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American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 08/2016, Volume 311, Issue 2, pp. E380 - E395
.... Here, we evaluated long-term (20 doses) and short-term (2-6 doses) effects of IMT504 (20 mg center dot kg(-1)center dot day(-1) sc) in an immunodependent diabetes model... 
Insulitis | β-cells | Islet gene expression | Serum cytokines | OLIGODEOXYNUCLEOTIDES | ACTIVATION | PHYSIOLOGY | serum cytokines | islet gene expression | REG FAMILY GENES | PROLIFERATION | MESENCHYMAL STEM-CELLS | IL-6 | insulitis | ENDOCRINOLOGY & METABOLISM | beta-cells | STREPTOZOTOCIN | EXPRESSION | ONSET | Islets of Langerhans - drug effects | Apoptosis - drug effects | Chemokine CXCL1 - drug effects | Diabetes Mellitus, Experimental - genetics | Diabetes Mellitus, Type 1 - metabolism | Male | Chemokine CXCL1 - genetics | RNA, Messenger - metabolism | Nestin - drug effects | Insulin - genetics | Interleukin-6 - metabolism | Disease Models, Animal | Somatostatin - genetics | Lithostathine - drug effects | Blood Glucose - drug effects | Insulin - metabolism | Protein Precursors - drug effects | Tumor Necrosis Factor-alpha - drug effects | Mice | Mice, Inbred BALB C | Proglucagon - genetics | Blood Glucose - metabolism | Oligodeoxyribonucleotides - pharmacology | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Tumor Necrosis Factor-alpha - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - drug effects | Stem Cells - metabolism | Insulin-Secreting Cells - metabolism | Proglucagon - drug effects | Somatostatin - drug effects | Islets of Langerhans - metabolism | Nestin - genetics | Diabetes Mellitus, Experimental - metabolism | RNA, Messenger - drug effects | Glucose Tolerance Test | Protein Precursors - genetics | Cytokines - metabolism | Islets of Langerhans - pathology | Lithostathine - genetics | Diabetes Mellitus, Type 1 - genetics | Transcriptome - drug effects | Pancreatitis-Associated Proteins | Proteins - genetics | Animals | Cytokines - drug effects | Insulin-Secreting Cells - drug effects | Platelet Endothelial Cell Adhesion Molecule-1 - drug effects | Proteins - drug effects | Stem Cells - drug effects | Cell Proliferation - drug effects | Physiological aspects | Models | Diabetes | Oligonucleotides | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2016, Volume 113, Issue 6, pp. E782 - E790
Epstein–Barr virus (EBV) is an oncogenic herpesvirus that has been causally linked to the development of B-cell and epithelial malignancies. Early after... 
B cell | Epstein-Barr virus | Metabolism | Oncogene-induced senescence | Autophagy | TRANSFORMATION | SURVIVAL | autophagy | DNA-DAMAGE RESPONSE | MULTIDISCIPLINARY SCIENCES | CANCER | REPLICATION | SIGNALING PATHWAY | metabolism | TUMORIGENESIS | oncogene-induced senescence | LYMPHOCYTES | Metabolomics | Cell Transformation, Viral - drug effects | TOR Serine-Threonine Kinases - metabolism | DNA Replication - drug effects | Humans | Herpesvirus 4, Human - drug effects | Cellular Senescence - drug effects | Dimethylformamide - pharmacology | Autophagy - drug effects | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Deoxyglucose - pharmacology | Cell Respiration - drug effects | B-Lymphocytes - virology | Stress, Physiological - drug effects | B-Lymphocytes - pathology | B-Lymphocytes - ultrastructure | Oncogenes | DNA Damage - drug effects | Herpesvirus 4, Human - physiology | Tumor Suppressor Protein p53 - metabolism | Mitochondria - metabolism | Transcriptome - genetics | Mitochondria - drug effects | Transcription Factors - metabolism | B-Lymphocytes - drug effects | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Cell Proliferation - drug effects | Cell interaction | B cells | Host-virus relationships | Observations | Health aspects | Biological Sciences | PNAS Plus | Epstein–Barr virus
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 500, Issue 7463, pp. 422 - 426
Journal Article
Aging cell, ISSN 1474-9718, 2015, Volume 14, Issue 4, pp. 644 - 658
...‐related chronic diseases. Here, we describe the rationale for identification and validation of a new class of drugs termed senolytics, which selectively kill senescent cells... 
dasatinib | plasminogen‐activated inhibitor | dependence receptors | quercetin | ephrins | PI3K delta | p21 | Dasatinib | Dependence receptors | Ephrins | Plasminogen-activated inhibitor | Quercetin | P21 | ENDOTHELIAL DYSFUNCTION | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | EXPRESSION PROFILES | plasminogen-activated inhibitor | CELLULAR SENESCENCE | CANCER-THERAPY | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | LUNG-CANCER | SET ENRICHMENT ANALYSIS | GENE-EXPRESSION | IONIZING-RADIATION | TUMOR-GROWTH | Carotid Arteries - drug effects | Endonucleases - genetics | Plasminogen Activator Inhibitor 2 - genetics | Transcriptome | Gene Expression Profiling | Adipocytes - drug effects | Aging - genetics | Osteoporosis - metabolism | Ephrins - metabolism | Plasminogen Activator Inhibitor 2 - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Osteoporosis - genetics | Intervertebral Disc - pathology | Fibroblasts - metabolism | Endothelial Cells - metabolism | Intervertebral Disc - chemistry | Fibroblasts - pathology | Mesenchymal Stem Cells - pathology | Mice, Knockout | Dasatinib - pharmacology | Osteoporosis - pathology | Ephrins - genetics | Fibroblasts - drug effects | Mice | Endothelial Cells - pathology | bcl-X Protein - metabolism | Aging - metabolism | Aging - drug effects | bcl-X Protein - genetics | Cellular Senescence - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Endonucleases - metabolism | DNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Mesenchymal Stem Cells - drug effects | Mesenchymal Stem Cells - metabolism | Heart - physiopathology | Cellular Senescence - genetics | Osteoporosis - prevention & control | DNA-Binding Proteins - genetics | Adipocytes - pathology | Aging - pathology | Phosphatidylinositol 3-Kinases - genetics | Animals | Quercetin - pharmacology | Adipocytes - metabolism | Heart - drug effects | Carotid Arteries - pathology | Intervertebral Disc - drug effects | Drug Combinations | Endothelial Cells - drug effects | Original
Journal Article
Nature medicine, ISSN 1546-170X, 2016, Volume 22, Issue 5, pp. 547 - 556
...–response cardiotoxic side effect that can lead to heart failure. At present, it is not possible to predict which patients will be affected by doxorubicin-induced cardiotoxicity (DIC... 
MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | RISK-FACTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEXRAZOXANE | INDUCED CARDIOMYOPATHY | MATURATION | MUSCLE GENE-EXPRESSION | CELL BIOLOGY | CHILDHOOD-CANCER | INHIBITION | ANTHRACYCLINE-INDUCED CARDIOTOXICITY | CONGESTIVE-HEART-FAILURE | Mitochondria, Heart - metabolism | Reactive Oxygen Species - metabolism | Antibiotics, Antineoplastic - pharmacology | Apoptosis - drug effects | Calcium - metabolism | Humans | Middle Aged | Transcriptome | Antibiotics, Antineoplastic - adverse effects | Mitochondria, Heart - drug effects | Membrane Potential, Mitochondrial - drug effects | Flow Cytometry | Adult | Female | Real-Time Polymerase Chain Reaction | Cardiotoxicity - genetics | DNA Damage - drug effects | Cell Survival - drug effects | Disease Susceptibility | Heart Failure - genetics | Breast Neoplasms - drug therapy | Myocytes, Cardiac - drug effects | Fluorescent Antibody Technique | Myocytes, Cardiac - metabolism | Aged | Polymorphism, Single Nucleotide | Oxidative Stress - drug effects | Induced Pluripotent Stem Cells | Doxorubicin - adverse effects | Doxorubicin - pharmacology | Heart Failure - chemically induced | Complications and side effects | Patient outcomes | Stem cells | Development and progression | Breast cancer | Transplantation | Cardiovascular diseases | Drug therapy | Doxorubicin | Methods | Heart failure | Chemotherapy | Toxicity | Index Medicus
Journal Article
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2011, Volume 141, Issue 4, pp. 1486 - 1497.e14
...) in 2-dimensional and 3-dimensional culture conditions (physiomimetic organotypic culture). The effects of all-trans retinoic acid (ATRA... 
Gastroenterology and Hepatology | 9RA | Therapy | Secreted Frizzled-Related Protein 4 | 13RA | Mouse Model | ACTIVATION | CANCER CELLS | TRANSCRIPTOME | ADENOCARCINOMA | STABILIZATION | MODEL | CULTURE | IN-VITRO | GASTROENTEROLOGY & HEPATOLOGY | IMMORTALIZATION | EXPRESSION | Transcription, Genetic - drug effects | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Humans | Pancreatic Stellate Cells - drug effects | Carcinoma, Pancreatic Ductal - metabolism | Cellular Senescence - drug effects | Wnt Proteins - metabolism | Carcinoma, Pancreatic Ductal - genetics | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | RNA Interference | Time Factors | Mice, Mutant Strains | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Pancreatic Stellate Cells - pathology | Disease Models, Animal | Tretinoin - pharmacology | Proto-Oncogene Proteins - metabolism | Isotretinoin - pharmacology | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - pathology | beta Catenin - metabolism | Disease Progression | Carcinoma, Pancreatic Ductal - drug therapy | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Paracrine Communication - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Pancreatic Stellate Cells - metabolism
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 548, Issue 7668, pp. 471 - 475
Cyclin-dependent kinases 4 and 6 (CDK4/6) are fundamental drivers of the cell cycle and are required for the initiation and progression of various... 
BREAST-CANCER | CELLS | METHYLATION | MULTIDISCIPLINARY SCIENCES | SENESCENCE | EXPRESSION | REQUIREMENT | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Viruses - genetics | Breast Neoplasms - immunology | Humans | Transcriptome | T-Lymphocytes, Regulatory - immunology | T-Lymphocytes, Regulatory - cytology | Female | Biological Mimicry - drug effects | Phosphorylation - drug effects | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Disease Models, Animal | Viruses - drug effects | Viruses - immunology | Antigen Presentation - immunology | Breast Neoplasms - drug therapy | T-Lymphocytes, Regulatory - drug effects | Animals | Breast Neoplasms - genetics | Repressor Proteins - biosynthesis | Signal Transduction - drug effects | Breast Neoplasms - pathology | Cell Cycle Checkpoints - drug effects | Protein Kinase Inhibitors - therapeutic use | RNA, Double-Stranded - genetics | Cell Line, Tumor | Interferons - metabolism | Antigen Presentation - drug effects | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Cancer cells | Physiological aspects | Research | Protein kinases | Immunity | Cyclins | Cancer | Cell proliferation | Flow cytometry | Animal models | Phosphorylation | Senescence | Peptides | Genomics | Immune clearance | Cytotoxicity | Lymphocytes T | Genomes | Kinases | Cancer therapies | Cyclin-dependent kinase 4 | E2F protein | Breast carcinoma | Cell growth | Lymphocytes | New combinations | Cell cycle | Inhibition | Deoxyribonucleic acid--DNA | Immune system | Antigen presentation | Medical research | Immune response | Immunoregulation | Intracellular levels | Double-stranded RNA | Breast cancer | Pharmacology | Gene expression | Ribonucleic acid--RNA | Inhibitors | Immune checkpoint | Immunogenicity | DNA methyltransferase | Interferon | Retinoblastoma | Tumors | Apoptosis
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 12/2012, Volume 92, Issue 6, pp. 1147 - 1154
Journal Article
Plant physiology (Bethesda), ISSN 1532-2548, 2013, Volume 161, Issue 4, pp. 1795 - 1805
There is growing evidence that for a comprehensive insight into the function of plant genes, it is crucial to assess their functionalities under a wide range... 
Plant growth regulators | Cell death | Genes | Environmental laboratories | Phytotrons | Gene expression regulation | Plants | Drought | ECOPHYSIOLOGY AND SUSTAINABILITY | Genotypes | Plant cells | ALTERNATIVE OXIDASE | REACTIVE OXYGEN | SALICYLIC-ACID | GENE | NATURAL VARIATION | ZINC-FINGER PROTEIN | RESISTANCE | HYDROGEN-PEROXIDE | DEATH | STRESS | PLANT SCIENCES | Seeds - radiation effects | Reactive Oxygen Species - metabolism | Salicylic Acid - metabolism | Adaptation, Physiological - drug effects | Transcriptome - radiation effects | Stress, Physiological - radiation effects | Arabidopsis Proteins - metabolism | DNA-Binding Proteins - metabolism | Arabidopsis - radiation effects | Seeds - growth & development | Adaptation, Physiological - genetics | Droughts | Light | Stress, Physiological - drug effects | Homeostasis - drug effects | Signal Transduction - radiation effects | Photosynthesis - radiation effects | Gene Expression Regulation, Plant - radiation effects | Arabidopsis - drug effects | Seeds - metabolism | Seeds - drug effects | Water - metabolism | Homeostasis - radiation effects | Transcriptome - drug effects | Transcriptome - genetics | Adaptation, Physiological - radiation effects | Arabidopsis - metabolism | Hydrogen Peroxide - metabolism | Photosystem II Protein Complex - metabolism | Arabidopsis - genetics | Transcription Factors - metabolism | Gene Expression Regulation, Plant - drug effects | Signal Transduction - drug effects | Photosynthesis - drug effects | Plant Growth Regulators - pharmacology | Carboxylic Ester Hydrolases - metabolism | Cluster Analysis | Arabidopsis thaliana | Plant defenses | Cellular control mechanisms | Plant genetics | Genetic aspects | Research | Observations
Journal Article