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by Fitzgerald, T.W and Gerety, S.S and Jones, W.D and Van Kogelenberg, M and King, D.A and McRae, J and Morley, K.I and Parthiban, V and Al-Turki, S and Ambridge, K and Barrett, D.M and Bayzetinova, T and Clayton, S and Coomber, E.L and Gribble, S and Jones, P and Krishnappa, N and Mason, L.E and Middleton, A and Miller, R and Prigmore, E and Rajan, D and Sifrim, A and Tivey, A.R and Ahmed, M and Akawi, N and Andrews, R and Anjum, U and Archer, H and Armstrong, R and Balasubramanian, M and Banerjee, R and Baralle, D and Batstone, P and Baty, D and Bennett, C and Berg, J and Bernhard, B and Bevan, A.P and Blair, E and Blyth, M and Bohanna, D and Bourdon, L and Bourn, D and Brady, A and Bragin, E and Brewer, C and Brueton, L and Brunstrom, K and Bumpstead, S.J and Bunyan, D.J and Burn, J and Burton, J and Canham, N and Castle, B and Chandler, K and Clasper, S and Clayton-Smith, J and Cole, T and Collins, A and Collinson, M.N and Connell, F and Cooper, N and Cox, H and Cresswell, L and Cross, G and Crow, Y and D'Alessandro, M and Dabir, T and Davidson, R and Davies, S and Dean, J and Deshpande, C and Devlin, G and Dixit, A and Dominiczak, A and Donnelly, C and Donnelly, D and Douglas, A and Duncan, A and Eason, J and Edkins, S and Ellard, S and Ellis, P and Elmslie, F and Evans, K and Everest, S and Fendick, T and Fisher, R and Flinter, F and Foulds, N and Fryer, A and Fu, B and Gardiner, C and Gaunt, L and Ghali, N and Gibbons, R and Gomes Pereira, S.L and Goodship, J and Goudie, D and ... and Deciphering Dev Disorders Study and Deciphering Developmental Disorders Study and The Deciphering Developmental Disorders Study
Nature, ISSN 0028-0836, 03/2015, Volume 519, Issue 7542, pp. 223 - 228
Despite three decades of successful, predominantly phenotype-driven discovery of the genetic causes of monogenic disorders(1), up to half of children with... 
INTELLECTUAL DISABILITY | HUMAN-DISEASE | DE-NOVO MUTATIONS | MULTIDISCIPLINARY SCIENCES | FRAMEWORK | MODEL | AUTISM SPECTRUM DISORDERS | COPY-NUMBER VARIATION | CHILDREN | Rare Diseases - genetics | Humans | Parents | Child, Preschool | Infant | Male | Developmental Disabilities - genetics | Dynamin I - genetics | Mutation, Missense - genetics | Polycomb Repressive Complex 1 - genetics | Gene Expression Regulation, Developmental | Transposases - genetics | Female | Nuclear Proteins - genetics | Child | Developmental Disabilities - diagnosis | Infant, Newborn | Guanine Nucleotide Exchange Factors - genetics | Protein Phosphatase 2 - genetics | Protein-Serine-Threonine Kinases - genetics | United Kingdom | Phosphoproteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Genome, Human - genetics | Homeodomain Proteins - genetics | Zebrafish - genetics | Chromosomal Proteins, Non-Histone - genetics | Carrier Proteins - genetics | DEAD-box RNA Helicases - genetics | Exome - genetics | Animals | Adolescent | Chromosome Aberrations | Genes, Dominant - genetics | Usage | Genomics | Child development deviations | Genetic aspects | Research | Risk factors | Developmental disabilities | Studies | Hypotheses | Genes | Developmental psychology | Families & family life | Genomes | Mutation | Children & youth | Index Medicus
Journal Article
Journal Article
Nature Methods, ISSN 1548-7091, 05/2009, Volume 6, Issue 5, pp. 363 - 369
Induced pluripotent stem cells (iPSCs) have been generated from somatic cells by transgenic expression of Oct4 (Pou5f1), Sox2, Klf4 and Myc. A major difficulty... 
DEFINED FACTORS | BIOCHEMICAL RESEARCH METHODS | DYSPLASIA | HUMAN FIBROBLASTS | KERATINOCYTES | INDUCTION | DIFFERENTIATION | HUMAN SOMATIC-CELLS | EFFICIENT | EXPRESSION | VECTORS | RNA-Binding Proteins - genetics | Gene Expression - genetics | Homeodomain Proteins - metabolism | Humans | Alkaline Phosphatase - metabolism | Valproic Acid - pharmacology | Embryo, Mammalian - metabolism | SOXB1 Transcription Factors - metabolism | Moths - genetics | Octamer Transcription Factor-3 - genetics | Chimera - embryology | Transfection | SOXB1 Transcription Factors - genetics | Kruppel-Like Transcription Factors - metabolism | Transposases - genetics | DNA Transposable Elements - genetics | Transgenes | Cell Differentiation - physiology | Nanog Homeobox Protein | Pluripotent Stem Cells - cytology | Cell Dedifferentiation - drug effects | Repressor Proteins - genetics | Proto-Oncogene Proteins c-myc - metabolism | Genetic Vectors - genetics | Pluripotent Stem Cells - metabolism | Teratoma - pathology | Animals | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Octamer Transcription Factor-3 - metabolism | Pluripotent Stem Cells - transplantation | Fibroblasts - cytology | Mice | Proto-Oncogene Proteins c-myc - genetics | Cell Dedifferentiation - genetics | Chimera - metabolism | Kruppel-Like Transcription Factors - genetics | RNA-Binding Proteins - metabolism | Physiological aspects | Transposons | Nuclear reprogramming | Research | Gene expression | Genetic engineering | Rodents | Research methodology | Stem cells | Index Medicus
Journal Article
Nature Biotechnology, ISSN 1087-0156, 06/2004, Volume 22, Issue 6, pp. 695 - 700
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 509, Issue 7502, pp. 612 - 616
Journal Article
Nature Biotechnology, ISSN 1087-0156, 01/2000, Volume 18, Issue 1, pp. 81 - 84
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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2014, Volume 111, Issue 26, pp. 9591 - 9596
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Nucleic Acids Research, ISSN 0305-1048, 11/2000, Volume 28, Issue 21, pp. 4317 - 4331
Journal Article