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Nature Reviews Drug Discovery, ISSN 1474-1776, 03/2010, Volume 9, Issue 3, pp. 215 - 236
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 04/2018, Volume 556, Issue 7702, pp. 457 - 462
Every cancer originates from a single cell. During expansion of the neoplastic cell population, individual cells acquire genetic and phenotypic differences... 
Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | Transcriptome | Mutation Rate | Colorectal Neoplasms/drug therapy | Antineoplastic Agents/pharmacology | DNA Methylation | DNA Mutational Analysis | Intestines/cytology | Intestinal Mucosa/metabolism | Organoids/cytology | Clone Cells/drug effects | Mutation | Single-Cell Analysis | Evolution, Molecular | HUMAN COLON | GENOMIC INSTABILITY | MUTATIONAL PROCESSES | BIOCONDUCTOR PACKAGE | EXPRESSION ANALYSIS | DNA METHYLATION | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | CHRONIC LYMPHOCYTIC-LEUKEMIA | SEQUENCING REVEALS | SOMATIC MUTATIONS | Intestines - drug effects | Intestinal Mucosa - metabolism | Clone Cells - drug effects | Colorectal Neoplasms - genetics | Colorectal Neoplasms - drug therapy | Organoids - metabolism | Antineoplastic Agents - pharmacology | Colorectal Neoplasms - metabolism | Intestines - pathology | Organoids - pathology | Organoids - cytology | Clone Cells - metabolism | Clone Cells - pathology | Organoids - drug effects | Colorectal Neoplasms - pathology | Intestines - cytology | Physiological aspects | Development and progression | Colorectal cancer | Genomics | Colorectal carcinoma | Genomes | Phylogeny | Population genetics | Antitumor agents | Organoids | Intestine | DNA methylation | Phylogenetics | Bioinformatics | Deoxyribonucleic acid--DNA | Trees | Phenotypes | Cloning | Genetic diversity | Diversification | Gene expression | Algorithms | Crypts | Methylation | Cancer | Tumors
Journal Article