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Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7409, pp. 106 - 110
Medulloblastomas are themost commonmalignant brain tumours in children(1). Identifying and understanding the genetic events that drive these tumours is... 
COMPLEX | STRUCTURAL BASIS | LANDSCAPE | CHILDHOOD | MULTIDISCIPLINARY SCIENCES | GENES | Transcription Factors - chemistry | Humans | Hedgehog Proteins - metabolism | Wnt Proteins - metabolism | Promoter Regions, Genetic - genetics | Tumor Suppressor Protein p53 - genetics | TCF Transcription Factors - metabolism | Patched Receptors | Cerebellar Neoplasms - classification | DEAD-box RNA Helicases - metabolism | Medulloblastoma - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Child | DEAD-box RNA Helicases - chemistry | DNA Helicases - genetics | Intracellular Signaling Peptides and Proteins - genetics | DNA Helicases - chemistry | Histone-Lysine N-Methyltransferase - genetics | Signal Transduction | Models, Molecular | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Protein Structure, Tertiary - genetics | Cerebellar Neoplasms - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Nuclear Proteins - chemistry | beta Catenin - metabolism | Genome, Human - genetics | beta Catenin - genetics | DEAD-box RNA Helicases - genetics | Exome - genetics | Histone-Lysine N-Methyltransferase - metabolism | LIM Domain Proteins - genetics | Medulloblastoma - classification | Patched-1 Receptor | Receptors, Cell Surface - genetics | Medulloblastoma | Physiological aspects | Development and progression | Genetic aspects | Research | Nucleotide sequencing | Metastasis | DNA sequencing | Cancer | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7339, pp. 467 - 472
Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenesis is poorly understood. Here we report the massively parallel sequencing of 38... 
PATHOGENESIS | B-CELL LYMPHOMA | BLIMP-1 | GENE | MULTIDISCIPLINARY SCIENCES | STRESS-RESPONSE | EXOSOME | CLASSIFICATION | DIFFERENTIATION | HUMAN CANCER | SOMATIC MUTATIONS | Ribonucleases - genetics | Ribonucleases - chemistry | Genomics | Humans | Molecular Sequence Data | NF-kappa B - metabolism | DNA Repair - genetics | Multiple Myeloma - drug therapy | DNA Mutational Analysis | Protein Biosynthesis - genetics | Multiple Myeloma - enzymology | Proto-Oncogene Proteins B-raf - metabolism | Amino Acid Sequence | Oncogenes - genetics | Models, Molecular | Exons - genetics | Signal Transduction - genetics | Multiple Myeloma - metabolism | Mutation - genetics | Open Reading Frames - genetics | Genome, Human - genetics | Homeodomain Proteins - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | RNA Processing, Post-Transcriptional - genetics | Proto-Oncogene Proteins B-raf - genetics | CpG Islands - genetics | Blood Coagulation - genetics | Protein Conformation | Histones - metabolism | Transcription, Genetic - genetics | Exosome Multienzyme Ribonuclease Complex | Methylation | Homeostasis - genetics | Multiple Myeloma - genetics | Usage | Multiple myeloma | Development and progression | Genetic aspects | Research | Nucleotide sequencing | Methods | Cancer | Proteins | Pathogenesis | Homeostasis | Genetics | Genomes | Mutation | Kinases | Mass spectrometry | Index Medicus
Journal Article
2007, ISBN 9781588298829, 2 v.
Particular attention is given to apoptosis in human diseasesAll of the contributors are at the forefront of scientific discovery. 
genetics | Signal Transduction | Cell Transformation, Neoplastic | Gene Therapy | physiology | Cellular signal transduction | Pathology, Molecular | Apoptosis | Cytology | Life Sciences | Cell Biology
Book
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7413, pp. 660 - 664
Journal Article
by Burk, Robert D and Chen, Zigui and Saller, Charles and Tarvin, Katherine and Carvalho, Andre L and Scapulatempo-Neto, Cristovam and Silveira, Henrique C and Fregnani, José H and Creighton, Chad J and Anderson, Matthew L and Castro, Patricia and Wang, Sophia S and Yau, Christina and Benz, Christopher and Gordon Robertson, A and Mungall, Karen and Lim, Lynette and Bowlby, Reanne and Sadeghi, Sara and Brooks, Denise and Sipahimalani, Payal and Mar, Richard and Ally, Adrian and Clarke, Amanda and Mungall, Andrew J and Tam, Angela and Lee, Darlene and Chuah, Eric and Schein, Jacqueline E and Tse, Kane and Kasaian, Katayoon and Ma, Yussanne and Marra, Marco A and Mayo, Michael and Balasundaram, Miruna and Thiessen, Nina and Dhalla, Noreen and Carlsen, Rebecca and Moore, Richard A and Holt, Robert A and Jones, Steven J. M and Wong, Tina and Pantazi, Angeliki and Parfenov, Michael and Kucherlapati, Raju and Hadjipanayis, Angela and Seidman, Jonathan and Kucherlapati, Melanie and Ren, Xiaojia and Xu, Andrew W and Yang, Lixing and Park, Peter J and Lee, Semin and Rabeno, Brenda and Huelsenbeck-Dill, Lori and Borowsky, Mark and Cadungog, Mark and Iacocca, Mary and Petrelli, Nicholas and Swanson, Patricia and Ojesina, Akinyemi I and Ojesina, Akinyemi I and Ojesina, Akinyemi I and Le, Xuan and Sandusky, George and Adebamowo, Sally N and Akeredolu, Teniola and Adebamowo, Clement and Reynolds, Sheila M and Shmulevich, Ilya and Shelton, Candace and Crain, Daniel and Mallery, David and Curley, Erin and Gardner, Johanna and Penny, Robert and Morris, Scott and Shelton, Troy and Liu, Jia and Lolla, Laxmi and Chudamani, Sudha and Wu, Ye and Birrer, Michael and McLellan, Michael D and Bailey, Matthew H and Miller, Christopher A and Wyczalkowski, Matthew A and Fulton, Robert S and Fronick, Catrina C and Lu, Charles and Mardis, Elaine R and Appelbaum, Elizabeth L and Schmidt, Heather K and Fulton, Lucinda A and Cordes, Matthew G and Li, Tiandao and Ding, Li and Wilson, Richard K and Rader, Janet S and Behmaram, Behnaz and ... and Canc Genome Atlas Res Network and Eli &Edythe L. Broad Institute of Massachusetts Institute of Technology &Harvard University and Research Institute at Nationwide Children's Hospital and University of Alabama at Birmingham and McDonnell Genome Institute at Washington University and Washington University in St Louis and University of Wisconsin School of Medicine &Public Health and National Hospital, Abuja, Nigeria and Baylor College of Medicine and Barretos Cancer Hospital and Indiana University School of Medicine and Ontario Tumour Bank, The Ottawa Hospital and Massachusetts General Hospital and University of New Mexico Health Sciences Center and National Institute on Deafness &Other Communication Disorders and University of North Carolina at Chapel Hill and Buck Institute for Research on Aging and Cancer Genome Atlas Research Network and Medical College of Wisconsin and University of Abuja Teaching Hospital and University of Oklahoma Health Sciences Center and Institute of Human Virology and St Joseph's Candler Health System and University of Pittsburgh and University of Texas MD Anderson Cancer Center and National Cancer Institute and Montefiore Medical Center and University of Southern California and Institute for Systems Biology and University of Washington and Analytical Biological Services and Harvard Medical School and National Human Genome Research Institute and Memorial Sloan Kettering Cancer Center and Medical University of South Carolina and Ontario Tumour Bank, London Health Sciences Centre and SRA International and University of Kansas Medical Center and University of Lausanne and ILSbio, LLC and University of Bergen and University of California, Irvine and Canada's Michael Smith Genome Sciences Centre and International Genomics Consortium and Oregon Health &Science University and NantOmics and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University and University of São Paulo, Ribeir ão Preto Medical School and HudsonAlpha Institute for Biotechnology and Albert Einstein College of Medicine and Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center and National Institute of Environmental Health Sciences and Van Andel Research Institute and Ontario Tumour Bank, Ontario Institute for Cancer Research and University of California Santa Cruz and Beckman Research Institute of City of Hope and Leidos Biomedical and Helen F. Graham Cancer Center &Research Institute at Christiana Care Health Services and The Cancer Genome Atlas Research Network
Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7645, pp. 378 - 384
Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary... 
TRANSCRIPTION FACTORS | BREAST-CANCER | TO-MESENCHYMAL TRANSITION | ACCURATE | DNA METHYLATION | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | 14-3-3-SIGMA | RESISTANCE | EXPRESSION | SIGNATURE | Receptors, Transforming Growth Factor beta - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Carcinoma, Squamous Cell - genetics | Genomics | Humans | APOBEC-1 Deaminase - genetics | Phosphatidylinositol 3-Kinases - metabolism | Molecular Targeted Therapy | Caspase 8 - genetics | Mitogen-Activated Protein Kinase Kinases - metabolism | Human papillomavirus 16 - isolation & purification | Female | Adenocarcinoma - genetics | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | PTEN Phosphohydrolase - genetics | Signal Transduction | Programmed Cell Death 1 Ligand 2 Protein - genetics | Protein-Serine-Threonine Kinases - genetics | Uterine Cervical Neoplasms - drug therapy | RNA, Long Noncoding - genetics | Receptor, ErbB-3 - genetics | Transcription Factors - genetics | Uterine Cervical Neoplasms - genetics | Virus Integration | B7-H1 Antigen - genetics | Receptors, Transforming Growth Factor beta - metabolism | HLA-A Antigens - genetics | Proteomics | Mutation | Keratins - genetics | Human papillomavirus 16 - genetics | Uterine Cervical Neoplasms - classification | Causes of | Care and treatment | Genetic aspects | Gene mutations | Health aspects | Cervical cancer | Human papillomavirus | Gynecology | Molecular biology | Cancer therapies | Tumors | Index Medicus
Journal Article
by Kool, Marcel and Jones, David T.W and Jäger, Natalie and Northcott, Paul A and Pugh, Trevor J and Hovestadt, Volker and Piro, Rosario M and Esparza, L. Adriana and Markant, Shirley L and Remke, Marc and Milde, Till and Bourdeaut, Franck and Ryzhova, Marina and Sturm, Dominik and Pfaff, Elke and Stark, Sebastian and Hutter, Sonja and Şeker-Cin, Huriye and Johann, Pascal and Bender, Sebastian and Schmidt, Christin and Schmidt, Sabine and Rausch, Tobias and Shih, David and Reimand, Jüri and Sieber, Laura and Wittmann, Andrea and Linke, Linda and Witt, Olaf and Witt, Hendrik and Weber, Ursula D and Zapatka, Marc and König, Rainer and Beroukhim, Rameen and Bergthold, Guillaume and van Sluis, Peter and Volckmann, Richard and Koster, Jan and Versteeg, Rogier and Wolf, Stephan and Lawerenz, Chris and Bartholomae, Cynthia C and von Kalle, Christof and Unterberg, Andreas and Herold-Mende, Christel and Hofer, Silvia and Kulozik, Andreas E and von Deimling, Andreas and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Hasselblatt, Martin and Crawford, John R and Grant, Gerald A and Jabado, Nada and Perry, Arie and Cowdrey, Cynthia and Croul, Sydney and Zadeh, Gelareh and Korbel, Jan O and Doz, Francois and Delattre, Olivier and Bader, Gary D and McCabe, Martin G and Collins, V. Peter and Kieran, Mark W and Cho, Yoon-Jae and Pomeroy, Scott L and Brors, Benedikt and Taylor, Michael D and Schüller, Ulrich and Korshunov, Andrey and Eils, Roland and Wechsler-Reya, Robert J and Lichter, Peter and Pfister, Stefan M and ICGC PedBrain Tumor Project
Cancer Cell, ISSN 1535-6108, 03/2014, Volume 25, Issue 3, pp. 393 - 405
Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB). Clinical response is highly variable. To... 
NERVOUS-SYSTEM | TERT PROMOTER MUTATIONS | ONCOLOGY | GROWTH | HEDGEHOG PATHWAY INHIBITOR | ITRACONAZOLE | PEDIATRIC MEDULLOBLASTOMA | CANCER | TUMORS | MOUSE MODELS | ADULT | CELL BIOLOGY | Neoplasm Transplantation | Oncogene Proteins - genetics | Humans | Zinc Finger Protein Gli2 | Child, Preschool | Molecular Sequence Data | Infant | Male | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - metabolism | Biphenyl Compounds - therapeutic use | Promoter Regions, Genetic - genetics | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Young Adult | Telomerase - genetics | Hedgehog Proteins - genetics | Base Sequence | Smoothened Receptor | Adult | Female | N-Myc Proto-Oncogene Protein | Patched Receptors | Medulloblastoma - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Child | Pyridines - therapeutic use | Cerebellar Neoplasms - drug therapy | Repressor Proteins - genetics | DNA Copy Number Variations - genetics | Signal Transduction - genetics | Cerebellar Neoplasms - genetics | Mice, SCID | Phosphatidylinositol 3-Kinases - genetics | DEAD-box RNA Helicases - genetics | Drug Resistance, Neoplasm - genetics | Animals | Adolescent | Receptors, G-Protein-Coupled - antagonists & inhibitors | Mice, Inbred NOD | High-Throughput Nucleotide Sequencing | Mice | Receptors, G-Protein-Coupled - genetics | Medulloblastoma - drug therapy | Kruppel-Like Transcription Factors - genetics | Patched-1 Receptor | Receptors, Cell Surface - genetics | Genetic aspects | Nucleotide sequencing | Analysis | Medulloblastoma | Genomics | DNA sequencing | Index Medicus
Journal Article
by Jones, David T. W and Jäger, Natalie and Kool, Marcel and Zichner, Thomas and Hutter, Barbara and Sultan, Marc and Cho, Yoon-Jae and Pugh, Trevor J and Hovestadt, Volker and Stütz, Aian M and Rausch, Tobias and Warnatz, Hans-Jörg and Ryzhova, Marina and Bender, Sebastian and Sturm, Dominik and Pleier, Sabrina and Cin, Huriye and Pfaff, Elke and Sieber, Laura and Wittmann, Anea and Remke, Marc and Witt, Henik and Hutter, Sonja and Tzaridis, Theophilos and Weischenfeldt, Joachim and Raeder, Benjamin and Avci, Meryem and Amstislavskiy, Vyacheslav and Zapatka, Marc and Weber, Ursula D and Wang, Qi and Lasitschka, Bärbel and Bartholomae, Cynthia C and Schmidt, Manfred and von Kalle, Christof and Ast, Volker and Lawerenz, Chris and Eils, Jürgen and Kabbe, Rolf and Benes, Vladimir and van Sluis, Peter and Koster, Jan and Volckmann, Richard and Shih, David and Betts, Matthew J and Russell, Robert B and Coco, Simona and Tonini, Gian Paolo and Schüller, Ulrich and Hans, Volkmar and Graf, Norbert and Kim, Yoo-Jin and Monoranu, Camelia and Roggendorf, Wolfgang and Unterberg, Aneas and Herold-Mende, Christel and Milde, Till and Kulozik, Aneas E and von Deimling, Aneas and Witt, Olaf and Maass, Eberhard and Rössler, Jochen and Ebinger, Martin and Schuhmann, Martin U and Frühwald, Michael C and Hasselblatt, Martin and Jabado, Nada and Rutkowski, Stefan and von Bueren, Ané O and Williamson, Dan and Clifford, Steven C and McCabe, Martin G and Collins, V. Peter and Wolf, Stephan and Wiemann, Stefan and Lehrach, Hans and Brors, Benedikt and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Northcott, Paul A and Taylor, Michael D and Meyerson, Matthew and Pomeroy, Scott L and Yaspo, Marie-Laure and Korbel, Jan O and Korshunov, Aney and Eils, Roland and Pfister, Stefan M and Lichter, Peter
Nature, ISSN 0028-0836, 2012, Volume 488, Issue 7409, pp. 100 - 105
Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain stem. It is the most common malignant brain tumour in children,... 
ACTIVATION | PATHWAY | LANDSCAPE | MULTIDISCIPLINARY SCIENCES | GENES | TETRAPLOID TUMOR-CELLS | TBR1 | MUTATIONS | SUBGROUPS | CANCER | Chromatin - metabolism | Cerebellar Neoplasms - diagnosis | Genomics | Humans | Hedgehog Proteins - metabolism | Wnt Proteins - metabolism | Histone Demethylases - genetics | Aging - genetics | Medulloblastoma - pathology | Cerebellar Neoplasms - pathology | Patched Receptors | Cerebellar Neoplasms - classification | Medulloblastoma - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Child | DNA Helicases - genetics | Amino Acid Sequence | Polyploidy | Signal Transduction | Chromosomes, Human - genetics | Medulloblastoma - diagnosis | Mutation Rate | Cerebellar Neoplasms - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | T-Box Domain Proteins - genetics | Genome, Human - genetics | beta Catenin - genetics | DEAD-box RNA Helicases - genetics | Phosphoprotein Phosphatases - genetics | Sequence Analysis, RNA | Cell Transformation, Neoplastic | Oncogene Proteins, Fusion - genetics | High-Throughput Nucleotide Sequencing | Methylation | Medulloblastoma - classification | Patched-1 Receptor | Receptors, Cell Surface - genetics | Medulloblastoma | Physiological aspects | Development and progression | Genetic aspects | Research | Metastasis | Cancer | Index Medicus
Journal Article