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1. Full Text Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets
by Luan Shu and Nadine S. Sauter and Fabienne T. Schulthess and Aleksey V. Matveyenko and José Oberholzer and Kathrin Maedler
Diabetes (New York, N.Y.), ISSN 0012-1797, 03/2008, Volume 57, Issue 3, pp. 645 - 653
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Humans | Cells, Cultured | Gene Expression Regulation | Glucose - pharmacology | Transcription Factor 7-Like 2 Protein | TCF Transcription Factors - metabolism | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Animals | Insulin-Secreting Cells - drug effects | Insulin-Secreting Cells - cytology | Mice | RNA, Small Interfering | Apoptosis - physiology | TCF Transcription Factors - genetics | Cytokines - pharmacology | Index Medicus | Abridged Index Medicus
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2. Full Text Variant of Transcription Factor 7-Like 2 (TCF7L2) Gene and the Risk of Type 2 Diabetes in Large Cohorts of U.S. Women and Men
by Cuilin Zhang and Lu Qi and David J. Hunter and James B. Meigs and JoAnn E. Manson and Rob M. van Dam and Frank B. Hu
Diabetes (New York, N.Y.), ISSN 0012-1797, 09/2006, Volume 55, Issue 9, pp. 2645 - 2648
GLP-1, glucagon-like peptide 1 | HPFS, Health Professionals Follow-up Study | NHS, Nurses' Health Study | LD, linkage disequilibrium | TCF-4, transcription factor 4 | SNP, single nucleotide polymorphism | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Genetics, Population | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Prospective Studies | United States | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Risk Factors | Male | Transcription Factor 7-Like 2 Protein | Adult | Female | Aged | Polymorphism, Single Nucleotide | TCF Transcription Factors - genetics | Cohort Studies | Type 2 diabetes | Diabetics | Analysis | Genetic aspects | Genetic transcription | Health aspects | Risk factors | Index Medicus | Abridged Index Medicus
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3. Full Text Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: Replication and evidence for a role in both insulin secretion and insulin resistance
by Damcott, Coleen M and Pollin, Toni I and Reinhart, Laurie J and Ott, Sandra H and Shen, Haiqing and Silver, Kristi D and Mitchell, Braxton D and Shuldiner, Alan R
Diabetes (New York, N.Y.), ISSN 0012-1797, 09/2006, Volume 55, Issue 9, pp. 2654 - 2659
IVGTT, intravenous glucose tolerance test | AIRg, acute insulin response to glucose | LD, linkage disequilibrium | IGT, impaired glucose tolerance | AFDS, Amish Family Diabetes Study | DI, disposition index | NGT, normal glucose tolerance | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | European Continental Ancestry Group - genetics | TCF Transcription Factors - physiology | Diabetes Mellitus, Type 2 - genetics | Gene Frequency | Humans | Middle Aged | Male | Transcription Factor 7-Like 2 Protein | Linkage Disequilibrium | Pennsylvania | Insulin - metabolism | Ethnic Groups - genetics | Insulin Resistance - genetics | Adult | Female | Aged | Polymorphism, Single Nucleotide | Blood Glucose - metabolism | TCF Transcription Factors - genetics | Insulin Secretion | Type 2 diabetes | Cell proliferation | Analysis | Genetic aspects | Research | Genetic transcription | Risk factors | Genetic polymorphisms | Index Medicus | Abridged Index Medicus
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4. Full Text The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/β-catenin signaling
by Hammond, Elizabeth and Lang, Jordan and Maeda, Yoshiko and Pleasure, David and Angus-Hill, Melinda and Xu, Jie and Horiuchi, Makoto and Deng, Wenbin and Guo, Fuzheng
The Journal of neuroscience, ISSN 0270-6474, 03/2015, Volume 35, Issue 12, pp. 5007 - 5022
canonical Wnt/beta-catenin signaling | myelination | BMP signaling | oligodendrocyte differentiation | remyelination | TCF7l2(TCF4) | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Myelin Sheath - physiology | Transcription Factor 7-Like 2 Protein - genetics | Bone Morphogenetic Proteins - physiology | Gene Expression Regulation, Developmental - genetics | Wnt Signaling Pathway - physiology | Mice, Transgenic | Signal Transduction - genetics | beta Catenin - metabolism | Gene Knockdown Techniques | Cell Differentiation - genetics | Animals | Oligodendroglia - physiology | Wnt Signaling Pathway - genetics | Myelin Sheath - genetics | Transcription Factor 7-Like 2 Protein - physiology | Signal Transduction - physiology | Mice | Oligodendroglia - cytology | Cell Differentiation - physiology | Gene Expression Regulation, Developmental - physiology | Index Medicus | canonical Wnt | beta-catenin signaling
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5. Full Text Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms
by Schäfer, S A and Tschritter, O and Machicao, F and Thamer, C and Stefan, N and Gallwitz, B and Holst, J J and Dekker, J M and t’Hart, L M and Nijpels, G and van Haeften, T W and Häring, H U and Fritsche, A
Diabetologia, ISSN 0012-186X, 12/2007, Volume 50, Issue 12, pp. 2443 - 2450
TCF7L2 | GLP-1 | Medicine & Public Health | Human Physiology | Metabolic Diseases | Internal Medicine | Insulin secretion | Polymorphism | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Blood Glucose - physiology | Glucose Intolerance - genetics | Glucose Tolerance Test | Blood Glucose - analysis | Glucagon-Like Peptide 1 - metabolism | Humans | Middle Aged | Polymorphism, Single Nucleotide - physiology | Glucagon-Like Peptide 1 - blood | Glucagon-Like Peptide 1 - physiology | Male | Transcription Factor 7-Like 2 Protein | Insulin - metabolism | Arginine - pharmacology | Insulin Resistance - genetics | Adult | Female | Heterozygote | Glucose Clamp Technique | TCF Transcription Factors - genetics | Insulin Secretion | Gene mutations | Peptides | Physiological aspects | Genetic research | Genetic aspects | Diabetes | Glucose tolerance tests | Insulin | Type 2 diabetes | Glucagon | Genes | Glucose | Cells | Dextrose | Index Medicus
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6. Full Text Transcription factor 7-like 2 (TCF7L2) gene polymorphism and progression from single to multiple autoantibody positivity in individuals at risk for type 1 diabetes
by Redondo, Maria J and Steck, Andrea K and Sosenko, Jay and Anderson, Mark and Antinozzi, Peter and Michels, Aaron and Wentworth, John M and Atkinson, Mark A and Pugliese, Alberto and Geyer, Susan and Type 1 Diabet TrialNet Study Grp and Type 1 Diabetes TrialNet Study Group and the Type 1 Diabetes TrialNet Study Group
Diabetes care, ISSN 0149-5992, 12/2018, Volume 41, Issue 12, pp. 2480 - 2486
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Antibody Specificity | Overweight - complications | Autoantibodies - blood | Humans | Middle Aged | Autoimmunity - genetics | Child, Preschool | Infant | Male | Diabetes Mellitus, Type 1 - complications | Obesity - blood | Obesity - genetics | Young Adult | Adult | Female | Child | Genetic Predisposition to Disease | Transcription Factor 7-Like 2 Protein - genetics | Obesity - complications | Gene Frequency | Risk Factors | Diabetes Mellitus, Type 1 - pathology | Diabetes Mellitus, Type 1 - genetics | Overweight - genetics | Disease Progression | Autoantibodies - immunology | Overweight - blood | Diabetes Mellitus, Type 1 - blood | Adolescent | Polymorphism, Single Nucleotide | Autoantibodies - genetics | Cohort Studies | Transcription factors | Type 1 diabetes | Analysis | Development and progression | Genetic aspects | Research | Genetic polymorphisms | Risk factors | Haplotypes | Linkage disequilibrium | Body weight | Risk | Statistical methods | Diabetes mellitus (insulin dependent) | Single-nucleotide polymorphism | Gene polymorphism | Genotype & phenotype | Mathematical models | Pancreas | Diabetes mellitus (non-insulin dependent) | Age | Obesity | Immunoglobulins | Phenotypes | Autoantibodies | Statistical analysis | Diabetes mellitus | Health risks | Hazards | Risk analysis | Insulin | Loci | Statistical models | Gene frequency | Alleles | Histocompatibility antigen HLA | Research design | Diabetes | Islets of Langerhans | Median (statistics) | Polymorphism | Index Medicus | Epidemiology | Health Services Research | 0408
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7. Full Text Liver-specific expression of dominant- negative transcription factor 7-like 2 causes progressive impairment in glucose homeostasis
by Ip, Wilfred and Shao, Weijuan and Song, Zhuolun and Chen, Zonglan and Wheeler, Michael B and Jin, Tianru
Diabetes (New York, N.Y.), ISSN 0012-1797, 06/2015, Volume 64, Issue 6, pp. 1923 - 1932
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Transcription Factor 7-Like 2 Protein - genetics | Signal Transduction | Humans | Liver - metabolism | Mice, Inbred C57BL | Male | Mice, Transgenic | Transcription Factor 7-Like 2 Protein - metabolism | beta Catenin - metabolism | Animals | Forkhead Transcription Factors - metabolism | Homeostasis - physiology | Glucose - metabolism | Female | Forkhead Box Protein O1 | Mice | Homeostasis - genetics | Genetically modified mice | Transcription factors | Research | Biological control systems | Gluconeogenesis | Homeostasis | Signal transduction | Gene expression | Rodents | Binding sites | Index Medicus | Abridged Index Medicus
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8. Full Text Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism
by Norton, L and Fourcaudot, M and Abdul-Ghani, M A and Winnier, D and Mehta, F F and Jenkinson, C P and DeFronzo, R A
Diabetologia, ISSN 0012-186X, 12/2011, Volume 54, Issue 12, pp. 3132 - 3142
Type 2 diabetes | TCF7L2 | Medicine & Public Health | Human Physiology | Metabolic Diseases | Internal Medicine | Hepatic glucose metabolism | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Cell Line | Chromatin - metabolism | Glucose-6-Phosphatase - genetics | Insulin - pharmacology | Transcription Factor 7-Like 2 Protein - genetics | Diabetes Mellitus, Type 2 - genetics | Metformin - pharmacology | Gene Expression Regulation | Gene Silencing | Molecular Sequence Data | Rats | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Transcription Factor 7-Like 2 Protein - metabolism | Hypoglycemic Agents - pharmacology | Animals | Chromatin Immunoprecipitation | Glucose-6-Phosphatase - biosynthesis | Base Sequence | Glucose - metabolism | Gluconeogenesis | Chromatin | Genes | Glucose | Insulin | Dextrose | Glucose metabolism | Anopheles | Hyperglycemia | Multiprocessing | Analysis | DNA | Physiological aspects | Genomics | Nucleotide sequencing | DNA-ligand interactions | DNA sequencing | Transcription factors | Fasting | Diabetes mellitus | Liver | AKT2 protein | Data processing | Genomes | Gene polymorphism | Hepatocytes | Metformin | Index Medicus
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9. Full Text Polymorphism in the Transcription Factor 7-Like 2 (TCF7L2) Gene Is Associated With Reduced Insulin Secretion in Nondiabetic Women
by Julian Munoz and Kerry H. Lok and Barbara A. Gower and Jose R. Fernandez and Gary R. Hunter and Cristina Lara-Castro and Maria De Luca and W. Timothy Garvey
Diabetes (New York, N.Y.), ISSN 0012-1797, 12/2006, Volume 55, Issue 12, pp. 3630 - 3634
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Diabetes Mellitus, Type 2 - genetics | Humans | Reference Values | Insulin - blood | Transcription Factor 7-Like 2 Protein | Polymorphism, Genetic | Insulin - metabolism | Adult | Female | Blood Glucose - metabolism | Insulin - genetics | TCF Transcription Factors - genetics | Insulin Secretion | Type 2 diabetes | Genetic aspects | Diagnosis | Research | Genetic polymorphisms | Index Medicus | Abridged Index Medicus
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10. Full Text Polymorphism in the transcription factor 7-like 2 ( TCF7L2 ) gene is associated with impaired proinsulin conversion—A meta-analysis
by Shen, Jizhong and Fang, Yun and Ge, Weihong
Diabetes research and clinical practice, ISSN 0168-8227, 2015, Volume 109, Issue 1, pp. 117 - 123
Endocrinology & Metabolism | TCF7L2 | Impaired proinsulin conversion | rs7903146 | Type 2 diabetes mellitus | Meta-analysis | Rs7903146 | Life Sciences & Biomedicine | Science & Technology | Glucose Intolerance - metabolism | Genetic Predisposition to Disease | Glucose Intolerance - genetics | Transcription Factor 7-Like 2 Protein - genetics | Genetic Association Studies | Proinsulin - metabolism | Diabetes Mellitus, Type 2 - genetics | Humans | Risk Factors | Asian Continental Ancestry Group - genetics | Male | Diabetes Mellitus, Type 2 - metabolism | Diabetes Mellitus, Type 2 - epidemiology | Alleles | Female | Polymorphism, Single Nucleotide | Genetic research | Genetic aspects | Genes | Analysis | Genetic polymorphisms | Index Medicus
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11. Full Text Association of Transcription Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish Sample
by Laura J. Scott and Lori L. Bonnycastle and Cristen J. Willer and Andrew G. Sprau and Anne U. Jackson and Narisu Narisu and William L. Duren and Peter S. Chines and Heather M. Stringham and Michael R. Erdos and Timo T. Valle and Jaakko Tuomilehto and Richard N. Bergman and Karen L. Mohlke and Francis S. Collins and Michael Boehnke
Diabetes (New York, N.Y.), ISSN 0012-1797, 09/2006, Volume 55, Issue 9, pp. 2649 - 2653
LD, linkage disequilibrium | FUSION, Finland-United States Investigation of NIDDM Genetics | SNP, single nucleotide polymorphism | GIST, Genotype-IBD Sharing Test | NGT, normal glucose tolerance | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Genetics, Population | Genetic Predisposition to Disease | Diabetes Mellitus, Type 2 - genetics | Gene Frequency | Humans | Middle Aged | Male | Transcription Factor 7-Like 2 Protein | Case-Control Studies | Finland | Adult | Female | Aged | Polymorphism, Single Nucleotide | TCF Transcription Factors - genetics | Type 2 diabetes | Genetic aspects | Finns | Health aspects | Risk factors | Index Medicus | Abridged Index Medicus
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