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Journal Article
Cancer Treatment Reviews, ISSN 0305-7372, 2014, Volume 41, Issue 2, pp. 170 - 178
Highlights • Inhibition of signaling and immunotherapy are emerging treatments for bladder cancer. • FGFR mutations/translocations are promising biomarkers for... 
Hematology, Oncology and Palliative Medicine | Treatment | Targeted therapy | Bladder cancer | Immunotherapy | Urothelial bladder carcinoma | URINARY-BLADDER | HEAT-SHOCK PROTEIN-27 | KINASE INHIBITOR | ANTITUMOR-ACTIVITY | AURORA KINASE | GROWTH-FACTOR RECEPTOR | SELECTIVE INHIBITOR | TRANSITIONAL-CELL-CARCINOMA | ONCOLOGY | VOLASERTIB BI 6727 | PHASE-I | Cyclin D1 - metabolism | Translocation, Genetic | Immunotherapy - methods | TOR Serine-Threonine Kinases - metabolism | Humans | Receptor, ErbB-2 - metabolism | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Maytansine - pharmacology | Cell Cycle Proteins - antagonists & inhibitors | Antibodies, Monoclonal, Humanized - pharmacology | Tumor Suppressor Proteins - genetics | Urinary Bladder Neoplasms - pathology | Biomarkers, Tumor - metabolism | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Urinary Bladder Neoplasms - metabolism | Molecular Targeted Therapy - methods | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Aurora Kinases - metabolism | Maytansine - analogs & derivatives | Neoplasm Invasiveness | Heat-Shock Proteins - metabolism | Cell Cycle Proteins - metabolism | Carcinoma, Transitional Cell - metabolism | Clinical Trials as Topic | Urinary Bladder Neoplasms - drug therapy | Cyclin-Dependent Kinase 4 - metabolism | B7-H1 Antigen - antagonists & inhibitors | Carcinoma, Transitional Cell - pathology | Signal Transduction - drug effects | Carcinoma, Transitional Cell - drug therapy | Mutation | CTLA-4 Antigen - antagonists & inhibitors | Trastuzumab | Heat shock proteins | Chemotherapy | Health aspects | Cancer
Journal Article
Cancer Cell, ISSN 1535-6108, 2004, Volume 6, Issue 2, pp. 117 - 127
Journal Article
American Journal of Pathology, ISSN 0002-9440, 2010, Volume 177, Issue 4, pp. 1647 - 1656
Phosphatase and tensin homolog (PTEN) is a key modulator of trastuzumab sensitivity in HER2-overexpressing breast cancer. Because PTEN opposes the downstream... 
ADJUVANT CHEMOTHERAPY | CELLS | INHIBITION | THERAPY | HUMAN-BREAST-CANCER | MUTATIONS | PATHOLOGY | RECEPTORS | TRASTUZUMAB RESISTANCE | EXPRESSION | CARCINOMA | Lung Neoplasms - drug therapy | Receptors, Estrogen - metabolism | Receptor, ErbB-2 - genetics | Lung Neoplasms - mortality | Humans | Middle Aged | Bone Neoplasms - secondary | Antibodies, Monoclonal - therapeutic use | Immunoenzyme Techniques | Receptors, Progesterone - metabolism | Young Adult | Carcinoma, Ductal, Breast - drug therapy | Brain Neoplasms - mortality | Liver Neoplasms - secondary | Proto-Oncogene Proteins c-akt - metabolism | Carcinoma, Ductal, Breast - metabolism | PTEN Phosphohydrolase - genetics | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Survival Rate | Lymphatic Metastasis | Brain Neoplasms - drug therapy | Mutation - genetics | Breast Neoplasms - drug therapy | Class I Phosphatidylinositol 3-Kinases | Carcinoma, Lobular - metabolism | Trastuzumab | Bone Neoplasms - mortality | Phosphorylation | Prognosis | Receptor, ErbB-2 - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Liver Neoplasms - mortality | Carcinoma, Ductal, Breast - mortality | Carcinoma, Lobular - mortality | Breast Neoplasms - metabolism | Antibodies, Monoclonal, Humanized | Brain Neoplasms - secondary | In Situ Hybridization | Lung Neoplasms - secondary | Adult | Female | Bone Neoplasms - drug therapy | Neoplasm Invasiveness | Liver Neoplasms - drug therapy | PTEN Phosphohydrolase - metabolism | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - mortality | Aged | Carcinoma, Lobular - drug therapy | Regular
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2012, Volume 18, Issue 9, pp. 2502 - 2514
Purpose: The clinical use of BRAF inhibitors is being hampered by the acquisition of drug resistance. This study shows the potential therapeutic use of the... 
BREAST-CANCER | MULTIPLE-MYELOMA | APOPTOSIS | PHASE-II TRIAL | TANESPIMYCIN 17-AAG | TRASTUZUMAB | ONCOLOGY | BIM | ACQUIRED-RESISTANCE | MELANOMA-CELLS | POTENTIAL MECHANISM | Prospective Studies | Apoptosis - drug effects | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Immunoenzyme Techniques | Forkhead Transcription Factors - metabolism | Colony-Forming Units Assay | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Phthalic Acids - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Real-Time Polymerase Chain Reaction | Proto-Oncogene Proteins B-raf - metabolism | Membrane Proteins - genetics | Melanoma - pathology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Indoles - adverse effects | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Mice | Mice, Inbred BALB C | Forkhead Box Protein O3 | Azabicyclo Compounds - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Flow Cytometry | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Forkhead Transcription Factors - antagonists & inhibitors | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Phosphatidylinositol 3-Kinases - genetics | Animals | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Myeloid Cell Leukemia Sequence 1 Protein | Apoptosis Regulatory Proteins - antagonists & inhibitors | Fluorescent Antibody Technique | Sulfonamides - adverse effects | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-bcl-2 - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects
Journal Article
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2012, Volume 47, Issue 4, pp. 570 - 584
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 35, pp. 37269 - 37280
Journal Article
Annals of Oncology, ISSN 0923-7534, 2015, Volume 26, Issue 8, pp. 1533 - 1546
The 14th St Gallen International Breast Cancer Conference (2015) reviewed substantial new evidence on locoregional and systemic therapies for early breast... 
Radiation therapy | Early breast cancer | St Gallen Consensus | Systemic adjuvant therapies | Surgery | early breast cancer | ADJUVANT CHEMOTHERAPY | ENDOCRINE THERAPY | PREMENOPAUSAL WOMEN | ESTROGEN-RECEPTOR | PATHOLOGICAL COMPLETE RESPONSE | TUMOR-INFILTRATING LYMPHOCYTES | OVARIAN-FUNCTION SUPPRESSION | NEOADJUVANT CHEMOTHERAPY | ONCOLOGY | radiation therapy | SENTINEL NODE | CONTRALATERAL PROPHYLACTIC MASTECTOMY | systemic adjuvant therapies | surgery | Carcinoma, Lobular - pathology | Receptors, Estrogen - metabolism | Humans | Carcinoma, Intraductal, Noninfiltrating - metabolism | Mastectomy - methods | Receptor, ErbB-2 - metabolism | Tamoxifen - administration & dosage | Breast Neoplasms - metabolism | Receptors, Progesterone - metabolism | Breast Neoplasms - therapy | Anthracyclines - administration & dosage | Carcinoma, Lobular - therapy | Carcinoma, Intraductal, Noninfiltrating - therapy | Antineoplastic Agents, Hormonal - therapeutic use | Axilla | Carcinoma, Ductal, Breast - pathology | Female | Carcinoma, Ductal, Breast - metabolism | Mastectomy, Segmental - methods | Trastuzumab - administration & dosage | Carcinoma, Ductal, Breast - therapy | Taxoids - administration & dosage | Carcinoma, Intraductal, Noninfiltrating - pathology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Chemotherapy, Adjuvant - methods | Radiotherapy, Adjuvant - methods | Carcinoma, Lobular - metabolism | Platinum Compounds - administration & dosage | Lymph Node Excision - methods | Neoplasm Staging | Practice Guidelines as Topic | Special
Journal Article