X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (105411) 105411
Publication (14166) 14166
Book Review (14076) 14076
Book Chapter (1224) 1224
Newspaper Article (429) 429
Conference Proceeding (378) 378
Dissertation (311) 311
Patent (123) 123
Book / eBook (44) 44
Data Set (19) 19
Web Resource (9) 9
Magazine Article (8) 8
Paper (7) 7
Trade Publication Article (7) 7
Government Document (4) 4
Reference (3) 3
Journal / eJournal (2) 2
Newsletter (2) 2
Streaming Video (1) 1
Technical Report (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (89299) 89299
animals (46978) 46978
humans (46430) 46430
male (24523) 24523
biochemistry & molecular biology (21450) 21450
female (18532) 18532
mice (17468) 17468
rats (16032) 16032
expression (15498) 15498
transporter (14685) 14685
pharmacology & pharmacy (13810) 13810
neurosciences (13337) 13337
proteins (13099) 13099
gene expression (10244) 10244
analysis (10192) 10192
cell biology (10137) 10137
research (9318) 9318
physiological aspects (8991) 8991
atp-binding cassette transporters - genetics (8742) 8742
atp-binding cassette transporters - metabolism (8339) 8339
molecular sequence data (8180) 8180
adult (7774) 7774
metabolism (7759) 7759
biological transport (7695) 7695
article (7366) 7366
mutation (7167) 7167
p-glycoprotein (7057) 7057
genes (7056) 7056
genetic aspects (6950) 6950
amino acid sequence (6792) 6792
cells (6784) 6784
middle aged (6641) 6641
physiology (6258) 6258
protein (6023) 6023
cell line (5934) 5934
glucose (5680) 5680
gene (5672) 5672
brain (5584) 5584
microbiology (5559) 5559
transporters (5518) 5518
cancer (5464) 5464
cells, cultured (5460) 5460
multidisciplinary sciences (5397) 5397
rats, sprague-dawley (5383) 5383
oncology (5321) 5321
carrier proteins - metabolism (5227) 5227
identification (5017) 5017
plant sciences (4998) 4998
gene-expression (4949) 4949
research article (4935) 4935
rna, messenger - metabolism (4903) 4903
biophysics (4850) 4850
kinetics (4847) 4847
glucose - metabolism (4777) 4777
escherichia-coli (4644) 4644
cell line, tumor (4605) 4605
endocrinology & metabolism (4561) 4561
rodents (4499) 4499
life sciences (4375) 4375
cell membrane - metabolism (4336) 4336
protein binding (4321) 4321
aged (4259) 4259
immunohistochemistry (4200) 4200
base sequence (4181) 4181
carrier proteins - genetics (4100) 4100
signal transduction (4036) 4036
genetics & heredity (4026) 4026
medicine (3984) 3984
rats, wistar (3977) 3977
genotype (3972) 3972
dose-response relationship, drug (3948) 3948
multidrug-resistance (3932) 3932
abc transporters (3913) 3913
membrane transport proteins - metabolism (3909) 3909
abc transporter (3892) 3892
mice, inbred c57bl (3866) 3866
in-vitro (3829) 3829
transport (3731) 3731
health aspects (3711) 3711
insulin (3709) 3709
drug resistance (3652) 3652
brain - metabolism (3641) 3641
biology (3598) 3598
homeostasis (3590) 3590
psychiatry (3576) 3576
oxidative stress (3540) 3540
serotonin transporter (3530) 3530
binding (3520) 3520
biochemistry (3512) 3512
dopamine transporter (3511) 3511
in-vivo (3482) 3482
phosphorylation (3479) 3479
binding sites (3462) 3462
time factors (3459) 3459
mice, knockout (3456) 3456
neurons (3434) 3434
genetics (3410) 3410
blotting, western (3402) 3402
monosaccharide transport proteins - metabolism (3398) 3398
amino acids (3397) 3397
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (11) 11
Online Resources - Online (6) 6
Engineering & Comp. Sci. - Stacks (4) 4
UofT at Mississauga - Stacks (4) 4
Collection Dvlpm't (Acquisitions) - Vendor file (3) 3
Chemistry (A D Allen) - Stacks (1) 1
Earth Sciences (Noranda) - Stacks (1) 1
St. Michael's Hospital - Online (1) 1
UofT at Scarborough - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (104941) 104941
Chinese (447) 447
Japanese (442) 442
French (437) 437
German (436) 436
Russian (98) 98
Dutch (75) 75
Spanish (73) 73
Polish (49) 49
Korean (47) 47
Portuguese (18) 18
Hungarian (15) 15
Danish (13) 13
Swedish (13) 13
Czech (12) 12
Norwegian (11) 11
Turkish (9) 9
Italian (8) 8
Ukrainian (3) 3
Croatian (2) 2
Finnish (2) 2
Persian (2) 2
Afrikaans (1) 1
Amharic (1) 1
Serbian (1) 1
Slovak (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature Neuroscience, ISSN 1097-6256, 11/2012, Volume 15, Issue 11, pp. 1488 - 1497
FUS/TLS (fused in sarcoma/translocated in liposarcoma) and TDP-43 are integrally involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.... 
NEURODEGENERATIVE DISEASE | GENE | AMYOTROPHIC-LATERAL-SCLEROSIS | FAMILY PROTEINS | FUS PATHOLOGY | MUTATIONS | FRONTOTEMPORAL LOBAR DEGENERATION | BINDING | NEUROSCIENCES | BRAIN | NASCENT TRANSCRIPTION | RNA, Small Interfering - genetics | Protein Binding - genetics | Oligonucleotide Array Sequence Analysis | Humans | tau Proteins - metabolism | Gene Expression Profiling | RNA, Messenger - metabolism | Kv Channel-Interacting Proteins - metabolism | Brain - metabolism | Frontotemporal Dementia - metabolism | RNA Splicing - genetics | Frontotemporal Dementia - genetics | RNA-Binding Protein FUS - deficiency | Amyotrophic Lateral Sclerosis - genetics | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | RNA-Binding Protein FUS - genetics | Mice, Knockout | Motor Neurons - metabolism | Amyotrophic Lateral Sclerosis - pathology | Shal Potassium Channels - metabolism | Brain - pathology | Mice | Neurofilament Proteins - metabolism | RNA, Small Interfering - metabolism | Immunoprecipitation | Spinal Cord - metabolism | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | tau Proteins - genetics | Cell Cycle Proteins - genetics | Female | RNA Precursors - metabolism | Excitatory Amino Acid Transporter 2 - genetics | Membrane Proteins - metabolism | Frontotemporal Dementia - pathology | Gene Expression Regulation - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | RNA Precursors - genetics | Protein Structure, Tertiary - genetics | RNA-Binding Protein FUS - metabolism | DNA-Binding Proteins - genetics | Excitatory Amino Acid Transporter 2 - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Histone-Lysine N-Methyltransferase - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Neural Cell Adhesion Molecules - metabolism | Neural Stem Cells - metabolism | Cell Line, Transformed | Amyotrophic lateral sclerosis | Development and progression | Genetic aspects | Messenger RNA | Health aspects | Index Medicus
Journal Article
2012, ISBN 0470874325, xii, 289
Examines new research on the role of cholesterol in regulating ion channels and receptors and its effect on health Drawing together and analyzing all the... 
Ion channels | Metabolism | Cholesterol | Membrane proteins | Life Sciences | Science | Biology | Molecular Biology
Book
Journal Article
Science, ISSN 0036-8075, 7/2012, Volume 337, Issue 6090, pp. 96 - 100
Pyruvate constitutes a critical branch point in cellular carbon metabolism. We have identified two proteins, Mpc1 and Mpc2, as essential for mitochondrial... 
Yeasts | Mitochondria | Diet | Plasmids | Drosophila | REPORTS | Amino acids | Oxidation | Respiration | Sugars | Medical schools | RAT-LIVER | TRANSPORT | COMPLEX | MECHANISM | IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | Metabolomics | Humans | Molecular Sequence Data | Mitochondrial Proteins - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Anion Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - genetics | Drosophila melanogaster - metabolism | Saccharomyces cerevisiae - metabolism | Amino Acids - metabolism | Biological Transport | Mitochondrial Proteins - metabolism | Pyruvic Acid - metabolism | Amino Acid Sequence | Mitochondrial Membrane Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - metabolism | Oxidation-Reduction | Carbohydrate Metabolism | Mitochondria - metabolism | Drosophila Proteins - chemistry | Saccharomyces cerevisiae Proteins - genetics | Anion Transport Proteins - metabolism | Citric Acid Cycle | Mitochondrial Membranes - metabolism | Point Mutation | Animals | Drosophila melanogaster - chemistry | Mitochondrial Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Drosophila Proteins - genetics | Anion Transport Proteins - genetics | Saccharomyces cerevisiae Proteins - chemistry | Cell metabolism | Pyruvates | Chemical properties | Research | Molecular biology | Proteins | Yeast | Metabolism | Index Medicus | Carriers | Human | Bacteria | Transport | Transporter
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2012, Volume 109, Issue 41, pp. 16696 - 16701
The AcrAB–TolC multidrug efflux pump confers resistance to a wide variety of antibiotics and other compounds in Escherichia coli. Here we show that AcrZ... 
Proteins | Antibiotics | RNA | Pumps | Escherichia coli | Genes | Gene expression regulation | Molybdenum | Genetic mutation | Membrane proteins | Resistance-nodulation-division | Multidrug resistance | RND superfamily | resistance-nodulation-division | SYSTEM | multidrug resistance | MECHANISM | MEMBRANE | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | GENES | TRANSPORTER ACRB | SUBSTRATE PATH | BINDING POCKET | PROMOTER | Conserved Sequence - genetics | Lipoproteins - genetics | Escherichia coli - drug effects | Molecular Sequence Data | Immunoblotting | DNA-Binding Proteins - metabolism | Microbial Sensitivity Tests | Membrane Transport Proteins - genetics | Periplasm - metabolism | Escherichia coli - metabolism | Lipoproteins - metabolism | Trans-Activators - genetics | Carrier Proteins - chemistry | Membrane Transport Proteins - metabolism | Multidrug Resistance-Associated Proteins - genetics | Bacterial Outer Membrane Proteins - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Multidrug Resistance-Associated Proteins - chemistry | Bacterial Outer Membrane Proteins - chemistry | Models, Molecular | Escherichia coli Proteins - metabolism | Lipoproteins - chemistry | DNA-Binding Proteins - genetics | Membrane Transport Proteins - chemistry | Sequence Homology, Amino Acid | Carrier Proteins - genetics | Drug Resistance, Microbial | Two-Hybrid System Techniques | Carrier Proteins - metabolism | Bacterial Outer Membrane Proteins - metabolism | Escherichia coli - genetics | Escherichia coli Proteins - genetics | Protein Binding | Trans-Activators - metabolism | Anti-Bacterial Agents - pharmacology | Mutation | Escherichia coli Proteins - chemistry | Multidrug Resistance-Associated Proteins - metabolism | Physiological aspects | Drug resistance | Health aspects | Amino acids | Membranes | E coli | Index Medicus | Biological Sciences
Journal Article
Science, ISSN 0036-8075, 5/2005, Volume 308, Issue 5726, pp. 1321 - 1323
The protein complement of cellular membranes is notoriously resistant to standard proteomic analysis and structural studies. As a result, membrane proteomes... 
Proteins | Datasets | Child abuse | Escherichia coli | Fluorescence | Reports | Cell membranes | Topology | Proteomes | Modeling | Membrane proteins | GREEN FLUORESCENT PROTEIN | EVOLUTION | EFFLUX | MULTIDRUG TRANSPORTER EMRE | ANGSTROM | MULTIDISCIPLINARY SCIENCES | X-RAY-STRUCTURE | CONDUCTING CHANNEL | SELECTIVITY | PREDICTION | Gene Duplication | Green Fluorescent Proteins - genetics | Escherichia coli Proteins - physiology | Membrane Proteins - analysis | Recombinant Fusion Proteins | Cell Membrane - chemistry | Membrane Proteins - physiology | Cloning, Molecular | Alkaline Phosphatase - analysis | Periplasm - chemistry | Escherichia coli Proteins - analysis | Cytoplasm - chemistry | Genes, Bacterial | Alkaline Phosphatase - genetics | Green Fluorescent Proteins - analysis | Protein Structure, Secondary | Membrane Proteins - genetics | Computational Biology | Proteome | Escherichia coli - chemistry | Membrane Proteins - chemistry | Escherichia coli - genetics | Escherichia coli Proteins - genetics | Escherichia coli Proteins - chemistry | Escherichia coli - ultrastructure | Gene amplification | Physiological aspects | Genetic aspects | Research | Pathogens | Membranes | Bioinformatics | Genomics | Index Medicus | Green Fluorescent Proteins/analysis/genetics | Periplasm/chemistry | Escherichia coli/chemistry/genetics/ultrastructure | Cytoplasm/chemistry | Alkaline Phosphatase/analysis/genetics | Cloning; Molecular | Protein Structure; Secondary | Escherichia coli Proteins/analysis/chemistry/genetics/physiology | Cell Membrane/chemistry | Membrane Proteins/analysis/chemistry/genetics/physiology | Genes; Bacterial
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2017, Volume 114, Issue 47, pp. 12572 - 12577
MacB is an ABC transporter that collaborates with the MacA adaptor protein and TolC exit duct to drive efflux of antibiotics and enterotoxin STII out of the... 
X-ray crystallography | ABC transporter | Tripartite efflux pump | HEAT-STABLE ENTEROTOXIN | EFFLUX TRANSPORTER | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | HYDROLYSIS | ATP-BINDING | MEMBRANE-FUSION PROTEIN | TOLC | tripartite efflux pump | MACROLIDE TRANSPORTER | MULTIDRUG EFFLUX | INHIBITORS | Protein Multimerization | Aggregatibacter actinomycetemcomitans - metabolism | Substrate Specificity | Crystallography, X-Ray | Cell Cycle Proteins - chemistry | ATP-Binding Cassette Transporters - chemistry | ATP-Binding Cassette Transporters - genetics | Biological Transport | Adenosine Triphosphate - metabolism | Escherichia coli - metabolism | ATP-Binding Cassette Transporters - metabolism | Cell Cycle Proteins - genetics | Protein Interaction Domains and Motifs | Binding Sites | Bacterial Outer Membrane Proteins - genetics | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Gene Expression | Cell Cycle Proteins - metabolism | Bacterial Outer Membrane Proteins - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Escherichia coli Proteins - metabolism | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Recombinant Proteins - genetics | Cystic Fibrosis Transmembrane Conductance Regulator - chemistry | Bacterial Outer Membrane Proteins - metabolism | Protein Conformation, beta-Strand | Escherichia coli - genetics | Aggregatibacter actinomycetemcomitans - genetics | Escherichia coli Proteins - genetics | Protein Binding | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Adenosine Triphosphate - chemistry | Escherichia coli Proteins - chemistry | Research | Carrier proteins | Structure | Crystals | Efflux | Trafficking | Cell division | Homology | Crystallography | Substrates | Coupling (molecular) | Bellows | Signaling | Cellular biology | Antibiotics | Bacteria | ABC transporters | Dimerization | Transporter | ATP | Cytoplasm | Adenosine triphosphate | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 27, pp. 10832 - 10836
The study of membrane proteins remains a challenging task, and approaches to unravel their dynamics are scarce. Here, yve applied hydrogen/deuterium exchange... 
ATP binding cassette transporters | Deuterium | Hydrolysis | Average linear density | Mass spectroscopy | Biochemistry | Dimers | Detergents | Exporters | Membrane proteins | ATPase cycle | Structural biology | Detergent | DOMAIN | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | HYDROLYSIS | MASS-SPECTROMETRY | ATP-BINDING | BINDING CASSETTE TRANSPORTER | detergent | P-GLYCOPROTEINS | ALTERNATING ACCESS | structural biology | MOLECULAR-BASIS | HYDROGEN-EXCHANGE | Protein Structure, Tertiary | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Multidrug Resistance-Associated Proteins - chemistry | Adenosine Triphosphatases - metabolism | Trypsin - metabolism | Bacillus subtilis - genetics | Membrane Transport Proteins - chemistry | Deuterium Exchange Measurement | Trypsin - pharmacology | Peptide Mapping | Escherichia coli - genetics | Membrane Transport Proteins - genetics | Mass Spectrometry | Bacterial Proteins - metabolism | Membrane Transport Proteins - metabolism | Multidrug Resistance-Associated Proteins - genetics | Protein Conformation | Mutagenesis - physiology | Catalysis | Multidrug Resistance-Associated Proteins - metabolism | Bacillus subtilis - metabolism | Physiological aspects | Molecular dynamics | Research | Binding proteins | Adenosine triphosphate | Proteins | Bacteria | ABC transporters | Peptides | Simulation | Mass spectrometry | Index Medicus | Bacillus subtilis | Escherichia coli | Biochemistry, Molecular Biology | Bacterial Proteins | Life Sciences | Trypsin | Mutagenesis | Adenosine Triphosphatases | Membrane Transport Proteins | Biomolecules | Multidrug Resistance-Associated Proteins | Biological Sciences
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 07/2013, Volume 20, Issue 7, pp. 900 - 907
The 70-kilodalton (kDa) heat-shock proteins (Hsp70s) are ubiquitous molecular chaperones essential for cellular protein folding and proteostasis. Each Hsp70... 
INTERDOMAIN COMMUNICATION | WILD-TYPE | PEPTIDE-BINDING | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | SHOCK COGNATE PROTEIN | MOLECULAR CHAPERONE DNAK | SUBSTRATE-BINDING | CONFORMATIONAL-CHANGES | BIOPHYSICS | STRUCTURE VALIDATION | STRUCTURAL BASIS | Allosteric Regulation | Molecular Sequence Data | Crystallography, X-Ray | Mutation, Missense | Recombinant Fusion Proteins - metabolism | Peptides - metabolism | Adenosine Triphosphate - metabolism | Escherichia coli - metabolism | Conserved Sequence | HSP70 Heat-Shock Proteins - chemistry | Binding Sites | Dimerization | Protein Structure, Tertiary | Amino Acid Sequence | Models, Molecular | Escherichia coli Proteins - metabolism | HSP70 Heat-Shock Proteins - genetics | Recombinant Fusion Proteins - chemistry | Saccharomyces cerevisiae Proteins - genetics | Protein Folding | HSP70 Heat-Shock Proteins - metabolism | Protein Interaction Mapping | Sequence Homology, Amino Acid | Sequence Alignment | Hydrogen Bonding | Escherichia coli - genetics | Escherichia coli Proteins - genetics | Protein Binding | Adenosine Triphosphatases - chemistry | Protein Conformation | Adenosine Triphosphatases - genetics | Escherichia coli Proteins - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Heat shock proteins | Physiological aspects | Homeostasis | Research | Structure | ABC transporters | Biochemistry | Polypeptides | Molecular biology | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2009, Volume 106, Issue 37, pp. 15750 - 15755
Magnesium (Mg²⁺) is the second most abundant cation in cells, yet relatively few mechanisms have been identified that regulate cellular levels of this ion. The... 
T lymphocytes | Proteins | Yeasts | Vertebrates | Messenger RNA | Cell lines | Small interfering RNA | Homeostasis | Magnesium | Embryos | Zebrafish | KMG104-AM | ALR1 | TRPM | Transporter | SECONDARY HYPOCALCEMIA | HUMAN SOLUTE CARRIER | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | FAMILIAL HYPOMAGNESEMIA | CARDIAC MYOCYTES | FUNCTIONAL-CHARACTERIZATION | SACCHAROMYCES-CEREVISIAE | INTRACELLULAR MAGNESIUM | transporter | CYTOSOLIC FREE MAGNESIUM | zebrafish | MGTE MG2+ TRANSPORTERS | Cation Transport Proteins - antagonists & inhibitors | Tumor Suppressor Proteins - antagonists & inhibitors | Saccharomyces cerevisiae - genetics | Humans | Male | Oligodeoxyribonucleotides, Antisense - genetics | RNA, Messenger - metabolism | Zebrafish - embryology | Genetic Complementation Test | Saccharomyces cerevisiae - metabolism | Tissue Distribution | Cation Transport Proteins - metabolism | Base Sequence | Tumor Suppressor Proteins - genetics | Cation Transport Proteins - genetics | Female | Ion Transport | Membrane Proteins - metabolism | Recombinant Proteins - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Protein Structure, Secondary | Animals, Genetically Modified | Jurkat Cells | Membrane Proteins - genetics | Zebrafish Proteins - metabolism | RNA, Messenger - genetics | Zebrafish Proteins - antagonists & inhibitors | Embryonic Development - genetics | Embryonic Development - physiology | Magnesium - metabolism | Recombinant Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Zebrafish - genetics | Pregnancy | Animals | Membrane Proteins - antagonists & inhibitors | Zebrafish - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Zebrafish Proteins - genetics | Cation Transport Proteins - chemistry | Saccharomyces cerevisiae - growth & development | Embryonic development | Biological transport | Physiological aspects | Tumor suppressor genes | Genetic aspects | Research | Magnesium in the body | Index Medicus | Biological Sciences
Journal Article
2003, 1st ed., ISBN 9780123525512, xxiii, 647
ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of... 
Carrier proteins | ATP-binding cassette transporters | Biology, life sciences
Book