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Nature, ISSN 0028-0836, 05/2018, Volume 557, Issue 7707, pp. 724 - 728
Microglia and astrocytes modulate inflammation and neurodegeneration in the central nervous system (CNS)(1-3). Microglia modulate pro-inflammatory and... 
ACTIVATION | ARYL-HYDROCARBON RECEPTOR | MULTIDISCIPLINARY SCIENCES | TGF-ALPHA | CENTRAL-NERVOUS-SYSTEM | SPINAL-CORD-INJURY | DIVERSITY | VEGF-B | EXPRESSION | CNS INFLAMMATION | ENDOTHELIAL GROWTH-FACTOR | Inflammation - pathology | Microglia - metabolism | Central Nervous System - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Astrocytes - pathology | Central Nervous System - pathology | Vascular Endothelial Growth Factor B - biosynthesis | Tryptophan - metabolism | Lipopolysaccharide Receptors - metabolism | Inflammation - metabolism | Tryptophan - deficiency | Microglia - pathology | Receptors, Aryl Hydrocarbon - metabolism | Female | Transforming Growth Factor alpha - metabolism | Central Nervous System - microbiology | Disease Models, Animal | Encephalomyelitis, Autoimmune, Experimental - microbiology | Multiple Sclerosis - metabolism | Transforming Growth Factor alpha - biosynthesis | Symbiosis | Inflammation - microbiology | Encephalomyelitis, Autoimmune, Experimental - pathology | ErbB Receptors - metabolism | Mice, Inbred C57BL | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Animals | Vascular Endothelial Growth Factor B - metabolism | Encephalomyelitis, Autoimmune, Experimental - prevention & control | Multiple Sclerosis - pathology | Inflammation - prevention & control | Mice | Astrocytes - metabolism | Physiological aspects | Microbiological research | Metabolites | Transforming growth factors | Astrocytes | Vascular endothelial growth factor | Regulators | Multiple sclerosis | Encephalomyelitis | Transcription | Central nervous system | Hydrocarbons | Nervous system | CD14 antigen | Recruitment | Angiogenesis | Signal transduction | Neurotoxicity | Microorganisms | Neurodegeneration | Aromatic compounds | Bone marrow | ErbB-1 protein | Tryptophan | Inflammation | Gene expression | Experimental allergic encephalomyelitis | Microglia | Neurological diseases | Diet | Lymphocytes B | Flora | Spinal cord injuries | Alzheimers disease | Life Sciences | Immunology
Journal Article
Cellular Signalling, ISSN 0898-6568, 05/2014, Volume 26, Issue 5, pp. 1030 - 1039
Sorafenib, the first-line systemic drug for advanced hepatocellular carcinoma (HCC), has demonstrated limited benefits with very low response rates. Thus it is... 
Hepatocellular carcinoma | Hypoxia | Hypoxia-inducible factor-2 α | Epidermal growth factor receptor-α | Sorafenib | Transforming growth factor-α | Hypoxia-inducible factor-2 alpha | DOXORUBICIN | Transforming growth factor-alpha | CANCER | EGFR | HYPOXIA-INDUCIBLE FACTORS | CELL BIOLOGY | GROWTH-FACTOR RECEPTOR | OVEREXPRESSION | Epidermal growth factor receptor-alpha | HIF-1-ALPHA | EXPRESSION | PROMOTES | Niacinamide - analogs & derivatives | Receptor, Epidermal Growth Factor - genetics | Humans | Gene Expression Regulation, Neoplastic | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacology | Transforming Growth Factor alpha - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Transforming Growth Factor alpha - antagonists & inhibitors | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Transforming Growth Factor alpha - genetics | Up-Regulation - drug effects | Drug Resistance, Neoplasm - genetics | Animals | Signal Transduction - drug effects | Mice, Nude | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Mice, Inbred BALB C | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Quinazolines - pharmacology | Carcinoma, Hepatocellular - metabolism | Cellular | Inhibitors | Effectiveness | Pathways | Activation | Growth factors | Apoptosis | Tumors
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 3/2004, Volume 164, Issue 5, pp. 769 - 779
All ligands of the epidermal growth factor receptor (EGFR), which has important roles in development and disease, are released from the membrane by proteases.... 
EGF receptor | Growth factor signaling | EGF receptor ligands | ADAMs | Ectodomain shedding | CELLS | ectodomain shedding | HB-EGF | TACE | PROTEIN-COUPLED RECEPTORS | ALPHA-CONVERTING-ENZYME | growth factor signaling | MICE LACKING | FAMILY | CELL BIOLOGY | EPIDERMAL-GROWTH-FACTOR | TGF-ALPHA | METALLOPROTEASE-DISINTEGRIN | ADAM17 Protein | Metalloendopeptidases - genetics | Phenylalanine - analogs & derivatives | Glycoproteins - metabolism | Metalloendopeptidases - metabolism | Thiophenes - metabolism | Epiregulin | Amphiregulin | Disintegrins - genetics | ADAM12 Protein | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | EGF Family of Proteins | Embryo, Mammalian - anatomy & histology | Aspartic Acid Endopeptidases | Amyloid Precursor Protein Secretases | Muscle Proteins - metabolism | Membrane Proteins - metabolism | Transforming Growth Factor alpha - metabolism | Fibroblasts - metabolism | Tetradecanoylphorbol Acetate - metabolism | Protein Structure, Tertiary | Endopeptidases - metabolism | Phenylalanine - metabolism | Disintegrins - metabolism | Membrane Proteins - genetics | Cells, Cultured | Epidermal Growth Factor - metabolism | Genotype | Protease Inhibitors - metabolism | ADAM Proteins | Mice, Knockout | Muscle Proteins - genetics | Heparin-binding EGF-like Growth Factor | Animals | Endopeptidases - genetics | Betacellulin | Ligands | Fibroblasts - cytology | Mice | Cytology | Research | Proteins | Enzymes | Cellular biology | Rodents | EGF receptor; EGF receptor ligands; ADAMs; ectodomain shedding; growth factor signaling
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 08/2010, Volume 207, Issue 8, pp. 1617 - 1624
The protease a disintegrin and metalloprotease (ADAM) 17 cleaves tumor necrosis factor (TNF), L-selectin, and epidermal growth factor receptor (EGF-R) ligands... 
MEDICINE, RESEARCH & EXPERIMENTAL | STAT3 ACTIVATION | EPITHELIAL-CELLS | SULFATE-INDUCED COLITIS | EPIDERMAL-GROWTH-FACTOR | IN-VIVO | DISEASE | IMMUNOLOGY | FACTOR RECEPTOR | CANCER | T-CELLS | FACTOR-ALPHA | ADAM17 Protein | Tumor Necrosis Factor-alpha - metabolism | Cyclin D1 - metabolism | Epithelial Cells - metabolism | Animal Structures - abnormalities | Gene Expression - genetics | Epithelial Cells - drug effects | Inflammatory Bowel Diseases - immunology | Gene Expression Profiling | L-Selectin - metabolism | Brain - metabolism | Mammary Glands, Animal - growth & development | Receptors, Tumor Necrosis Factor, Type II - blood | Inflammatory Bowel Diseases - enzymology | Intestinal Mucosa - immunology | Inflammatory Bowel Diseases - pathology | Intestinal Mucosa - enzymology | Female | Inflammatory Bowel Diseases - chemically induced | Phosphorylation - drug effects | Epithelial Cells - cytology | Transforming Growth Factor alpha - metabolism | STAT3 Transcription Factor - metabolism | Transforming Growth Factor alpha - pharmacology | Dextran Sulfate - pharmacology | Cytokines - metabolism | Colon - pathology | Liver - metabolism | Mice, Inbred C57BL | ADAM Proteins - deficiency | Mice, Transgenic | Permeability | Colon - metabolism | Intestinal Mucosa - physiology | Regeneration | ADAM Proteins - metabolism | Animals | Cell Proliferation - drug effects | Chemokines - metabolism | Mice | ADAM Proteins - genetics | Animal Structures - metabolism | Intestinal Mucosa - pathology | Peroxidase - metabolism | Brief Definitive Report
Journal Article
Traffic, ISSN 1398-9219, 2009, Volume 10, Issue 8, pp. 1115 - 1127
We have compared the effect of six different ligands on endocytic trafficking of EGFR. We find that, whereas they all stimulate receptor internalization, they... 
Epidermal growth factor | Betacellulin | Heparin-binding EGF-like growth factor | Transforming growth factor-α | Endocytic trafficking | Epiregulin | Amphiregulin | Epidermal growth factor receptor | betacellulin | heparin-binding EGF-like growth factor | transforming growth factor-alpha | epidermal growth factor receptor | CBL | METASTATIC COLORECTAL-CANCER | FACTOR-ALPHA | CELL BIOLOGY | amphiregulin | UBIQUITINATION | CETUXIMAB | INTERNALIZATION | epiregulin | EPIDERMAL-GROWTH-FACTOR | DEGRADATION | endocytic trafficking | epidermal growth factor | ERBB RECEPTORS | Cell Line | Receptor, Epidermal Growth Factor - genetics | Phosphorylation | Proto-Oncogene Proteins c-cbl - metabolism | Vesicular Transport Proteins - metabolism | Humans | Glycoproteins - metabolism | Epidermal Growth Factor - metabolism | Protein Transport - physiology | Endocytosis - physiology | Heparin-binding EGF-like Growth Factor | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Ubiquitination | Animals | EGF Family of Proteins | Ligands | Lysosomal-Associated Membrane Protein 1 - metabolism | Signal Transduction - physiology | Transforming Growth Factor alpha - metabolism | Hydrogen-Ion Concentration | Ubiquitin | Universities and colleges | Transforming growth factors | Ligases | transforming growth factor-α | Original
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 06/2014, Volume 89, Issue 4, pp. 453 - 463
Osteosarcoma is the most common primary malignancy of bone and is characterized by a high malignant and metastatic potential. Transforming growth factor alpha... 
Osteosarcoma | TGF-α | Migration | TGF-alpha | ADHESION MOLECULES | HUMAN CHONDROSARCOMA CELLS | BREAST-CANCER CELLS | HEPATOCELLULAR-CARCINOMA | GASTRIC-CANCER | COLORECTAL-CANCER | PI3K-AKT PATHWAY | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | TRANSGENIC MICE | Osteosarcoma - drug therapy | Receptor, Epidermal Growth Factor - agonists | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Male | NF-kappa B - metabolism | Antineoplastic Agents - therapeutic use | Bone Neoplasms - pathology | Proto-Oncogene Proteins c-akt - genetics | Bone Neoplasms - metabolism | Receptor, Epidermal Growth Factor - metabolism | Lung Neoplasms - secondary | RNA Interference | Antineoplastic Agents - pharmacology | Bone Neoplasms - drug therapy | Proto-Oncogene Proteins c-akt - metabolism | Transforming Growth Factor alpha - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Osteosarcoma - metabolism | Recombinant Proteins - metabolism | NF-kappa B - antagonists & inhibitors | Second Messenger Systems - drug effects | Transforming Growth Factor alpha - antagonists & inhibitors | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Mice, SCID | Transforming Growth Factor alpha - genetics | Phosphatidylinositol 3-Kinase - chemistry | Up-Regulation - drug effects | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Intercellular Adhesion Molecule-1 - metabolism | Animals | Intercellular Adhesion Molecule-1 - chemistry | Lung Neoplasms - prevention & control | NF-kappa B - genetics | Phosphatidylinositol 3-Kinase - genetics | Tumor Burden - drug effects | Intercellular Adhesion Molecule-1 - genetics | Proto-Oncogene Proteins c-akt - agonists | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Osteosarcoma - secondary | Osteosarcoma - pathology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Metastasis
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2015, Volume 10, Issue 2, p. e0116799
Oral mucositis (OM) is a common complication of treatments for head and neck cancer, particularly radiotherapy with or without chemotherapy. OM is... 
RECEPTOR BLOCKER | ACTIVATION | CYTOKINES | CELL-MIGRATION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | GROWTH-FACTORS | WOUND MACROPHAGES | EXPERIMENTAL PERIODONTITIS | PREVENTION | CANCER | Tumor Necrosis Factor-alpha - metabolism | Up-Regulation | Cricetinae | Cytokines - metabolism | Male | Vascular Endothelial Growth Factor A - metabolism | Stomatitis - metabolism | Fibroblast Growth Factors - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Bacteremia - metabolism | Fibroblast Growth Factor 7 - metabolism | Oxadiazoles - adverse effects | Animals | Stomatitis - pathology | Interleukin-1beta - metabolism | Stomatitis - chemically induced | Interleukin-10 - metabolism | Benzimidazoles - adverse effects | Transforming Growth Factor alpha - metabolism | Leukocytes - metabolism | Disease Models, Animal | Peroxidase - metabolism | Immunohistochemistry | Transcription factors | 5-Fluorouracil | Pathogenesis | Mucosa | Transforming growth factor | Damage prevention | Cancer therapies | Metastases | Fibroblasts | Vascular endothelial growth factor | Public health | Head | Wound healing | Mucositis | Granulation | Cytokines | Keratinocyte growth factor | Chemotherapy | Morphology | Interleukin 10 | Infiltration | Animal welfare | AZT | Erythema | Fibroblast growth factor | Cheek | Interleukin | Kinases | Ethics | Pain | Rodents | Interleukin 1 | Tumor necrosis factor-TNF | Peroxidase | Neck | Angiotensin II | Enzyme-linked immunosorbent assay | Hypertension | Neutrophils | Inflammation | Pharmacology | Radiation therapy | Biophysics | Variance analysis | Hamsters | Angiotensin | Head and neck cancer | Cheek pouch | Tumors | Cancer
Journal Article