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Biochemical Journal, ISSN 0264-6021, 03/2014, Volume 458, Issue 3, pp. 559 - 573
Precise homoeostasis of the intracellular concentration of Cl- is achieved via the co-ordinated activities of the Cl- influx and efflux. We demonstrate that... 
Signal transduction | co-transporter 1 (NKCC1) | co-transporter (NCC) | Protein kinase | γ-aminobutyric acid (GABA) | Cl | Blood pressure/hypertension | 2Cl | co-transporter 2 (KCC2) | Ion homoeostasis | co-transporter 3 (KCC3) | SALT TRANSPORT | CELL-VOLUME | signal transduction | CATION-CHLORIDE COTRANSPORTERS | ION-TRANSPORT | BIOCHEMISTRY & MOLECULAR BIOLOGY | blood pressure/hypertension | ion homoeostasis | HYPOKALEMIC ALKALOSIS | K+-Cl- co-transporter 3 (KCC3) | Na+-K+-2Cl(-) co-transporter 1 (NKCC1) | K+-Cl- co-transporter 2 (KCC2) | protein kinase | BLOOD-PRESSURE | PROTEIN-KINASES | BARTTERS-SYNDROME | Na+-Cl- co-transporter (NCC) | ALANINE-RICH KINASE | MOLECULAR PHYSIOLOGY | gamma-aminobutyric acid (GABA) | Potassium - metabolism | Amino Acid Sequence | Cell Line | Phosphorylation | Signal Transduction | Humans | Molecular Sequence Data | Sodium-Potassium-Chloride Symporters - metabolism | Symporters - metabolism | Transcription Factors - metabolism | Protein Isoforms - metabolism | Chlorides - metabolism | Symporters - antagonists & inhibitors | Phosphopeptides - metabolism | Protein Isoforms - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | N[K]CC, Na+–K+ ion co-transporter | HEK, human embryonic kidney | TTBS, Tris-buffered saline containing Tween 20 | HRP, horseradish peroxidase | ES, embryonic stem | Na+–Cl− co-transporter (NCC) | CCT, conserved C-terminal | NCC, Na+–Cl− co-transporter | Na+–K+–2Cl− co-transporter 1 (NKCC1) | OSR1, oxidative stress-responsive kinase 1 | CCC, cation–Cl− co-transporter | K+–Cl− co-transporter 3 (KCC3) | KCC, K+–Cl− co-transporter | blood pressure | ERK1, extracellular-signal-regulated kinase 1 | SLC12, solute carrier family 12 | LDS, lithium dodecyl sulfate | NKCC, Na+–K+–2Cl− co-transporter | SPAK, SPS1-related proline | NTD, N-terminal cytoplasmic domain | WNK, WNK lysine-deficient protein kinase | CTD, C-terminal cytoplasmic domain | hypertension | XIC, extracted ion chromatogram | K+–Cl− co-transporter 2 (KCC2) | alanine-rich kinase
Journal Article
Journal Article
Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 12/2012, Volume 464, Issue 6, pp. 601 - 611
Acquiring a mechanistic understanding of the processes underlying the renal clearance of drug molecules in man has been hampered by a lack of robust in vitro... 
Biomedicine | Proximal tubule cells | Human Physiology | Drug transporters | PHYSIOLOGY | MEMBRANE | INTESTINE | ORGANIC ANION TRANSPORTERS | HUMAN KIDNEY | P-CRESYL SULFATE | UREMIC TOXIN | PROTEIN MRP | MOLECULAR-CLONING | GLYCOPROTEIN | MULTIDRUG-RESISTANCE | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Epithelial Cells - metabolism | Kidney Cortex - metabolism | Humans | Neoplasm Proteins - metabolism | Monocarboxylic Acid Transporters - metabolism | ATP-Binding Cassette Transporters - genetics | Biological Transport | Monocarboxylic Acid Transporters - biosynthesis | Membrane Transport Proteins - genetics | ATP-Binding Cassette Transporters - metabolism | Membrane Transport Proteins - metabolism | Neoplasm Proteins - genetics | Cell Line | Kidney Cortex - cytology | Kidney Tubules, Proximal - cytology | Neoplasm Proteins - biosynthesis | RNA, Messenger - genetics | Symporters - metabolism | ATP-Binding Cassette Transporters - biosynthesis | Membrane Transport Proteins - biosynthesis | ATP Binding Cassette Transporter, Sub-Family B - biosynthesis | Symporters - genetics | Kidney Tubules, Proximal - metabolism | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Monocarboxylic Acid Transporters - genetics | Symporters - biosynthesis | ATP Binding Cassette Transporter, Sub-Family B - genetics | Index Medicus
Journal Article
Neuroscience, ISSN 0306-4522, 2008, Volume 155, Issue 2, pp. 423 - 438
Abstract Nutrient transporters and ABC efflux pumps at the blood–brain barrier are major determinants of drug penetration into the brain. Immunohistochemical... 
Neurology | abluminal | cerebral microvessels | luminal | ABC transporter | choroid plexus | NEUROSCIENCES | P-GLYCOPROTEIN ABCB1 | MICROVESSEL ENDOTHELIUM | AMINO-ACID TRANSPORTER | ABLUMINAL MEMBRANE | GLUCOSE-TRANSPORTER | RESISTANCE-ASSOCIATED PROTEIN-1 | CENTRAL-NERVOUS-SYSTEM | CAPILLARY ENDOTHELIAL-CELLS | CHOROID-PLEXUS | MULTIDRUG TRANSPORTERS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Ependyma - blood supply | Cerebrovascular Circulation - physiology | Large Neutral Amino Acid-Transporter 1 - metabolism | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Choroid Plexus - metabolism | Glucose Transporter Type 1 - metabolism | Male | Gene Expression Profiling | Choroid Plexus - ultrastructure | Blood-Brain Barrier - ultrastructure | Microcirculation - physiology | Choroid Plexus - blood supply | Monocarboxylic Acid Transporters - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Membrane Transport Proteins - genetics | ATP-Binding Cassette Transporters - metabolism | Blood-Brain Barrier - physiology | Membrane Transport Proteins - metabolism | Multidrug Resistance-Associated Proteins - genetics | Cell Line | Biotinylation | Rats | Ependyma - metabolism | Large Neutral Amino Acid-Transporter 1 - genetics | Kidney - cytology | Rats, Sprague-Dawley | Blotting, Western | Symporters - metabolism | Animals | Glucose Transporter Type 1 - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Symporters - genetics | Microcirculation - ultrastructure | Monocarboxylic Acid Transporters - genetics | Multidrug Resistance-Associated Proteins - metabolism | Ependyma - ultrastructure | Phosphates | Glucose metabolism | Brain | Fluorescein | Biotin | Glucose | Drug resistance | Intermediate filament proteins | Dextrose | Protein binding
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, pp. e0121232 - e0121232
Diesel exhaust particles (DEPs) are common environmental air pollutants primarily affecting the lung. DEPs or chemicals adsorbed on DEPs also exert... 
PRIMARY HUMAN HEPATOCYTES | OXIDATIVE STRESS | ORGANIC EXTRACT | RAT HEPATOCYTES | ARYL-HYDROCARBON RECEPTOR | BILIARY-EXCRETION | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | MULTIDRUG-RESISTANCE | BLOOD-BRAIN-BARRIER | CANCER RESISTANCE PROTEIN | Taurocholic Acid - pharmacology | Inactivation, Metabolic | Humans | Liver - metabolism | Cells, Cultured | Organic Cation Transporter 1 - metabolism | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Symporters - metabolism | Liver - drug effects | ATP-Binding Cassette Transporters - metabolism | Vehicle Emissions | Primary Cell Culture | Multidrug Resistance-Associated Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | Hepatocytes - drug effects | Enzymes | Diesel motor exhaust gas | Polycyclic aromatic hydrocarbons | RNA | Dioxin | Lung cancer | Liver | TCDD | Hydrocarbons | Proteins | Blood-brain barrier | Diesel engines | Aromatic compounds | Rodents | Transporting | Pollutants | P-Glycoprotein | Efflux | Organic cation transporter | Polypeptides | Cytokines | Multidrug resistance | Detoxification | Glycoprotein | Glycoproteins | Breast cancer | Chemical contaminants | Gene expression | Chemicals | Substrates | Asthma | Organic chemistry | Organic anion transporting polypeptide | Sodium | Hepatocytes | Air pollution | Diesel | Transporter | Cancer | Bile | Index Medicus | Life Sciences
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 2009, Volume 1791, Issue 7, pp. 584 - 593
Journal Article