp. 924 - 929
Background Salivary gland neoplasms are relatively rare and comprise only 1%‐4% of all human neoplasms. Salivary gland neoplasms also show an extremely wide... 
salivary gland | MAP3K8 | tumorigenesis | transgenic mouse | squamous cell carcinoma | SURGERY | NEOPLASMS | TPL2 | RAS | KINASE | KAPPA-B | TUMORS | LOCUS | MYC | OTORHINOLARYNGOLOGY | EXPRESSION | Squamous cell carcinoma | Analysis | Genetic engineering | Molecular modelling | Transgenic animals | Epithelial cells | Invasiveness | Rodents | Fibrosis | Transgenic mice | Salivary gland | Tumorigenesis | Genetic diversity | Tumors
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 07/2019, Volume 116, Issue 28, pp. 14039 - 14048
Most normal and tumor cells are protected from tumor necrosis factor alpha (TNF alpha)-induced apoptosis. Here, we identify the MAP3 kinase tumor progression... 
TNF alpha | TPL2 | MULTIDISCIPLINARY SCIENCES | synthetic lethality | KINASE | SIGNALS | apoptosis | DEATH | INDUCTION | CANCER | caspase | RIPK1 | MITOCHONDRIAL RELEASE | INHIBITOR | NF-KAPPA-B | Biotechnology | Phenotypes | Threonine | Tumor cells | Feasibility studies | Caspase | c-FLIP protein | Activation | Lethality | siRNA | Tumor cell lines | Tumor necrosis factor-α | Gene expression | Kinases | Clustering | Caspase-8 | Cell activation | Protein kinase | Tumors | Apoptosis
Journal Article
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, ISSN 1756-9966, 11/2018, Volume 37, Issue 1
BackgroundDrugs that inhibit the MEK/ERK pathway have therapeutic benefit in bladder cancer treatment but responses vary with patients, for reasons that are... 
COX-2 | TPL2 | ALPHA SUPPRESSES | PHOSPHORYLATION | PDE4D | MAP KINASE | PKA | INDUCTION | cAMP | CROSS-TALK | IN-VITRO | ONCOLOGY | PATHWAY | PROSTATE-CANCER | Interferon | Diagnosis | Research | Gene expression | Bladder cancer | Carcinogenesis
Journal Article
Bioscience reports, ISSN 0144-8463, 12/2018, Volume 38, Issue 6, p. BSR20182019
Dendritic cells (DCs) constantly sample peripheral tissues for antigens, which are subsequently ingested to derive peptides for presentation to T cells in... 
hypoxia | tumour necrosis factors | dendritic cells | inflammation | mitogen-activated protein kinases | SIGNALING PATHWAYS | DNA-BINDING | ACTIVATED PROTEIN-KINASE | INDUCIBLE FACTOR-I | TPL2 KINASE | INFLAMMATION | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | P38 MAPK | NF-KAPPA-B | EXPRESSION | CELL BIOLOGY
Journal Article
Human Pathology, ISSN 0046-8177, 09/2018, Volume 79, pp. 50 - 56
Tumor progression locus 2 (TPL2) is a mitogen-activated protein kinase (MAPK) kinase kinase (MAP3K). The present study aimed to elucidate the... 
Immunohistochemistry | Prognosis | TPL2 | Immunoscore | Colorectal cancer | TPL-2/COT | MAP KINASE | TRANSCRIPTION | KAPPA-B | INDUCTION | PATHOLOGY | ACTIVATE ERK | ONCOGENE | INFLAMMATION | TUMOR-GROWTH | PROGRESSION | Medical colleges | Medical research | Analysis | Medicine, Experimental | Metastasis | Mitogens | Protein kinases | Ethics | Lymphatic system | Lymphocytes | Medical prognosis | Kinases
Journal Article
Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, 11/2018, Volume 37, Issue 1, pp. 288 - 15
Drugs that inhibit the MEK/ERK pathway have therapeutic benefit in bladder cancer treatment but responses vary with patients, for reasons that are still not... 
Interferon | COX-2 | cAMP | TPL2 | PDE4D | Proteins | Enzymes | Phosphorylation | Medical prognosis | Response rates | Cytotoxicity | Tumorigenesis | Gene expression | Kinases | Bladder cancer | Cancer therapies
Journal Article