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1. Full Text Tranexamic Acid Impairs γ-Aminobutyric Acid Receptor Type A–mediated Synaptic Transmission in the Murine Amygdala: A Potential Mechanism for Drug-induced Seizures?
by Kratzer, Stephan and Irl, Hedwig and Mattusch, Corinna and Bürge, Martina and Kurz, Jörg and Kochs, Eberhard and Eder, Matthias and Rammes, Gerhard and Haseneder, Rainer
Anesthesiology, ISSN 0003-3022, 03/2014, Volume 120, Issue 3, pp. 639 - 649
BACKGROUND:Tranexamic acid (TXA) is commonly used to reduce blood loss in cardiac surgery and in trauma patients. High-dose application of TXA is associated... 
Amygdala - drug effects | Mice, Inbred C57BL | Tranexamic Acid - pharmacology | Male | Patch-Clamp Techniques - methods | Seizures - chemically induced | Animals | Photolysis | Receptors, GABA-A - drug effects | Antifibrinolytic Agents - pharmacology | Synaptic Transmission - drug effects | Mice | Electric Stimulation - methods | Disease Models, Animal | Index Medicus | Abridged Index Medicus
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2. Full Text Aprotinin May Increase Mortality in Low and Intermediate Risk but Not in High Risk Cardiac Surgical Patients Compared to Tranexamic Acid and ε-Aminocaproic Acid - A Meta-Analysis of Randomised and Observational Trials of over 30.000 Patients
by Meybohm, Patrick and Herrmann, Eva and Nierhoff, Julia and Zacharowski, Kai
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, pp. e58009 - e58009
Background: To compare the effect of aprotinin with the effect of lysine analogues (tranexamic acid and e-aminocaproic acid) on early mortality in three... 
SURGERY | SYSTEMATIC REVIEWS | OPERATIONS | BLOOD-LOSS | MULTIDISCIPLINARY SCIENCES | LOW-DOSE APROTININ | DOUBLE-BLIND | CARDIOPULMONARY BYPASS | POSTOPERATIVE OUTCOMES | METHODOLOGICAL QUALITY | TRANSFUSION REQUIREMENTS | Aminocaproic Acid - adverse effects | Humans | Risk Factors | Cardiac Surgical Procedures - mortality | Tranexamic Acid - adverse effects | Aprotinin - adverse effects | Randomized Controlled Trials as Topic | Heart | Intensive care | Transfusion | Renal function | Heart surgery | Erythrocytes | Clinical trials | Risk | Systematic review | Epidemiology | Bleeding | Subgroups | Randomization | Red blood cells | Lists | Surgery | Heart diseases | Drug dosages | Postoperative period | Complications | Mortality | Blood cells | Patients | Meta-analysis | Studies | Hospitals | Acids | Lysine | Renal failure | Anesthesiology | Kidney transplantation | Veins & arteries | Index Medicus
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3. Full Text Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial
by Olldashi, Fatos and Kerçi, Mihal and Zhurda, Tefik and Ruçi, Klotilda and Banushi, Arben and Traverso, Mario Sardón and Jiménez, Juan and Balbi, Jorge and Dellera, Christian and Svampa, Silvana and Quintana, Gustavo and Piñero, Gustavo and Teves, Jorge and Seppelt, Ian and Mountain, David and Hunter, John and Balogh, Zsolt and Zaman, Maniruz and Druwé, Patrick and Rutsaert, Robert and Mazairac, Guy and Pascal, Fogang and Yvette, Zognou and Chancellin, Djeuchon and Okwen, Patrick and Djokam-Liapoe, Jules and Jangwa, Ernest and Mbuagbaw, Lawrence and Fointama, Ninying and Pascal, Nguemo and Baillie, Frank and Jiang, Ji-Yao and Gao, Guo-Yi and Bao, Yin-Hui and Morales, Carlos and Sierra, Juan and Naranjo, Santiago and Correa, Camilo and Gómez, Carolina and Herrera, Jorge and Caicedo, Liliana and Rojas, Alexei and Pastas, Henry and Miranda, Hugo and Constaín, Alfredo and Perdomo, Mayla and Muñoz, Diego and Duarte, Álvaro and Vásquez, Edwin and Ortiz, Camilo and Ayala, Bernardo and Delgado, Hernán and Benavides, Gloria and Rosero, Lorena and Mejía-Mantilla, Jorge and Varela, Ana and Calle, Maríaisabel and Castillo, José and García, Alberto and Ciro, Juan and Villa, Clara and Panesso, Roberto and Flórez, Luz and Gallego, Argemiro and Puentes-Manosalva, Fabián and Medina, Leonor and Márquez, Kelly and Romero, Adalgiza Reyes and Hernández, Ricardo and Martínez, Julio and Gualteros, Wilson and Urbina, Zulma and Velandia, Julio and Benítez, Federico and Trochez, Adolfo and Villarreal, Andrés and Pabón, Pamela and López, Héctor and Quintero, Laureano and Rubiano, Andrés and Tamayo, Juan and Piñera, Marjoris and Navarro, Zadis and Rondón, Deborah and Bujan, Bárbara and Palacios, Leonel and Martínez, Daymis and Hernández, Yalisa and Fernández, Yaimara and Casola, Eugenio and Delgado, Rodolfo and Herrera, Carlos and Arbolaéz, Migdacelys and Domínguez, Mario and Iraola, Marcos and Rojas, Omar and Enseñat, Alba and Pastrana, Irene and Rodríguez, Daniel and De La Campa, Sergio Álvarez and ... and Crash 2 Trial Collaborators and CRASH-2 trial collaborators
Lancet, The, ISSN 0140-6736, 2010, Volume 376, Issue 9734, pp. 23 - 32
Summary Background Tranexamic acid can reduce bleeding in patients undergoing elective surgery. We assessed the effects of early administration of a short... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | BRAIN-INJURY | EPIDEMIOLOGY | Antifibrinolytic Agents - therapeutic use | Hemorrhage - therapy | Humans | Wounds and Injuries - complications | Hemorrhage - mortality | Male | Tranexamic Acid - therapeutic use | Hemorrhage - drug therapy | Blood Transfusion | Thrombosis - etiology | Hemorrhage - etiology | Adult | Female | Thrombosis - prevention & control | Prevention | Complications and side effects | Tranexamic acid | Dosage and administration | Research | Blood transfusion | Health aspects | Hemorrhage | Risk factors | Colleges & universities | Clinical trials | Blood pressure | Charitable foundations | Trauma | Injuries | Binding sites | Teaching hospitals | Index Medicus | Abridged Index Medicus
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4. Full Text Topical Application of Tranexamic Acid Reduces Postoperative Blood Loss in Total Knee Arthroplasty: A Randomized, Controlled Trial
by Wong, Jean and Abrishami, Amir and El Beheiry, Hossam and Mahomed, Nizar N and Roderick Davey, J and Gandhi, Rajiv and Syed, Khalid A and Muhammad Ovais Hasan, Syed and De Silva, Yoshani and Chung, Frances
The Journal of Bone & Joint Surgery, ISSN 0021-9355, 11/2010, Volume 92, Issue 15, pp. 2503 - 2513
BACKGROUND:Topical application of tranexamic acid to bleeding wound surfaces reduces blood loss in patients undergoing some major surgeries, without systemic... 
REPLACEMENT | SURGERY | ORTHOPEDIC-SURGERY | METAANALYSIS | TOTAL HIP | TRANSFUSION | CARDIAC-SURGERY | HIGH-RISK | FIBRIN SEALANT | ANTIFIBRINOLYTIC THERAPY | ANEMIA | ORTHOPEDICS | Antifibrinolytic Agents - therapeutic use | Bone Cements | Prospective Studies | Double-Blind Method | Humans | Male | Treatment Outcome | Tranexamic Acid - therapeutic use | Chi-Square Distribution | Postoperative Hemorrhage - drug therapy | Antifibrinolytic Agents - administration & dosage | Placebos | Arthroplasty, Replacement, Knee | Female | Aged | Tranexamic Acid - administration & dosage | Administration, Topical | Index Medicus | Abridged Index Medicus
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5. Full Text Seizures After Open Heart Surgery: Comparison of ε-Aminocaproic Acid and Tranexamic Acid
by Martin, Klaus, MD and Knorr, Jürgen, MD and Breuer, Tamás, MD and Gertler, Ralph, MD and MacGuill, Martin, MD and Lange, Rüdiger, PhD and Tassani, Peter, PhD and Wiesner, Gunther, PhD
Journal of Cardiothoracic and Vascular Anesthesia, ISSN 1053-0770, 2011, Volume 25, Issue 1, pp. 20 - 25
Objective Although the lysine analogs tranexamic acid (TXA) and aminocaproic acid (EACA) are used widely for antifibrinolytic therapy in cardiac surgery,... 
Anesthesia & Perioperative Care | Critical Care | aminocaproic acid | cardiac surgery | bleeding | seizure | clinical outcome | tranexamic acid | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK | CONVULSIONS | LYSINE ANALOGS | THERAPY | RESPIRATORY SYSTEM | ANESTHESIOLOGY | PERIPHERAL VASCULAR DISEASE | APROTININ | Antifibrinolytic Agents - therapeutic use | Blood Loss, Surgical - prevention & control | Aminocaproic Acid - adverse effects | Hospital Mortality | Risk Assessment | Humans | Middle Aged | Male | Treatment Outcome | Antifibrinolytic Agents - adverse effects | Cardiac Surgical Procedures - adverse effects | Postoperative Complications - epidemiology | Tranexamic Acid - therapeutic use | Tranexamic Acid - adverse effects | Ischemic Attack, Transient - epidemiology | Seizures - epidemiology | Coronary Artery Bypass | Aminocaproic Acid - therapeutic use | Anesthesia | Female | Stroke - epidemiology | Aged | Retrospective Studies | Cohort Studies | Index Medicus
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6. Full Text Tranexamic Acid Treatment for Heavy Menstrual Bleeding: A Randomized Controlled Trial
by Lukes, Andrea S and Moore, Keith A and Muse, Ken N and Gersten, Janet K and Hecht, Bryan R and Edlund, Måns and Richter, Holly E and Eder, Scott E and Attia, George R and Patrick, Donald L and Rubin, Arkady and Shangold, Gary A
Obstetrics & Gynecology, ISSN 0029-7844, 10/2010, Volume 116, Issue 4, pp. 865 - 875
OBJECTIVE:To assess the efficacy and safety of an oral formulation of tranexamic acid for the treatment of heavy menstrual bleeding. METHODS:Adult women with... 
MENORRHAGIA | WOMEN | MANAGEMENT | BLOOD-LOSS | RISK | QUALITY-OF-LIFE | OBSTETRICS & GYNECOLOGY | Antifibrinolytic Agents - therapeutic use | Double-Blind Method | Administration, Oral | Menorrhagia - drug therapy | Humans | Middle Aged | Treatment Outcome | Antifibrinolytic Agents - adverse effects | Tranexamic Acid - therapeutic use | Motor Activity | Tranexamic Acid - adverse effects | Young Adult | Adolescent | Antifibrinolytic Agents - administration & dosage | Least-Squares Analysis | Quality of Life | Adult | Female | Tranexamic Acid - administration & dosage | Index Medicus | Abridged Index Medicus
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7. Full Text Topical (Intra-Articular) Tranexamic Acid Reduces Blood Loss and Transfusion Rates Following Total Knee Replacement: A Randomized Controlled Trial (TRANX-K)
by Alshryda, Sattar and Mason, James and Vaghela, Manesh and Sarda, Praveen and Nargol, Antoni and Maheswaran, S and Tulloch, Chris and Anand, Sanjeev and Logishetty, Raj and Stothart, Brian and Hungin, A. Pali S
The Journal of Bone & Joint Surgery, ISSN 0021-9355, 11/2013, Volume 95, Issue 21, pp. 1961 - 1968
BACKGROUND:Approximately one-third of patients undergoing total knee replacement require one to three units of blood postoperatively. Tranexamic acid (TXA) is... 
SURGERY | DOUBLE-BLIND | ORTHOPEDICS | ARTHROPLASTY | Antifibrinolytic Agents - therapeutic use | Blood Loss, Surgical - prevention & control | Arthroplasty, Replacement, Knee - adverse effects | Double-Blind Method | Humans | Middle Aged | Male | Treatment Outcome | Tranexamic Acid - therapeutic use | Blood Transfusion | Injections, Intra-Articular | Aged, 80 and over | Antifibrinolytic Agents - administration & dosage | Female | Aged | Tranexamic Acid - administration & dosage | Index Medicus | Abridged Index Medicus
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8. Full Text Tranexamic Acid Administration in Primary Total Hip Arthroplasty: A Randomized Controlled Trial of Intravenous Combined with Topical Versus Single-Dose Intravenous Administration
by Yi, Zeng and Bin, Shen and Jing, Yang and Zongke, Zhou and Pengde, Kang and Fuxing, Pei
The Journal of Bone and Joint Surgery, ISSN 0021-9355, 06/2016, Volume 98, Issue 12, pp. 983 - 991
BACKGROUND:The use of tranexamic acid (TXA) in primary total hip arthroplasty is well documented. However, considering the potential side effects, including... 
REPLACEMENT | SURGERY | REDUCES BLOOD-LOSS | REDUCTION | COAGULATION | TOURNIQUET | THROMBOEMBOLISM | ORTHOPEDICS | TOTAL KNEE ARTHROPLASTY | TRANSFUSION RATES | Antifibrinolytic Agents - therapeutic use | Postoperative Hemorrhage - prevention & control | Humans | Middle Aged | Male | Treatment Outcome | Antifibrinolytic Agents - adverse effects | Tranexamic Acid - therapeutic use | Tranexamic Acid - adverse effects | Venous Thrombosis - etiology | Postoperative Hemorrhage - drug therapy | Arthroplasty, Replacement, Hip - methods | Administration, Intravenous | Pulmonary Embolism - etiology | Antifibrinolytic Agents - administration & dosage | Adult | Female | Aged | Tranexamic Acid - administration & dosage | Administration, Topical | Index Medicus | Abridged Index Medicus
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9. Full Text Topical Intra-Articular Compared with Intravenous Tranexamic Acid to Reduce Blood Loss in Primary Total Knee Replacement: A Double-Blind, Randomized, Controlled, Noninferiority Clinical Trial
by Gomez-Barrena, Enrique and Ortega-Andreu, Miguel and Padilla-Eguiluz, Norma G and Pérez-Chrzanowska, Hanna and Figueredo-Zalve, Reyes
The Journal of Bone and Joint Surgery, ISSN 0021-9355, 12/2014, Volume 96, Issue 23, pp. 1937 - 1944
BACKGROUND:Abundant literature regarding the use of intravenous tranexamic acid (TXA) in primary total knee replacement is available. Randomized controlled... 
SURGERY | PRIMARY TOTAL HIP | METAANALYSIS | SAFETY | ARTHROPLASTY | ORTHOPEDICS | TRANSFUSION RATES | Antifibrinolytic Agents - therapeutic use | Blood Loss, Surgical - prevention & control | Blood Loss, Surgical - statistics & numerical data | Double-Blind Method | Humans | Middle Aged | Male | Treatment Outcome | Tranexamic Acid - therapeutic use | Blood Transfusion - statistics & numerical data | Administration, Intravenous | Injections, Intra-Articular | Intention to Treat Analysis | Aged, 80 and over | Antifibrinolytic Agents - administration & dosage | Arthroplasty, Replacement, Knee | Female | Aged | Tranexamic Acid - administration & dosage | Index Medicus | Abridged Index Medicus
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10. Full Text Efficacy of tranexamic acid in pediatric craniosynostosis surgery: A double-blind, placebo-controlled trial
by Goobie, Susan M and Meier, Petra M and Pereira, Luis M and McGowan, Francis X and Prescilla, Randy P and Scharp, Laurie A and Rogers, Gary F and Proctor, Mark R and Meara, John G and Soriano, Sulpicio G and Zurakowski, David and Sethna, Navil F
Anesthesiology, ISSN 0003-3022, 2011, Volume 114, Issue 4, pp. 862 - 871
Background: Extensive blood loss is common in pediatric craniosynostosis reconstruction surgery. Tranexamic acid (TXA) is increasingly used to reduce... 
SCOLIOSIS SURGERY | ANTIFIBRINOLYTIC DRUGS | TOPICAL APPLICATION | BLOOD-LOSS | CARDIAC-SURGERY | SURGICAL-CORRECTION | RECOMBINANT ERYTHROPOIETIN | NORMOVOLEMIC HEMODILUTION | ANESTHESIOLOGY | CRANIOFACIAL SURGERY | TRANSFUSION RATES | Antifibrinolytic Agents - therapeutic use | Blood Loss, Surgical - prevention & control | Double-Blind Method | Humans | Craniosynostoses - surgery | Child, Preschool | Infant | Male | Treatment Outcome | Tranexamic Acid - therapeutic use | Blood Transfusion - statistics & numerical data | Intraoperative Care | Female | Child | Index Medicus | Abridged Index Medicus
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11. Full Text Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery
by Myles, Paul S and Smith, Julian A and Forbes, Andrew and Silbert, Brendan and Jayarajah, Mohandas and Painter, Thomas and Cooper, D. James and Marasco, Silvana and McNeil, John and Bussières, Jean S and McGuinness, Shay and Byrne, Kelly and Chan, Matthew T.V and Landoni, Giovanni and Wallace, Sophie and ANZCA Clinical Trials Network and ATACAS Investigators of the ANZCA Clinical Trials Network
The New England Journal of Medicine, ISSN 0028-4793, 01/2017, Volume 376, Issue 2, pp. 136 - 148
In a randomized trial, over 4500 patients undergoing cardiac surgery were assigned to receive tranexamic acid or placebo. There was no difference between... 
MEDICINE, GENERAL & INTERNAL | SEIZURES | MYOCARDIAL-INFARCTION | PHARMACOKINETICS | CARDIAC-SURGERY | ADULTS | RISK | APROTININ | Antifibrinolytic Agents - therapeutic use | Coronary Artery Disease - surgery | Thrombosis - chemically induced | Humans | Middle Aged | Male | Antifibrinolytic Agents - adverse effects | Hemorrhage - prevention & control | Blood Transfusion - statistics & numerical data | Seizures - chemically induced | Heart Valves - surgery | Reoperation - statistics & numerical data | Aged, 80 and over | Female | Aspirin - therapeutic use | Platelet Aggregation Inhibitors - therapeutic use | Postoperative Complications - chemically induced | Double-Blind Method | Intraoperative Complications - prevention & control | Coronary Artery Disease - mortality | Tranexamic Acid - therapeutic use | Tranexamic Acid - adverse effects | Coronary Artery Bypass | Aged | Hemorrhage - chemically induced | Usage | Care and treatment | Tranexamic acid | Diagnosis | Hemorrhage | Patients | Health aspects | Risk factors | Coronary arteries | Heart | Surgical outcomes | Myocardial infarction | Cerebral infarction | Aspirin | Heart surgery | Clinical trials | Bleeding | Embolism | Tamponade | Acids | Intestine | Coronary vessels | Surgery | Renal failure | Seizures | Index Medicus | Abridged Index Medicus
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