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animals (143) 143
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Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e56837
Background: Posterior capsular opacification (PCO) is a common complication of cataract surgery. Transforming growth factor-beta 2 (TGF-beta 2) plays important... 
COLLAGEN PRODUCTION | GROWTH-FACTOR-BETA | IN-VITRO | IMPLANTATION | MULTIDISCIPLINARY SCIENCES | INTRAOCULAR-LENS | BAG | POSTERIOR CAPSULE OPACIFICATION | IDIOPATHIC PULMONARY-FIBROSIS | CATARACT-SURGERY | TRANSDIFFERENTIATION | Cell Survival - drug effects | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Humans | RNA, Messenger - genetics | Epithelial-Mesenchymal Transition - drug effects | Smad Proteins - genetics | RNA, Messenger - metabolism | Transforming Growth Factor beta2 - pharmacology | Gene Expression Regulation - drug effects | Cell Movement - drug effects | Phenotype | Cell Nucleus - metabolism | Active Transport, Cell Nucleus - drug effects | Cell Proliferation - drug effects | Lens, Crystalline - drug effects | Lens, Crystalline - cytology | Smad Proteins - metabolism | Cell Line, Transformed | Pyridones - pharmacology | Fibroblasts - metabolism | Eye | Fibronectins | RNA | Surgery | Stem cells | Bone morphogenetic proteins | Hostages | Transforming growth factors | Cell proliferation | Cataracts | Glaucoma | Mesenchyme | Laboratories | Toxicity | Epithelial cells | Transforming growth factor | Cytotoxicity | mRNA | Assaying | Fibronectin | Prevention | Cell growth | Fibroblasts | Inhibition | Growth factors | Translocation | Lactate dehydrogenase | Pharmacology | Eye surgery | L-Lactate dehydrogenase | Nuclear transport | Polymerase chain reaction | Signaling | Side effects | Pulmonary fibrosis | Collagen | Lactic acid | Immunofluorescence | Viability | Cell migration | Lenses
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, p. e45221
Background/Aims: Dietary supplementation with transforming growth factor-beta (TGF-beta) has been proven to minimize intestinal damage and facilitate... 
APOPTOSIS | CELLS | MULTIDISCIPLINARY SCIENCES | MUCOSITIS | PROLIFERATION | CANCER | EXPRESSION | CHEMOTHERAPY | Mucositis - metabolism | Intestinal Mucosa - metabolism | Apoptosis - drug effects | Enterocytes - metabolism | Humans | Body Weight - drug effects | Male | Methotrexate - toxicity | Mucositis - prevention & control | Intestinal Mucosa - drug effects | Transforming Growth Factor beta2 - administration & dosage | Interleukin-1beta - metabolism | Enterocytes - pathology | bcl-2-Associated X Protein - genetics | Caco-2 Cells | Cell Survival - drug effects | bcl-2-Associated X Protein - metabolism | Rats | Recombinant Proteins - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | beta Catenin - metabolism | Blotting, Western | Mucositis - chemically induced | Recombinant Proteins - administration & dosage | Transforming Growth Factor beta2 - pharmacology | Animals | Enterocytes - drug effects | Receptors, Transforming Growth Factor beta - metabolism | Antimetabolites, Antineoplastic - toxicity | Transforming Growth Factor beta2 - genetics | Dietary Supplements | Proto-Oncogene Proteins c-bcl-2 - genetics | Intestinal Mucosa - pathology | Bone morphogenetic proteins | RNA | Methotrexate | Transforming growth factors | Dietary supplements | Apoptosis | Cell proliferation | Cell culture | Pediatrics | Flow cytometry | Bax protein | Bcl-2 protein | Laboratories | Mucosa | Villus | mRNA | Kinases | Small intestine | β-catenin | Cell growth | Jejunum | Intestine | Rodents | Surgery | Cell cycle | Interleukin 1 | Tumor necrosis factor-TNF | Supplementation | Growth factors | Deoxyribonucleic acid--DNA | Mucositis | Transforming growth factor-b1 | Cytokines | Extracellular signal-regulated kinase | Gene expression | Ileum | Regeneration | Chemotherapy | Injury prevention | Diet | Structural damage | Stem cells | Viability | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Clinical & Experimental Ophthalmology, ISSN 1442-6404, 03/2015, Volume 43, Issue 2, pp. 173 - 179
Background Fibrosis is the most common side effect after anti‐vascular epithelial growth factor (VEGF) therapy (intravitreal bevacizumab) for retinal or... 
bevacizumab | fibrosis | cytokines | anti‐VEGF | Anti-VEGF | Cytokines | Fibrosis | Bevacizumab | anti-VEGF | MATRIX METALLOPROTEINASES | TISSUE GROWTH-FACTOR | PIGMENT EPITHELIAL-CELLS | PROLIFERATIVE DIABETIC-RETINOPATHY | INJECTION | SUBRETINAL FIBROSIS | OPHTHALMOLOGY | AGERELATED MACULAR DEGENERATION | INTRAVITREAL BEVACIZUMAB | FIBROVASCULAR MEMBRANES | EXPRESSION | Human Umbilical Vein Endothelial Cells - metabolism | Transforming Growth Factor beta2 - metabolism | Humans | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Antimutagenic Agents - toxicity | Cell Hypoxia | Retinal Vessels - pathology | Antibodies, Monoclonal, Humanized - pharmacology | Fibroblast Growth Factor 2 - metabolism | Cytokines - genetics | Real-Time Polymerase Chain Reaction | Human Umbilical Vein Endothelial Cells - drug effects | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Matrix Metalloproteinase 2 - metabolism | RNA, Messenger - genetics | Cells, Cultured | Angiogenesis Inhibitors - pharmacology | Blotting, Western | Cobalt - toxicity | Matrix Metalloproteinase 2 - genetics | Fibroblast Growth Factor 2 - genetics | Human Umbilical Vein Endothelial Cells - pathology | Connective Tissue Growth Factor - genetics | Transforming Growth Factor beta2 - genetics | Connective Tissue Growth Factor - metabolism | Enzymes | RNA | Neovascularization | Angiogenesis inhibitors | Growth factors | Enzyme-linked immunosorbent assay
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 07/2009, Volume 8, Issue 14, pp. 1313 - 1317
Colon cancer is the third most common cancer and third most common cause of cancer-related death in the USA according to 2008 American Cancer Society... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | β-catenin | Signal pathway | Azoxymethane | Colon cancer | K-ras | TGFβ | MAPK | PI3K/Akt | beta-catenin | colon cancer | RATS | CELL-CYCLE ARREST | azoxymethane | MOUSE MODELS | CARCINOGENESIS | INHIBITION | ONCOLOGY | RESISTANT STARCH | COLORECTAL-CANCER | signal pathway | TGF beta | EXPRESSION | ABERRANT CRYPT FOCI | Colonic Neoplasms - prevention & control | Adenocarcinoma - chemically induced | Humans | Adenoma - prevention & control | Colonic Neoplasms - chemically induced | Adiponectin - physiology | Cytochrome P-450 CYP2E1 - metabolism | Methylazoxymethanol Acetate - analogs & derivatives | Azoxymethane - toxicity | Carcinogens - toxicity | Colonic Neoplasms - physiopathology | Adenocarcinoma - physiopathology | Adiponectin - genetics | Adiponectin - deficiency | Transforming Growth Factor beta - antagonists & inhibitors | Carcinogens - pharmacokinetics | Anticarcinogenic Agents - pharmacology | Anticarcinogenic Agents - therapeutic use | Methylazoxymethanol Acetate - toxicity | DNA Damage - drug effects | Rats | Proto-Oncogene Proteins c-akt - physiology | Azoxymethane - pharmacokinetics | Mice, Knockout | Adenoma - physiopathology | Adenocarcinoma - prevention & control | Animals | MAP Kinase Signaling System - drug effects | Diet | Signal Transduction - drug effects | Phosphatidylinositol 3-Kinases - physiology | Mice | Transforming Growth Factor beta2 - genetics | Genes, ras | Adenoma - chemically induced | Transforming Growth Factor beta2 - deficiency | Apoptosis
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, p. e0168240
Accurate diagnosis of fibrosis is of paramount clinical importance. A human fibrosis classifier based on metzincins and related genes (MARGS) was described... 
MATRIX METALLOPROTEINASES | CELLS | GROWTH-FACTOR-BETA | METZINCINS | MULTIDISCIPLINARY SCIENCES | GENES | THERAPEUTIC TARGETS | INDUCED NDI | ALTERED EXPRESSION | NEPHROPATHY | CD44 | Immunohistochemistry | Lithium - toxicity | Kidney - drug effects | Fibrosis - physiopathology | Kidney - pathology | Oligonucleotide Array Sequence Analysis | Rats, Wistar | Matrix Metalloproteinase 2 - metabolism | Transforming Growth Factor beta2 - metabolism | Rats | Male | RNA, Messenger - metabolism | Fibrosis - diagnosis | Hyaluronan Receptors - genetics | Nephroblastoma Overexpressed Protein - metabolism | Up-Regulation - drug effects | Matrix Metalloproteinase 2 - genetics | Kidney - metabolism | Nephroblastoma Overexpressed Protein - genetics | Animals | Hyaluronan Receptors - metabolism | Transforming Growth Factor beta2 - genetics | Usage | Fibrosis | Diagnosis | Kidney diseases | Research | Transforming growth factors | Health aspects | Enrichment | Plasma | Classifiers | Transplants & implants | Syngeneic grafts | Pathogenesis | Genes | Lithium | Statistical methods | Matrix metalloproteinase | CD44 antigen | Rodents | Extracellular matrix | Metalloproteinase | Growth factors | Immune system | Kidneys | Statistical analysis | Immune response | Gene expression | Gelatinase A | Medicine | Nephropathy | Biopsy | Species classification | Diagnostic systems | Renal cortex
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2015, Volume 10, Issue 2, pp. e0118459 - e0118459
Obliterative bronchiolitis (OB) is an irreversible lung disease characterized by progressive fibrosis in the small airways with eventual occlusion of the... 
BRONCHOALVEOLAR LAVAGE FLUID | LUNG | GROWTH-FACTOR-BETA | TGF-BETA | PROTEIN | THROMBOSPONDIN-2 | MULTIDISCIPLINARY SCIENCES | FIBRONECTIN | RECEPTOR | PULMONARY-FIBROSIS | TENASCIN-C | Immunohistochemistry | Pentanones - toxicity | Rats, Wistar | Transforming Growth Factor beta2 - metabolism | Rats | Male | Down-Regulation - drug effects | Up-Regulation - drug effects | Bronchiolitis Obliterans - genetics | RNA - isolation & purification | Animals | Inhalation Exposure | Bronchi - metabolism | Fibrosis - pathology | Transforming Growth Factor beta2 - genetics | Bronchi - pathology | Bronchiolitis Obliterans - chemically induced | Bronchiolitis Obliterans - pathology | Principal Component Analysis | Real-Time Polymerase Chain Reaction | Disease Models, Animal | RNA - metabolism | DNA microarrays | RNA | Genes | Flavoring essences | Transforming growth factors | Gene expression | Bronchiolitis | Occlusion | Health sciences | Transplants & implants | Syngeneic grafts | Pathogenesis | Bronchopneumonia | Bronchi | Vapors | Lung transplantation | Metastasis | Occupational exposure | Obliterative bronchiolitis | Proteins | Respiratory tract | Lumens | Toxicology | Lasers | Humidity | Extracellular matrix | Physiology | Lesions | Peptidase | Cytokines | Therapeutic applications | Lung diseases | Environmental health | Bronchus | Exposure | Inflammation | Ribonucleic acid--RNA | Molecular chains | Graft rejection | Peptidases | Molecular modelling | Lungs | Collagen | Fibrosis | Laboratory animals | Chemokines | Cancer | Index Medicus | Ribonucleic acid
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2009, Volume 234, Issue 1, pp. 107 - 116
Azole derivatives are teratogenic in rats and mice and . The postulated mechanism for the dysmorphogenetic effects is the inhibition of retinoic acid... 
Teratogenesis | Triazoles | CRABP | Hindbrain | TGF-β | Whole embryo culture | NCC | TGF-BETA-2 EXPRESSION | MOUSE EMBRYOS | RETINOIC ACID RECEPTORS | HOX GENES | BINDING PROTEIN | HOMEOBOX GENES | TRIAZOLE ANTIFUNGAL AGENT | TGF-beta | CRANIAL NEURAL CREST | BRANCHIAL ARCH ABNORMALITIES | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Immunohistochemistry | Teratogens - toxicity | Transforming Growth Factor beta2 - metabolism | Transforming Growth Factor beta1 - metabolism | Fungicides, Industrial - toxicity | Embryo Culture Techniques | RNA, Messenger - metabolism | Transforming Growth Factor beta3 - metabolism | Proteoglycans - drug effects | Triazoles - toxicity | Time Factors | Transforming Growth Factor beta2 - drug effects | Transforming Growth Factor beta1 - drug effects | Female | Protein-Serine-Threonine Kinases - metabolism | Receptors, Retinoic Acid - drug effects | Transforming Growth Factor beta3 - drug effects | Gene Expression Regulation, Developmental - drug effects | Proteoglycans - metabolism | Rats | Receptors, Retinoic Acid - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Blotting, Western | Animals | Receptors, Transforming Growth Factor beta - drug effects | Receptors, Transforming Growth Factor beta - metabolism | Protein-Serine-Threonine Kinases - drug effects | Index Medicus
Journal Article
Journal Article