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The New England Journal of Medicine, ISSN 0028-4793, 05/2008, Volume 358, Issue 22, pp. 2319 - 2331
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2017, Volume 376, Issue 2, pp. 136 - 148
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2013, Volume 368, Issue 2, pp. 128 - 137
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2006, Volume 354, Issue 4, pp. 353 - 365
The antifibrinolytic agent aprotinin is often used to control blood loss in patients undergoing cardiac surgery. This observational study found that the use of... 
PROTEASE INHIBITOR | HIGH-DOSE APROTININ | MEDICINE, GENERAL & INTERNAL | INTRAVASCULAR COAGULATION | HYPOTHERMIC CIRCULATORY ARREST | ENDOTHELIAL-CELLS | RENAL-FUNCTION | DOUBLE-BLIND | CARDIOPULMONARY BYPASS | PLACEBO-CONTROLLED TRIAL | BYPASS GRAFT-SURGERY | Antifibrinolytic Agents - therapeutic use | Multivariate Analysis | Myocardial Infarction - chemically induced | Myocardial Infarction - epidemiology | Prospective Studies | Postoperative Hemorrhage - prevention & control | Humans | Male | Antifibrinolytic Agents - adverse effects | Renal Insufficiency - epidemiology | Aprotinin - therapeutic use | Aprotinin - adverse effects | Serine Proteinase Inhibitors - therapeutic use | Cardiac Surgical Procedures | Renal Insufficiency - chemically induced | Serine Proteinase Inhibitors - adverse effects | Cardiovascular Diseases - epidemiology | Adult | Female | Cerebrovascular Disorders - epidemiology | Aminocaproates - therapeutic use | Aminocaproates - adverse effects | Blood Loss, Surgical - prevention & control | Cerebrovascular Disorders - chemically induced | Logistic Models | Tranexamic Acid - therapeutic use | Tranexamic Acid - adverse effects | Cardiovascular Diseases - chemically induced | Tranexamic acid | Usage | Kidney failure | Hemodialysis | Risk factors | Methods | Coma | Heart attacks | Acids | Surgery | Drug therapy | Acute coronary syndromes | Patients | Regulatory approval | Veins & arteries | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2012, Volume 122, Issue 12, pp. 4654 - 4666
Antifibrinolytic drugs are widely used to reduce blood loss during surgery. One serious adverse effect of these drugs is convulsive seizures; however, the... 
MEDICINE, RESEARCH & EXPERIMENTAL | SUBSTANTIA-GELATINOSA NEURONS | INDUCED EPILEPTIFORM ACTIVITY | ENTORHINAL CORTEX | INHERITED MYOCLONUS | CARDIAC-SURGERY | SODIUM-CHANNELS | GABAERGIC TONIC INHIBITION | GABA(A) RECEPTORS | HIPPOCAMPAL-NEURONS | FLUID DRAINAGE | Isoflurane - pharmacology | Humans | Middle Aged | Tranexamic Acid - pharmacology | Propofol - pharmacology | Mice, 129 Strain | Anticonvulsants - pharmacology | Receptors, Glycine - antagonists & inhibitors | Seizures - chemically induced | Young Adult | Aprotinin - pharmacology | Spinal Cord - pathology | Neurons - physiology | Aged, 80 and over | Inhibitory Concentration 50 | Adult | Synaptic Transmission - drug effects | Neurons - metabolism | Neurons - drug effects | GABA-A Receptor Antagonists - pharmacology | Binding, Competitive | Membrane Potentials - drug effects | Aminocaproic Acid - adverse effects | GABA-A Receptor Antagonists - pharmacokinetics | Mice, Inbred C57BL | Cells, Cultured | gamma-Aminobutyric Acid - pharmacology | GABA-A Receptor Antagonists - adverse effects | Tranexamic Acid - adverse effects | Aminocaproic Acid - pharmacology | Patch-Clamp Techniques | Animals | Glycine - pharmacology | Protein Binding | Tranexamic Acid - pharmacokinetics | Aged | Mice | Receptors, GABA-A - metabolism | In Vitro Techniques | Inhibitory Postsynaptic Potentials - drug effects | Dose-response relationship (Biochemistry) | Complications and side effects | Care and treatment | Glycine receptors | Tranexamic acid | Research | Seizures (Medicine) | Diagnosis | Properties | Index Medicus | Abridged Index Medicus | Drugs | Neurotransmitters | Side effects | Surgery | Antagonists | Cerebrospinal fluid | Propofol | Anesthetics | Blood | Isoflurane | Seizures
Journal Article