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Oncogene, ISSN 1476-5594, 2010, Volume 29, Issue 49, pp. 6485 - 6498
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 3, p. e90353
Background: In advanced cancers, transforming growth factor-beta (TGFb) promotes tumor growth and metastases and suppresses host antitumor immunity... 
SURVIVAL | EPITHELIAL-MESENCHYMAL TRANSDIFFERENTIATION | INHIBITION | SOLID TUMORS | EFFICACY | VIVO | MULTIDISCIPLINARY SCIENCES | METASTATIC BREAST-CANCER | KERATOACANTHOMAS | T-CELLS | PROGRESSION | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Male | Tomography, X-Ray Computed | Antineoplastic Agents - therapeutic use | Positron-Emission Tomography | Kidney Neoplasms - diagnosis | Aged, 80 and over | Transforming Growth Factor beta - antagonists & inhibitors | Adult | Female | Antineoplastic Agents - pharmacology | Carcinoma, Renal Cell - drug therapy | Carcinoma, Renal Cell - pathology | Antibodies, Monoclonal - pharmacology | Treatment Outcome | Melanoma - pathology | Transforming Growth Factor beta - blood | Carcinoma, Renal Cell - diagnosis | Melanoma - drug therapy | Kidney Neoplasms - pathology | Aged | Kidney Neoplasms - drug therapy | Neoplasm Staging | Oncology, Experimental | Melanoma | Clinical trials | Monoclonal antibodies | Bone morphogenetic proteins | Research | Carcinoma, Renal cell | Metastasis | Transforming growth factors | Cancer | Intravenous administration | Toxicity | Transforming growth factor-b | Medical treatment | Transforming growth factor-a | Pharmacology | Patients | Immunity | Constraining | Metastases | Anticancer properties | Isoforms | Biomarkers | Antitumor activity | Safety | Clear cell-type renal cell carcinoma
Journal Article
Sports Medicine, ISSN 0112-1642, 2003, Volume 33, Issue 5, pp. 381 - 394
.... Growth factors represent one of the most important of the molecular families involved in healing, and a considerable number of studies have been undertaken in an effort to elucidate their many functions... 
Tendon injuries | Connective tissue disorders | Growth factors, pharmacodynamics | Medicine & Public Health | Sports Medicine | SPORT SCIENCES | FACTOR-BETA | MEDIAL COLLATERAL LIGAMENT | MESSENGER-RNA | FACTOR-BB | RAT | TISSUE-REPAIR | FACTOR EXPRESSION | FACTOR-I | MODEL | BINDING-PROTEINS | Vascular Endothelial Growth Factor A | Insulin-Like Growth Factor I - pharmacology | Tendons - drug effects | Vascular Endothelial Growth Factors | Humans | Fibroblast Growth Factor 2 - pharmacology | Tendon Injuries - physiopathology | Endothelial Growth Factors - pharmacology | Intercellular Signaling Peptides and Proteins - physiology | Ligaments - physiopathology | Fibroblast Growth Factor 2 - physiology | Lymphokines - pharmacology | Wound Healing - drug effects | Endothelial Growth Factors - physiology | Ligaments - drug effects | Lymphokines - physiology | Transforming Growth Factor beta - physiology | Platelet-Derived Growth Factor - pharmacology | Transforming Growth Factor beta - pharmacology | Tendons - physiopathology | Animals | Insulin-Like Growth Factor I - physiology | Growth Substances - physiology | Intercellular Signaling Peptides and Proteins - pharmacology | Growth Substances - pharmacology | Wound Healing - physiology | Platelet-Derived Growth Factor - physiology
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2017, Volume 94, Issue 4, pp. 759 - 773.e8
... ramified adult microglia under defined-medium conditions. We find that astrocyte-derived factors prevent microglial death ex... 
CSF1R | phagocytosis | maturation | inflammation | neurodegeneration | TGF-β | cholesterol | transplant | microglia | astrocyte | IDENTITY | GROWTH-FACTOR-BETA | PROGENITOR-CELL | BRAIN-INJURY | RNA-SEQ | ASTROCYTE | MACROPHAGES | MOUSE | RAMIFICATION | EXPRESSION | NEUROSCIENCES | Microglia - metabolism | Transforming Growth Factor beta2 - metabolism | Humans | Transcriptome | Interleukins - metabolism | Microglia - immunology | Macrophage Colony-Stimulating Factor - pharmacology | Serum | Cell Culture Techniques | Interleukins - pharmacology | Microglia - cytology | Cell Survival - drug effects | Phagocytosis - drug effects | Microglia - drug effects | Phagocytosis - immunology | Rats | Macrophage Colony-Stimulating Factor - metabolism | Cholesterol - metabolism | Transforming Growth Factor beta2 - pharmacology | Transforming Growth Factor beta - pharmacology | Animals | Cholesterol - pharmacology | Mice | Transforming Growth Factor beta - metabolism | Astrocytes - metabolism | Culture Media, Conditioned - metabolism | Medical colleges | Bone morphogenetic proteins | Macrophages | Transforming growth factors | Gene expression | Neurophysiology | Genes | Cell culture | Cell survival | Macrophage colony-stimulating factor | Central nervous system | Homeostasis | Exposure | Survival | Cholesterol | Microglia | Phagocytes | Rodents | Morphology | Growth factors
Journal Article
Breast cancer research : BCR, ISSN 1465-542X, 2013, Volume 15, Issue 6, pp. R106 - R106
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 1, p. e54001
... of extracellular matrix (ECM) proteins [1], [2]. It has been demonstrated that transforming growth factor-beta1 (TGF-beta1) is the most important growth factor in inducing... 
GROWTH-FACTOR-BETA | SOLID TUMORS | OBSTRUCTIVE NEPHROPATHY | MULTIDISCIPLINARY SCIENCES | CARDIAC-HYPERTROPHY | INTERSTITIAL FIBROSIS | INJURY | ANGIOTENSIN-II | CHRONIC KIDNEY-DISEASE | FACTOR RECEPTOR | MOLECULAR-MECHANISMS | Kidney - pathology | Transforming Growth Factor beta1 - metabolism | Actins - metabolism | Smad3 Protein - metabolism | Ureteral Obstruction - metabolism | Leukocytes - immunology | Kidney - metabolism | Receptor, Epidermal Growth Factor - metabolism | Benzamides - therapeutic use | Benzamides - pharmacology | Phosphorylation - drug effects | Ureteral Obstruction - drug therapy | Protein-Serine-Threonine Kinases - metabolism | Transforming Growth Factor beta1 - biosynthesis | Fibroblasts - metabolism | Pyridines - therapeutic use | Collagen Type I - metabolism | Kidney - drug effects | Histone Deacetylases - metabolism | Fibroblasts - pathology | Fibronectins - metabolism | Ureteral Obstruction - immunology | Gene Expression Regulation - drug effects | Acetylation - drug effects | Animals | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Fibroblasts - drug effects | Ureteral Obstruction - pathology | Fibrosis | Histone Deacetylase Inhibitors - pharmacology | Leukocytes - drug effects | Cell Proliferation - drug effects | Histone Deacetylase Inhibitors - therapeutic use | Mice | Pyridines - pharmacology | Histones - metabolism | Fibronectins | Muscle proteins | Growth factors | Collagen | Analysis | Drugs | Histone deacetylase | Phosphorylation | Smad protein | Animal models | Collagen (type I) | Nephrology | Transcription | Syngeneic grafts | Transforming growth factor-b | Smooth muscle | Activation | Kinases | Fibronectin | Medical schools | Epidermal growth factor | Actin | Rodents | Cell cycle | Fibroblasts | Ureter | Inhibition | Kidneys | Transforming growth factor-b1 | Epidermal growth factor receptors | Pulmonary arteries | Fibrils | Muscles | Medicine | Signaling | Hospitals | Kidney diseases | Cancer
Journal Article
Cancer immunology, immunotherapy, ISSN 1432-0851, 2008, Volume 58, Issue 7, pp. 1033 - 1045
Lenalidomide (Revlimid®; CC-5013) and pomalidomide (CC-4047) are IMiDs® proprietary drugs having immunomodulatory properties that have both shown activity in... 
Immunomodulatory drugs | Biomedicine | Immunology | Lenalidomide | T regulatory cells | Cancer Research | Oncology | Pomalidomide | IMiDs | MULTIPLE-MYELOMA | DENILEUKIN DIFTITOX | THERAPEUTIC IMPLICATIONS | IMiDs (R) | PERIPHERAL-BLOOD | IMMUNOLOGY | TUMOR-INFILTRATING LYMPHOCYTES | CANCER-PATIENTS | ONCOLOGY | IN-VIVO | THALIDOMIDE ANALOG | ANTITUMOR IMMUNITY | Forkhead Transcription Factors - immunology | Receptors, Nerve Growth Factor - immunology | Receptors, Transforming Growth Factor beta - immunology | Receptors, Nerve Growth Factor - drug effects | Humans | Receptors, Nerve Growth Factor - metabolism | Thalidomide - pharmacology | Colonic Neoplasms - metabolism | Receptors, OX40 - immunology | T-Lymphocytes, Regulatory - immunology | Thalidomide - analogs & derivatives | Receptors, OX40 - metabolism | Transforming Growth Factor beta - drug effects | Colonic Neoplasms - immunology | Forkhead Transcription Factors - metabolism | Interleukin-10 - metabolism | Female | Antineoplastic Agents - pharmacology | Forkhead Transcription Factors - antagonists & inhibitors | Immunosuppressive Agents - pharmacology | Receptors, Tumor Necrosis Factor - metabolism | Transforming Growth Factor beta - immunology | Glucocorticoid-Induced TNFR-Related Protein | T-Lymphocytes, Regulatory - drug effects | Animals | Receptors, Transforming Growth Factor beta - drug effects | Receptors, Transforming Growth Factor beta - metabolism | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Receptors, Tumor Necrosis Factor - immunology | Interleukin-10 - immunology | Transforming Growth Factor beta - metabolism | Receptors, Tumor Necrosis Factor - drug effects | Receptors, OX40 - antagonists & inhibitors | Care and treatment | Dexamethasone | Multiple myeloma | Angiogenesis inhibitors | Transforming growth factors | T cells | Cancer
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2009, Volume 29, Issue 28, pp. 8927 - 8935
.... Here, we identify TGF-beta pathway activation as the underlying mechanism. We demonstrate that direct activation of the TGF-beta pathway by TGF-beta 1 results in epileptiform activity similar to that after exposure to albumin... 
TEMPORAL-LOBE EPILEPSY | ALZHEIMERS-DISEASE | TRANSFORMING GROWTH-FACTOR-BETA-1 | IN-VIVO | NEOCORTICAL EPILEPTOGENESIS | STATUS EPILEPTICUS | NECROSIS-FACTOR-ALPHA | FACTOR-KAPPA-B | RAT HIPPOCAMPUS | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | Electric Stimulation - adverse effects | Rats, Wistar | Transforming Growth Factor beta2 - metabolism | gamma-Aminobutyric Acid - metabolism | Glutamic Acid - genetics | Ion Channels - genetics | Male | Epilepsy - etiology | Brain - metabolism | Transforming Growth Factor beta2 - immunology | Gene Expression - physiology | Statistics, Nonparametric | Dioxoles - pharmacology | Benzamides - pharmacology | Disease Models, Animal | Microarray Analysis - methods | Transforming Growth Factor beta - immunology | gamma-Aminobutyric Acid - genetics | Immunoprecipitation - methods | Albumins - metabolism | Brain - physiopathology | Gene Expression Regulation | Smad2 Protein - metabolism | Rats | Gene Expression Profiling - methods | Blood-Brain Barrier - drug effects | Inflammation - etiology | Epilepsy - complications | Action Potentials - physiology | Antibodies - pharmacology | Transforming Growth Factor beta - pharmacology | Animals | Transforming Growth Factor beta - genetics | Ion Channels - metabolism | Transforming Growth Factor beta2 - antagonists & inhibitors | Signal Transduction - physiology | Glutamic Acid - metabolism | Genome-Wide Association Study - methods | In Vitro Techniques | Epilepsy - pathology | Transforming Growth Factor beta - metabolism | Astrocytes - metabolism | Cluster Analysis
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2012, Volume 72, Issue 16, pp. 4119 - 4129
Journal Article
Nature (London), ISSN 1476-4687, 2014, Volume 508, Issue 7494, pp. 118 - 122
.... In contrast, colon cancers that harbour the same BRAF(V600E) mutation are intrinsically resistant to BRAF inhibitors, due to feedback activation of the epidermal growth factor receptor (EGFR... 
Antineoplastic Agents/administration & dosage | Transforming Growth Factor beta/metabolism | Humans | Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors | Indoles/administration & dosage | Flow Cytometry | Receptor, Platelet-Derived Growth Factor beta/biosynthesis | Proto-Oncogene Proteins B-raf/antagonists & inhibitors | ErbB Receptors/biosynthesis | Melanoma/drug therapy | Female | Cell Proliferation/drug effects | Sulfonamides/administration & dosage | Gene Library | Cellular Senescence/drug effects | Receptor Protein-Tyrosine Kinases/biosynthesis | Drug Resistance, Neoplasm/drug effects | Gene Expression Regulation, Neoplastic/drug effects | SOXE Transcription Factors/deficiency | Signal Transduction/drug effects | Protein Kinase Inhibitors/administration & dosage | Vemurafenib | Animals | Mice | RNA, Small Interfering | GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Melanoma - genetics | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article