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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2017, Volume 292, Issue 34, pp. 14270 - 14278
Smooth muscle cell (SMC) differentiation is essential for vascular development, and TGF-β signaling plays a critical role in this process. Although long... 
Muscle, Smooth, Vascular - metabolism | Transforming Growth Factor beta1 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | Smad3 Protein - metabolism | Transforming Growth Factor beta1 - chemistry | Mesenchymal Stromal Cells - cytology | Isoquinolines - pharmacology | RNA Interference | Muscle Proteins - metabolism | Nucleic Acid Conformation | Muscle, Smooth, Vascular - drug effects | RNA - metabolism | Binding, Competitive | Biomarkers - metabolism | Mesenchymal Stromal Cells - drug effects | RNA, Long Noncoding - chemistry | Gene Expression Regulation, Developmental - drug effects | Mesenchymal Stromal Cells - metabolism | In Situ Hybridization, Fluorescence | Transforming Growth Factor beta1 - genetics | Muscle, Smooth, Vascular - cytology | Smad3 Protein - antagonists & inhibitors | Muscle Proteins - genetics | Response Elements - drug effects | Muscle Proteins - agonists | Pyrroles - pharmacology | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Cell Line, Tumor | Genes, Reporter - drug effects | Smad3 Protein - chemistry | Mice | Pyridines - pharmacology | RNA, Long Noncoding - antagonists & inhibitors | RNA, Long Noncoding - metabolism | Index Medicus | Smad3 | differentiation | signal transduction | smooth muscle | TGF-β | GAS5 | Cell Biology | long non-coding RNA (long ncRNA, lncRNA)
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2009, Volume 183, Issue 1, pp. 97 - 105
TGF-beta, together with IL-6 and IL-21, promotes Th17 cell development. IL-6 and IL-21 induce activation of STAT3, which is crucial for Th17 cell... 
T(H)17 CELLS | ROR-GAMMA-T | IN-VIVO | STAT3 | HOST-DEFENSE | GENERATION | CYTOKINE | DIFFERENTIATION | IMMUNOLOGY | LINEAGE | FOXP3 | Protein-Serine-Threonine Kinases - deficiency | Intestinal Mucosa - metabolism | Receptors, Transforming Growth Factor beta - genetics | Interleukin-6 - antagonists & inhibitors | Transforming Growth Factor beta1 - antagonists & inhibitors | Interleukin-17 - physiology | Receptors, Transforming Growth Factor beta - physiology | Intestinal Mucosa - cytology | Cell Differentiation - genetics | Signal Transduction - immunology | Mucous Membrane - cytology | STAT3 Transcription Factor - physiology | Interleukins - physiology | Intestinal Mucosa - immunology | T-Lymphocytes, Helper-Inducer - immunology | Interleukin-6 - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | T-Lymphocytes, Helper-Inducer - cytology | STAT3 Transcription Factor - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | Protein-Serine-Threonine Kinases - physiology | Mice, Inbred C57BL | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Mice, Transgenic | Up-Regulation - genetics | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Interleukin-17 - biosynthesis | Transforming Growth Factor beta1 - physiology | Down-Regulation - genetics | Interleukins - antagonists & inhibitors | Mice, Knockout | Mucous Membrane - metabolism | Cell Differentiation - immunology | Suppressor of Cytokine Signaling 3 Protein | Animals | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Mucous Membrane - immunology | Up-Regulation - immunology | Down-Regulation - immunology | Suppressor of Cytokine Signaling Proteins - antagonists & inhibitors | Mice | Suppressor of Cytokine Signaling Proteins - biosynthesis | Receptors, Transforming Growth Factor beta - deficiency | Index Medicus | Abridged Index Medicus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2017, Volume 37, Issue 11, pp. 2102 - 2102
OBJECTIVE—The role of TGF-β (transforming growth factor-β) signaling in abdominal aortic aneurysm (AAA) formation is controversial. Others reported that... 
aneurysm | smooth muscle | SERVICES TASK-FORCE | ATHEROSCLEROSIS | RECEPTOR | mice | macrophages | TGF-beta | DISRUPTION | angiotensin II | ANEURYSM MOUSE MODEL | PERIPHERAL VASCULAR DISEASE | aorta | SMOOTH-MUSCLE-CELLS | APOE(-/-) MICE | HEMATOLOGY | E-DEFICIENT MICE | PROMOTES | PROGRESSION | Protein-Serine-Threonine Kinases - deficiency | Tunica Media - pathology | Aortic Aneurysm, Abdominal - chemically induced | Receptors, Transforming Growth Factor beta - genetics | Aortic Aneurysm, Abdominal - prevention & control | Muscle, Smooth, Vascular - metabolism | Transforming Growth Factor beta1 - antagonists & inhibitors | Transforming Growth Factor beta2 - metabolism | Aortic Aneurysm, Thoracic - prevention & control | Transforming Growth Factor beta1 - metabolism | Male | Aortic Aneurysm, Thoracic - chemically induced | Transforming Growth Factor beta3 - metabolism | Aorta, Abdominal - drug effects | Aortic Aneurysm, Abdominal - metabolism | Adventitia - metabolism | Receptor, Transforming Growth Factor-beta Type II | Aortic Aneurysm, Thoracic - pathology | Tunica Media - metabolism | Transforming Growth Factor beta - antagonists & inhibitors | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Vascular Remodeling - drug effects | Angiotensin II | Aorta, Abdominal - metabolism | Dilatation, Pathologic | Aorta, Thoracic - pathology | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Severity of Illness Index | Genetic Predisposition to Disease | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Aorta, Thoracic - metabolism | Transforming Growth Factor beta3 - antagonists & inhibitors | Mice, Knockout | Antibodies - pharmacology | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Signal Transduction - drug effects | Aortic Aneurysm, Thoracic - metabolism | Transforming Growth Factor beta2 - antagonists & inhibitors | Adventitia - pathology | Transforming Growth Factor beta - metabolism | Receptors, Transforming Growth Factor beta - deficiency | Index Medicus | growth factor | Animal Models of Human Disease | Vascular Disease | Genetically Altered and Transgenic Models | Aortic Dissection | genetically altered mice
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2017, Volume 127, Issue 10, pp. 3675 - 3688
TGF-β1 signaling is a critical driver of collagen accumulation and fibrotic disease but also a vital suppressor of inflammation and epithelial cell... 
Lung Neoplasms - drug therapy | Receptors, Transforming Growth Factor beta - genetics | Transforming Growth Factor beta1 - antagonists & inhibitors | Humans | Lung Neoplasms - metabolism | Transforming Growth Factor beta1 - metabolism | Neoplasm Proteins - antagonists & inhibitors | Pulmonary Fibrosis - genetics | Neoplasm Proteins - metabolism | Amino Acid Oxidoreductases - metabolism | Amino Acid Oxidoreductases - genetics | Neoplasm Metastasis | Enzyme Inhibitors - chemistry | Epithelial-Mesenchymal Transition | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Pulmonary Fibrosis - metabolism | Neoplasm Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Phenols - pharmacology | Lung Neoplasms - genetics | A549 Cells | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Pulmonary Fibrosis - pathology | Transforming Growth Factor beta1 - genetics | Fibroblasts - pathology | Animals | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - drug effects | Phenols - chemistry | Mice | Protein Kinase Inhibitors - pharmacology | Pulmonary Fibrosis - drug therapy | Drug Screening Assays, Antitumor | Cell proliferation | Mesenchyme | Epithelial cells | Mortality | Lung cancer | Lung diseases | Lysyl oxidase | Kinases | Metastases | Tea | Lysine | Collagen | Fibrosis | Fibroblasts | Polyphenols | Index Medicus | Abridged Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 11/2011, Volume 17, Issue 21, pp. 6754 - 6765
Journal Article
Experimental Cell Research, ISSN 0014-4827, 10/2012, Volume 318, Issue 16, pp. 2105 - 2115
The activation of transforming growth factor-β1(TGF-β1)/Smad signaling pathway and increased expression of connective tissue growth factor (CTGF) induced by... 
TGFβ1 | Angiotensin II | Atrial fibroblasts | TRAF6 | CTGF | MAPKs | TGFΒ1 | Heart Atria - pathology | Gene Expression - drug effects | Heart Atria - drug effects | Transforming Growth Factor beta1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | TNF Receptor-Associated Factor 6 - antagonists & inhibitors | Fibrosis - metabolism | MAP Kinase Kinase 4 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | MAP Kinase Kinase 4 - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - metabolism | TNF Receptor-Associated Factor 6 - genetics | MAP Kinase Kinase Kinases - antagonists & inhibitors | Fibroblasts - metabolism | Angiotensin II - pharmacology | Fibrosis - genetics | Mitogen-Activated Protein Kinase 3 - genetics | MAP Kinase Kinase Kinases - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Losartan - pharmacology | p38 Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Fibroblasts - pathology | Heart Atria - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Fibroblasts - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | TNF Receptor-Associated Factor 6 - metabolism | MAP Kinase Kinase 4 - genetics | Connective Tissue Growth Factor - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Primary Cell Culture | Angiotensin II - physiology | Connective Tissue Growth Factor - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article
Journal of clinical investigation, ISSN 0021-9738, 2011, Volume 121, Issue 6, pp. 2301 - 2312
The cardiac pathological response to sustained pressure overload involves myocyte hypertrophy and dysfunction along with interstitial changes such as fibrosis... 
MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-FACTOR-BETA | ACTIVATION | INHIBITION | MYOCARDIAL FIBROSIS | FIBROBLAST | CARDIAC-HYPERTROPHY | HEART-FAILURE | RECEPTOR | ANGIOTENSIN-II | PREVENTS | Receptors, Transforming Growth Factor beta - genetics | Transforming Growth Factor beta1 - antagonists & inhibitors | Male | Receptors, Transforming Growth Factor beta - physiology | Constriction, Pathologic - physiopathology | Gene Knockdown Techniques | Ligation | Ultrasonography | Coronary Circulation | Signal Transduction | Protein-Serine-Threonine Kinases - physiology | Hypertrophy, Left Ventricular - etiology | Hypertrophy, Left Ventricular - prevention & control | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Myocardium - pathology | Smad Proteins - physiology | Ventricular Remodeling - physiology | Constriction, Pathologic - complications | Pressure | Transforming Growth Factor beta1 - physiology | Myocytes, Cardiac - pathology | Aortic Diseases - physiopathology | Animals | Connective Tissue Growth Factor - physiology | Myocytes, Cardiac - physiology | Aortic Diseases - complications | MAP Kinase Kinase Kinases - physiology | Mice | Hypertrophy, Left Ventricular - physiopathology | Bone Morphogenetic Protein 7 - physiology | Hypertrophy, Left Ventricular - diagnostic imaging | Index Medicus | Abridged Index Medicus
Journal Article
Angiogenesis, ISSN 0969-6970, 10/2013, Volume 16, Issue 4, pp. 903 - 917
Hypoxia-inducible factors (HIFs) and STAT-3 play essential roles in angiogenesis. HIF-1α and STAT-3 are clients of the heat shock protein 90 (HSP90). We... 
HSP90 | Angiogenesis | Biomedicine | Cancer Research | Oncology | HIF-1α | STAT-3 | Ophthalmology | Cardiology | Biomedicine general | Cell Biology | CELLS | HIF-1 alpha | HEAT-SHOCK-PROTEIN-90 | HYPOXIA | HIF-1 | THERAPY | O-2 | PERIPHERAL VASCULAR DISEASE | TUMOR-GROWTH | EXPRESSION | Adenocarcinoma - pathology | Humans | Vesicular Transport Proteins - biosynthesis | Antineoplastic Agents - therapeutic use | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Vascular Endothelial Growth Factor A - genetics | Gene Knockdown Techniques | Ribonuclease, Pancreatic - biosynthesis | RNA, Messenger - biosynthesis | Vesicular Transport Proteins - antagonists & inhibitors | Laminin | Platelet-Derived Growth Factor - biosynthesis | Rectal Neoplasms - genetics | STAT3 Transcription Factor - physiology | Rectal Neoplasms - pathology | Ribonuclease, Pancreatic - antagonists & inhibitors | Rectal Neoplasms - drug therapy | STAT3 Transcription Factor - genetics | Transforming Growth Factor beta1 - biosynthesis | Triazoles - therapeutic use | Proteoglycans | Specific Pathogen-Free Organisms | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Down-Regulation | Ribonuclease, Pancreatic - genetics | Angiogenesis Inhibitors - pharmacology | Adenocarcinoma - drug therapy | Chick Embryo | Adenocarcinoma - blood supply | Fibroblast Growth Factor 2 - antagonists & inhibitors | Fibroblast Growth Factor 2 - genetics | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Mice, Nude | Cell Line, Tumor | Human Umbilical Vein Endothelial Cells | Vascular Endothelial Growth Factor A - biosynthesis | Transforming Growth Factor beta1 - antagonists & inhibitors | HSP90 Heat-Shock Proteins - physiology | Gene Expression Regulation, Neoplastic | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Platelet-Derived Growth Factor - genetics | HEK293 Cells | Angiogenesis Inhibitors - therapeutic use | Female | Antineoplastic Agents - pharmacology | Hypoxia-Inducible Factor 1, alpha Subunit - physiology | Chorioallantoic Membrane - blood supply | Colorectal Neoplasms - blood supply | Vesicular Transport Proteins - genetics | Fibroblast Growth Factor 2 - biosynthesis | Transforming Growth Factor beta1 - genetics | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Animals | Collagen | Colorectal Neoplasms - pathology | STAT3 Transcription Factor - antagonists & inhibitors | Platelet-Derived Growth Factor - antagonists & inhibitors | Drug Combinations | Index Medicus
Journal Article
Brain, ISSN 0006-8950, 2013, Volume 136, Issue 2, pp. 564 - 576
Journal Article
Biomaterials, ISSN 0142-9612, 2015, Volume 77, pp. 173 - 185
Abstract Transforming growth factor beta (TGF-β) has become one of the most widely utilized mediators of engineered cartilage growth. It is typically... 
Advanced Basic Science | Dentistry | Cartilage tissue engineering | Growth factor delivery | Finite element model | Biochemical gradients | Transforming growth factor beta | Heterogeneous growth | STEM-CELLS | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | SEEDED AGAROSE GELS | BINDING PROTEOGLYCANS | IN-VITRO | RABBIT ARTICULAR CHONDROCYTES | PLATE CHONDROCYTES | EXTRACELLULAR-MATRIX | TRANSIENT EXPOSURE | NUTRIENT CHANNELS | ORGAN-CULTURES | Transforming Growth Factor beta3 - pharmacology | Autocrine Communication | Chondrocytes - cytology | Tissue Engineering - methods | Cell Culture Techniques - instrumentation | Transforming Growth Factor beta1 - antagonists & inhibitors | Humans | Cells, Cultured | Organoids - cytology | Recombinant Proteins - pharmacology | Transforming Growth Factor beta1 - secretion | Dose-Response Relationship, Drug | Chondrocytes - drug effects | Extracellular Matrix Proteins - secretion | Mesenchymal Stromal Cells - cytology | Animals | Osmolar Concentration | Cattle | Models, Biological | Computer Simulation | Cartilage - cytology | Culture Media - pharmacology | Chondrocytes - secretion | Transforming Growth Factor beta1 - pharmacology | Index Medicus | Cartilage | Biomedical materials | Cellular | Construction | Biosynthesis | Biochemistry | Culture | Concentration gradient | growth factor delivery | cartilage tissue engineering | biochemical gradients | finite element model | heterogeneous growth
Journal Article