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PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, p. e0131177
Antibody drug conjugates (ADCs) have recently been proven to be highly potent anti-tumor drugs, typically exceeding the efficacy of conventional monoclonal... 
RECOMBINANT IMMUNOTOXIN | IMMUNOGENICITY | MULTIDISCIPLINARY SCIENCES | PURIFICATION | SURFACE-PROTEINS | STAPHYLOCOCCUS-AUREUS | ANTITUMOR-ACTIVITY | MONOCLONAL-ANTIBODIES | FRAGMENTATION | CANCER-THERAPY | PROTEIN LIGATION | Cysteine Endopeptidases - chemistry | Staphylococcus aureus - enzymology | Aminoacyltransferases - immunology | Receptor, ErbB-2 - genetics | Humans | Bacterial Proteins - chemistry | Ovarian Neoplasms - pathology | Ki-1 Antigen - immunology | Maytansine - pharmacology | Immunoconjugates - immunology | Immunoconjugates - pharmacology | Antibodies, Monoclonal, Humanized - pharmacology | Protein Engineering | Maytansine - chemistry | Female | Antineoplastic Agents - pharmacology | Bacterial Proteins - immunology | Receptor, ErbB-2 - antagonists & inhibitors | Receptor, ErbB-2 - immunology | Oligopeptides - chemistry | Ovarian Neoplasms - drug therapy | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Aminoacyltransferases - chemistry | Antineoplastic Agents - immunology | Maytansine - analogs & derivatives | Antibodies, Monoclonal - pharmacology | Oligopeptides - immunology | Antineoplastic Agents - chemistry | Immunoconjugates - chemistry | Staphylococcus aureus - chemistry | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Ki-1 Antigen - antagonists & inhibitors | Mice | Antibodies, Monoclonal, Humanized - immunology | Cysteine Endopeptidases - immunology | Maytansine - immunology | Trastuzumab | Antibodies, Monoclonal, Humanized - chemistry | Ki-1 Antigen - genetics | Ovarian Neoplasms - immunology | Monoclonal antibodies | Enzymes | Cysteine | Peptides | Biopharmaceutics | Drugs | Conjugates | Addition polymerization | Ovarian carcinoma | Clinical trials | Pentaglycine | Cancer therapies | Molecular weight | Ovarian cancer | Proteins | Tubulin | CD30 antigen | Xenografts | Medical research | Immunoglobulins | Polypeptides | Cloning | Polymerization | Breast cancer | ErbB-2 protein | Substrates | Chemotherapy | Lysine | Heavy chains | Toxins | Conjugation | Sortase | Tumors | Cancer
Journal Article
Journal of Immunology, ISSN 0022-1767, 06/2013, Volume 190, Issue 11, pp. 5588 - 5599
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2011, Volume 108, Issue 17, pp. 7142 - 7147
Trastuzumab, a monoclonal antibody targeting human epidermal growth factor receptor-2 (HER2/ErbB-2), has become the mainstay of treatment for HER2-positive... 
T lymphocytes | Inoculation | Medical treatment | Antibodies | Cytotoxicity | Breast cancer | Adaptive immunity | Natural killer cells | Tumors | Cancer | Natural killer cell | Innate | Adaptive | Tumor immunology | tumor immunology | TRASTUZUMAB | MECHANISM | MULTIDISCIPLINARY SCIENCES | innate | OVEREXPRESSING HER2 | COMBINATION | HER2-POSITIVE BREAST-CANCER | ADAPTIVE IMMUNITY | adaptive | IMMUNOTHERAPY | MICE | natural killer cell | PHASE-I | ESTABLISHED TUMORS | Receptor, ErbB-2 - genetics | Receptors, Interleukin-1 Type I - immunology | CD8-Positive T-Lymphocytes - transplantation | Humans | Receptors, Interleukin-17 - immunology | Receptors, Interleukin-17 - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | Adoptive Transfer | Interferon Type I - immunology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Antibodies, Monoclonal, Humanized | Receptor, ErbB-2 - immunology | Interferon-gamma - genetics | Antibodies, Monoclonal - immunology | Mammary Neoplasms, Animal - genetics | Mammary Neoplasms, Animal - immunology | Antibodies, Monoclonal - pharmacology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Mice, Transgenic | Antineoplastic Combined Chemotherapy Protocols - immunology | Mice, SCID | Animals | Apoptosis Regulatory Proteins | Interferon-gamma - immunology | Receptors, Interleukin-1 Type I - genetics | Cell Line, Tumor | Interferon Type I - genetics | Programmed Cell Death 1 Receptor | Antigens, Surface | Mammary Neoplasms, Animal - drug therapy | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Trastuzumab | Biological Sciences
Journal Article
Breast cancer research : BCR, ISSN 1465-5411, 2014, Volume 16, Issue 1, pp. 488 - 488
Journal Article
Nature Biotechnology, ISSN 1087-0156, 01/2012, Volume 30, Issue 2, pp. 184 - 189
Journal Article
Cancer Research, ISSN 0008-5472, 02/2007, Volume 67, Issue 4, pp. 1842 - 1852
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2014, Volume 193, Issue 10, pp. 5161 - 5170
Previous investigations demonstrated that protein tyrosine phosphatase, receptor type, O (PTPRO) acts as a tumor suppressor in liver cancer; however, little is... 
BREAST-CANCER | PROTEIN | TRASTUZUMAB | INDUCED APOPTOSIS | PHOSPHATASE | DISEASE | MOUSE | IMMUNOLOGY | BETA-CATENIN | MEDIATED LIVER-INJURY | EXPRESSION | Inflammation - chemically induced | Inflammation - pathology | Liver - pathology | Receptor, ErbB-2 - genetics | Humans | NF-kappa B - immunology | Glycogen Synthase Kinase 3 beta | Hepatocytes - pathology | Male | Killer Cells, Natural - pathology | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - genetics | Glycogen Synthase Kinase 3 - immunology | Proto-Oncogene Proteins c-akt - genetics | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - deficiency | beta Catenin - immunology | Liver - immunology | Hepatitis, Animal - mortality | Killer Cells, Natural - immunology | Receptor, ErbB-2 - immunology | T-Lymphocytes - pathology | Inflammation - mortality | Hepatitis, Animal - chemically induced | NF-kappa B - agonists | Hepatitis, Animal - pathology | Severity of Illness Index | Acute Disease | Signal Transduction | Hepatitis, Animal - immunology | Interferon-gamma - secretion | Gene Expression Regulation | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - immunology | Inflammation - immunology | Concanavalin A | Hepatocytes - immunology | beta Catenin - genetics | Mice, Knockout | Animals | Proto-Oncogene Proteins c-akt - immunology | Glycogen Synthase Kinase 3 - genetics | NF-kappa B - genetics | Interferon-gamma - immunology | Survival Analysis | T-Lymphocytes - immunology | Mice
Journal Article
Journal Article
Breast Cancer Research, ISSN 1465-5411, 06/2014, Volume 16, Issue 3, pp. R61 - R61
Introduction: The human epidermal growth factor receptor 2 (HER2) represents one of the most studied tumor-associated antigens (TAAs) for cancer immunotherapy.... 
REGRESSION | ONCOLOGY | IN-VIVO | ANTIBODY | MODIFIED T-CELLS | ANTITUMOR-ACTIVITY | ANTIGEN RECEPTOR | SIGNALING DOMAIN | EXPRESSION | ADOPTIVE IMMUNOTHERAPY | CD28 COSTIMULATION | Recombinant Fusion Proteins - immunology | Neoplasm Transplantation | Receptor, ErbB-2 - genetics | Breast Neoplasms - immunology | Humans | Drug Resistance, Neoplasm | Transplantation, Heterologous | Chromium Isotopes - chemistry | CD3 Complex - genetics | Interleukin-2 - immunology | Single-Chain Antibodies - genetics | CD28 Antigens - genetics | MCF-7 Cells | T-Lymphocytes - metabolism | Antibodies, Monoclonal, Humanized - pharmacology | Female | Receptor, ErbB-2 - antagonists & inhibitors | Receptor, ErbB-2 - immunology | Ovarian Neoplasms - drug therapy | Antibodies, Monoclonal - immunology | Gene Transfer Techniques | Antineoplastic Agents | CD28 Antigens - immunology | Mice, SCID | Breast Neoplasms - drug therapy | Antibodies, Monoclonal - genetics | Animals | Interferon-gamma - immunology | CD3 Complex - immunology | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Mice, Inbred NOD | T-Lymphocytes - immunology | Mice | Single-Chain Antibodies - immunology | Trastuzumab | Ovarian Neoplasms - immunology | Care and treatment | Epidermal growth factor | Immunity | Enzyme-linked immunosorbent assay | Cancer | Interferon gamma | Ovarian cancer
Journal Article
Blood, ISSN 0006-4971, 10/2013, Volume 122, Issue 18, pp. 3160 - 3164
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2017, Volume 23, Issue 17, pp. 5210 - 5217
Purpose: The immune microenvironment of breast ductal carcinoma in situ (DCIS) has yet to be fully explored, and the relationship of immune cells to genetic... 
TUMOR-INFILTRATING LYMPHOCYTES | CANCER PATIENTS | SURVIVAL | TRASTUZUMAB | ONCOLOGY | PD-L1 | RISK | NIVOLUMAB | BLOCKADE | EXPRESSION | DOCETAXEL | GATA3 Transcription Factor - genetics | CD8-Positive T-Lymphocytes - pathology | Class I Phosphatidylinositol 3-Kinases - genetics | Receptor, ErbB-2 - genetics | Breast Neoplasms - immunology | Carcinoma, Ductal - genetics | Carcinoma, Ductal - pathology | GATA3 Transcription Factor - immunology | Humans | Middle Aged | Carcinoma, Ductal - immunology | Gene Expression Regulation, Neoplastic | Class I Phosphatidylinositol 3-Kinases - immunology | Tumor Suppressor Protein p53 - genetics | Tumor Microenvironment - genetics | Adult | Female | Receptor, ErbB-2 - immunology | Tumor Suppressor Protein p53 - immunology | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Disease Progression | Tumor Microenvironment - immunology | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Aged | Biomarkers, Tumor - genetics | CD8-Positive T-Lymphocytes - immunology | Biomarkers, Tumor - immunology | Immunohistochemistry | Copy number | Invasiveness | p53 Protein | Stroma | Staining | Aneuploidy | L1 protein | Breast cancer | Genomes | Mammography | ErbB-2 protein | Experimental design | Lymphocytes | Quality | PD-L1 protein | GATA-3 protein | Breast | Mutation | Tumors | Cancer | Immune system
Journal Article
Journal of Immunological Methods, ISSN 0022-1759, 12/2014, Volume 414, pp. 69 - 81
Journal Article