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Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2017, Volume 140, pp. 1 - 7
Steroid receptor coactivators (SRCs) are essential regulators of nuclear hormone receptor function. SRCs coactivate transcription mediated by hormone... 
Transcription | Hormone-dependent cancer | Drug development | Coregulator | Steroid receptor coactivator | ANDROGEN RECEPTOR | ACTIVATION | AIB1 | CELL-PROLIFERATION | HISTONE ACETYLTRANSFERASE | TRANSCRIPTIONAL COACTIVATOR | BREAST-CANCER | STRUCTURAL BASIS | ESTROGEN | PHARMACOLOGY & PHARMACY | EXPRESSION | Neoplasms, Hormone-Dependent - metabolism | Drug Resistance, Multiple | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Nuclear Receptor Coactivator 1 - chemistry | Nuclear Receptor Coactivator 2 - metabolism | Molecular Targeted Therapy | Neoplasm Proteins - metabolism | Neoplasms, Hormone-Dependent - immunology | Nuclear Receptor Coactivator 2 - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Nuclear Receptor Coactivator 1 - metabolism | Nuclear Receptor Coactivator 3 - chemistry | Drug Design | Anti-Inflammatory Agents - therapeutic use | Antineoplastic Agents - pharmacology | Protein Interaction Domains and Motifs | Nuclear Receptor Coactivator 3 - antagonists & inhibitors | Nuclear Receptor Coactivator 1 - antagonists & inhibitors | Anti-Inflammatory Agents - pharmacology | Neoplasm Proteins - chemistry | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents - chemistry | Nuclear Receptor Coactivator 2 - antagonists & inhibitors | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Nuclear Receptor Coactivator 3 - metabolism | Ligands | Neoplasms, Hormone-Dependent - drug therapy | Drugs | Medical colleges | Estrogen | DNA binding proteins | Metastasis | Chemotherapy | Epidermal growth factor | Interleukins | Methyltransferases | Pancreatic cancer | Physiological aspects | Progesterone | Drug therapy | Protein binding | Cancer
Journal Article
Molecular Cell, ISSN 1097-2765, 01/2013, Volume 49, Issue 1, pp. 145 - 157
The production of pigment by melanocytes tans the skin and protects against skin cancers. UV-exposed keratinocytes secrete α-MSH, which then activates melanin... 
SKIN PIGMENTATION | CUTANEOUS MALIGNANT-MELANOMA | CELLS | MICROPHTHALMIA TRANSCRIPTION FACTOR | METABOLISM | PGC-1-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | PROGNOSTIC MARKER | MASTER REGULATOR | MELANOCYTES | CELL BIOLOGY | Keratinocytes - radiation effects | Humans | Transcriptional Activation | Melanocytes - metabolism | Case-Control Studies | Melanins - biosynthesis | Monophenol Monooxygenase - metabolism | Heat-Shock Proteins - genetics | Melanoma - genetics | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Protein Stability | Carrier Proteins - physiology | Melanoma - metabolism | Skin Neoplasms - pathology | Promoter Regions, Genetic | Gene Expression | Genetic Predisposition to Disease | Melanocytes - enzymology | Transcription Factors - physiology | Microphthalmia-Associated Transcription Factor - metabolism | Genetic Association Studies | Heat-Shock Proteins - metabolism | Mice, Inbred C57BL | Keratinocytes - secretion | Melanoma - pathology | Transcription Factors - genetics | Suntan - genetics | Skin Neoplasms - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Keratinocytes - metabolism | Skin Neoplasms - genetics | alpha-MSH - secretion | Cell Line, Tumor | alpha-MSH - physiology | Mice | Polymorphism, Single Nucleotide | Heat-Shock Proteins - physiology | Microphthalmia-Associated Transcription Factor - genetics | Genetically modified animals | Medical colleges | Tanning | Oncology, Experimental | Genes | Melanoma | Animal genetic engineering | Research | Skin cancer | Prevention | Proteins | Quantitative genetics | Stem cells | Skin | Intermedin | Free radicals (Chemistry) | Public health | Cancer
Journal Article
Journal Article
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2013, Volume 34, Issue 6, pp. 1581 - 1588
Abstract Nicotinamide adenine dinucleotide (NAD)+ , a coenzyme involved in redox activities in the mitochondrial electron transport chain, has been identified... 
Neurology | Internal Medicine | Mitochondrial metabolism | Long-term potentiation | Synaptic plasticity | β-secretase (BACE1) | Nicotinamide riboside | Alzheimer's disease | Promotes peroxisome proliferator-activated receptor (PPAR)-γ coactivator 1 (PGC)-1α | Ubiquitin–proteasome system | Ubiquitin-proteasome system | OXIDATIVE STRESS | SYNAPTIC FUNCTION | DEMENTIA | MECHANISM | PGC-1-ALPHA | Promotes peroxisome proliferator-activated receptor (PPAR)-gamma coactivator 1 (PGC)-1 alpha | SIRT1 | NEUROSCIENCES | PERMEABILITY TRANSITION | GERIATRICS & GERONTOLOGY | beta-secretase (BACE1) | DISEASE | NAD(+) | TRANSGENIC MICE | Niacinamide - analogs & derivatives | Cognition Disorders - metabolism | Mitochondria - genetics | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Up-Regulation - physiology | Organ Culture Techniques | Disease Models, Animal | Aspartic Acid Endopeptidases - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Alzheimer Disease - drug therapy | Niacinamide - therapeutic use | Mice, Transgenic | Transcription Factors - biosynthesis | Cognition Disorders - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Cognition Disorders - drug therapy | Up-Regulation - drug effects | Amyloid Precursor Protein Secretases - metabolism | Animals | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Niacinamide - pharmacology | Alzheimer Disease - genetics | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2016, Volume 291, Issue 13, pp. 6714 - 6722
The transcriptional coactivators CREB-binding protein (CBP) and p300 undergo a particularly rich set of interactions with disordered and partly ordered... 
ACTIVATION DOMAIN | UNSTRUCTURED PROTEINS | viral oncoprotein | intrinsically disordered protein | coupled folding and binding | intrinsically disordered region | BIOCHEMISTRY & MOLECULAR BIOLOGY | structure-function | STAT transcription factor | C-MYB | transcriptional coactivator | VIRAL-PROTEINS | transcriptional activation | P53 TRANSACTIVATION DOMAIN | COMPLEX-FORMATION | cAMP response element-binding protein (CREB) | hypoxia-inducible factor (HIF) | IDP | STRUCTURAL BASIS | IDR | KIX DOMAIN | TAZ2 DOMAIN | PEPTIDE MOTIFS | protein-protein interaction | Humans | E1A-Associated p300 Protein - genetics | STAT Transcription Factors - metabolism | CREB-Binding Protein - chemistry | NF-kappa B - metabolism | E1A-Associated p300 Protein - metabolism | NF-kappa B - chemistry | Viral Proteins - metabolism | Tumor Suppressor Protein p53 - genetics | CREB-Binding Protein - genetics | CREB-Binding Protein - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - chemistry | Transcription, Genetic | Protein Interaction Domains and Motifs | Protein Structure, Secondary | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Viral Proteins - chemistry | E1A-Associated p300 Protein - chemistry | Tumor Suppressor Protein p53 - metabolism | Models, Molecular | Viral Proteins - genetics | Intrinsically Disordered Proteins - genetics | Protein Folding | STAT Transcription Factors - genetics | NF-kappa B - genetics | Intrinsically Disordered Proteins - chemistry | Protein Binding | STAT Transcription Factors - chemistry | Tumor Suppressor Protein p53 - chemistry | Intrinsically Disordered Proteins - metabolism | Minireviews
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 10/1996, Volume 10, Issue 10, pp. 1167 - 1177
Abstract The nuclear receptors belong to a superfamily of proteins, many of which are ligand-regulated, that bind to specific DNA sequences and control... 
GLUCOCORTICOID RECEPTOR | TATA-BINDING PROTEIN | ENDOCRINOLOGY & METABOLISM | TRANSCRIPTION FACTOR-TFIIB | CO-REPRESSOR | RETINOIC ACID RECEPTORS | PROGESTERONE-RECEPTOR | THYROID-HORMONE RECEPTOR | TRANSACTIVATION FUNCTION | ESTROGEN-RECEPTOR | STEROID-RECEPTORS | Animals | Signal Transduction | Receptors, Cytoplasmic and Nuclear | Humans
Journal Article