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PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 11, pp. e112945 - e112945
The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants,... 
OXIDATIVE STRESS | QUINOLINIC ACID | MAMMALIAN BRAIN | POOR-PROGNOSIS | MULTIDISCIPLINARY SCIENCES | INDOLEAMINE 2,3-DIOXYGENASE | TRYPTOPHAN 2,3-DIOXYGENASE | TUMORAL IMMUNE RESISTANCE | T-CELLS | IDO EXPRESSION | BRAIN-TUMORS | Immunohistochemistry | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Kynurenic Acid - blood | Gene Expression - drug effects | Humans | Kynurenine - biosynthesis | Brain Neoplasms - physiopathology | Picolinic Acids - blood | Quinolinic Acid - blood | Chromatography, High Pressure Liquid | Glial Fibrillary Acidic Protein - metabolism | Kynurenic Acid - metabolism | Carboxy-Lyases - genetics | Tryptophan - metabolism | Brain Neoplasms - metabolism | Picolinic Acids - metabolism | Antigens, CD - metabolism | Glioma - metabolism | Glioma - genetics | Kynurenine - blood | Tryptophan - blood | Carboxy-Lyases - metabolism | Tumor Cells, Cultured | Astrocytes - drug effects | Disaccharides | Cells, Cultured | Brain Neoplasms - genetics | Biosynthetic Pathways | Reverse Transcriptase Polymerase Chain Reaction | Glucuronates | Tryptophan Oxygenase - metabolism | Tryptophan Oxygenase - genetics | Antigens, Differentiation, Myelomonocytic - metabolism | Quinolinic Acid - metabolism | CD11b Antigen - metabolism | Glioma - physiopathology | Interferon-gamma - pharmacology | Astrocytes - metabolism | Tryptophan | Niacinamide | Methyl aspartate | Enzymes | Metabolites | Gliomas | NADPH | Neuroprotection | Brain | Brain tumors | Brain cancer | Glioblastoma | Tryptophan 2,3-dioxygenase | Immunity | DNA repair | Picolinic acid | Rodents | Glioma cells | L-Tryptophan | Kynurenic acid | Quinolinic acid | Deoxyribonucleic acid--DNA | Pyridines | Medical research | Hydroxylase | Adenine | Kynurenine-oxoglutarate transaminase | NAD | Acids | γ-Interferon | Nicotinamide adenine dinucleotide | Catabolism | Nicotinamide | Interferon | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Gut, ISSN 0017-5749, 04/2017, Volume 66, Issue 4, pp. 620 - 632
ObjectiveTo examine the role of hepatocyte myeloid differentiation primary-response gene 88 (MyD88) on glucose and lipid metabolism.DesignTo study the impact... 
INTESTINAL MICROBIOTA | FATTY LIVER-DISEASE | INSULIN-RESISTANCE | MICE | PROLIFERATOR-ACTIVATED-RECEPTOR | DIET-INDUCED OBESITY | LARGE GENE LISTS | GASTROENTEROLOGY & HEPATOLOGY | EPOXYEICOSATRIENOIC ACIDS | FARNESOID X-RECEPTOR | ADIPOSE-TISSUE | Body Weight | Humans | Immunity, Innate - genetics | Cytochrome P-450 Enzyme System - metabolism | Alanine Transaminase - blood | Hepatocytes - metabolism | Obesity - genetics | Adiposity | Diet, High-Fat | Myeloid Differentiation Factor 88 - immunology | Lipid Metabolism - genetics | STAT3 Transcription Factor - metabolism | Gene Expression | Non-alcoholic Fatty Liver Disease - genetics | Liver - metabolism | Mice, Inbred C57BL | Myeloid Differentiation Factor 88 - genetics | Bile Acids and Salts - metabolism | Liver X Receptors - metabolism | Non-alcoholic Fatty Liver Disease - metabolism | Gastrointestinal Microbiome - genetics | Metabolome - genetics | Mice, Knockout | Obesity - metabolism | Animals | Aspartate Aminotransferases - blood | Insulin Resistance - genetics | Cytochrome P-450 Enzyme System - genetics | Glucose - metabolism | Mice | PPAR alpha - metabolism | Myeloid Differentiation Factor 88 - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Research | Lipid metabolism | Microbiota (Symbiotic organisms) | Liver cells | Index Medicus | Abridged Index Medicus | LIPID METABOLISM | Gut Microbiota | BILE ACID METABOLISM | GLUCOSE METABOLISM | DIABETES MELLITUS | 1506 | INTESTINAL BACTERIA | liver-disease | Gastroenterologi | adipose-tissue | mice | diet-induced obesity | farnesoid x-receptor | epoxyeicosatrienoic acids | Gastroenterology & Hepatology | intestinal microbiota | insulin-resistance | fatty | proliferator-activated-receptor | large gene lists | Gastroenterology and Hepatology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2014, Volume 111, Issue 3, pp. 984 - 989
Journal Article
by Peng, JH and Cui, T and Huang, F and Chen, L and Zhao, Y and Xu, L and Xu, LL and Feng, Q and Hu, YY
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 03/2013, Volume 344, Issue 3, pp. 646 - 654
Puerarin, an isoflavone component extracted from Kudzu (Pueraria lobata), has been demonstrated to alleviate alcohol-related disorders. Our study examined... 
HEPATITIS | LIPOPOLYSACCHARIDE-BINDING PROTEIN | DISEASE | BARRIER | FATTY LIVER | RATS | ETHANOL | PHARMACOLOGY & PHARMACY | MICE | KAPPA-B | INTESTINAL PERMEABILITY | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Tight Junctions - genetics | Isoflavones - pharmacology | Male | Alanine Transaminase - blood | Alcohol-Related Disorders - genetics | Antigens, CD - genetics | Receptors, Immunologic - antagonists & inhibitors | Antigens, CD - metabolism | Liver Diseases, Alcoholic - drug therapy | Zonula Occludens-1 Protein - metabolism | Neutrophil Infiltration - drug effects | Disease Models, Animal | Tight Junctions - drug effects | Tight Junctions - metabolism | Zonula Occludens-1 Protein - genetics | Fatty Liver - metabolism | Portal Vein - metabolism | Liver - metabolism | Rats | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 2 - metabolism | Neutrophil Infiltration - genetics | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | Fatty Liver - drug therapy | Triglycerides - metabolism | Microvilli - genetics | Aspartate Aminotransferases - blood | Diet | Microvilli - metabolism | Receptors, Immunologic - genetics | Intestines - drug effects | Tumor Necrosis Factor-alpha - metabolism | Liver - enzymology | Intestines - metabolism | Acute-Phase Proteins - genetics | Alcohol-Related Disorders - drug therapy | Lipopolysaccharide Receptors - metabolism | Alcohol-Related Disorders - metabolism | Liver Diseases, Alcoholic - genetics | Receptors, Immunologic - biosynthesis | Kupffer Cells - metabolism | Endotoxins - metabolism | Fatty Liver - genetics | Portal Vein - drug effects | Acute-Phase Proteins - metabolism | Endotoxins - genetics | gamma-Glutamyltransferase - metabolism | Antigens, Differentiation, Myelomonocytic - genetics | Liver Diseases, Alcoholic - metabolism | Kupffer Cells - drug effects | Membrane Glycoproteins - genetics | Carrier Proteins - genetics | Microvilli - drug effects | Endotoxins - antagonists & inhibitors | Animals | Carrier Proteins - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | Lipopolysaccharide Receptors - genetics | Receptors, Immunologic - metabolism | Index Medicus
Journal Article
Journal of Gastroenterology and Hepatology (Australia), ISSN 0815-9319, 2009, Volume 24, Issue 3, pp. 443 - 452
We examined extrinsic and intrinsic (endogenous) mitochondrial apoptosis pathways in experimental non-alcoholic steatohepatitis (NASH). To assess extrinsic... 
Cell death pathways | TRAIL-R killer/DR5 | Methionine and choline deficiency | Mitochondria | Insulin-like growth factor-1 | TNF receptors | P53 | HEPATOCYTE APOPTOSIS | ACIDS | DR5 | mitochondria | FATTY LIVER-DISEASE | insulin-like growth factor-1 | NONALCOHOLIC STEATOHEPATITIS | cell death pathways | p53 | PATHOGENESIS | HEPATIC INFLAMMATION | NECROSIS | methionine and choline deficiency | MICE | TNF-ALPHA | GASTROENTEROLOGY & HEPATOLOGY | TRAIL-R killer | NF-KAPPA-B | Liver - pathology | Liver - enzymology | Fatty Liver - pathology | Mitochondria, Liver - metabolism | Caspase 3 - metabolism | Choline Deficiency - complications | Male | Alanine Transaminase - blood | Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | RNA, Messenger - metabolism | fas Receptor - metabolism | Tumor Suppressor Protein p53 - genetics | Time Factors | Receptors, Tumor Necrosis Factor, Type II - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Nutritional Status | Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics | BH3 Interacting Domain Death Agonist Protein - metabolism | Disease Models, Animal | Methionine - deficiency | Receptors, Tumor Necrosis Factor - metabolism | Fatty Liver - metabolism | Mitochondria, Liver - pathology | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Mitochondria, Liver - enzymology | Animals | Mice | bcl-X Protein - metabolism | Insulin-Like Growth Factor I - metabolism | Apoptosis | Fatty Liver - etiology | BH3 Interacting Domain Death Agonist Protein, metabolism | Receptors, Tumor Necrosis Factor, Type II, metabolism | Fatty Liver, pathology | Mitochondria, Liver, metabolism | Receptors, Tumor Necrosis Factor, metabolism | Cyclin-Dependent Kinase Inhibitor p21, metabolism | Insulin-Like Growth Factor I, metabolism | Caspase 3, metabolism | Antigens, CD95, metabolism | RNA, Messenger, metabolism | Tumor Suppressor Protein p53, metabolism | Methionine, deficiency | Choline Deficiency, complications | Tumor Suppressor Protein p53, genetics | bcl-X Protein, metabolism | Mitochondria, Liver, pathology | Liver, pathology | Alanine Transaminase, blood | Liver, metabolism | Fatty Liver, metabolism | Receptors, TNF-Related Apoptosis-Inducing Ligand, metabolism | Liver, enzymology | Fatty Liver, etiology | Mitochondria, Liver, enzymology | Receptors, Tumor Necrosis Factor, Type I, metabolism | Receptors, TNF-Related Apoptosis-Inducing Ligand, genetics | Messenger RNA | Choline | Methionine | Mitochondrial DNA | Tumor proteins | Peptide hormones | Growth factors | Index Medicus
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 12/2011, Volume 15, Issue 11, pp. 2837 - 2854
Hepatic energy depletion has been described in severe sepsis, and lipopolysaccharide (LPS) has been shown to cause mitochondrial DNA (mtDNA) damage. To clarify... 
Original Research Communications | OXIDATIVE STRESS | LIVER-INJURY | PEROXYNITRITE | MANGANESE SUPEROXIDE-DISMUTASE | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | ETHANOL | MICE | TRANSCRIPTION-FACTOR | RESPIRATORY FACTOR-I | EXPRESSION | Aconitate Hydratase - metabolism | Electron Transport Complex III - metabolism | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | Humans | Tumor Necrosis Factor-alpha - blood | Alanine Transaminase - blood | Electron Transport Complex I - metabolism | Tyrosine - analogs & derivatives | Electron Transport Complex IV - metabolism | DNA-Binding Proteins - metabolism | Nitric Oxide Synthase Type II - antagonists & inhibitors | Sepsis - metabolism | Adenosine Triphosphate - metabolism | ATP Synthetase Complexes - metabolism | Nitrites - blood | Transcription, Genetic | Superoxide Dismutase - metabolism | Iron - blood | Nitrates - blood | DNA, Mitochondrial - metabolism | High Mobility Group Proteins - metabolism | Liver - metabolism | Mice, Inbred C57BL | Mice, Transgenic | Thiobarbituric Acid Reactive Substances - metabolism | Iron - metabolism | Toll-Like Receptor 4 - metabolism | Hep G2 Cells | Transcription Factors - metabolism | Tyrosine - metabolism | Animals | Interferon-beta - pharmacology | Nitric Oxide Synthase Type II - genetics | Lipopolysaccharides - pharmacology | Interferon-beta - blood | Mice | Nitric Oxide Synthase Type II - metabolism | DNA damage | Physiological aspects | Septic shock | Mitochondrial DNA | Genetic aspects | Research | Health aspects | Risk factors | Lipopolysaccharides | Index Medicus
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 03/2010, Volume 298, Issue 3, pp. G364 - G374
Shen Z, Liang X, Rogers CQ, Rideout D, You M. Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty... 
Signal transduction | Acetylation | Lipid metabolism | Transcriptional regulators | DIETARY SATURATED FAT | PHYSIOLOGY | ACTIVATED PROTEIN-KINASE | LIPID-METABOLISM | signal transduction | lipid metabolism | PHOSPHATIDATE PHOSPHOHYDROLASE | TNF-ALPHA PRODUCTION | INSULIN SENSITIVITY | acetylation | MAMMALIAN SIRTUIN-1 | ENERGY-EXPENDITURE | GENE-EXPRESSION | transcriptional regulators | GASTROENTEROLOGY & HEPATOLOGY | HEPATIC STEATOSIS | RNA, Small Interfering - genetics | Liver - pathology | Gene Expression - genetics | Tumor Necrosis Factor-alpha - genetics | Ion Channels - genetics | Male | Fatty Liver, Alcoholic - metabolism | Liver - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Lipid Metabolism - genetics | Thiazolidinediones - pharmacology | PPAR gamma - genetics | Adiponectin - pharmacology | Liver - metabolism | Rats | Intra-Abdominal Fat - metabolism | Phosphatidate Phosphatase | Triglycerides - metabolism | Acetylation - drug effects | Signal Transduction - drug effects | Models, Biological | Cell Line, Tumor | Transaminases - blood | Mice | Transcription Factors | Histones - metabolism | AMP-Activated Protein Kinases - genetics | Acetyl-CoA Carboxylase - metabolism | Receptors, Adiponectin - genetics | Sirtuin 1 - metabolism | AMP-Activated Protein Kinases - metabolism | Gene Expression - drug effects | Mitochondrial Proteins - genetics | Adiponectin - physiology | Fatty Liver, Alcoholic - prevention & control | Sirtuin 1 - genetics | Fatty Liver, Alcoholic - blood | Thiazolidinediones - therapeutic use | Trans-Activators - genetics | Intra-Abdominal Fat - drug effects | Fatty Liver, Alcoholic - pathology | Nuclear Proteins - genetics | Mice, Inbred C57BL | Nuclear Proteins - metabolism | Ethanol - pharmacology | Animals | Lipid Metabolism - drug effects | Retinoid X Receptor alpha - genetics | Triglycerides - blood | Signal Transduction - physiology | Trans-Activators - metabolism | Uncoupling Protein 2 | Fatty liver | Physiological aspects | Cellular signal transduction | Research | Rosiglitazone maleate | Health aspects | Protein kinases | Ethanol | Metabolism | Fatty acids | Liver | Rodents | Index Medicus | Hormones and Signaling
Journal Article
Diabetes/Metabolism Research and Reviews, ISSN 1520-7552, 10/2016, Volume 32, Issue 7, pp. 754 - 761
Journal Article
Ecotoxicology and Environmental Safety, ISSN 0147-6513, 02/2018, Volume 148, pp. 684 - 692
Journal Article