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Journal of Cellular Biochemistry, ISSN 0730-2312, 10/2009, Volume 108, Issue 3, pp. 651 - 659
Notch signaling plays a key role in osteoblast differentiation. A major transcriptional downstream regulator of this pathway is the helix-loop-helix (HLH)... 
Promoter | E-box | Notch signaling | Osteoblast | Bone | HLH protein | Osteogenesis | OSTEOBLAST | HLH PROTEIN | E-BOX | MAMMALIAN HAIRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DROSOPHILA HAIRY | NOTCH SIGNALING | ENHANCER | OSTEOGENESIS | CELL BIOLOGY | SIGNALING PATHWAY | SEX DETERMINATION | BONE | HELIX-LOOP-HELIX | DIFFERENTIATION | PROMOTER | PROTEINS | EXPRESSION | GENE-TRANSCRIPTION | Transcription Factor HES-1 | Receptors, Notch - metabolism | Homeodomain Proteins - metabolism | Osteocalcin - genetics | Molecular Sequence Data | Basic Helix-Loop-Helix Transcription Factors - metabolism | Transcription, Genetic | Repressor Proteins - metabolism | Biomarkers - metabolism | Amino Acid Sequence | Promoter Regions, Genetic | Basic Helix-Loop-Helix Transcription Factors - genetics | Osteocalcin - metabolism | Gene Expression Regulation | Rats | E-Box Elements - genetics | Homeodomain Proteins - chemistry | Organ Specificity | Homeodomain Proteins - genetics | Amino Acid Motifs | Animals | Protein Binding | Mice | Osteoblasts - metabolism | Basic Helix-Loop-Helix Transcription Factors - chemistry | Enhancer-of-split protein | HES-1 protein | Osteocalcin | Transcription factors | Gene deletion | Hes-1 gene | Osteoblasts | Promoters | Signal transduction | Osteoblastogenesis | DNA | Helix-loop-helix proteins | Notch protein | Protein interaction
Journal Article
Carcinogenesis, ISSN 0143-3334, 11/2012, Volume 33, Issue 11, pp. 2276 - 2282
Notch pathway plays critical role in stem cell maintenance and angiogenesis, as well as cell fate decisions of cancer. However, concrete mechanisms of notch... 
CELLS | ACTIVATION | INHIBITION | ONCOLOGY | PATHWAY | THERAPEUTIC TARGET | DISTINCT | DOWN-REGULATION | NOTCH | MICRORNA-34A | CANCER | RNA, Small Interfering - genetics | Transcription Factor HES-1 | Cell Proliferation | Luciferases - metabolism | Oligonucleotide Array Sequence Analysis | Homeodomain Proteins - metabolism | Humans | Calcium-Binding Proteins - antagonists & inhibitors | Gene Expression Profiling | Brain Neoplasms - metabolism | Immunoenzyme Techniques | Glioma - metabolism | Glioma - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Chromatin Immunoprecipitation | Serrate-Jagged Proteins | Biomarkers, Tumor - metabolism | Female | Membrane Proteins - metabolism | Brain Neoplasms - mortality | Genes, Tumor Suppressor | Real-Time Polymerase Chain Reaction | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Glioma - mortality | Membrane Proteins - genetics | RNA, Messenger - genetics | Intercellular Signaling Peptides and Proteins - genetics | Brain Neoplasms - genetics | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Homeodomain Proteins - genetics | Animals | Membrane Proteins - antagonists & inhibitors | Mice, Nude | Homeodomain Proteins - antagonists & inhibitors | Biomarkers, Tumor - genetics | Mice | MicroRNAs - genetics | Apoptosis | Calcium-Binding Proteins - genetics | Cell Movement | Index Medicus
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 05/2010, Volume 113, Issue 4, pp. 807 - 818
P>Hes-1 and Hes-5 are downstream effectors of Notch signaling that are known to be involved in different aspects of neural stem cell proliferation and... 
Notch signaling | JNK signaling | Proliferation | Embryonic stem cells | Hes-1 | FGF2 | Neural progenitors | TRANSCRIPTION FACTORS | proliferation | INDUCED APOPTOSIS | embryonic stem cells | notch signaling | HELIX FACTOR HES-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-TERMINAL KINASE | RETINAL STEM CELLS/PROGENITORS | neural progenitors | PROMOTER ANALYSIS | NEUROSCIENCES | IN-VITRO | SIGNALING PATHWAY | NEGATIVE AUTOREGULATION | CENTRAL-NERVOUS-SYSTEM | Transcription Factor HES-1 | Receptors, Notch - metabolism | Homeodomain Proteins - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | Neurons - cytology | Receptors, Notch - genetics | Stem Cells - cytology | Stem Cells - metabolism | Central Nervous System - embryology | Promoter Regions, Genetic - genetics | Activating Transcription Factor 2 - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Fibroblast Growth Factor 2 - metabolism | Neurons - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Cell Differentiation - physiology | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Gene Expression Regulation, Developmental - physiology | Cell Line | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Activating Transcription Factor 2 - metabolism | Homeodomain Proteins - genetics | Animals | Fibroblast Growth Factor 2 - genetics | Signal Transduction - physiology | Mice | Transcriptional Activation - physiology | Fibroblast growth factors | Research | Oncology, Experimental | Analysis | Cancer | Signal transduction | Neurology | Biochemistry | Binding sites | Stem cells
Journal Article
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, p. e76274
Background: Notch signaling plays a critical role in the maintenance of intestinal crypt epithelial cell proliferation. The aim of this study was to... 
PROGENITOR CELLS | DECARBOXYLASE | MULTIDISCIPLINARY SCIENCES | NOTCH | RAT SMALL-INTESTINE | CELL-PROLIFERATION | DIFFERENTIATION | FATE | EXPRESSION | PROMOTES | P27(KIP1) | Intestinal Mucosa - metabolism | Transcription Factor HES-1 | Homeodomain Proteins - metabolism | Male | Basic Helix-Loop-Helix Transcription Factors - metabolism | RNA Interference | Regeneration - genetics | Jagged-2 Protein | Membrane Proteins - metabolism | Reperfusion Injury - genetics | Reperfusion Injury - metabolism | Disease Models, Animal | Cell Line | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Membrane Proteins - genetics | Dipeptides - pharmacology | Gene Silencing | Rats | Receptor, Notch1 - metabolism | Homeodomain Proteins - genetics | Animals | Cell Proliferation - drug effects | Proliferating Cell Nuclear Antigen - metabolism | Receptor, Notch1 - genetics | Intestinal Mucosa - pathology | Immunohistochemistry | RNA | Epithelium | Analysis | Intestinal ischemia | Cell proliferation | Occlusion | Cell culture | Epithelial cells | mRNA | Small intestine | Proteins | Signal transduction | Reperfusion | Ischemia | Intestine | Rodents | Surgery | Proliferating cell nuclear antigen | Inhibition | Injuries | Medical research | siRNA | Gene expression | Regeneration | Signaling | Crypts | Ligands | Notch protein | Laboratory animals | Immunofluorescence | Secretase
Journal Article