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1. Full Text Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists
by Prost, Stéphane and Relouzat, Francis and Spentchian, Marc and Ouzegdouh, Yasmine and Saliba, Joseph and Massonnet, Gérald and Beressi, Jean-Paul and Verhoeyen, Els and Raggueneau, Victoria and Maneglier, Benjamin and Castaigne, Sylvie and Chomienne, Christine and Chrétien, Stany and Rousselot, Philippe and Leboulch, Philippe
Nature (London), ISSN 0028-0836, 09/2015, Volume 525, Issue 7569, pp. 380 - 383
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Piperazines - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Cell Proliferation | Neoplastic Stem Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | PPAR gamma - metabolism | Thiazolidinediones - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - pharmacology | STAT5 Transcription Factor - metabolism | Benzamides - administration & dosage | Thiazolidinediones - therapeutic use | Benzamides - therapeutic use | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Neoplastic Stem Cells - pathology | Benzamides - pharmacology | Thiazolidinediones - pharmacology | Repressor Proteins - metabolism | Pyrimidines - administration & dosage | Piperazines - therapeutic use | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Pyrimidines - therapeutic use | PPAR gamma - agonists | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Trans-Activators - metabolism | Index Medicus | Life Sciences | Microbiology and Parasitology | Immunology | Bacteriology | Virology
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2. Full Text PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein
by Ohno, Haruya and Shinoda, Kosaku and Spiegelman, Bruce M and Kajimura, Shingo
Cell metabolism, ISSN 1550-4131, 03/2012, Volume 15, Issue 3, pp. 395 - 404
Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Mice, Inbred C57BL | Adipose Tissue, White - metabolism | Male | Transcription Factors - genetics | DNA-Binding Proteins - genetics | PPAR gamma - metabolism | Blotting, Western | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Animals | Oxygen Consumption - drug effects | Protein Stability - drug effects | PPAR gamma - agonists | Indoles - pharmacology | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | Thiazolidinediones - pharmacology | Adipose Tissue, White - drug effects | Sulfides - pharmacology | Index Medicus
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3. Full Text Neuroprotective effects of PPAR‐γ agonist rosiglitazone in N171‐82Q mouse model of Huntington's disease
by Jin, Jing and Albertz, Jennifer and Guo, Zhihong and Peng, Qi and Rudow, Gay and Troncoso, Juan C and Ross, Christopher A and Duan, Wenzhen
Journal of neurochemistry, ISSN 0022-3042, 05/2013, Volume 125, Issue 3, pp. 410 - 419
PPAR‐γ | BDNF | glucose metabolism | Sirt6 | huntingtin | PGC‐1α | PGC-1α | PPAR-γ | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | L-Lactate Dehydrogenase - metabolism | Neuroprotective Agents - therapeutic use | Humans | Huntington Disease - pathology | Brain - enzymology | Male | Intracellular Signaling Peptides and Proteins - metabolism | RNA, Messenger - metabolism | Hyperglycemia - drug therapy | Thiazolidinediones - therapeutic use | Neuroprotective Agents - pharmacology | Transfection | Adenosine Triphosphate - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Trans-Activators - genetics | Brain-Derived Neurotrophic Factor - metabolism | Neurons - metabolism | Huntington Disease - drug therapy | Neurons - drug effects | Thiazolidinediones - pharmacology | Disease Models, Animal | Cell Line | Orexins | Gene Expression Regulation - genetics | Glutamates - genetics | Mice, Transgenic | Neuropeptides - metabolism | Nerve Tissue Proteins - genetics | Brain - drug effects | Gene Expression Regulation - drug effects | Huntington Disease - complications | Huntingtin Protein | Animals | PPAR gamma - antagonists & inhibitors | Movement Disorders - etiology | Anilides - pharmacology | Brain - pathology | Huntington Disease - genetics | Trinucleotide Repeat Expansion - genetics | Trans-Activators - metabolism | Hyperglycemia - etiology | Mice | Transcription Factors | Sirtuins - metabolism | Movement Disorders - drug therapy | Index Medicus
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4. Full Text Ligand promiscuity of aryl hydrocarbon receptor agonists and antagonists revealed by site-directed mutagenesis
by Soshilov, Anatoly A and Denison, Michael S
Molecular and cellular biology, ISSN 0270-7306, 2014, Volume 34, Issue 9, pp. 1707 - 1719
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Line | Basic Helix-Loop-Helix Transcription Factors - agonists | Basic Helix-Loop-Helix Transcription Factors - genetics | Mutagenesis, Site-Directed | Receptors, Aryl Hydrocarbon - antagonists & inhibitors | Receptors, Aryl Hydrocarbon - genetics | Models, Molecular | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Receptors, Aryl Hydrocarbon - agonists | Animals | Basic Helix-Loop-Helix Transcription Factors - metabolism | HSP90 Heat-Shock Proteins - metabolism | Protein Binding | Receptors, Aryl Hydrocarbon - metabolism | Ligands | Mice | Binding Sites | Index Medicus
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5. Full Text Antineoplastic effects of peroxisome proliferator-activated receptor γ agonists
by Grommes, Christian and Landreth, Gary E and Heneka, Michael T
The lancet oncology, ISSN 1470-2045, 07/2004, Volume 5, Issue 7, pp. 419 - 429
Life Sciences & Biomedicine | Oncology | Science & Technology | Transcription Factors - therapeutic use | Apoptosis - drug effects | Humans | Receptors, Cytoplasmic and Nuclear - therapeutic use | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Receptors, Cytoplasmic and Nuclear - agonists | Neoplasms - drug therapy | Animals | Transcription Factors - pharmacology | Cell Line, Tumor | Models, Animal | Signal Transduction - physiology | Antineoplastic Agents - pharmacology | Transcription Factors - agonists | Index Medicus
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6. Full Text PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
by Ting, Adrian T and Jiang, Chengyu and Seed, Brian
Nature (London), ISSN 0028-0836, 01/1998, Volume 391, Issue 6662, pp. 82 - 86
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Inflammation | Molecular and cellular biology | Cell Line | Leukocytes, Mononuclear - metabolism | Promoter Regions, Genetic | Inflammation Mediators | Transcription Factors - physiology | Leukocytes, Mononuclear - drug effects | Humans | Receptors, Cytoplasmic and Nuclear - physiology | Receptors, Cytoplasmic and Nuclear - agonists | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Chromans - pharmacology | Tumor Necrosis Factor-alpha - physiology | Prostaglandin D2 - analogs & derivatives | Prostaglandin D2 - pharmacology | Thiazoles - pharmacology | Transcription Factors - agonists | Cytokines - genetics | Thiazolidinediones | Tumor Necrosis Factor-alpha - biosynthesis | Cytokines - biosynthesis | Cytokines | Observations | Peroxisomes | Arthritis | Hormones | Cells | Immune system | Index Medicus
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7. Full Text (S)‐4‐Amino‐5‐phenoxypentanoate designed as a potential selective agonist of the bacterial transcription factor GabR
by Catlin, Daniel S and Reidl, Cory T and Trzupek, Thomas R and Silverman, Richard B and Cannon, Brian L and Becker, Daniel P and Liu, Dali
Protein science, ISSN 0961-8368, 08/2020, Volume 29, Issue 8, pp. 1816 - 1828
single‐molecule FRET | bacterial transcriptional regulation | MocR | organic synthesis | PLP | X‐ray crystallography | GabR | DNA distortion | structure‐based ligand design | Enzymes | Transcription factors | Gene regulation | Fluorescence | Homology | Antagonists | Selectivity | Metabolism | Modulators | γ-Aminobutyric acid | Bacteria | Agonists | Ligands | Metabolic pathways | Fluorescence resonance energy transfer | Energy transfer | Binding sites | Deoxyribonucleic acid--DNA | Crystal structure | Index Medicus
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8. Full Text Peroxisome proliferator-activated receptor γ agonists induce cell cycle arrest through transcriptional regulation of Kruppel-like factor 4 (KLF4)
by Li, Sheng and Zhou, Qibing and He, Huan and Zhao, Yahui and Liu, Zhihua
The Journal of biological chemistry, ISSN 0021-9258, 02/2013, Volume 288, Issue 6, pp. 4076 - 4084
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Neoplasms - metabolism | Kruppel-Like Transcription Factors - biosynthesis | Transcriptional Activation - genetics | Response Elements | Signal Transduction | Humans | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - metabolism | PPAR gamma - metabolism | S Phase Cell Cycle Checkpoints | Neoplasms - therapy | Animals | Neoplasms - genetics | Mice, Nude | PPAR gamma - agonists | Cell Line, Tumor | G1 Phase Cell Cycle Checkpoints | Mice | Neoplasm Proteins - genetics | Neoplasms - pathology | Kruppel-Like Transcription Factors - genetics | PPAR gamma - genetics | Index Medicus | Transcriptional Promoter | Cell Cycle | PPRE | TGZ | Krüppel-like Factor (KLF) | Peroxisome Proliferator-activated Receptor (PPAR) | Cell Biology
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9. Full Text Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB
by Daniel A. Cunha and Laurence Ladrière and Fernanda Ortis and Mariana Igoillo-Esteve and Esteban N. Gurzov and Roberto Lupi and Piero Marchetti and Décio L. Eizirik and Miriam Cnop
Diabetes (New York, N.Y.), ISSN 0012-1797, 12/2009, Volume 58, Issue 12, pp. 2851 - 2862
Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Up-Regulation | Rats, Wistar | Endoplasmic Reticulum - metabolism | Male | Diabetes Mellitus, Type 2 - metabolism | Exenatide | DNA-Binding Proteins - metabolism | Heat-Shock Proteins - genetics | Insulin-Secreting Cells - metabolism | RNA Interference | Glucagon-Like Peptide 1 - agonists | Polymerase Chain Reaction | Antigens, Differentiation - metabolism | Proto-Oncogene Proteins - metabolism | Glucagon-Like Peptide 1 - metabolism | Cell Survival | Colforsin - pharmacology | Proto-Oncogene Proteins c-jun - genetics | Heat-Shock Proteins - metabolism | Diabetes Mellitus, Type 2 - prevention & control | Rats | Receptors, Glucagon - metabolism | Regulatory Factor X Transcription Factors | Blotting, Western | Hypoglycemic Agents - pharmacology | Peptides - pharmacology | Transcription Factors - metabolism | Animals | Glucagon-Like Peptide-1 Receptor | Proto-Oncogene Proteins c-jun - metabolism | Lipid Metabolism - drug effects | Venoms - pharmacology | Apoptosis | Index Medicus | Abridged Index Medicus | Original
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