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Nature Communications, ISSN 2041-1723, 06/2015, Volume 6, Issue 1, pp. 7320 - 7320
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2014, Volume 53, Issue 3, pp. 369 - 379
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 651 - 17
Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However,... 
NITROGEN CATABOLITE REPRESSION | GATA FACTORS | YEAST | LIFE-SPAN | REGULATOR | AMINO-ACID CONTROL | TOR PROTEINS | MECHANISM | MULTIDISCIPLINARY SCIENCES | NUCLEAR GLN3 IMPORT | HEALTH | GATA Transcription Factors - drug effects | Longevity - drug effects | Plant Extracts - pharmacology | Angelica - chemistry | Humans | Aging - drug effects | Male | Saccharomyces cerevisiae - drug effects | Autophagy - drug effects | Transcription Factors - drug effects | Saccharomyces cerevisiae - metabolism | Cell Line - drug effects | Medicine, East Asian Traditional | Flavonoids - administration & dosage | Cation Transport Proteins - genetics | Flavonoids - pharmacology | Cell Death - drug effects | Signal Transduction | Mice, Inbred C57BL | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | Myocardial Ischemia - drug therapy | Sirolimus - pharmacology | Drosophila melanogaster - drug effects | Mechanistic Target of Rapamycin Complex 1 - metabolism | Gene Expression Regulation - drug effects | Animals | Caenorhabditis elegans - drug effects | Aging - physiology | Mice | Longevity - physiology | Senescence | Transcription factors | Yeast | Neurodegenerative diseases | Health promotion | Deceleration | Pharmacology | Longevity | Metabolism | Risk analysis | Autophagy | Risk factors | Neurological diseases | Flavonoids | Life span | Ischemia | Aging | Aging (natural) | Phagocytosis | Index Medicus
Journal Article
Endocrinology, ISSN 0013-7227, 02/2016, Volume 157, Issue 2, pp. 774 - 787
Severe thyroid hormone (TH) deficiency during critical phases of brain development results in irreversible neurological and cognitive impairments. The... 
PROPYLTHIOURACIL PTU | MESSENGER-RNA | GYRUS IN-VIVO | ENDOCRINOLOGY & METABOLISM | NEUROTROPHIC FACTOR BDNF | GESTATIONAL MATERNAL HYPOTHYROXINEMIA | LONG-TERM POTENTIATION | DENTATE GYRUS | SYNAPTIC PLASTICITY | INCREASED AUTISM RISK | NERVE GROWTH-FACTOR | TOR Serine-Threonine Kinases - metabolism | Cytoskeletal Proteins - genetics | Rats, Long-Evans | Congenital Hypothyroidism - chemically induced | Neuronal Plasticity - drug effects | Male | Neuronal Plasticity - physiology | TOR Serine-Threonine Kinases - genetics | Triiodothyronine - drug effects | Behavior, Animal - drug effects | Brain-Derived Neurotrophic Factor - metabolism | Kruppel-Like Transcription Factors - drug effects | TOR Serine-Threonine Kinases - drug effects | Disease Models, Animal | Hippocampus - embryology | Maze Learning - physiology | Propylthiouracil - toxicity | Rats | Behavior, Animal - physiology | Nerve Growth Factor - genetics | Antithyroid Agents - toxicity | Nerve Tissue Proteins - drug effects | Thyroxine - metabolism | Neurotrophin 3 - drug effects | Kruppel-Like Transcription Factors - genetics | Brain-Derived Neurotrophic Factor - genetics | Neurotrophin 3 - genetics | Early Growth Response Protein 1 - drug effects | Brain-Derived Neurotrophic Factor - drug effects | Triiodothyronine - metabolism | Kruppel-Like Transcription Factors - metabolism | Early Growth Response Protein 1 - genetics | Cytoskeletal Proteins - metabolism | Female | Cytoskeletal Proteins - drug effects | Nerve Growth Factor - drug effects | Congenital Hypothyroidism - embryology | Severity of Illness Index | Nerve Growth Factor - metabolism | Conditioning (Psychology) - drug effects | Conditioning (Psychology) - physiology | Triiodothyronine - deficiency | Congenital Hypothyroidism - metabolism | Maze Learning - drug effects | Nerve Tissue Proteins - genetics | Prenatal Exposure Delayed Effects - metabolism | Nerve Tissue Proteins - metabolism | Pregnancy | Thyroxine - drug effects | Fear | Hippocampus - metabolism | Animals | Neurotrophin 3 - metabolism | Thyroxine - deficiency | Early Growth Response Protein 1 - metabolism | Prenatal Exposure Delayed Effects - chemically induced | Index Medicus | Abridged Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2016, Volume 22, Issue 10, pp. 1160 - 1169
Orthopedic implants containing biodegradable magnesium have been used for fracture repair with considerable efficacy; however, the underlying mechanisms by... 
MEDICINE, RESEARCH & EXPERIMENTAL | GENE-RELATED PEPTIDE | VIVO | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNERVATION | OSTEOPOROSIS | CELL BIOLOGY | IN-VITRO | TRAUMATIC BRAIN-INJURY | ALLOYS | DIFFERENTIATION | OSTEOARTHRITIS | EXPRESSION | Bone Nails | Humans | Fracture Fixation, Intramedullary | Ganglia, Spinal - cytology | Cyclic AMP Response Element-Binding Protein - drug effects | Gene Knockdown Techniques | Transcription Factors - drug effects | Stem Cells | Fracture Healing - drug effects | Osteoporosis, Postmenopausal | Cation Transport Proteins - metabolism | Female | Neurons - metabolism | Calcitonin Gene-Related Peptide - metabolism | Neurons - drug effects | Osteogenesis - genetics | Osteoporotic Fractures | Calcitonin Gene-Related Peptide - drug effects | Ovariectomy | Calcitonin Gene-Related Peptide - pharmacology | Osteogenesis - drug effects | Capsaicin - toxicity | Femoral Fractures | Rats | Femur - drug effects | Sensory System Agents - toxicity | Receptor Activity-Modifying Protein 1 - genetics | Magnesium - pharmacology | Gene Knock-In Techniques | Periosteum - cytology | Transcription Factors - metabolism | Animals | Cell Differentiation - drug effects | Calcitonin Receptor-Like Protein - genetics | Cyclic AMP Response Element-Binding Protein - metabolism | TRPM Cation Channels - metabolism | Fracture Healing - genetics | Denervation | Neuropeptides | Fracture fixation | Genetic aspects | Wound healing | Health aspects | Surgical implants | Femur | Transplants & implants | Biodegradability | Capsaicin | Genes | Menopause | Differentiation (biology) | Stem cell transplantation | Cortex (somatosensory) | Receptor activity modifying proteins | Proteins | Osteoporosis | Biomedical materials | Bone growth | Allografts | Dorsal root ganglia | Surgery | Calcitonin | Nerves | Sensory neurons | Biocompatibility | Ion channels | Magnesium | Bone (cortical) | Repair | Adenosine triphosphate | Biodegradation | Periosteum | Implantation | Bone healing | Ganglia | Calcitonin gene-related peptide | Bone implants | Fractures | Orthopedics | Stem cells | Healing | Bone | ATP | Transporter | Osteogenesis | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 09/2017, Volume 23, Issue 9, pp. 1055 - 1062
Bromodomain and extraterminal domain (BET) protein inhibitors are emerging as promising anticancer therapies. The gene encoding the E3 ubiquitin ligase... 
SELECTIVE-INHIBITION | TARGET | MEDICINE, RESEARCH & EXPERIMENTAL | ANDROGEN RECEPTOR | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE MYELOID-LEUKEMIA | ENHANCERS | CELL BIOLOGY | RNA-SEQ | BROMODOMAIN INHIBITION | MUTATIONS | BRD4 | Prostatic Neoplasms - metabolism | Immunoprecipitation | TOR Serine-Threonine Kinases - metabolism | Humans | Drug Resistance, Neoplasm | Male | Gene Expression Profiling | Molecular Targeted Therapy | Mechanistic Target of Rapamycin Complex 1 | Transcription Factors - drug effects | Multiprotein Complexes - metabolism | Prostatic Neoplasms - genetics | Proteasome Endopeptidase Complex - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Nuclear Proteins - drug effects | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | TOR Serine-Threonine Kinases - drug effects | Multiprotein Complexes - drug effects | Prostatic Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Triazoles - therapeutic use | Cell Survival | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Azepines - therapeutic use | RNA-Binding Proteins - drug effects | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Nuclear Proteins - antagonists & inhibitors | Protein-Serine-Threonine Kinases - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mutation | RNA-Binding Proteins - metabolism | rac1 GTP-Binding Protein - metabolism | Proto-Oncogene Proteins c-akt - drug effects | rac1 GTP-Binding Protein - genetics | Gene mutations | Physiological aspects | Genetic aspects | Research | Drug resistance | Drug therapy | Prostate cancer | Ubiquitin | Inhibitor drugs | Stabilization | AKT protein | Activation | Biosynthesis | Degradation | Proteins | Ubiquitination | Transcription activation | Bioindicators | Ubiquitin-protein ligase | Binding | Rac1 protein | Tumor cell lines | Gene expression | Cholesterol | Mutants | Inhibitors | Proteasomes | Biomarkers | Bet protein | Prostate | Cancer | Guanosinetriphosphatase | Index Medicus
Journal Article
Developmental Cell, ISSN 1534-5807, 2005, Volume 9, Issue 5, pp. 617 - 628
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 2016, Volume 311, Issue 5, pp. E836 - E849
Alcohol ingestion decreases postexercise rates of muscle protein synthesis, but the mechanism( s) (e.g., increased protein breakdown) underlying this... 
Alcohol | Exercise | Autophagy | Protein | Apoptosis | alcohol | ACTIVATION | PHYSIOLOGY | autophagy | MITOCHONDRIAL BIOGENESIS | INCREASES | exercise | apoptosis | HUMAN SKELETAL-MUSCLE | MTOR | CELL-DEATH | DIRECT PHOSPHORYLATION | P53 | MESSENGER-RNA | RESISTANCE EXERCISE | protein | ENDOCRINOLOGY & METABOLISM | Molecular Chaperones - metabolism | Apoptosis - drug effects | Humans | Male | Autophagy - physiology | Alcohol Drinking | Carrier Proteins - drug effects | Autophagy - drug effects | Electron Transport Complex IV - metabolism | Transcription Factors - drug effects | Central Nervous System Depressants - pharmacology | Mitochondrial Proteins - drug effects | Young Adult | Organelle Biogenesis | Mitochondrial Proteins - metabolism | Dietary Proteins - pharmacology | Nuclear Respiratory Factor 1 - metabolism | Mitochondrial Proton-Translocating ATPases - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - drug effects | Voltage-Dependent Anion Channel 1 - drug effects | Mitochondrial Degradation - physiology | Mitochondrial Proton-Translocating ATPases - metabolism | Cross-Over Studies | Signal Transduction - drug effects | Mitochondrial Degradation - drug effects | Adolescent | Electron Transport Complex IV - drug effects | Membrane Proteins - drug effects | Exercise - physiology | RNA-Binding Proteins - metabolism | Protein Kinases - metabolism | Muscle Fibers, Skeletal - drug effects | Healthy Volunteers | DNA-Binding Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Adult | Molecular Chaperones - drug effects | Membrane Proteins - metabolism | DNA Fragmentation - drug effects | Muscle Fibers, Skeletal - physiology | Proto-Oncogene Proteins - metabolism | Protein Kinases - drug effects | Proto-Oncogene Proteins - drug effects | Dietary Carbohydrates - pharmacology | DNA-Binding Proteins - drug effects | Tumor Suppressor Protein p53 - metabolism | Voltage-Dependent Anion Channel 1 - metabolism | Tumor Suppressor Protein p53 - drug effects | Nuclear Respiratory Factor 1 - drug effects | RNA-Binding Proteins - drug effects | Transcription Factors - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - drug effects | Ethanol - pharmacology | Carrier Proteins - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Apoptosis - physiology | Autophagy (Cytology) | Cell research | Alcoholic beverages | Physiological aspects | Cellular signal transduction | Research | Physiology | Protein synthesis | Alcohol use | Index Medicus
Journal Article