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Developmental Cell, ISSN 1534-5807, 02/2010, Volume 18, Issue 2, pp. 288 - 299
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2010, Volume 16, Issue 4, pp. 438 - 445
Class Ia phosphoinositide 3-kinase (PI3K), an essential mediator of the metabolic actions of insulin, is composed of a catalytic (p110 alpha or p110 beta) and... 
MEDICINE, RESEARCH & EXPERIMENTAL | METABOLIC SYNDROME | PHOSPHATIDYLINOSITOL 3-KINASE | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM STRESS | P85-ALPHA SUBUNIT | CELL BIOLOGY | SKELETAL-MUSCLE | MESSENGER-RNA | INSULIN-RESISTANCE | PURIFICATION METHOD | ADIPOSE-TISSUE | Insulin - physiology | Endoplasmic Reticulum - metabolism | Activating Transcription Factor 6 | Phosphatidylinositol 3-Kinases - metabolism | Cell Nucleus - physiology | X-Box Binding Protein 1 | Endoribonucleases - physiology | Gene Knockdown Techniques | Trans-Activators - physiology | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | Membrane Proteins - physiology | Stress, Physiological - physiology | Cell Line | Unfolded Protein Response - drug effects | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Protein-Serine-Threonine Kinases - physiology | Liver - metabolism | Endoplasmic Reticulum - physiology | Regulatory Factor X Transcription Factors | Transcription Factors - metabolism | Animals | Tunicamycin - pharmacology | Liver - physiology | Phosphatidylinositol 3-Kinases - physiology | Mice | Apoptosis - physiology | Unfolded Protein Response - physiology | Transcription factors | Physiological aspects | Causes of | Insulin resistance | Genetic aspects | Research | Binding proteins | Protein kinases | Catalysis | Kinases | Metabolism | Protein folding | Insulin | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 01/2008, Volume 29, Issue 1, pp. 102 - 111
Polycomb genes encode critical regulators of both normal stem cells and cancer stem cells. A gene signature that includes Polycomb genes and additional genes... 
DNA | METASTATIC CANCER | HISTONE H2B | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | C-MYC | GENE-EXPRESSION | BINDING DOMAIN | MYC TRANSGENIC MICE | PROTEIN COMPLEXES | SACCHAROMYCES-CEREVISIAE | MASS-SPECTROMETRY | CELL BIOLOGY | Protein Subunits | Neoplastic Stem Cells - cytology | Nuclear Proteins - analysis | Transcription Factors - chemistry | p300-CBP Transcription Factors - physiology | Humans | Recombinant Fusion Proteins - physiology | Lung Neoplasms - pathology | Gene Expression Profiling | Promoter Regions, Genetic - genetics | Trans-Activators - physiology | Proto-Oncogene Proteins c-myc - physiology | Neoplastic Stem Cells - metabolism | Ubiquitination - physiology | Cell Line, Tumor - metabolism | Cell Line, Transformed - cytology | Carcinoma, Non-Small-Cell Lung - pathology | Transcription Factors - physiology | Thiolester Hydrolases - physiology | Histone Acetyltransferases - physiology | Protein Processing, Post-Translational - physiology | Adaptor Proteins, Signal Transducing - analysis | Adaptor Proteins, Signal Transducing - physiology | Transcription, Genetic - physiology | Cell Line, Tumor - cytology | Histone Acetyltransferases - analysis | Cell Line, Transformed - metabolism | Biomarkers | Cell Cycle - physiology | p300-CBP Transcription Factors - analysis | Nuclear Proteins - physiology | Stem cells | Cancer | Index Medicus
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 07/2006, Volume 208, Issue 1, pp. 87 - 96
Canonical Wnt signaling (β‐catenin/TCF) has emerged as a key regulator of skeletogenesis. In this study, chondrogenesis is examined in a mouse model in which... 
ENDOCHONDRAL OSSIFICATION | IN-VITRO | PHYSIOLOGY | TGF-BETA | BONE-FORMATION | GENE-EXPRESSION | GROWTH-PLATE | INDIAN HEDGEHOG | BETA-CATENIN | CARTILAGE DEVELOPMENT | N-CADHERIN | CELL BIOLOGY | Growth Plate - pathology | Immunohistochemistry | Intercellular Signaling Peptides and Proteins - analysis | Chondrocytes - chemistry | Osteogenesis - physiology | Bone Morphogenetic Proteins - physiology | Fibroblasts - physiology | Collagen Type II - analysis | Core Binding Factor Alpha 1 Subunit - analysis | Gene Expression Profiling | Hypertrophy - pathology | Membrane Proteins - analysis | Trans-Activators - physiology | Hedgehog Proteins | Membrane Proteins - physiology | beta Catenin - physiology | Gene Expression Regulation, Developmental - physiology | Chondrocytes - pathology | Membrane Proteins - genetics | High Mobility Group Proteins - analysis | Core Binding Factor Alpha 1 Subunit - physiology | Signal Transduction - genetics | Fibroblasts - pathology | Reverse Transcriptase Polymerase Chain Reaction | Wnt Proteins - analysis | Blotting, Western | Mice, Knockout | Mice | Transcription Factors - analysis | Wnt Proteins - physiology | Growth Plate - physiopathology | SOX9 Transcription Factor | Collagen Type X - analysis | Collagen Type X - physiology | beta Catenin - analysis | Gene Expression Regulation, Developmental - genetics | RNA, Messenger - analysis | Trans-Activators - analysis | Hypertrophy - physiopathology | Intercellular Signaling Peptides and Proteins - physiology | Cell Differentiation - genetics | Transforming Growth Factor beta - analysis | Wnt Proteins - genetics | Chondrocytes - physiology | Trans-Activators - genetics | Bone Morphogenetic Proteins - genetics | Cell Differentiation - physiology | Osteogenesis - genetics | Fibroblasts - chemistry | Bone Morphogenetic Proteins - analysis | Collagen Type II - physiology | Transcription Factors - physiology | Bone Morphogenetic Protein 2 | RNA, Messenger - genetics | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Transforming Growth Factor beta - physiology | Collagen Type X - genetics | Transcription Factors - genetics | Collagen Type II - genetics | beta Catenin - genetics | Animals | Transforming Growth Factor beta - genetics | Signal Transduction - physiology | High Mobility Group Proteins - physiology | Core Binding Factor Alpha 1 Subunit - genetics | Growth Plate - chemistry | High Mobility Group Proteins - genetics | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 10/2013, Volume 128, Issue 18, pp. 2047 - 2057
Journal Article
Molecular Cell, ISSN 1097-2765, 01/2008, Volume 29, Issue 1, pp. 92 - 101
Transcriptional activators, several different coactivators, and general transcription factors are necessary to access specific loci in the dense chromatin... 
DNA | UBIQUITINATION | COMPLEX | ACTIVATION | UBP8 | CHROMATIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | UBIQUITYLATION | DEUBIQUITYLATION | MESSENGER-RNA EXPORT | SAGA | CELL BIOLOGY | Transcription Factors - chemistry | p300-CBP Transcription Factors - physiology | Histone Acetyltransferases - chemistry | Humans | Recombinant Fusion Proteins - physiology | Molecular Sequence Data | Trans-Activators - chemistry | Drosophila melanogaster - genetics | Promoter Regions, Genetic - genetics | Trans-Activators - physiology | Drosophila melanogaster - metabolism | Drosophila Proteins - physiology | Endopeptidases - chemistry | Conserved Sequence | Ubiquitination - physiology | p300-CBP Transcription Factors - chemistry | Amino Acid Sequence | Cell Line | Transcription Factors - physiology | Transcription Factors, General - chemistry | Animals, Genetically Modified | Gene Silencing | Thiolester Hydrolases - physiology | RNA Polymerase II - physiology | Drosophila Proteins - chemistry | Transcription Factors - genetics | Histone Acetyltransferases - physiology | Multiprotein Complexes - physiology | Protein Interaction Mapping | Sequence Homology, Amino Acid | Transcription Factors, General - physiology | Multiprotein Complexes - chemistry | Sequence Alignment | Animals | Endopeptidases - genetics | Heterochromatin - genetics | Receptors, Androgen - genetics | Drosophila Proteins - genetics | Thiolester Hydrolases - chemistry | Transcription, Genetic - genetics | Endopeptidases - physiology | Histones | Index Medicus | p300-CBP Transcription Factors | Histone Acetyltransferases | Multiprotein Complexes | Receptors, Androgen | Recombinant Fusion Proteins | Life Sciences | Ubiquitination | Heterochromatin | Transcription, Genetic | Promoter Regions (Genetics) | Drosophila Proteins | Transcription Factors, General | Trans-Activators | Biochemistry, Molecular Biology | Thiolester Hydrolases | Transcription Factors | RNA Polymerase II | Drosophila melanogaster | Endopeptidases
Journal Article
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 01/2004, Volume 15, Issue 1, pp. 176 - 188
Journal Article
PLoS Genetics, ISSN 1553-7390, 02/2008, Volume 4, Issue 2, pp. e24 - e24
In many organisms, dietary restriction appears to extend lifespan, at least in part, by down-regulating the nutrient-sensor TOR (Target Of Rapamycin). TOR... 
CANINE KIDNEY-CELLS | MESSENGER-RNA | SIGNALING PATHWAY | INDUCED LONGEVITY | TOR | GENES | GENETICS & HEREDITY | NEMATODE CAENORHABDITIS-ELEGANS | SACCHAROMYCES-CEREVISIAE | MEMBRANE-TRANSPORT | 3-KINASE COMPLEX | Phosphotransferases (Alcohol Group Acceptor) - physiology | Genes, Helminth | rab GTP-Binding Proteins - genetics | Autophagy - physiology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Trans-Activators - physiology | Caenorhabditis elegans - physiology | RNA Interference | Receptor, Insulin - genetics | Trans-Activators - genetics | Autophagy - genetics | Vesicular Transport Proteins | Caenorhabditis elegans - growth & development | Animals, Genetically Modified | Caenorhabditis elegans - genetics | Phosphotransferases (Alcohol Group Acceptor) - genetics | Longevity - genetics | Receptor, Insulin - physiology | Phosphatidylinositol 3-Kinases - genetics | rab GTP-Binding Proteins - physiology | Animals | Caenorhabditis elegans Proteins - antagonists & inhibitors | Diet | Receptors, Nicotinic - physiology | Models, Biological | Phosphatidylinositol 3-Kinases - physiology | rab GTP-Binding Proteins - antagonists & inhibitors | Caenorhabditis elegans Proteins - physiology | Mutation | Trans-Activators - antagonists & inhibitors | Caenorhabditis elegans Proteins - genetics | Longevity - physiology | Receptors, Nicotinic - genetics | Index Medicus | Proteins | Medical research | Kinases | Metabolism
Journal Article
2003, ISBN 1402075863, xiii, 263
Book