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Cell metabolism, ISSN 1550-4131, 2012, Volume 15, Issue 5, pp. 725 - 738
.... The liver is a key organ in insulin-mediated regulation of metabolism. To assess the role of hepatic mTORC2, we generated liver-specific rictor knockout (LiRiKO) mice... 
TRANSCRIPTION FACTORS | LIPID-METABOLISM | INSULIN-RESISTANCE | ELEMENT-BINDING PROTEIN-1C | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | MOTIF PHOSPHORYLATION | DIABETIC-NEPHROPATHY | GLUCOSE-UTILIZATION | CELL-GROWTH | PHOSPHOINOSITIDE 3-KINASE | CELL BIOLOGY | Glucose Intolerance - metabolism | Phosphorylation | Liver - enzymology | TOR Serine-Threonine Kinases - metabolism | Homeostasis | Glycogen Synthase Kinase 3 beta | Male | Hepatocytes - metabolism | Mechanistic Target of Rapamycin Complex 2 | Hyperglycemia - genetics | Proto-Oncogene Proteins c-akt - genetics | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Forkhead Transcription Factors - metabolism | Trans-Activators - genetics | Hyperinsulinism - genetics | Insulin - genetics | Lipogenesis | Proto-Oncogene Proteins c-akt - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Gluconeogenesis | Hyperinsulinism - metabolism | Glucose Intolerance - genetics | Signal Transduction | Liver - metabolism | Glucokinase - genetics | Glucose - genetics | Lipid Metabolism | Forkhead Transcription Factors - genetics | Glucokinase - metabolism | Glycogen Synthase Kinase 3 - metabolism | Mice, Knockout | Hyperglycemia - metabolism | Proteins - genetics | Insulin - metabolism | Animals | Proteins - metabolism | Trans-Activators - deficiency | Glycogen Synthase Kinase 3 - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Glucose - metabolism | Glycolysis | Trans-Activators - metabolism | Forkhead Box Protein O1 | Mice | Transcription Factors | Glucose metabolism | Hyperglycemia | Glucose | Isoenzymes | Dextrose
Journal Article
Molecular and cellular biology, ISSN 0270-7306, 2007, Volume 27, Issue 13, pp. 4953 - 4967
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
CELLS | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | PGC-1-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | GENE-EXPRESSION | TRANSCRIPTIONAL COACTIVATOR | DIFFERENTIATION | MICROARRAY DATA | TRANSGENIC MICE | CELL BIOLOGY | Gene Expression Regulation, Enzymologic - drug effects | Acetyltransferases - metabolism | Multienzyme Complexes - metabolism | Adipocytes - drug effects | Glucose Intolerance | AMP-Activated Protein Kinases | Oxidative Phosphorylation - drug effects | Adipose Tissue, White - cytology | Body Composition - drug effects | Isoenzymes - metabolism | Adenosine Triphosphate - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Trans-Activators - genetics | Food Deprivation | p38 Mitogen-Activated Protein Kinases - metabolism | Homeostasis - drug effects | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Isoenzymes - genetics | Hydrogen Peroxide - pharmacology | Protein-Serine-Threonine Kinases - genetics | Mitochondria - metabolism | Multienzyme Complexes - genetics | Macrophages - cytology | Mitochondria - drug effects | Feeding Behavior - drug effects | Polyamines - metabolism | Macrophages - metabolism | Organ Size - drug effects | Animals | Adipocytes - metabolism | Fibroblasts - drug effects | Adipose Tissue, White - enzymology | Adipose Tissue, White - growth & development | Glucose - metabolism | Macrophages - drug effects | Trans-Activators - metabolism | Mice | Transcription Factors | Adipose Tissue, White - drug effects | Energy Metabolism - drug effects | White/cytology/drug effects/enzymology/growth | Hydrogen Peroxide/pharmacology | Macrophages/cytology/drug effects/metabolism | Mitochondria/drug effects/metabolism | Fibroblasts/drug effects/metabolism | p38 Mitogen-Activated Protein Kinases/metabolism | MEDICIN OCH HÄLSOVETENSKAP | Homeostasis/drug effects | Multienzyme Complexes/genetics/metabolism | Protein-Serine-Threonine Kinases/genetics/metabolism | Trans-Activators/genetics/metabolism | Enzymologic/drug effects | Glucose/metabolism | Adipose Tissue | Feeding Behavior/drug effects | Organ Size/drug effects | Oxidative Phosphorylation/drug effects | MEDICAL AND HEALTH SCIENCES | development | Acetyltransferases/metabolism | Adipocytes/drug effects/metabolism | Gene Expression Regulation | Adenosine Triphosphate/metabolism | Body Composition/drug effects | Polyamines/metabolism | Energy Metabolism/drug effects | Isoenzymes/genetics/metabolism | Phosphorylation/drug effects
Journal Article
Nature cell biology, ISSN 1476-4679, 2014, Volume 16, Issue 4, pp. 357 - 366
.... However, how their biological properties intersect with cellular metabolism remains unexplained... 
ORGAN GROWTH | CHOLESTEROL | YAP/TAZ | TRANSCRIPTION | HIPPO PATHWAY | STATINS | CELL BIOLOGY | Phosphorylation - physiology | Cell Proliferation | Active Transport, Cell Nucleus - physiology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Phosphoproteins - metabolism | Sterol Regulatory Element Binding Proteins - genetics | Breast Neoplasms - metabolism | Drosophila melanogaster - metabolism | RNA Interference | Tumor Suppressor Proteins - genetics | HEK293 Cells | Trans-Activators - genetics | Female | Transcription, Genetic | Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent - metabolism | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | HCT116 Cells | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Sterol Regulatory Element Binding Proteins - metabolism | Transcription Factors - genetics | Mevalonic Acid - metabolism | Polyisoprenyl Phosphates - metabolism | Transcription Factors - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | rho GTP-Binding Proteins - metabolism | Trans-Activators - metabolism | Mice | Polyisoprenyl Phosphates - biosynthesis | Pyridines - pharmacology | RNA, Small Interfering | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cell metabolism | Genetic research | Genetic aspects | Research | Cellular control mechanisms
Journal Article
Genes and Development, ISSN 0890-9369, 08/2011, Volume 25, Issue 16, pp. 1680 - 1685
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 481, Issue 7382, pp. 463 - 468
Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional... 
SKELETAL-MUSCLE | COACTIVATOR | PHOSPHORYLATION | ROLES | PGC-1-ALPHA | MULTIDISCIPLINARY SCIENCES | SWITCH | MYOBLAST | EXPRESSION | EXERCISE | PROTECTS | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Adipocytes - drug effects | Obesity - blood | Adipose Tissue, White - cytology | Mitochondrial Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Models, Animal | Energy Metabolism - physiology | Intracellular Signaling Peptides and Proteins - genetics | Obesity - chemically induced | Mice, Transgenic | Trans-Activators - deficiency | Obesity - prevention & control | Plasma - chemistry | Adipose Tissue, Brown - drug effects | Exercise - physiology | Mice | Mice, Inbred BALB C | Transcription Factors | Energy Metabolism - drug effects | Thermogenesis - genetics | Adipose Tissue, White - metabolism | Adipocytes - cytology | Culture Media, Conditioned - pharmacology | Subcutaneous Fat - metabolism | Insulin Resistance - physiology | Cell Respiration - drug effects | Subcutaneous Fat - drug effects | Trans-Activators - genetics | Energy Metabolism - genetics | Gene Expression Regulation - genetics | Cells, Cultured | Hormones - secretion | Muscle Cells - metabolism | Physical Conditioning, Animal - physiology | Subcutaneous Fat - cytology | Gene Expression Regulation - drug effects | Adipose Tissue, Brown - cytology | Animals | Hormones - metabolism | Ion Channels - metabolism | Adipocytes - metabolism | Trans-Activators - secretion | Trans-Activators - metabolism | Adipose Tissue, Brown - metabolism | Thermogenesis - drug effects | Uncoupling Protein 1 | Adipose Tissue, White - drug effects
Journal Article
PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 1, p. e0169648
The structural maintenance of chromosome 5/6 complex (Smc5/6) is a restriction factor that represses hepatitis B virus (HBV) transcription. HBV counters this... 
CELLS | NUCLEAR-BODIES | HEPATITIS-B-VIRUS | REPLICATION | DNA | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | EPIGENETIC REGULATION | COMPONENTS | BINDING | HUMANIZED MICE | Autoantigens - metabolism | Hepatitis B - metabolism | Antigens, Nuclear - metabolism | Humans | Hepatitis B - virology | Male | Hepatocytes - metabolism | Autoantigens - genetics | Hepatitis B - immunology | Hepatocytes - cytology | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Promyelocytic Leukemia Protein - metabolism | Nuclear Proteins - genetics | Cytokines - genetics | Hepatitis B virus - immunology | Promyelocytic Leukemia Protein - genetics | Cytokines - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Chromosomal Proteins, Non-Histone | Nuclear Proteins - metabolism | Mice, SCID | Immunity, Innate - immunology | Animals | Antigens, Nuclear - genetics | Virus Replication | Trans-Activators - metabolism | Mice | Immune response | Analysis | Genetic aspects | Hepatitis B virus | Research | Genetic transcription | Hepatitis B | Cell culture | HBX protein | Pathogenesis | Viruses | Infections | Genomes | Degradation | Proteins | Hepatitis | Hepatology | Localization | Bioinformatics | Chromosomes | Deoxyribonucleic acid--DNA | Immune system | Antigens | Cytokines | Chromosome 5 | Gene expression | Ribonucleic acid--RNA | Hepatocytes | Interferon | Kinetics | X protein | RNA | Deoxyribonucleic acid | Ribonucleic acid
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2007, Volume 130, Issue 6, pp. 1120 - 1133
Coordination of cell proliferation and cell death is essential to attain proper organ size during development and for maintaining tissue homeostasis throughout... 
DEVBIO | SIGNALING | YES-ASSOCIATED PROTEIN | WW | APOPTOSIS | DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | TUMOR-SUPPRESSOR | YAP | MICE | CELL | CANCER | CELL BIOLOGY | Protein Kinases - metabolism | Phosphorylation | Cell Proliferation | Large Neutral Amino Acid-Transporter 1 - metabolism | Humans | Liver Neoplasms, Experimental - chemically induced | Homeostasis | Cytoplasm - metabolism | Drosophila Proteins - metabolism | Doxorubicin | Drosophila - enzymology | Liver Neoplasms, Experimental - metabolism | Cell Nucleus - metabolism | Transfection | Trans-Activators - genetics | Active Transport, Cell Nucleus | Liver Neoplasms, Experimental - pathology | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Drosophila - genetics | Cell Line | Mammals - metabolism | Mammals - growth & development | Signal Transduction | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Intracellular Signaling Peptides and Proteins | Organ Size | Drosophila - cytology | Mice, Transgenic | Nuclear Proteins - metabolism | Transcription Factors - genetics | Serine - metabolism | Transcription Factors - metabolism | Animals | Liver Neoplasms, Experimental - enzymology | Trans-Activators - metabolism | Drosophila - growth & development | Mice | Drosophila - metabolism | Drosophila Proteins - genetics | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Apoptosis | Drosophila | Knowledge-based systems
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 2012, Volume 287, Issue 35, pp. 29579 - 29588
Mammalian target of rapamycin complex 2 (mTORC2) is a key activator of protein kinases that act downstream of insulin and growth factor signaling. Here we... 
TRANSCRIPTION FACTORS | DIABETES-MELLITUS | LIPID-METABOLISM | AKT/PKB | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER | MOTIF PHOSPHORYLATION | RICTOR | MICE | KINASE-B | INDUCED INSULIN-RESISTANCE | Phosphorylation - physiology | Humans | Glycogen Synthase Kinase 3 beta | GTPase-Activating Proteins - metabolism | Phosphoproteins - metabolism | Cholesterol - genetics | Proto-Oncogene Proteins c-akt - genetics | Fatty Acids - genetics | Forkhead Transcription Factors - metabolism | Insulin Resistance - physiology | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Insulin - genetics | Proto-Oncogene Proteins c-akt - metabolism | Fatty Acids - metabolism | Lipogenesis - physiology | Sterol Regulatory Element Binding Protein 1 - metabolism | Tumor Suppressor Proteins - metabolism | Liver - metabolism | Gene Expression Regulation - physiology | Glucose - genetics | Mice, Transgenic | Phosphoproteins - genetics | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Glycogen Synthase Kinase 3 - metabolism | Hep G2 Cells | Transcription Factors - metabolism | Insulin - metabolism | Animals | Glycogen Synthase Kinase 3 - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Adaptor Proteins, Signal Transducing - genetics | Glucose - metabolism | Trans-Activators - metabolism | Forkhead Box Protein O1 | Mice | GTPase-Activating Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cholesterol - biosynthesis | mTOR Complex (mTORC) | Liver Metabolism | mTOR Complex 2 (mTORC2) | Akt | Metabolism | Lipogenesis | Insulin | Gluconeogenesis
Journal Article
Gastroenterology, ISSN 0016-5085, 2007, Volume 133, Issue 2, pp. 559 - 573
Background & Aims: Recent studies have revealed that murine intestinal mucosa contains several kinds of lineage markers (lin)– c-kit+ immune precursor cells.... 
Gastroenterology and Hepatology | INFLAMMATORY-BOWEL-DISEASE | GUT CRYPTOPATCHES | NK CELLS | DENDRITIC CELLS | PEYERS-PATCHES | ALPHA-BETA | LYMPH-NODES | DELTA-T-CELLS | GASTROENTEROLOGY & HEPATOLOGY | LYMPHOCYTES-T | FETAL THYMUS | Membrane Glycoproteins - metabolism | Humans | Colitis, Ulcerative - genetics | Crohn Disease - metabolism | Hematopoietic Stem Cells - pathology | Lymphotoxin-alpha - metabolism | Interferon-gamma - metabolism | RNA, Messenger - metabolism | Colitis, Ulcerative - immunology | Antigens, CD - metabolism | Immunoglobulins - metabolism | Lymphotoxin-alpha - genetics | Time Factors | Intestinal Mucosa - immunology | Inhibitor of Differentiation Protein 2 - genetics | Cell Differentiation | Gene Expression | Colitis, Ulcerative - metabolism | Colitis, Ulcerative - pathology | Inhibitor of Differentiation Protein 2 - metabolism | Cell Lineage | Adult Stem Cells - metabolism | Interleukin-2 Receptor alpha Subunit - metabolism | Crohn Disease - pathology | ADP-ribosyl Cyclase 1 - metabolism | Killer Cells, Natural - metabolism | Intestinal Mucosa - pathology | Crohn Disease - genetics | Intestinal Mucosa - metabolism | Antigens, CD34 - metabolism | Killer Cells, Natural - pathology | Proto-Oncogene Proteins c-kit - metabolism | Adult Stem Cells - immunology | DNA-Binding Proteins - metabolism | Hematopoietic Stem Cells - immunology | Trans-Activators - genetics | Killer Cells, Natural - immunology | Adult Stem Cells - pathology | Sialic Acid Binding Ig-like Lectin 3 | Proto-Oncogene Proteins - metabolism | CD56 Antigen - metabolism | Receptors, Interleukin-7 - metabolism | Cells, Cultured | Immunophenotyping | Proto-Oncogene Proteins - genetics | Hematopoietic Stem Cells - metabolism | Integrin alpha Chains - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Crohn Disease - immunology | Transcription Factors - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | Trans-Activators - metabolism
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2015, Volume 35, Issue 4, pp. 960 - 972
Journal Article
Developmental cell, ISSN 1534-5807, 2015, Volume 33, Issue 1, pp. 36 - 46
Organ wasting, related to changes in nutrition and metabolic activity of cells and tissues, is observed under conditions of starvation and in the context... 
HYPERTROPHY | PROTEIN | GENE | RNA | MECHANISM | PATHWAY | GROWTH | STEM-CELL PROLIFERATION | INFECTION | DEVELOPMENTAL BIOLOGY | DROSOPHILA | CELL BIOLOGY | Metabolomics | Wasting Syndrome - metabolism | Oligonucleotide Array Sequence Analysis | Male | Muscle, Skeletal - metabolism | Gene Expression Profiling | Stem Cells - cytology | Drosophila Proteins - metabolism | Muscle, Skeletal - cytology | Ovary - cytology | Stem Cells - metabolism | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Fat Body - cytology | Hyperglycemia - pathology | Trans-Activators - genetics | Female | Nuclear Proteins - genetics | Fat Body - metabolism | Insulin Secretion | Real-Time Polymerase Chain Reaction | Ovary - metabolism | Biomarkers - metabolism | RNA, Messenger - genetics | Cells, Cultured | Hemolymph - metabolism | Nuclear Proteins - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Animals, Genetically Modified - metabolism | Blotting, Western | Gastrointestinal Tract - metabolism | Hyperglycemia - metabolism | Insulin - metabolism | Animals | Animals, Genetically Modified - growth & development | Animals, Genetically Modified - genetics | Insulin - chemistry | Drosophila melanogaster - growth & development | Trans-Activators - metabolism | Gastrointestinal Tract - cytology | Drosophila Proteins - genetics | Insulin-Like Growth Factor I - antagonists & inhibitors | Insulin-Like Growth Factor I - metabolism | Wasting Syndrome - pathology | Enzymes | Starvation | Analysis | Stem cells | Physiological aspects | Development and progression | Cellular signal transduction | Ovarian cancer | Medical colleges | Resveratrol
Journal Article