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Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7642, pp. 484 - 488
Synthetic lethality and collateral lethality are two well-validated conceptual strategies for identifying therapeutic targets in cancers with tumour-suppressor... 
VULNERABILITIES | BETA-TRCP | PHOSPHORYLATION | MUTANT-CELLS | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | DELETION | Neoplasms - metabolism | Tumor Necrosis Factor-alpha - metabolism | Prostatic Neoplasms - metabolism | Phosphorylation | Humans | Gene Expression Regulation, Neoplastic | Chromatin Assembly and Disassembly - genetics | Male | NF-kappa B - metabolism | Molecular Targeted Therapy | DNA-Binding Proteins - deficiency | Breast Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Ubiquitination | beta-Transducin Repeat-Containing Proteins - metabolism | Prostatic Neoplasms - genetics | Neoplasms - genetics | Proteolysis | Female | Lysine - metabolism | Protein Stability | DNA Helicases - genetics | Genes, Essential - genetics | DNA Helicases - chemistry | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | PTEN Phosphohydrolase - deficiency | PTEN Phosphohydrolase - metabolism | DNA Helicases - deficiency | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Glycogen Synthase Kinase 3 beta - metabolism | DNA Helicases - metabolism | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Histones - metabolism | Proteasome Endopeptidase Complex - metabolism | Methylation | Neoplasms - pathology | Physiological aspects | Chromatin | Genetic aspects | Research | Oncology, Experimental | Cancer | Cell growth | Genes | Breast cancer | Genomes | Mutation | Kinases | Prostate cancer | Data bases | Tumors | Cell adhesion & migration | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1423 - 12
Beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC) is crucial for the degradation of I kappa B alpha. Our previous transcriptome sequencing... 
UBIQUITINATION | HEPATOCELLULAR-CARCINOMA | INVASION | GENE | MIR-339-5P | MULTIDISCIPLINARY SCIENCES | KINASE | ALPHA | TETRASPANIN FUNCTIONS | CANCER | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | Neoplasm Transplantation | RNA, Small Interfering - genetics | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Tumor Necrosis Factor-alpha - genetics | Gene Expression Regulation, Neoplastic | Male | MicroRNAs - metabolism | NF-KappaB Inhibitor alpha - genetics | NF-kappa B - metabolism | Esophageal Neoplasms - pathology | Matrix Metalloproteinase 9 - metabolism | beta-Transducin Repeat-Containing Proteins - metabolism | Neoplasm Grading | Matrix Metalloproteinase 9 - genetics | Esophageal Neoplasms - metabolism | Female | Vascular Cell Adhesion Molecule-1 - genetics | Chemokine CCL2 - metabolism | Tetraspanins - genetics | Tetraspanins - metabolism | beta-Transducin Repeat-Containing Proteins - genetics | Esophageal Squamous Cell Carcinoma | Signal Transduction | Chemokine CCL2 - genetics | Lymphatic Metastasis | Urokinase-Type Plasminogen Activator - genetics | Tetraspanins - antagonists & inhibitors | Intercellular Adhesion Molecule-1 - metabolism | Animals | Esophageal Neoplasms - genetics | NF-kappa B - genetics | Urokinase-Type Plasminogen Activator - metabolism | Mice, Nude | Intercellular Adhesion Molecule-1 - genetics | NF-KappaB Inhibitor alpha - metabolism | Cell Line, Tumor | Aged | Mice | MicroRNAs - genetics | Neoplasm Staging | Vascular Cell Adhesion Molecule-1 - metabolism | RNA, Small Interfering - metabolism | Ubiquitin | Transducin | Metastasis | Tissues | Lymph nodes | Metastases | Degradation | Ubiquitination | Transcription activation | Bioindicators | Ubiquitin-protein ligase | Translocation | NF-κB protein | Squamous cell carcinoma | Intercellular adhesion molecule 1 | Therapeutic applications | Tumor necrosis factor-α | Gene expression | Nuclear transport | Gelatinase B | Esophagus | Signaling | Proteasomes | Biomarkers | Monocyte chemoattractant protein 1 | Index Medicus
Journal Article
The Journal of Physiology, ISSN 0022-3751, 07/2007, Volume 582, Issue 1, pp. 379 - 392
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 9, pp. 4698 - 4710
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2014, Volume 111, Issue 16, pp. 6075 - 6080
Solitary chemosensory cells (SCCs) of the nasal cavity are specialized epithelial chemosensors that respond to irritants through the canonical taste... 
Cholinergics | Nerve endings | Nerve fibers | Receptors | Nasal cavity | Nociceptors | Mast cells | Inflammation | Epithelium | Cholinergic receptors | Innate immunity | Quorum sensing | Rhinitis | Chemesthesis | Airway irritation | airway irritation | quorum sensing | GENE-RELATED PEPTIDE | PRIMARY AFFERENT NEURONS | UPPER RESPIRATORY-INFECTION | MULTIDISCIPLINARY SCIENCES | MAST-CELLS | BRUSH CELLS | rhinitis | GUINEA-PIG | NICOTINIC ACETYLCHOLINE-RECEPTORS | chemesthesis | innate immunity | SUBSTANCE-P | TASTE RECEPTORS | PLASMA LEAKAGE | Inflammation - pathology | Trigeminal Nerve - metabolism | Chemoreceptor Cells - metabolism | Nasal Mucosa - pathology | Synaptic Transmission | Inflammation - metabolism | Receptors, Neurokinin-1 - metabolism | Transducin - metabolism | Nasal Mucosa - metabolism | Nose - metabolism | Extravasation of Diagnostic and Therapeutic Materials - pathology | Nose - physiopathology | Receptors, Nicotinic - metabolism | Cell Degranulation | Signal Transduction | Cholinergic Neurons - metabolism | Nose - pathology | Trigeminal Nerve - pathology | Mast Cells - physiology | Extravasation of Diagnostic and Therapeutic Materials - metabolism | Extravasation of Diagnostic and Therapeutic Materials - physiopathology | Chemoreceptor Cells - pathology | Animals | Models, Biological | Mice | Nociceptors - metabolism | TRPM Cation Channels - metabolism | Nasal Mucosa - physiopathology | Inflammation - physiopathology | Physiological aspects | Neural transmission | Research | Neurological research | Chemoreceptors | Molecules | Peptides | Rodents | Cells | Animal cognition | Index Medicus | Biological Sciences
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 30, pp. 13450 - 13455
A chronic proinflammatory state precedes pathological change in arterial endothelial cells located within regions of susceptibility to atherosclerosis. The... 
Untranslated regions | Up regulation | Phenotypes | MicroRNA | Genes | Atherosclerosis | Gene expression regulation | Endothelial cells | Binding sites | Endothelium | NF-κB | β-transducing repeat-containing gene | Mitogen-activated kinase kinase kinase 7 | Hemodynamics | TRANSCRIPTION FACTORS | ACTIVATION | ANGIOGENESIS | FLUID SHEAR-STRESS | MULTIDISCIPLINARY SCIENCES | mitogen-activated kinase kinase kinase 7 | ATHEROSCLEROSIS | hemodynamics | FLOW | NF-kappa B | REGIONS | beta-transducing repeat-containing gene | NF-KAPPA-B | EXPRESSION | PORCINE AORTA | Oligonucleotide Array Sequence Analysis | Atherosclerosis - genetics | Homeodomain Proteins - metabolism | Humans | MicroRNAs - metabolism | NF-kappa B - metabolism | Gene Expression Profiling | I-kappa B Proteins - metabolism | Gene Knockdown Techniques | beta-Transducin Repeat-Containing Proteins - metabolism | Swine | Aorta, Thoracic - pathology | beta-Transducin Repeat-Containing Proteins - genetics | Endothelium - pathology | Cell Line | Genetic Predisposition to Disease | NF-KappaB Inhibitor alpha | Endothelial Cells - metabolism | MAP Kinase Kinase Kinases - genetics | Cells, Cultured | Aorta, Thoracic - metabolism | In Situ Hybridization, Fluorescence | MAP Kinase Kinase Kinases - metabolism | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Phenotype | Animals | Endothelium - metabolism | Inflammation - genetics | MicroRNAs - genetics | Endothelial Cells - pathology | Hogs | Molecules | Genotype & phenotype | Biomarkers | Ribonucleic acid--RNA | Kinases | Cells | Index Medicus | Biological Sciences
Journal Article
Cell Cycle, ISSN 1538-4101, 04/2012, Volume 11, Issue 7, pp. 1374 - 1382
Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer in the world; the main risk factors are alcohol and tobacco use. Advancements in... 
metformin | cell viability | chemoprevention | growth inhibition | head and neck cancer | cell cycle arrest | Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Cell cycle arrest | Cell viability | Head and neck cancer | Metformin | Growth inhibition | Chemoprevention | Cyclin D1 - metabolism | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Neoplasm Proteins - metabolism | Head and Neck Neoplasms - metabolism | Cyclin-Dependent Kinase Inhibitor p16 | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Squamous Cell Carcinoma of Head and Neck | beta-Transducin Repeat-Containing Proteins - metabolism | Cyclin-Dependent Kinase 2 - metabolism | Metformin - pharmacology | Head and Neck Neoplasms - drug therapy | Cyclin-Dependent Kinase 6 - metabolism | Cyclin-Dependent Kinase 4 - metabolism | S-Phase Kinase-Associated Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p18 - metabolism | Head and Neck Neoplasms - pathology | Carcinoma, Squamous Cell - drug therapy | Cyclin E - analysis | rho GTP-Binding Proteins - metabolism | Cell Line, Tumor | Protein Biosynthesis - drug effects | Cell Proliferation - drug effects | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | G1 Phase Cell Cycle Checkpoints - drug effects | Cyclin E - drug effects | Index Medicus | Report
Journal Article
Neuron, ISSN 0896-6273, 2010, Volume 67, Issue 1, pp. 49 - 60
Using the photopigment melanopsin, intrinsically photosensitive retinal ganglion cells (ipRGCs) respond directly to light to drive circadian clock resetting... 
SYSNEURO | DEVBIO | MOLNEURO | Sysneuro | Devbio | Molneuro | SYSTEM | RESPONSES | LIGHT | MOUSE | SPATIAL VISION | KNOCKOUT MICE | PROJECTIONS | CONE | HYPOTHALAMIC SUPRACHIASMATIC NUCLEUS | NEUROSCIENCES | REVEALS | Alkaline Phosphatase - metabolism | Green Fluorescent Proteins - genetics | Membrane Potentials - radiation effects | Retinal Ganglion Cells - metabolism | Patch-Clamp Techniques - methods | Space Perception - physiology | Vision, Ocular - physiology | Nystagmus, Optokinetic - genetics | Retina - cytology | Light | Rod Opsins - metabolism | Transducin - metabolism | Rod Opsins - deficiency | Light Signal Transduction - physiology | Cyclic Nucleotide-Gated Cation Channels - metabolism | Transducin - genetics | GTP-Binding Protein alpha Subunits - metabolism | Maze Learning - physiology | Gene Expression Regulation - genetics | Cyclic Nucleotide-Gated Cation Channels - genetics | GTP-Binding Protein alpha Subunits - genetics | Circadian Rhythm | Membrane Potentials - physiology | Visual Acuity - genetics | Mice, Knockout | Animals | Photoreceptor Cells - metabolism | Neural Pathways - metabolism | Mice | Visual Cortex - metabolism | Eye Enucleation - methods | In Vitro Techniques | Physiological aspects | Neurosciences | Universities and colleges | Neurons | Visual perception | Proteins | Brain | Retina | Gene expression | Index Medicus | melanopsin | ipRGCs | visual water task | pupillary light response | retinal ganglion cells | OPN | optokinetic tracking | circadian photoentrainment | SCN
Journal Article